Research Achievements - Original paper -

Recurrence of Mania or Depression Among Adult Bipolar Patients Who Continued Using Lithium: A Single-group Summary Meta-analysis of Randomized Trials

Kishi T.

Journal of clinical psychopharmacology ( Journal of clinical psychopharmacology )  40 ( 5 ) 468 - 474   2020.09  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia.

Yuya Takahashi, Sho Shindo, Takashi Kanbayashi, Masahiro Takeshima, Aya Imanishi, Kazuo Mishima

Neuropsychopharmacology reports ( Wiley )  40 ( 1 ) 10 - 15   2020.03  [Refereed]

Research paper (journal)   Domestic Co-author

We examined whether symptoms of dementia are improved by olfactory nerve stimulation in Alzheimer type dementia patients. First, a stick-type olfactory identification ability test was performed in patients with Alzheimer type dementia, to select patients without olfactory dysfunctions. Then, these patients were randomly assigned into the intervention (n = 19) and the control groups (n = 17). To evaluate the effects of olfactory nerve stimulation, we exposed the intervention group to a disinfecting ethanol with added aroma extracts from ceder and the control group to the ethanol without the added aroma extracts. Each group underwent the intervention for 8 weeks, cognitive and behavioral functions were evaluated before and after treatments using the Neuropsychiatric Inventory (NPI), the Japanese version of Zarit Caregiver Burden interview (J-ZBI), and the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog). A significant improvement was observed in the NPI score and J-ZBI in the intervention group compared to the control group at 4 and 8 weeks. On the other hand, there was no significant difference in the score of ADAS-cog. Exposure to cedar fragrance improved behavioral and psychological symptoms of dementia (BPSD) in Alzheimer type dementia and may reduce the burden of nursing care. In addition to its effectiveness, the procedure is simple and minimally invasive and would be a valuable non-pharmaceutical treatment.

DOI PubMed

Tracking intermediate performance of vigilant attention using multiple eye metrics

Takashi Abe, Kazuo Mishima, Shingo Kitamura, Akiko Hida, Yuichi Inoue, Koh Mizuno, Kosuke Kaida, Kyoko Nakazaki, Yuki Motomura, Kazushi Maruo, Toshiko Ohta, Satoshi Furukawa, David F Dinges, Katsuhiko Ogata

Sleep ( Oxford University Press (OUP) )  43 ( 3 )   2020.03  [Refereed]

Research paper (journal)   Domestic Co-author

<title>Abstract</title>
Vigilance deficits account for a substantial number of accidents and errors. Current techniques to detect vigilance impairment measure only the most severe level evident in eyelid closure and falling asleep, which is often too late to avoid an accident or error. The present study sought to identify ocular biometrics of intermediate impairment of vigilance and develop a new technique that could detect a range of deficits in vigilant attention (VA). Sixteen healthy adults performed well-validated Psychomotor Vigilance Test (PVT) for tracking vigilance attention while undergoing simultaneous recording of eye metrics every 2 hours during 38 hours of continuous wakefulness. A novel marker was found that measured VA when the eyes were open—the prevalence of microsaccades. Notably, the prevalence of microsaccades decreased in response to sleep deprivation and time-on-task. In addition, a novel algorithm for detecting multilevel VA was developed, which estimated performance on the PVT by integrating the novel marker with other eye-related indices. The novel algorithm also tracked changes in intermediate level of VA (specific reaction times in the PVT, i.e. 300–500 ms) during prolonged time-on-task and sleep deprivation, which had not been tracked previously by conventional techniques. The implication of the findings is that this novel algorithm, named “eye-metrical estimation version of the PVT: PVT-E,” can be used to reduce human-error-related accidents caused by vigilance impairment even when its level is intermediate.

DOI PubMed

Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia.

Takahashi Y, Shindo S, Kanbayashi T, Takeshima M, Imanishi A, Mishima K.

Neuropsychopharmacol Rep.   9 ( 10 ) 12096   2020.02  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Association Between the Use of Antidepressants and the Risk of Type 2 Diabetes Mellitus: A Large, Population-Based Cohort Study in Japan.

Miidera H, Enomoto M, Kitamura S, Tachimori H, Mishima K.

Diabetes Care   12 ( 10 ) dc19-1175   2020.02  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Tracking intermediate performance of vigilant attention using multiple eye metrics.

Abe T, Mishima K, Kitamura S, Hida A, Inoue Y, Mizuno K, Kaida K, Nakazaki K, Motomura Y, Maruo K, Ohta T, Furukawa S, Dinges DF, Ogata K.

Sleep   43   5733056   2020.02  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: a systematic review and network meta-analysis of randomized controlled trials

Kishi T.

