|
所属 |
高齢者医療先端研究センター |
|
ホームページ |
研究等業績 【 表示 ／ 非表示 】
-
Association between Kihon check list score and geriatric depression among older adults from ORANGE registry
Yu Kume, Seongryu Bae, Sangyoon Lee, Hyuma Makizako, Yuriko Matsuzaki-Kihara, Ichiro Miyano, Hunkyung Kim, Hiroyuki Shimada, Hidetaka Ota
PLoS One 2021年06月 [査読有り]
研究論文（学術雑誌） 国際共著
-
Examination of the effect of Deep Micro Vibrotactile stimulation on cognitive function for elderly with Aizheimer’s Disease.
Kodama A, Suzuki Y, Kume Y, Ota H.
Annals of Alzheimer’s and Dementia Care. 2021年01月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Characteristics of Mild Cognitive Impairment in Northern Japanese Community-Dwellers from the ORANGE Registry.
Kume Y, Takahashi T, Itakura Y, Lee S, Makizako H, Ono T, Shimada H, Ota H.
Jornal of clinical medicine 2019年11月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Effect of a dual-task exercise to motor and memory function for Japanese older individuals in depopulated rural districts: preliminary intervention research from 2016 to 2019.
Kume Y, Fujita T, Uemura S, Inomata S, Tsugaruya M, Sato A,Nakamura Y, Itakura Y, Ota H.
International Psychogeriatrics 2019年07月 [査読有り]
研究論文（学術雑誌） 国内共著
-
Dasatinib plus quercetin attenuates some frailty characteristics in SAMP10 mice
Ota H.
Scientific Reports ( Scientific Reports ) 12 ( 1 ) 2425 - 2425 2022年12月
Senolytics are a class of drugs that selectively remove senescent cells. Dasatinib and quercetin have been discovered, and their combination has shown various anti-ageing effects. The SAMP10 mouse strain is a model of brain ageing. Here, we investigated the effect of combination on frailty characteristics in SAMP10. By comparing SAMP10 with SAMR1 mice as normal ageing controls, we investigated some frailty characteristics. Frailty was assessed at 18-38 weeks of age with a clinical frailty index. Motor and cognitive function of these mice were evaluated using behavioral experiments. SAMP10 mice were divided into vehicle and combination, and these functions and histological changes in the brain hippocampus were investigated. Finally, the in vitro effects of combination on oxidative stress-induced senescent muscle and neuronal cells were investigated. As a result, we found that frailty index was higher in SAMP10 than SAMR1. Motor and cognitive function were worse in SAMP10 than SAMR1. Furthermore, combination therapy improved frailty, motor and cognitive function, and the senescent phenotype of the hippocampus compared with vehicle in SAMP10. In summary, SAMP10 showed more marked frailty characteristics than SAMR1, and dasatinib and quercetin attenuated them in SAMP10. From our results, senolytic therapy might contribute protective effects against frailty.
-
Kazawa K.
BMC Geriatrics ( BMC Geriatrics ) 22 ( 1 ) 107 - 107 2022年12月
BACKGROUND: Little is known about the actual impact of COVID-19 on caregivers of older people with dementia and resultant collaborations among them to provide continued person-centered care while undertaking infection control measures. In this study, we explored the impact of providing dementia care during COVID-19 on caregivers involved in dementia care. METHODS: This is an exploratory qualitative case study. The participants were family members living with older people with dementia, care managers, and the medical and long-term care facility staff. Data were collected from 46 caregivers via face-to-face and semi-structured interviews and analyzed using thematic analysis. RESULTS: The interviews identified 22 themes related to the impact of COVID-19 on different positions of the caregivers involved in dementia care and their collaboration, and we categorized them into six categories. The core themes were "re-acknowledgement of care priorities" and "rebuilding of relationships." When caregivers' perceptions were aligned in the decision-making processes regarding care priorities, "reaffirmation of trust" and "strengthening of intimate relationships" emerged as positive changes in their relationships. Furthermore, the differences in the ability of each caregiver to access and select correct and appropriate information about COVID-19, and the extent of infection spread in the region were related to "anxiety during COVID-19 pandemic" and caused a "gap in perception" regarding infection control. CONCLUSIONS: The present study clarified that the process of aligning the perceptions of caregivers to the objectives and priorities of care for older people with dementia during COVID-19 pandemic strengthened the relationships among caregivers. The findings of this study are useful for caregivers involved in person-centered dementia care.
-
【認知症の共生と予防】共生社会実現に向けた産官学連携の取り組み
大田 秀隆
Geriatric Medicine ( (株)ライフ・サイエンス ) 60 ( 7 ) 587 - 591 2022年07月
今までの新オレンジプランから2019年6月18日に認知症施策推進大綱が取りまとめられた。この大綱の中では認知症の「共生と予防」を車の両輪のように考え、この2つについて様々な施策を推進していくこととなっている。今回のテーマである「産官学連携」は、そういった取り組みの中でも今後重要なキーワードとなるものである。今回は、共生社会実現に向けた産官学連携と取り組みとその仕組みづくり、そして現在行っている当センターの産官学連携の研究の一端をご紹介したい。(著者抄録)
-
A Pilot Survey: Oral Function as One of the Risk Factors for Physical Frailty
Kodama A.
International Journal of Environmental Research and Public Health ( International Journal of Environmental Research and Public Health ) 19 ( 10 ) 2022年05月
BACKGROUND: The aim of this study was to examine the association of the multiple facets of oral, motor, and social functions in community-dwelling older adults, to identify factors that might influence the risk of frailty. METHODS: Of the 82 participants included in the study, 39 (5 males and 34 females) were young-old adults, with an average age of 70.5 ± 2.8 years, and 43 (14 males and 29 females) were old-old adults, with an average age of 78.7 ± 2.9 years. We assessed the risk factors for frailty among oral, motor, and social functions. RESULTS: Statistical analysis showed a significant difference in the oral diadochokinesis between the groups (p = 0.006). According to the Spearman correlation analysis, a significant association was observed with age and oral diadochokinesis (rs = -0.262, p = 0.018), and social support (rs = -0.219, p = 0.049). Moreover, binomial logistic regression analysis revealed a significant association of frailty with the occlusal force (odds ratio, 0.031; 95% confidence interval (95% CI), 0.002-0.430; p = 0.010), General Oral Health Index (odds ratio, 0.930; 95% CI, 0.867-0.999, p = 0.046), and availability of social support (odds ratio, 0.803, 95% CI, 0.690-0.934, p = 0.004). CONCLUSIONS: To prevent frailty at an early stage, assessments of oral functions, and also that of the availability of social support, are important.
-
当院における高齢者非小細胞肺癌に対するニボルマブの効果
奥田 佑道, 浅野 真理子, 佐藤 一洋, 熊谷 奈保, 坂本 祥, 竹田 正秀, 小玉 鮎人, 大田 秀隆, 中山 勝敏
日本老年医学会雑誌 ( (一社)日本老年医学会 ) 59 ( Suppl. ) 150 - 150 2022年05月