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Affiliation |
Advanced Research Center for Geriatric Medicine |
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Homepage URL |
OTA HIDETAKA
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Graduating School 【 display / non-display 】
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-2000.03
Kumamoto University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2006.03
The University of Tokyo Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2018.06-Now
Akita University Advanced Research Center for Geriatric Medicine Professor
Research Achievements 【 display / non-display 】
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Association between Kihon check list score and geriatric depression among older adults from ORANGE registry
Yu Kume, Seongryu Bae, Sangyoon Lee, Hyuma Makizako, Yuriko Matsuzaki-Kihara, Ichiro Miyano, Hunkyung Kim, Hiroyuki Shimada, Hidetaka Ota
PLoS One 2021.06 [Refereed]
Research paper (journal) International Co-author
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Examination of the effect of Deep Micro Vibrotactile stimulation on cognitive function for elderly with Aizheimer’s Disease.
Kodama A, Suzuki Y, Kume Y, Ota H.
Annals of Alzheimer’s and Dementia Care. 2021.01 [Refereed]
Research paper (journal) Domestic Co-author
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Characteristics of Mild Cognitive Impairment in Northern Japanese Community-Dwellers from the ORANGE Registry.
Kume Y, Takahashi T, Itakura Y, Lee S, Makizako H, Ono T, Shimada H, Ota H.
Jornal of clinical medicine 2019.11 [Refereed]
Research paper (journal) Domestic Co-author
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Effect of a dual-task exercise to motor and memory function for Japanese older individuals in depopulated rural districts: preliminary intervention research from 2016 to 2019.
Kume Y, Fujita T, Uemura S, Inomata S, Tsugaruya M, Sato A,Nakamura Y, Itakura Y, Ota H.
International Psychogeriatrics 2019.07 [Refereed]
Research paper (journal) Domestic Co-author
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Dasatinib plus quercetin attenuates some frailty characteristics in SAMP10 mice
Ota H.
Scientific Reports ( Scientific Reports ) 12 ( 1 ) 2425 - 2425 2022.12
Senolytics are a class of drugs that selectively remove senescent cells. Dasatinib and quercetin have been discovered, and their combination has shown various anti-ageing effects. The SAMP10 mouse strain is a model of brain ageing. Here, we investigated the effect of combination on frailty characteristics in SAMP10. By comparing SAMP10 with SAMR1 mice as normal ageing controls, we investigated some frailty characteristics. Frailty was assessed at 18-38 weeks of age with a clinical frailty index. Motor and cognitive function of these mice were evaluated using behavioral experiments. SAMP10 mice were divided into vehicle and combination, and these functions and histological changes in the brain hippocampus were investigated. Finally, the in vitro effects of combination on oxidative stress-induced senescent muscle and neuronal cells were investigated. As a result, we found that frailty index was higher in SAMP10 than SAMR1. Motor and cognitive function were worse in SAMP10 than SAMR1. Furthermore, combination therapy improved frailty, motor and cognitive function, and the senescent phenotype of the hippocampus compared with vehicle in SAMP10. In summary, SAMP10 showed more marked frailty characteristics than SAMR1, and dasatinib and quercetin attenuated them in SAMP10. From our results, senolytic therapy might contribute protective effects against frailty.
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Kazawa K.
BMC Geriatrics ( BMC Geriatrics ) 22 ( 1 ) 107 - 107 2022.12
BACKGROUND: Little is known about the actual impact of COVID-19 on caregivers of older people with dementia and resultant collaborations among them to provide continued person-centered care while undertaking infection control measures. In this study, we explored the impact of providing dementia care during COVID-19 on caregivers involved in dementia care. METHODS: This is an exploratory qualitative case study. The participants were family members living with older people with dementia, care managers, and the medical and long-term care facility staff. Data were collected from 46 caregivers via face-to-face and semi-structured interviews and analyzed using thematic analysis. RESULTS: The interviews identified 22 themes related to the impact of COVID-19 on different positions of the caregivers involved in dementia care and their collaboration, and we categorized them into six categories. The core themes were "re-acknowledgement of care priorities" and "rebuilding of relationships." When caregivers' perceptions were aligned in the decision-making processes regarding care priorities, "reaffirmation of trust" and "strengthening of intimate relationships" emerged as positive changes in their relationships. Furthermore, the differences in the ability of each caregiver to access and select correct and appropriate information about COVID-19, and the extent of infection spread in the region were related to "anxiety during COVID-19 pandemic" and caused a "gap in perception" regarding infection control. CONCLUSIONS: The present study clarified that the process of aligning the perceptions of caregivers to the objectives and priorities of care for older people with dementia during COVID-19 pandemic strengthened the relationships among caregivers. The findings of this study are useful for caregivers involved in person-centered dementia care.