Molecular Psychiatry ( Molecular Psychiatry )    2020  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Prevalence of asymptomatic venous thromboembolism in depressive inpatients

Takeshima M.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  16   579 - 587   2020  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Recurrence rates in stable bipolar disorder patients after drug discontinuation v. drug maintenance: A systematic review and meta-analysis

Kishi T.

Psychological Medicine ( Psychological Medicine )    2020  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Relationship between Indoor Daytime Light Exposure and Circadian Phase Response under Laboratory Free-Living Conditions

Yoshimura M.

Biological Rhythm Research ( Biological Rhythm Research )    2020  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Long-term use of hypnotics: Analysis of trends and risk factors.

Enomoto M, Kitamura S, Tachimori H, Takeshima M, Mishima K.

Gen Hosp Psychiatry   62   49 - 55   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

A missense variant in PER2 is associated with delayed sleep–wake phase disorder in a Japanese population

Miyagawa T.

Journal of Human Genetics ( Journal of Human Genetics )  64 ( 12 ) 1219 - 1225   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Psychosocial intervention for discontinuing benzodiazepine hypnotics in patients with chronic insomnia: A systematic review and meta-analysis.

Takaesu Y, Utsumi T, Okajima I, Shimura A, Kotorii N, Kuriyama K, Yamashita H, Suzuki M, Watanabe N, Mishima K.

Sleep Med Rev.   48   101214   2019.10  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials with an enrichment design

Oya K.

Neuropsychopharmacology Reports ( Neuropsychopharmacology Reports )  39 ( 3 ) 241 - 246   2019.09  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Brexpiprazole as adjunctive treatment for major depressive disorder following treatment failure with at least one antidepressant in the current episode: a systematic review and meta-analysis.

Kishi T, Sakuma K, Nomura I, Matsuda Y, Mishima K, Iwata N.

Int J Neuropsychopharmacol.   27   5539907   2019.07  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Melatonin receptor agonists-ramelteon and melatonin-for bipolar disorder: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials.

Kishi T, Nomura I, Sakuma K, Kitajima T, Mishima K, Iwata N.

Neuropsychiatr Dis Treat.   15   1479 - 1486   2019.06  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Sleep problem but not chronotype is associated with retirement from shift work: a cross-sectional retrospective study.

Kitamura S, Takahashi M, Mishima K.

Sleep and Biological Rhythms   17   331 - 337   2019.04  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

EXTRACTION OF BIOMETRIC INFORMATION VIA VIDEO ANALYSIS USING MACHINE LEARNING : MEASUREMENT OF PALPEBRAL FISSURE HEIGHT AS AN EXAMPLE APPLICATION

NISHIMURA Eigo, MOTOMURA Yuki, KATSUNUMA Ruri, YOSHIMURA Michitaka, MISHIMA Kazuo, OGATA Yoshito

Japanese Journal of Physiological Anthropology ( Japan Society of Physiological Anthropology )  24 ( 1 ) 35 - 45   2019  [Refereed]

Research paper (journal)   Domestic Co-author

Methods of human motion tracking for acquiring biometric information are needed in order to apply knowledgeof physiological anthropology. However, previous methods have difficulty in control of video shooting conditions.Thus, we developed a more robust motion tracking method using machine learning. In this report, we evaluated theaccuracy of our method by comparing palpebral fissure height measured using manually selected data and trackingdata obtained using YOLOv3. The results indicate that our method has practical accuracy in measuring palpebral fissureheight and suggest that including noise in training data contributes to its accuracy.

DOI

Prevalence of childhood obstructive sleep apnea syndrome and its role in daytime sleepiness.

Tsukada E, Kitamura S, Enomoto M, Moriwaki A, Kamio Y, Asada T, Arai T, Mishima K.

PLoS One   13 ( 10 ) e0204409   2018.10  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

A variant at 9q34.11 is associated with HLA-DQB1 06:02 negative essential hypersomnia.

Miyagawa T, Khor SS, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Ariyoshi Y, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Ikegami A, Wada Y, Takami M, Higashiyama Y, Miyake R, Kondo H, Fujimura Y, Tamura Y, Taniyama Y, Omata N, Tanaka Y, Moriya S, Furuya H, Kato M, Kawamura Y, Otowa T, Miyashita A, Kojima H, Saji H, Shimada M, Yamasaki M, Kobayashi T, Misawa R, Shigematsu Y, Kuwano R, Sasaki T, Ishigooka J, Wada Y, Tsuruta K, Chiba S, Tanaka F, Yamada N, Okawa M, Kuroda K, Kume K, Hirata K, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K.

J Hum Genet.   28 ( 10 ) 018 - 0518   2018.09  [Refereed]

Research paper (journal)   Domestic Co-author

DOI