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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of Neuropsychiatry |
Mishima Kazuo
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Research Interests 【 display / non-display 】
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精神神経科学／時間生物学/分子遺伝学/睡眠/加齢変化/精神薬理学的研究
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Psychiatry
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Chronobiology
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精神科学
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Sleep medicine
Graduating School 【 display / non-display 】
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-1987.03
Akita University Faculty of Medicine Graduated
Campus Career 【 display / non-display 】
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2018.09-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Professor
Research Areas 【 display / non-display 】
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Life Science / Psychiatry
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Life Science / Neuroscience-general
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Life Science / Neuroscience-general
Research Achievements 【 display / non-display 】
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Familial adenomatous polyposis family with clustering of psychiatric disorders.
Masako Funaki, Atsuko Noguchi, Hayahito Ishikawa, Rie Noutomi, Koji Fukuda, Kazuhiro Shimazu, Taichi Yoshida, Daiki Taguchi, Hanae Shinozaki, Naoaki Kodama, Kazuo Mishima, Hiroshi Nanjo, Tsutomu Takahashi, Hiroyuki Shibata
Japanese journal of clinical oncology 2025.01 [Refereed]
Research paper (journal) Domestic Co-author
Familial adenomatous polyposis (FAP) is an inherited disorder that follows an autosomal dominant inheritance pattern and is caused by a germline pathogenic variant in the APC gene. FAP also has extracolonic manifestations, including osteomas, brain tumors, and congenital hypertrophy of the retinal pigmented epithelium. Desmoid tumor is a rare soft-tissue tumor often associated with FAP. APC is a WNT signal transduction molecule that is abundantly expressed in the central nervous system. The truncation mutations of the APC gene are responsible for FAP. Further, the C-terminal domains of APC associate with proteins such as EB1 and hDLG, which are involved in central nervous system functions. In recent years, several reports have indicated an association between FAP and mental disorders. We have identified a family with FAP that has a cluster of mental disorders. The female probrand experienced FAP and desmoid tumors in her thirties. She underwent a total colectomy and tumor resection. Her genetic test revealed a pathogenic germline pathogenic variant in the APC gene, c.3183_3187del. Her maternal grandmother and great-grandmother had colorectal polyposis. She has some mental disorders, and her son and daughter both have autism spectrum disorder (ASD). It was reported that her younger sister and her two daughters have intellectual disability and symptoms of ASD. For these situations, we found that mental health care is crucial when providing genetic counseling and medical care, especially to younger patients with FAP and carriers of pathological variants of the APC gene.
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Successful Electroconvulsive Therapy for Tardive Dyskinesia and Tardive Dystonia Refractory to Valbenazine Treatment: A Case Report and Narrative Literature Review.
Keisuke Irinaka, Yu Itoh, Kazuhisa Yoshizawa, Masaya Ogasawara, Naoko Ayabe, Kazuo Mishima, Masahiro Takeshima
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 22 ( 4 ) 688 - 696 2024.11 [Refereed]
Research paper (journal) Domestic Co-author
Tardive dyskinesia and dystonia are intractable extrapyramidal symptoms caused by the blockade of dopamine receptors by antipsychotic drugs. In addition to the reduction or discontinuation of the causative drug, valbenazine for tardive dyskinesia and botulinum toxin for tardive dystonia have been reported to be effective. However, their efficacy has not been fully demonstrated. In this study, we report the case of a female patient with bipolar disorder, valbenazine-resistant tardive dystonia, and tardive dyskinesia who achieved improvement in extrapyramidal symptoms with electroconvulsive therapy. Additionally, we conducted a narrative literature review on the safety and efficacy of electroconvulsive therapy for tardive dyskinesia and dystonia.
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Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials.
