Graduate School of Medicine  Doctorial Course in Medicine  Bioregulatory Medicine  Department of Neuropsychiatry

Graduating School 【 display / non-display


    Akita University   Faculty of Medicine   Graduated

Campus Career 【 display / non-display

  • 2018.09

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Bioregulatory Medicine   Professor  


Published Papers 【 display / non-display

  • Prescribing Pattern of Hypnotic Medications in Patients Initiating Treatment at Japanese Hospitals: A Nationwide, Retrospective, Longitudinal, Observational Study Using a Claims Database

    Ken Inada, Minori Enomoto, Kentaro Yamato, Kazuo Mishima

    Drugs - Real World Outcomes ( Springer Science and Business Media LLC )    2021.03


  • Decreased activity in the reward network of chronic insomnia patients

    Motomura Y.

    Scientific Reports ( Scientific Reports )  11 ( 1 )   2021.02  [Refereed]

    Domestic Co-author

    DOI Repository

  • Tracking intermediate performance of vigilant attention using multiple eye metrics

    Takashi Abe, Kazuo Mishima, Shingo Kitamura, Akiko Hida, Yuichi Inoue, Koh Mizuno, Kosuke Kaida, Kyoko Nakazaki, Yuki Motomura, Kazushi Maruo, Toshiko Ohta, Satoshi Furukawa, David F Dinges, Katsuhiko Ogata

    Sleep ( Oxford University Press (OUP) )  43 ( 3 )   2020.03

    Vigilance deficits account for a substantial number of accidents and errors. Current techniques to detect vigilance impairment measure only the most severe level evident in eyelid closure and falling asleep, which is often too late to avoid an accident or error. The present study sought to identify ocular biometrics of intermediate impairment of vigilance and develop a new technique that could detect a range of deficits in vigilant attention (VA). Sixteen healthy adults performed well-validated Psychomotor Vigilance Test (PVT) for tracking vigilance attention while undergoing simultaneous recording of eye metrics every 2 hours during 38 hours of continuous wakefulness. A novel marker was found that measured VA when the eyes were open—the prevalence of microsaccades. Notably, the prevalence of microsaccades decreased in response to sleep deprivation and time-on-task. In addition, a novel algorithm for detecting multilevel VA was developed, which estimated performance on the PVT by integrating the novel marker with other eye-related indices. The novel algorithm also tracked changes in intermediate level of VA (specific reaction times in the PVT, i.e. 300–500 ms) during prolonged time-on-task and sleep deprivation, which had not been tracked previously by conventional techniques. The implication of the findings is that this novel algorithm, named “eye-metrical estimation version of the PVT: PVT-E,” can be used to reduce human-error-related accidents caused by vigilance impairment even when its level is intermediate.

    DOI PubMed

  • Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia.

    Takahashi Y, Shindo S, Kanbayashi T, Takeshima M, Imanishi A, Mishima K.

    Neuropsychopharmacol Rep.   9 ( 10 ) 12096   2020.02  [Refereed]

    Domestic Co-author


  • Association Between the Use of Antidepressants and the Risk of Type 2 Diabetes Mellitus: A Large, Population-Based Cohort Study in Japan.

    Miidera H, Enomoto M, Kitamura S, Tachimori H, Mishima K.

    Diabetes Care   12 ( 10 ) dc19-1175   2020.02  [Refereed]

    Domestic Co-author


display all >>

Review Papers 【 display / non-display

  • 睡眠・覚醒相後退障害に対する心理社会支援プログラム開発の試み

    綾部直子, 吉村道孝, 栗山健一, 三島和夫, 三島和夫

    日本睡眠環境学会学術大会抄録集   28th   106   2019.09



  • 潜在的睡眠不足からの回復は前頭前野による扁桃体賦活抑制機能の改善を介して気分を改善する ASL-fMRI研究

    元村 祐貴, 北村 真吾, 中崎 恭子, 大場 健太郎, 勝沼 るり, 寺澤 悠理, 肥田 昌子, 守口 善也, 三島 和夫

    日本睡眠学会定期学術集会プログラム・抄録集 ( (一社)日本睡眠学会 )  44回   207 - 207   2019.06


  • 精神科学と神経免疫学のクロストーク 精神科領域からみた自己免疫性辺縁系脳炎

    筒井 幸, 馬越 秋瀬, 奥口 悠紀, 神林 崇, 田中 惠子, 清水 徹男, 三島 和夫

    精神神経学雑誌 ( (公社)日本精神神経学会 )  ( 2019特別号 ) S340 - S340   2019.06


  • 【知っておきたい器質性・症状性・薬剤性の精神障害:Update】抗NMDA受容体脳炎

    筒井 幸, 馬越 秋瀬, 神林 崇, 田中 惠子, 清水 徹男, 三島 和夫

    臨床精神医学 ( (株)アークメディア )  48 ( 1 ) 11 - 16   2019.01


  • Q and A―神経科学の素朴な疑問 時差ぼけは東回りと西回りで違うのですか?


    Clinical Neuroscience   35 ( 12 ) 1478‐1479   2017.12



display all >>