研究等業績 - 原著論文 - 三島 和夫
-
Yuya Takahashi, Sho Shindo, Takashi Kanbayashi, Masahiro Takeshima, Aya Imanishi, Kazuo Mishima
Neuropsychopharmacology reports ( Wiley ) 40 ( 1 ) 10 - 15 2020年03月 [査読有り]
研究論文（学術雑誌） 国内共著
We examined whether symptoms of dementia are improved by olfactory nerve stimulation in Alzheimer type dementia patients. First, a stick-type olfactory identification ability test was performed in patients with Alzheimer type dementia, to select patients without olfactory dysfunctions. Then, these patients were randomly assigned into the intervention (n = 19) and the control groups (n = 17). To evaluate the effects of olfactory nerve stimulation, we exposed the intervention group to a disinfecting ethanol with added aroma extracts from ceder and the control group to the ethanol without the added aroma extracts. Each group underwent the intervention for 8 weeks, cognitive and behavioral functions were evaluated before and after treatments using the Neuropsychiatric Inventory (NPI), the Japanese version of Zarit Caregiver Burden interview (J-ZBI), and the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog). A significant improvement was observed in the NPI score and J-ZBI in the intervention group compared to the control group at 4 and 8 weeks. On the other hand, there was no significant difference in the score of ADAS-cog. Exposure to cedar fragrance improved behavioral and psychological symptoms of dementia (BPSD) in Alzheimer type dementia and may reduce the burden of nursing care. In addition to its effectiveness, the procedure is simple and minimally invasive and would be a valuable non-pharmaceutical treatment.
-
Tracking intermediate performance of vigilant attention using multiple eye metrics
Takashi Abe, Kazuo Mishima, Shingo Kitamura, Akiko Hida, Yuichi Inoue, Koh Mizuno, Kosuke Kaida, Kyoko Nakazaki, Yuki Motomura, Kazushi Maruo, Toshiko Ohta, Satoshi Furukawa, David F Dinges, Katsuhiko Ogata
Sleep ( Oxford University Press (OUP) ) 43 ( 3 ) 2020年03月 [査読有り]
研究論文（学術雑誌） 国内共著
<title>Abstract</title>
Vigilance deficits account for a substantial number of accidents and errors. Current techniques to detect vigilance impairment measure only the most severe level evident in eyelid closure and falling asleep, which is often too late to avoid an accident or error. The present study sought to identify ocular biometrics of intermediate impairment of vigilance and develop a new technique that could detect a range of deficits in vigilant attention (VA). Sixteen healthy adults performed well-validated Psychomotor Vigilance Test (PVT) for tracking vigilance attention while undergoing simultaneous recording of eye metrics every 2 hours during 38 hours of continuous wakefulness. A novel marker was found that measured VA when the eyes were open—the prevalence of microsaccades. Notably, the prevalence of microsaccades decreased in response to sleep deprivation and time-on-task. In addition, a novel algorithm for detecting multilevel VA was developed, which estimated performance on the PVT by integrating the novel marker with other eye-related indices. The novel algorithm also tracked changes in intermediate level of VA (specific reaction times in the PVT, i.e. 300–500 ms) during prolonged time-on-task and sleep deprivation, which had not been tracked previously by conventional techniques. The implication of the findings is that this novel algorithm, named “eye-metrical estimation version of the PVT: PVT-E,” can be used to reduce human-error-related accidents caused by vigilance impairment even when its level is intermediate. -
Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia.
Takahashi Y, Shindo S, Kanbayashi T, Takeshima M, Imanishi A, Mishima K.
Neuropsychopharmacol Rep. 9 ( 10 ) 12096 2020年02月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Association Between the Use of Antidepressants and the Risk of Type 2 Diabetes Mellitus: A Large, Population-Based Cohort Study in Japan.
Miidera H, Enomoto M, Kitamura S, Tachimori H, Mishima K.
Diabetes Care 12 ( 10 ) dc19-1175 2020年02月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Tracking intermediate performance of vigilant attention using multiple eye metrics.
Abe T, Mishima K, Kitamura S, Hida A, Inoue Y, Mizuno K, Kaida K, Nakazaki K, Motomura Y, Maruo K, Ohta T, Furukawa S, Dinges DF, Ogata K.
Sleep 43 5733056 2020年02月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Kishi T.
Molecular Psychiatry ( Molecular Psychiatry ) 2020年 [査読有り]
研究論文（学術雑誌） 国内共著
-
Prevalence of asymptomatic venous thromboembolism in depressive inpatients
Takeshima M.
Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment ) 16 579 - 587 2020年 [査読有り]
研究論文（学術雑誌） 国内共著
-
Kishi T.
Psychological Medicine ( Psychological Medicine ) 2020年 [査読有り]
研究論文（学術雑誌） 国内共著
-
Yoshimura M.