Mark H Gotfried, Sanford H Auerbach, Thien Thanh Dang-Vu, Kazuo Mishima, Dinesh Kumar, Margaret Moline, Manoj Malhotra
Drugs & aging 2024.08 [Refereed]
Research paper (journal) International Co-author
BACKGROUND: Insomnia is more common as people age. Several common hypnotics used to treat insomnia often do not adequately alleviate sleep issues in older adults and may be associated with negative residual effects such as an increased risk of falls, cognitive impairment, automobile accidents, and lack of response to auditory stimuli. The objective of these analyses of three clinical studies was to investigate the efficacy and safety of the dual orexin-receptor antagonist lemborexant (LEM) in older adults. METHODS: Study E2006-G000-304 (Study 304; NCT02783729) was a randomized, double-blind, placebo (PBO)-controlled, active-comparator trial where subjects with insomnia disorder received LEM 5 mg (LEM5), LEM 10 mg (LEM10), zolpidem tartrate extended-release 6.25 mg (ZOL), or PBO for 30 days. In crossover Study E2006-E044-106 (Study 106; NCT02583451), healthy subjects (good sleepers) received LEM 2.5 mg, LEM5, LEM10, or PBO for eight nights or zopiclone on days 1 and 8 (and PBO on days 2-7). In crossover Study E2006-A001-108 (Study 108; NCT03008447), healthy subjects received a single dose of LEM5, LEM10, PBO, or ZOL. Sleep assessments included polysomnography-based latency to persistent sleep (LPS), wake after sleep onset (WASO), WASO in the second half of the night (WASO2H), sleep efficiency, postural stability, middle-of-the-night and next-day cognitive performance, middle-of-the-night auditory awakening threshold and return-to-sleep latency, and driving performance. RESULTS: Overall, 453 of 1006 (45%; Study 304), 24 of 48 (50%; Study 106), and 28 of 56 (50%; Study 108) subjects were aged ≥ 65 years. In Study 304, LEM decreased (improved) LPS, WASO, and WASO2H from baseline more than ZOL and PBO; subjects treated with LEM had greater increases in sleep efficiency (improved) than with ZOL or PBO. In both Studies 304 and 108, postural stability was not impaired at waketime in subjects who received LEM compared with PBO. At waketime, LEM did not impair memory compared with PBO. In Study 108, following middle-of-the-night awakening, LEM and ZOL did not affect subjects' ability to awaken to auditory stimuli; LEM did not affect tests of memory and attention. In Study 106, LEM did not impair next-day driving performance in healthy elderly compared with PBO. LEM was well tolerated in subjects aged ≥ 65 years. CONCLUSIONS: LEM provided benefits on sleep variables without next-morning residual effects in subjects aged ≥ 65 years, supporting LEM as a treatment option for older adults with insomnia. TRIAL REGISTRATION NUMBERS AND DATES OF REGISTRATION: Study 304: ClinicalTrials.gov identifier, NCT02783729, date of registration, 26 May 2016. Study 106: ClinicalTrials.gov identifier, NCT02583451, date of registration, 22 October 2015. Study 108: ClinicalTrials.gov identifier, NCT03008447, date of registration, 2 January 2017.
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Pharmacokinetics, safety, and efficacy of daridorexant in Japanese subjects: Results from phase 1 and 2 studies.
Makoto Uchiyama, Kazuo Mishima, Tomoko Yagi, Tatsuya Yoshihara, Takashi Eto, Clemens Muehlan, Osamu Togo, Yuichi Inoue
Journal of sleep research e14302 2024.08 [Refereed]
Research paper (journal) Domestic Co-author
Daridorexant is a dual orexin receptor antagonist for the treatment of insomnia. We report results from the first two randomised, double-blind clinical studies of daridorexant in Japanese subjects. In the Phase 1 study, daridorexant (10, 25, 50 mg) or placebo were administered in the morning for 4 days in 24 young (mean age 26.9 years) and 24 older (mean age 69.7 years) healthy Japanese adults. Daridorexant reached a peak plasma concentration within 1.0 h across every dose and age group. For all doses, the mean plasma concentration of daridorexant showed a similar change between the age groups. Exposure parameters increased dose-dependently with minimal/no accumulation upon repeated dosing. The terminal half-life was ~8 h. In the Phase 2, four-period, four-way crossover study, 47 Japanese subjects (mean age 50.4 years) with insomnia disorder were randomised to receive four treatments (daridorexant 10, 25, 50 mg, placebo) during four treatment periods, each consisting of two treatment nights (5-12 day washout between treatment periods). Subjects continued their fourth treatment for 12 further days. A statistically significant dose-response relationship (multiple-comparison procedure-modelling, p < 0.0001) was found in the reduction of polysomnography-measured wake after sleep onset (WASO; primary endpoint) and latency to persistent sleep (secondary endpoint) from baseline to days 1/2. Statistically significant dose-response relationships were also observed for secondary subjective endpoints from baseline to days 1/2 (sWASO, latency to sleep onset). All daridorexant doses were well tolerated, with no treatment discontinuations and no next-morning residual effects. These results supported further investigation of daridorexant in Japanese patients with insomnia disorder.
