Research Achievements - Original paper -

Galectin-3 plays a role in neuroinflammation in the visual pathway in experimental optic neuritis.

Funaki M., Nio-Kobayashi J., Suzuki R., Bando Y.

Cells ( MDPI )  13   612   2024.03  [Refereed]  [Invited]

Research paper (journal)   Domestic Co-author

Expression levels of KATP channel subunits and morphological changes in the mouse liver after exposure to radiation

Ming Zhou, Tao-Sheng Li, Hiroshi Abe, Hideo Akashi, Ryoji Suzuki, Yoshio Bando

World Journal of Experimental Medicine     2024.03  [Refereed]

Research paper (journal)  

Mechanism of Demyelination and Remyelination in Multiple Sclerosis

Bando Y.

Clinical and Experimental Neuroimmunology   in press   2020.01  [Refereed]  [Invited]

Research paper (journal)   Single author

Localization of ATP-sensitive K+ channel subunits in rat liver.

Zhou M., Yoshikawa K., Akashi H., Miura M., Suzuki R., Sheng T., Abe H., Bando Y.

World Journal of Experimental Medicine.   9 ( 2 ) 14 - 31   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

An anomalous case of the flexor carpi radialis with an excessive muscular bundle.

Zhou M, Ishizawa A, Akashi H, Suzuki R, Kanatsu Y, Abe H, Bando Y

Anat Sci Int.   Dec 17   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

Disease modifying mitochondrial uncouplers, MP101, and a slow release ProDrug, MP201, in models of Multiple Sclerosis.

Bando Y, Geisler JG.

Neurochem Int   131   104561   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

Potential of Adult Endogenous Neural Stem/Progenitor Cells in the Spinal Cord to Contribute to Remyelination in Experimental Autoimmune Encephalomyelitis.

Maeda Y, Nakagomi N, Nakano-Doi A, Ishikawa H, Tatsumi Y, Bando Y, Yoshikawa H, Matsuyama T, Gomi F, Nakagomi T.

Cells   8 ( 9 ) E1025   2019.09  [Refereed]

Research paper (journal)   Domestic Co-author

Potential of Adult Endogenous Neural Stem/Progenitor Cells in the Spinal Cord to Contribute to Remyelination in Experimental Autoimmune Encephalomyelitis.

Maeda Y, Nakagomi N, Nakano-Doi A, Ishikawa H, Tatsumi Y, Bando Y, Yoshikawa H, Matsuyama T, Gomi F, Nakagomi T.

Cells.   8 ( (9) ) E1025   2019.09  [Refereed]

Research paper (journal)   Domestic Co-author

Dataset on the effect of knockout of KLK8 in social memory.

Nakazawa H, Suzuki Y, Ishikawa Y, Bando Y, Yoshida S, Shiosaka S.

Data Brief.   26   104458   2019.08  [Refereed]

Research paper (journal)   Domestic Co-author

Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse.

Nakazawa H, Suzuki Y, Ishikawa Y, Bando Y, Yoshida S, Shiosaka S.

Neurobiol Learn Mem.   162   47 - 58   2019.07  [Refereed]

Research paper (journal)   Domestic Co-author

Pathological changes in mice with long term cuprizone administration.

Nomura T, Bando Y, Nakazawa H, Kanemoto S, Yoshida S.

Neurochem Int.   126   229 - 238   2019.06  [Refereed]

Research paper (journal)   Domestic Co-author

Cell- and stage-specific localization of galectin-3, a β-galactoside-binding lectin, in a mouse model of experimental autoimmune encephalomyelitis.

Itabashi T, Arima Y, Kamimura D, Higuchi K, Bando Y, Takahashi-Iwanaga H, Murakami M, Watanabe M, Iwanaga T, Nio-Kobayashi J.

Neurochem Int.   118   176 - 184   2018.09  [Refereed]

Research paper (journal)   Domestic Co-author

Alterations of Both Dendrite Morphology and Weaker Electrical Responsiveness in the Cortex of Hip Area Occur Before Rearrangement of the Motor Map in Neonatal White Matter Injury Model.

Ueda Y, Bando Y, Misumi S, Ogawa S, Ishida A, Jung CG, Shimizu T, Hida H.

