Research Achievements - Original paper -
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Effectiveness of cognitive behavioral therapy for pharmacotherapy-resistant chronic insomnia: a multi-center randomized controlled trial in Japan.
Ayabe N, Okajima I, Nakajima S, Inoue Y, Watanabe N, Yamadera W, Uchimura N, Tachimori H, Kamei Y, Mishima K.
Sleep Med. 50 105 - 112 2018.06 [Refereed]
Research paper (journal) Domestic Co-author
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Effect of discontinuation v. maintenance of antipsychotic medication on relapse rates in patients with remitted/stable first-episode psychosis: a meta-analysis.
Kishi T, Ikuta T, Matsui Y, Inada K, Matsuda Y, Mishima K, Iwata N
Psychol Med. 18 1 - 8 2018.06 [Refereed]
Research paper (journal) Domestic Co-author
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Two Days' Sleep Debt Causes Mood Decline During Resting State Via Diminished Amygdala-Prefrontal Connectivity.
Motomura Y, Katsunuma R, Yoshimura M, Mishima K.
Sleep 40 ( 10 ) pii: zsx133 2017.10 [Refereed]
Research paper (journal) Domestic Co-author
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Unrecognized Sleep Loss Accumulated in Daily Life Can Promote Brain Hyperreactivity to Food Cue
Ruri Katsunuma, Kentaro Oba, Shingo Kitamura, Yuki Motomura, Yuri Terasawa, Kyoko Nakazaki, Akiko Hida, Yoshiya Moriguchi, Kazuo Mishima
SLEEP ( OXFORD UNIV PRESS INC ) 40 ( 10 ) 2017.10 [Refereed]
Research paper (journal) Domestic Co-author
Epidemiological studies have shown that sleep debt increases the risk of obesity. Experimental total sleep deprivation (TSD) has been reported to activate the reward system in response to food stimuli, but food-related responses in everyday sleep habits, which could lead to obesity, have not been addressed. Here, we report that habitual sleep time at home among volunteers without any sleep concerns was shorter than their optimal sleep time estimated by the 9-day extended sleep intervention, which indicates that participants had already been in sleep debt in their usual sleep habits. The amygdala and anterior insula, which are responsible for both affective responses and reward prediction, were found to exhibit significantly lowered activity in the optimal sleep condition. Additionally, a subsequent one-night period of TSD reactivated the right anterior insula in response to food images; however, the activity level of amygdala remained lowered. These findings indicate that (1) our brain is at risk of hyperactivation to food triggers in everyday life, which could be a risk factor for obesity and lifestyle diseases, and (2) optimal sleep appears to reduce this hypersensitivity to food stimuli.
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Validation of Brain-Derived Signals in Near-Infrared Spectroscopy Through Multivoxel Analysis of Concurrent Functional Magnetic Resonance Imaging
Yoshiya Moriguchi, Takamasa Noda, Kosei Nakayashiki, Yohei Takata, Shiori Setoyama, Shingo Kawasaki, Yoshihiko Kunisato, Kazuo Mishima, Kazuyuki Nakagome, Takashi Hanakawa
HUMAN BRAIN MAPPING ( WILEY ) 38 ( 10 ) 5274 - 5291 2017.10 [Refereed]
Research paper (journal) Domestic Co-author
Near-infrared spectroscopy (NIRS) is a convenient and safe brain-mapping tool. However, its inevitable confounding with hemodynamic responses outside the brain, especially in the frontotemporal head, has questioned its validity. Some researchers attempted to validate NIRS signals through concurrent measurements with functional magnetic resonance imaging (fMRI), but, counterintuitively, NIRS signals rarely correlate with local fMRI signals in NIRS channels, although both mapping techniques should measure the same hemoglobin concentration. Here, we tested a novel hypothesis that different voxels within the scalp and the brain tissues might have substantially different hemoglobin absorption rates of near-infrared light, which might differentially contribute to NIRS signals across channels. Therefore, we newly applied a multivariate approach, a partial least squares regression, to explain NIRS signals with multivoxel information from fMRI within the brain and soft tissues in the head. We concurrently obtained fMRI and NIRS signals in 9 healthy human subjects engaging in an n-back task. The multivariate fMRI model was quite successfully able to predict the NIRS signals by cross-validation (interclass correlation coefficient = similar to 0.85). This result confirmed that fMRI and NIRS surely measure the same hemoglobin concentration. Additional application of Monte-Carlo permutation tests confirmed that the model surely reflects temporal and spatial hemodynamic information, not random noise. After this thorough validation, we calculated the ratios of the contributions of the brain and soft-tissue hemodynamics to the NIRS signals, and found that the contribution ratios were quite different across different NIRS channels in reality, presumably because of the structural complexity of the frontotemporal regions. (C) 2017 Wiley Periodicals, Inc.
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Reliability and validity of a brief sleep questionnaire for children in Japan.
Okada M, Kitamura S, Iwadare Y, Tachimori H, Kamei Y, Higuchi S, Mishima K.
J Physiol Anthropol. 36 ( 1 ) 35 2017.09 [Refereed]
Research paper (journal) Domestic Co-author
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Pathophysiology and strategic treatment of sighted non-24-h sleep–wake rhythm disorders.
Mishima K.
Sleep and Biological Rhythms 15 11 - 20 2017.09 [Refereed]
Research paper (journal) Single author
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Recovery from Unrecognized Sleep Loss Accumulated in Daily Life Improved Mood Regulation via Prefrontal Suppression of Amygdala Activity.
Motomura Y, Kitamura S, Nakazaki K, Oba K, Katsunuma R, Terasawa Y, Hida A, Moriguchi Y, Mishima K.
Front Neurol. 8 306 2017.07 [Refereed]
Research paper (journal) Domestic Co-author
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Validation of brain-derived signals in near-infrared spectroscopy through multivoxel analysis of concurrent functional magnetic resonance imaging.
Moriguchi Y, Noda T, Nakayashiki K, Takata Y, Setoyama S, Kawasaki S, Kunisato Y, Mishima K, Nakagome K, Hanakawa T.
Hum Brain Mapp. 38 ( 10 ) 5274 - 5291 2017.07 [Refereed]
Research paper (journal) Domestic Co-author
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ASSOCIATION BETWEEN MINDFULNESS TENDENCY ASSESSED BY FIVE FACET MINDFULNESS QUESTIONNAIRE AND REGIONAL GRAY MATTER VOLUME IN A JAPANESE POPULATION
Hiroki Murakami, Ruri Katsunuma, Kentaro Oba, Kazuo Mishima, Yoshiya Moriguchi
PSYCHOSOMATIC MEDICINE ( LIPPINCOTT WILLIAMS & WILKINS ) 79 ( 4 ) A61 - A61 2017.05 [Refereed]
Research paper (journal) Domestic Co-author
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Personal lifestyle as a resource for work engagement.
Nishi D, Suzuki Y, Nishida J, Mishima K, Yamanouchi Y.
J Occup Health. 59 ( 1 ) 17 - 23 2017.01 [Refereed]
Research paper (journal) Domestic Co-author
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Hida A.
Translational Psychiatry ( Translational Psychiatry ) 7 ( 4 ) 2017 [Refereed]
Research paper (journal) Domestic Co-author