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Autoimmune Encephalitis in Psychiatry
筒井幸, 筒井幸, 筒井幸, 大森佑貴, 神林崇, 神林崇, 加藤倫紀, 嵯峨佑史, 三島和夫, 清水徹男, 加藤征夫, 田中惠子
精神神経学雑誌 126 ( 2 ) 2024.02
Introduction and explanation (scientific journal) Domestic Co-author
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岸太郎, 江角悟, 大矢一登, 奥谷理, 佐久間健二, 野村郁雄, 橋本保彦, 波多野正和, 波多野正和, 松井佑樹, 松田勇紀, 三宅誕実, 三島和夫, 岩田仲生
臨床精神薬理 24 ( 9 ) 937 - 942 2021
Introduction and explanation (scientific journal) Domestic Co-author
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How to use, reduce, and stop hypnotics after insomnia remission
22 ( 8 ) 815 - 820 2019.08
Introduction and explanation (scientific journal)
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Non-visual Effects of Light : Influence on alertness and cognitive function
61 ( 8 ) 883 - 889 2019.08
Introduction and explanation (scientific journal)
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【知っておきたい器質性・症状性・薬剤性の精神障害:Update】抗NMDA受容体脳炎
筒井 幸, 馬越 秋瀬, 神林 崇, 田中 惠子, 清水 徹男, 三島 和夫
臨床精神医学 ( (株)アークメディア ) 48 ( 1 ) 11 - 16 2019.01
Introduction and explanation (scientific journal)
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Association of stay-home order during COVID-19 pandemic with depressive symptoms and suicide-related ideation in university students in Japan
野村恭子, 南園佐知子, 前田恵理, KIM Roseline, 岩田豊人, 平山純子, 尾野恭一, 伏見雅人, 後藤猛, 三島和夫, 山本文雄
日本心身医学会総会ならびに学術講演会抄録集 62nd (CD-ROM) 2021
Summary of the papers read (national conference and other science council) Domestic Co-author
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睡眠・覚醒相後退障害に対する心理社会支援プログラム開発の試み
綾部直子, 吉村道孝, 栗山健一, 三島和夫, 三島和夫
日本睡眠環境学会学術大会抄録集 28th 106 2019.09
Summary of the papers read (national conference and other science council)
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精神科学と神経免疫学のクロストーク 精神科領域からみた自己免疫性辺縁系脳炎
筒井 幸, 馬越 秋瀬, 奥口 悠紀, 神林 崇, 田中 惠子, 清水 徹男, 三島 和夫
精神神経学雑誌 ( (公社)日本精神神経学会 ) ( 2019特別号 ) S340 - S340 2019.06
Summary of the papers read (national conference and other science council)
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北村真吾, 榎本みのり, 三井寺浩幸, 立森久照, 三島和夫
国立精神・神経医療研究センター精神保健研究所年報 ( 30 ) 235 2017.10
Summary of the papers read (national conference and other science council)
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多施設共同RCTによる不眠症に対する認知行動療法(Cognitive Behavioral Therapy for Insomnia:CBT‐I)の有効性
綾部直子, 鈴木みのり, 立森久照, 北村真吾, 亀井雄一, 三島和夫
国立精神・神経医療研究センター精神保健研究所年報 ( 30 ) 235 2017.10
Summary of the papers read (national conference and other science council)
◆Original paper【 display / non-display 】
◆Introduction and explanation【 display / non-display 】
◆Other【 display / non-display 】
Books 【 display / non-display 】
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Tasman’s Psychiatry
三島和夫
Springer 2023.01
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(B)
Project Year： 2023.04 - 2027.03
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Construction and feature analysis of a model for predicting clinical outcomes of psychiatric disorders using sleep, behavioral, and physiological parameters.
Grant-in-Aid for Scientific Research(B)
Project Year： 2022.04 - 2025.03
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Grant-in-Aid for Scientific Research(B)
Project Year： 2019.04 - 2022.03
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Grant-in-Aid for Scientific Research(B)
Project Year： 2016.04 - 2019.03
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Grant-in-Aid for Scientific Research(S)
Project Year： 2015.04 - 2016.03
Presentations 【 display / non-display 】
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A descriptive epidemiological study of pediatric sleep medications in Japan: a health insurance claims-based analysis
Fujimoto, K. Tanaka, S. Mishima, K. Sakata, Y. Kubota, N. Koebisu, M. Fukasawa,T. Mizuno, K. Ishii, M. Moline, M. Kawakami, K.
The ISPOR Europe 2024 conference (Barcelona, Spain) 2024.11 - 2024.11
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Effects of Japanese policies and novel hypnotics on long-term prescriptions of hypnotics
Masahiro Takeshima, Kazuhisa Yoshizawa, Masaya Ogasawara, Yu Itoh, Kazuo Mishima
35th WORLD CONGRESS World Congress Collegium Internationale Neuro-Psychopharmacologicum (Tokyo) 2024.05 - 2024.05
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Safety and Efficacy of Lemborexant in Patients with Insomnia Disorder: Report from a Post-marketing Observational Study
Kazuo Mishima1 Kenichi Fujimoto, Akira Endo,Mika Ishi
35th WORLD CONGRESS World Congress Collegium Internationale Neuro-Psychopharmacologicum (Tokyo) 2024.05 - 2024.05
Academic Activity 【 display / non-display 】
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2020.10-Now
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2020.10-Now
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2020.03-Now