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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of Neuropsychiatry |
Mishima Kazuo
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Research Interests 【 display / non-display 】
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Sleep medicine
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精神神経科学／時間生物学/分子遺伝学/睡眠/加齢変化/精神薬理学的研究
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Psychiatry
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Chronobiology
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精神科学
Graduating School 【 display / non-display 】
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-1987.03
Akita University Faculty of Medicine Graduated
Campus Career 【 display / non-display 】
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2018.09-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Professor
Research Areas 【 display / non-display 】
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Life Science / Psychiatry
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Life Science / Neuroscience-general
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Life Science / Neuroscience-general
Research Achievements 【 display / non-display 】
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Identification of Factors to Predict Transition to Schizophrenia in Subjects with Ultra-high Risk for Psychosis: A Protocol for a Multicenter, Longitudinal Study of Sleep Parameters and Cytokine Levels.
Yuji Yamada, Kazuo Mishima, Takashi Ohnishi, Michio Suzuki, Takahiro Nemoto, Masafumi Mizuno, Toshifumi Kishimoto, Hiroaki Tomita, Motohiro Ozone, Shingo Kitamura, Kenji Hashimoto, Kazuyuki Nakagome, Tomiki Sumiyoshi
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 23 ( 2 ) 266 - 277 2025.05 [Refereed]
Research paper (journal) Domestic Co-author
OBJECTIVE: Schizophrenia is a major psychiatric illness which mostly begins in adolescence and leads to impairments of social functioning. Some patients with schizophrenia have been associated with ultra-high risk state for psychosis (UHR), a condition used to operationally represent the prodromal stage of the illness. In previous studies, the UHR and the progression to overt psychosis has been reported to be accompanied with alterations in the quality of sleep and the immune system, as represented by change of blood levels of cytokines. Currently, biomarkers to predict the development of psychosis in persons at UHR have not yet reached a steady consensus. Therefore, we present a study protocol to explore predictors of transitions to psychosis, in the realm of monitoring of sleep condition and cytokine measurement, in subjects with the UHR. METHODS: This is a multicenter, longitudinal cohort study participated by 7 hospitals in Japan. We will recruit 50 UHR people and 30 healthy volunteers as a control group, and measure positive symptom, depressive symptoms, cognitive function, and social function. Blood cytokines levels and sleep indices, as well as actigraphy data will be monitored. After the baseline assessment, clinical symptoms, sleep indices, and cytokine levels will be measured every 12 weeks for 52 weeks. Actigraphy devices will continue to be worn for 52 weeks, while social function will be assessed over 104 weeks. The results of this study are expected to facilitate the development of novel intervention therapies to reduce the risk of psychosis and improve functional outcomes.
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Detection of sleep apnea using smartphone-embedded inertial measurement unit.
Junichiro Hayano, Masahiro Takeshima, Aya Imanishi, Masaya Ogasawara, Yasuko Yamada, Emi Yuda, Kazuo Mishima
Scientific reports 15 ( 1 ) 14923 - 14923 2025.04 [Refereed]
Research paper (journal) Domestic Co-author
We previously demonstrated that sleep apnea (SA) can be detected using acceleration and gyroscope signals from smartwatches. This study investigated whether an inertial measurement unit (IMU) embedded in non-wristwatch devices, such as smartphones, can also detect SA when worn during sleep. During polysomnography (PSG), subjects wore an IMU-embedded GPS device (Amue Link®) and/or smartphones (Xperia® or iPhone®) on their abdomen. Triaxial acceleration and gyroscope signals were recorded overnight. Data were split into training and test groups (2:1) for each device. An algorithm was developed in the training groups to extract respiratory movements (0.13-0.70 Hz) and detect respiratory events, which were validated in the test groups. IMU-derived respiratory events showed breath-by-breath concordance with PSG apnea-hypopnea events, yielding F1 scores of 0.786, 0.821, and 0.796, respectively. Regression model derived from IMU signals correlated with PSG AHI in the test groups (r = 0.90, 0.93, and 0.96), with limits of agreement of -16.7 to 25.9, -17.4 to 22.5, and - 18.4 to 20.5. Using cutoff values from the training groups, moderate-to-severe SA (AHI ≥ 15) was identified in the test groups with AUCs of 0.95, 0.98, and 0.94 and F1 scores of 0.89, 0.96, and 0.92, respectively. IMUs embedded in non-wristwatch devices, including smartphones, can quantitatively detect SA when worn during sleep.