Front Neurol.   9   443   2018.06  [Refereed]

Research paper (journal)   Domestic Co-author

Bando Y, Hagiwara Y, Suzuki Y, Yoshida K, Aburakawa Y, Kimura T, Murakami C, Ono M, Tanaka T, Jiang YP, Mitrovi B, Bochimoto H, Yahara O, Yoshida S.

Bando Y, Hagiwara Y, Suzuki Y, Yoshida K, Aburakawa Y, Kimura T, Murakami C, Ono M, Tanaka T, Jiang YP, Mitrovi B, Bochimoto H, Yahara O, Yoshida S.

GLIA   66 ( 2 ) 359 - 378   2018.02  [Refereed]

Research paper (journal)   Domestic Co-author

Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis.

Yoshio Bando, Yoshiaki Hagiwara, Yasuhiro Suzuki, Kosuke Yoshida, Yoko Aburakawa, Takashi Kimura, Chisato Murakami, Miyuki Ono, Tatsuhide Tanaka, Ying-Ping Jiang, Branka Mitrovi, Hiroki Bochimoto, Osamu Yahara, Shigetaka Yoshida

Glia ( WILEY )  66 ( 2 ) 359 - 378   2018.02  [Refereed]

Research paper (journal)  

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), and experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of the disease. Here, we examined the pathophysiological role of Kallikrein 6 (Klk6), a serine protease produced by oligodendrocytes (OLs), in EAE using Klk6 knockout (Klk6-/-) mice. Compared with Klk6+/+ (wild-type) mice, Klk6-/- mice showed milder EAE symptoms, including delayed onset and milder paralysis. Loss of Klk6 suppressed matrix metalloprotease-9 expression and diminished the infiltration of peripheral inflammatory cells into the CNS by decreasing blood-brain barrier (BBB) permeability and reducing expression levels of inflammatory cytokines, chemokines and their receptors. Scanning electron microscopic analysis revealed demyelination characterized by myelin detachment from the axons in the early phase of EAE progression (days 3-7) in Klk6+/+ mice but not in Klk6-/- mice. Interestingly, anti-MOG (myelin oligodendrocyte glycoprotein) autoantibody was also detected in the cerebrospinal fluid (CSF) and spinal cord on day 3 after MOG immunization. Furthermore, treatment of primary cultured OLs with anti-MOG autoantibody induced oligodendroglial morphological changes and increases in myelin basic protein and Klk6 expression. We also developed a novel enzyme-linked immunoabsorbent assay method for detecting activated KLK6 in human CSF. In human autopsy brain samples, expression of active KLK6 was detected in OLs using an antibody that specifically recognizes the protein's activated form. Taken together, our findings demonstrate that Klk6 secreted by OLs plays a critical role in the pathogenesis of EAE/MS and that it might serve as a potential therapeutic target for MS.

DOI PubMed

Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia.

Nomura T, Bando Y, You H, Tanaka T, Yoshida S.

Neurochem Res.   42 ( 12 ) 3525 - 3536   2017.12  [Refereed]

Research paper (journal)   Domestic Co-author

Microglia support ATF3-positive neurons following hypoglossal nerve axotomy.

Tanaka T, Murakami K, Bando Y, Nomura T, Isonishi A, Morita-Takemura S, Tatsumi K, Wanaka A, Yoshida S.

Neurochem Int.   108   332 - 342   2017.09  [Refereed]

Research paper (journal)   Domestic Co-author

Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism.

Iinuma S, Kishibe M, Saito N, Igawa S, Honma M, Bando Y, Yoshida S, Ishida-Yamamoto A.

Exp Dermatol.   26 ( 3 ) 289 - 291   2017.03  [Refereed]

Research paper (journal)   Domestic Co-author

Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism.

Shin Iinuma, Mari Kishibe, Nao Saito, Satomi Igawa, Masaru Honma, Yoshio Bando, Shigetaka Yoshida, Akemi Ishida-Yamamoto

Experimental dermatology ( WILEY )  26 ( 3 ) 289 - 291   2017.03  [Refereed]

Research paper (journal)  

DOI PubMed

Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells.

Yamashita T, Miyamoto Y, Bando Y, Ono T, Kobayashi S, Doi A, Araki T, Kato Y, Shirakawa T, Suzuki Y, Yamauchi J, Yoshida S, Sato N.