Biological Rhythm Research ( Biological Rhythm Research ) 2020年 [査読有り]
研究論文（学術雑誌） 国内共著
-
Long-term use of hypnotics: Analysis of trends and risk factors.
Enomoto M, Kitamura S, Tachimori H, Takeshima M, Mishima K.
Gen Hosp Psychiatry 62 49 - 55 2019年12月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Miyagawa T.
Journal of Human Genetics ( Journal of Human Genetics ) 64 ( 12 ) 1219 - 1225 2019年12月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Psychosocial intervention for discontinuing benzodiazepine hypnotics in patients with chronic insomnia: A systematic review and meta-analysis.
Takaesu Y, Utsumi T, Okajima I, Shimura A, Kotorii N, Kuriyama K, Yamashita H, Suzuki M, Watanabe N, Mishima K.
Sleep Med Rev. 48 101214 2019年10月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Oya K.
Neuropsychopharmacology Reports ( Neuropsychopharmacology Reports ) 39 ( 3 ) 241 - 246 2019年09月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Brexpiprazole as adjunctive treatment for major depressive disorder following treatment failure with at least one antidepressant in the current episode: a systematic review and meta-analysis.
Kishi T, Sakuma K, Nomura I, Matsuda Y, Mishima K, Iwata N.
Int J Neuropsychopharmacol. 27 5539907 2019年07月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Melatonin receptor agonists-ramelteon and melatonin-for bipolar disorder: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials.
Kishi T, Nomura I, Sakuma K, Kitajima T, Mishima K, Iwata N.
Neuropsychiatr Dis Treat. 15 1479 - 1486 2019年06月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Sleep problem but not chronotype is associated with retirement from shift work: a cross-sectional retrospective study.
Kitamura S, Takahashi M, Mishima K.
Sleep and Biological Rhythms 17 331 - 337 2019年04月 [査読有り]
研究論文（学術雑誌） 国内共著
-
機械学習を用いた動画解析による生体情報の自動追跡技術 ：瞼裂幅計測に用いた一例
西村 英伍, 元村 祐貴, 勝沼 るり, 吉村 道孝, 三島 和夫, 尾方 義人
日本生理人類学会誌 ( 日本生理人類学会 ) 24 ( 1 ) 35 - 45 2019年 [査読有り]
研究論文（学術雑誌） 国内共著
Methods of human motion tracking for acquiring biometric information are needed in order to apply knowledgeof physiological anthropology. However, previous methods have difficulty in control of video shooting conditions.Thus, we developed a more robust motion tracking method using machine learning. In this report, we evaluated theaccuracy of our method by comparing palpebral fissure height measured using manually selected data and trackingdata obtained using YOLOv3. The results indicate that our method has practical accuracy in measuring palpebral fissureheight and suggest that including noise in training data contributes to its accuracy.
-
Prevalence of childhood obstructive sleep apnea syndrome and its role in daytime sleepiness.
Tsukada E, Kitamura S, Enomoto M, Moriwaki A, Kamio Y, Asada T, Arai T, Mishima K.
PLoS One 13 ( 10 ) e0204409 2018年10月 [査読有り]
研究論文（学術雑誌） 国内共著
-
A variant at 9q34.11 is associated with HLA-DQB1 06:02 negative essential hypersomnia.
Miyagawa T, Khor SS, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Ariyoshi Y, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Ikegami A, Wada Y, Takami M, Higashiyama Y, Miyake R, Kondo H, Fujimura Y, Tamura Y, Taniyama Y, Omata N, Tanaka Y, Moriya S, Furuya H, Kato M, Kawamura Y, Otowa T, Miyashita A, Kojima H, Saji H, Shimada M, Yamasaki M, Kobayashi T, Misawa R, Shigematsu Y, Kuwano R, Sasaki T, Ishigooka J, Wada Y, Tsuruta K, Chiba S, Tanaka F, Yamada N, Okawa M, Kuroda K, Kume K, Hirata K, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K.
J Hum Genet. 28 ( 10 ) 018 - 0518 2018年09月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Evidence for the Efficacy of Bright Light Therapy for Bipolar Depression.
Benedetti F, Avery DH, Bauer M, Bunney WE, Çaliyurt O, Camardese G, Colombo C, Dallaspezia S, Henriksen TE, Kasper S, Kuriyama K, Lam RW, Martiny K, Meesters Y, Mishima K, Schulte R, Suzuki M, Święcicki Ł, Uchiyama M, Veale D, Winkler D, Wu J, Kupeli NY, Yoshiike T, Yu X
Am J Psychiatry ( American Psychiatric Association Publishing ) 175 ( 9 ) 905 - 906 2018年09月 [査読有り]
研究論文（学術雑誌） 国際共著