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A Pilot Survey: Oral Function as One of the Risk Factors for Physical Frailty
Kodama A.
International Journal of Environmental Research and Public Health ( International Journal of Environmental Research and Public Health ) 19 ( 10 ) 2022.05
BACKGROUND: The aim of this study was to examine the association of the multiple facets of oral, motor, and social functions in community-dwelling older adults, to identify factors that might influence the risk of frailty. METHODS: Of the 82 participants included in the study, 39 (5 males and 34 females) were young-old adults, with an average age of 70.5 ± 2.8 years, and 43 (14 males and 29 females) were old-old adults, with an average age of 78.7 ± 2.9 years. We assessed the risk factors for frailty among oral, motor, and social functions. RESULTS: Statistical analysis showed a significant difference in the oral diadochokinesis between the groups (p = 0.006). According to the Spearman correlation analysis, a significant association was observed with age and oral diadochokinesis (rs = -0.262, p = 0.018), and social support (rs = -0.219, p = 0.049). Moreover, binomial logistic regression analysis revealed a significant association of frailty with the occlusal force (odds ratio, 0.031; 95% confidence interval (95% CI), 0.002-0.430; p = 0.010), General Oral Health Index (odds ratio, 0.930; 95% CI, 0.867-0.999, p = 0.046), and availability of social support (odds ratio, 0.803, 95% CI, 0.690-0.934, p = 0.004). CONCLUSIONS: To prevent frailty at an early stage, assessments of oral functions, and also that of the availability of social support, are important.
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Kodama A.
International Journal of Environmental Research and Public Health ( International Journal of Environmental Research and Public Health ) 19 ( 7 ) 2022.04
BACKGROUND: The purpose of this study was to clarify the effect of Deep Micro Vibrotactile (DMV) stimulation on the cognitive functions in elderly people with mild cognitive impairment or mild dementia. METHODS: A total of 35 participants with dementia from three nursing homes, who had completed treatment with DMV stimulation at 15-40 Hz (hereinafter, 15-40 Hz DMV stimulation) for a month were recruited for this study. The subjects had received continuous 15-40 Hz DMV stimulation for 24 h a day for 1 month. We assessed the effect of the treatment on the cognitive functions (by the word list memory (WM) test, trail making test-part A (TMT-A) and part B (TMT-B), and symbol digit substitution task (SDST)) and physical functions (grip strength (GS) and usual walking speed (UWS)), by comparing the results at the baseline and after the 1-month intervention (DMV stimulation). RESULTS: The results revealed that the performances in the WM test (p < 0.05), TMT-B (p < 0.05), and SDST (p < 0.01) improved significantly after the intervention. CONCLUSION: Our findings suggest that 15-40 Hz DMV stimulation is might be effective for improving the cognitive functions in elderly people with dementia. Furthermore, our novel findings showed the different effectiveness of the treatment depending on the stage of cognitive impairments.
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Kume Y.
Geriatrics and Gerontology International ( Geriatrics and Gerontology International ) 22 ( 2 ) 145 - 151 2022.02
AIM: To clarify prevalence of social frailty among older adults living in a rural Japanese community, and factors associated with social frailty status. METHODS: In total, 322 adults aged ≥65 years living in a Japanese rural community took part in the study from 2018 to 2020. Social frailty was defined as deficiencies of: (i) living alone; (ii) talking with someone every day; (iii) feeling helpful to friends or family; (iv) going out less frequently compared with last year; and (v) visiting friends sometimes. Social frail status was categorized as robust (0), social prefrail (1), and social frail (≥2), according to the summated score of Makizako's criteria. Multiple logistic regression analysis was applied to clarify factors associated with social frailty status. RESULTS: Final samples were classified into 68 persons with social frailty, 98 persons with social prefrailty and 147 persons as robust. We observed the prevalence of social frailty (21.7%) and social prefrailty (31.3%) and the GDS-15 had significantly high scores in the social frail groups. Social frailty was significantly associated with the GDS-15 score (odds ratio, 1.33; 95% CI, 1.19-1.49) and TMT-A (odds ratio, 1.04; 95% CI, 1.01-1.08) and GDS-15 (odds ratio, 1.13; 95% CI, 1.03-1.26) were extracted as independent variables of social prefrail status, with adjustment for demographics, polypharmacy and lifestyle-related diseases. CONCLUSIONS: Our results suggest that social frailty tends to be increasing gradually in a Japanese rural area, and social prefrailty might be potentially associated with attentional function, as well as the GDS-15 score. Geriatr Gerontol Int 2022; 22: 145-151.