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Transforming growth factor-β serum levels associated with social function in subjects at ultra-high risk for psychosis: A multicenter study
Yuji Yamada, Naoko Kishimoto, Hiromi Tagata, Tsubasa Morimoto, Kazuho Tomimoto, Yutaro Sato, Yuko Higuchi, Hiroshi Hiejima, Hayato Ohshima, Takao Kato, Mari S. Oba, Shoki Izumi, Yui Tomo, Shingo Kitamura, Andrew Stickley, Toshifumi Kishimoto, Takahiro Nemoto, Masafumi Mizuno, Hiroaki Tomita, Michio Suzuki, Motohiro Ozone, Kenji Hashimoto, Kazuo Mishima, Takashi Ohnishi, Kazuyuki Nakagome, Tomiki Sumiyoshi
Clinical Psychopharmacology and Neuroscience 2025.02 [Refereed]
Research paper (journal) Domestic Co-author
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Ryoya Aoki, Takashi Miyachi, Yuta Sugano, Choichiro Kanke, Teiichiro Yamazaki, Kazuo Mishima, Kyoko Nomura
Journal of Occupational Health ( Oxford University Press (OUP) ) 2025.02 [Refereed]
Research paper (journal)
Abstract
Objectives: This study aimed to investigate how many drivers would have sleep disorders and what factors would be most associated with chronic insomnia symptoms.
Methods: A cross-sectional study of 505 truck drivers in Akita prefecture was conducted using a self-administered questionnaire and health checkup data. We defined insomnia based on the International Classification of Sleep Disorders, 3rd edition (ICSD-3), sleep apnea syndrome (SAS) with a simple four-variable screening tool, and restless legs syndrome (RLS) with RLS/Willis-Ekbom disease diagnostic criteria. Investigated factors included sleep duration, driving characteristics, caffeine types (foods and beverage) and amounts, caffeine intake timing, state-trait anxiety inventory (STAI), individual stress, and other covariates.
Results: The prevalence of suspected SAS was 23.2% (n = 154), and that of RLS was 0.8% (n = 5). After excluding those, chronic insomnia symptoms were present in 36/505 drivers (7.1%). After adjusting for covariates, a logistic model demonstrated that drinking habits (Odds ratio, OR 6.21, 95% Confidence Interval, CI:1.07–35.8), caffeine intake before sleep (OR 2.65, 95% CI:1.09–6.45), sleep duration on days off (OR 1.44, 95% CI: 1.01–2.05), and STAI score (OR 12.8, 95% CI: 2.53–64.2) were significantly associated with chronic insomnia symptoms. STAI was significantly positively correlated with individual stress, such as family worries (r = 0.22), relationships with non-partners (r = 0.28), and health (r = 0.23).
Conclusions: Our study revealed that one fourth of male truck drivers had sleep disorders that require further medical evaluation. For male truck drivers, a lifestyle modification and stress relief may be a key to address insomnia. -
Familial adenomatous polyposis family with clustering of psychiatric disorders.
Masako Funaki, Atsuko Noguchi, Hayahito Ishikawa, Rie Noutomi, Koji Fukuda, Kazuhiro Shimazu, Taichi Yoshida, Daiki Taguchi, Hanae Shinozaki, Naoaki Kodama, Kazuo Mishima, Hiroshi Nanjo, Tsutomu Takahashi, Hiroyuki Shibata
Japanese journal of clinical oncology 2025.01 [Refereed]
Research paper (journal) Domestic Co-author
Familial adenomatous polyposis (FAP) is an inherited disorder that follows an autosomal dominant inheritance pattern and is caused by a germline pathogenic variant in the APC gene. FAP also has extracolonic manifestations, including osteomas, brain tumors, and congenital hypertrophy of the retinal pigmented epithelium. Desmoid tumor is a rare soft-tissue tumor often associated with FAP. APC is a WNT signal transduction molecule that is abundantly expressed in the central nervous system. The truncation mutations of the APC gene are responsible for FAP. Further, the C-terminal domains of APC associate with proteins such as EB1 and hDLG, which are involved in central nervous system functions. In recent years, several reports have indicated an association between FAP and mental disorders. We have identified a family with FAP that has a cluster of mental disorders. The female probrand experienced FAP and desmoid tumors in her thirties. She underwent a total colectomy and tumor resection. Her genetic test revealed a pathogenic germline pathogenic variant in the APC gene, c.3183_3187del. Her maternal grandmother and great-grandmother had colorectal polyposis. She has some mental disorders, and her son and daughter both have autism spectrum disorder (ASD). It was reported that her younger sister and her two daughters have intellectual disability and symptoms of ASD. For these situations, we found that mental health care is crucial when providing genetic counseling and medical care, especially to younger patients with FAP and carriers of pathological variants of the APC gene.
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Autoimmune Encephalitis in Psychiatry
筒井幸, 筒井幸, 筒井幸, 大森佑貴, 神林崇, 神林崇, 加藤倫紀, 嵯峨佑史, 三島和夫, 清水徹男, 加藤征夫, 田中惠子
精神神経学雑誌 126 ( 2 ) 2024.02
Introduction and explanation (scientific journal) Domestic Co-author
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岸太郎, 江角悟, 大矢一登, 奥谷理, 佐久間健二, 野村郁雄, 橋本保彦, 波多野正和, 波多野正和, 松井佑樹, 松田勇紀, 三宅誕実, 三島和夫, 岩田仲生
臨床精神薬理 24 ( 9 ) 937 - 942 2021
Introduction and explanation (scientific journal) Domestic Co-author
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How to use, reduce, and stop hypnotics after insomnia remission
22 ( 8 ) 815 - 820 2019.08
Introduction and explanation (scientific journal)
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Non-visual Effects of Light : Influence on alertness and cognitive function
61 ( 8 ) 883 - 889 2019.08
Introduction and explanation (scientific journal)
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【知っておきたい器質性・症状性・薬剤性の精神障害:Update】抗NMDA受容体脳炎
筒井 幸, 馬越 秋瀬, 神林 崇, 田中 惠子, 清水 徹男, 三島 和夫
臨床精神医学 ( (株)アークメディア ) 48 ( 1 ) 11 - 16 2019.01
Introduction and explanation (scientific journal)
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Association of stay-home order during COVID-19 pandemic with depressive symptoms and suicide-related ideation in university students in Japan
野村恭子, 南園佐知子, 前田恵理, KIM Roseline, 岩田豊人, 平山純子, 尾野恭一, 伏見雅人, 後藤猛, 三島和夫, 山本文雄
日本心身医学会総会ならびに学術講演会抄録集 62nd (CD-ROM) 2021
Summary of the papers read (national conference and other science council) Domestic Co-author
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睡眠・覚醒相後退障害に対する心理社会支援プログラム開発の試み
綾部直子, 吉村道孝, 栗山健一, 三島和夫, 三島和夫
日本睡眠環境学会学術大会抄録集 28th 106 2019.09
Summary of the papers read (national conference and other science council)
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精神科学と神経免疫学のクロストーク 精神科領域からみた自己免疫性辺縁系脳炎
筒井 幸, 馬越 秋瀬, 奥口 悠紀, 神林 崇, 田中 惠子, 清水 徹男, 三島 和夫
精神神経学雑誌 ( (公社)日本精神神経学会 ) ( 2019特別号 ) S340 - S340 2019.06
Summary of the papers read (national conference and other science council)
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北村真吾, 榎本みのり, 三井寺浩幸, 立森久照, 三島和夫
国立精神・神経医療研究センター精神保健研究所年報 ( 30 ) 235 2017.10
Summary of the papers read (national conference and other science council)
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多施設共同RCTによる不眠症に対する認知行動療法(Cognitive Behavioral Therapy for Insomnia:CBT‐I)の有効性
綾部直子, 鈴木みのり, 立森久照, 北村真吾, 亀井雄一, 三島和夫
国立精神・神経医療研究センター精神保健研究所年報 ( 30 ) 235 2017.10
Summary of the papers read (national conference and other science council)
◆Original paper【 display / non-display 】
◆Introduction and explanation【 display / non-display 】
◆Other【 display / non-display 】
Books 【 display / non-display 】
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Tasman’s Psychiatry
三島和夫
Springer 2023.01
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(B)
Project Year： 2023.04 - 2027.03
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Construction and feature analysis of a model for predicting clinical outcomes of psychiatric disorders using sleep, behavioral, and physiological parameters.
Grant-in-Aid for Scientific Research(B)
Project Year： 2022.04 - 2025.03
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Grant-in-Aid for Scientific Research(B)
Project Year： 2019.04 - 2022.03
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Grant-in-Aid for Scientific Research(B)
Project Year： 2016.04 - 2019.03
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Grant-in-Aid for Scientific Research(S)
Project Year： 2015.04 - 2016.03
Presentations 【 display / non-display 】
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A descriptive epidemiological study of pediatric sleep medications in Japan: a health insurance claims-based analysis
Fujimoto, K. Tanaka, S. Mishima, K. Sakata, Y. Kubota, N. Koebisu, M. Fukasawa,T. Mizuno, K. Ishii, M. Moline, M. Kawakami, K.
The ISPOR Europe 2024 conference (Barcelona, Spain) 2024.11 - 2024.11
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Effects of Japanese policies and novel hypnotics on long-term prescriptions of hypnotics
Masahiro Takeshima, Kazuhisa Yoshizawa, Masaya Ogasawara, Yu Itoh, Kazuo Mishima
35th WORLD CONGRESS World Congress Collegium Internationale Neuro-Psychopharmacologicum (Tokyo) 2024.05 - 2024.05
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Safety and Efficacy of Lemborexant in Patients with Insomnia Disorder: Report from a Post-marketing Observational Study
Kazuo Mishima1 Kenichi Fujimoto, Akira Endo,Mika Ishi
35th WORLD CONGRESS World Congress Collegium Internationale Neuro-Psychopharmacologicum (Tokyo) 2024.05 - 2024.05
Academic Activity 【 display / non-display 】
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2020.10-Now
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2020.10-Now
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2020.03-Now