PLoS One.   12 ( 2 ) e0171947   2017.02  [Refereed]

Research paper (journal)   Domestic Co-author

A PLK4 mutation causing azoospermia in a man with Sertoli cell-only syndrome.

Miyamoto T, Bando Y, Koh E, Tsujimura A, Miyagawa Y, Iijima M, Namiki M, Shiina M, Ogata K, Matsumoto N, Sengoku K.

Andrology.   4 ( 1 ) 75 - 81   2016.01  [Refereed]

Research paper (journal)   Domestic Co-author

Klk8 is required for microabscess formation in a mouse imiquimod model of psoriasis.

Iinuma S, Kishibe M, Saito N, Igawa S, Honma M, Takahashi H, Bando Y, Yoshida S, Iizuka H, Ishida-Yamamoto A.

Exp Dermatol.   24 ( 11 ) 887 - 889   2015.11  [Refereed]

Research paper (journal)   Domestic Co-author

Myelin morphology and axon pathology in demyelination during experimental autoimmune encephalomyelitis.

Bando Y

Neural Regen Res.   10 ( 10 ) 1584 - 1584   2015.10  [Refereed]  [Invited]

Research paper (journal)   Single author

Nerve injury induces the expression of syndecan-1 heparan sulfate proteoglycan in primary sensory neurons.

Murakami K, Tanaka T, Bando Y, Yoshida S.

Neuroscience.   300   338 - 350   2015.08  [Refereed]

Research paper (journal)   Domestic Co-author

Interferon regulatory factor 7 participates in the M1-like microglial polarization switch.

Tanaka T, Murakami K, Bando Y, Yoshida S.

GLIA   63 ( 4 ) 595 - 610   2015.04  [Refereed]

Research paper (journal)   Domestic Co-author

Abnormal morphology of myelin and axon pathology in murine models of multiple sclerosis.

Bando Y, Nomura T, Bochimoto H, Murakami K, Tanaka T, Watanabe T, Yoshida S.

Neurochem Int.   81   16 - 27   2015.02  [Refereed]

Research paper (journal)   Domestic Co-author

Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains.

Murakami K, Tanaka T, Bando Y, Yoshida S.

Protein Pept Lett.   22 ( 3 ) 204 - 211   2014.03  [Refereed]

Research paper (journal)   Domestic Co-author

Minocycline reduces remyelination by suppressing ciliary neurotrophic factor expression after cuprizone-induced demyelination.

Tanaka T, Murakami K, Bando Y, Yoshida S.

J Neurochem   127 ( 2 ) 259 - 270   2013.10  [Refereed]

Research paper (journal)   Domestic Co-author

In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins.

Murakami K, Jiang YP, Tanaka T, Bando Y, Mitrovic B, Yoshida S.

Neuroscience.   236   1 - 11   2013.04  [Refereed]

Research paper (journal)   Domestic Co-author

Three-dimensional ultra-structures of myelin and the axons in the spinal cord: application of SEM with the osmium maceration method to the central nervous system in two mouse models.

Nomura T, Bando Y, Bochimoto H, Koga D, Watanabe T, Yoshida S.

Neurosci Res.   75 ( 3 ) 190 - 197   2013.03  [Refereed]

Research paper (journal)   Domestic Co-author

Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2.

Kishibe M, Bando Y, Tanaka T, Ishida-Yamamoto A, Iizuka H, Yoshida S.

J Invest Dermatol.   132 ( 6 ) 1717 - 1724   2012.06  [Refereed]

Research paper (journal)   Domestic Co-author

The functional role of stress proteins in ER stress mediated cell death.

Bando Y

Anat Sci Int.   87 ( 1 ) 14 - 23   2012.03  [Refereed]  [Invited]

Research paper (journal)   Single author

CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosis.

Liu Y, Bando Y, Vargas-Lowy D, Elyaman W, Khoury SJ, Huang T, Reif K, Chitnis T.

J Neurosci.   30 ( 6 ) 2025 - 2038   2010.02  [Refereed]

Research paper (journal)   Domestic Co-author

Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression.

Sanson M, Augé N, Vindis C, Muller C, Bando Y, Thiers JC, Marachet MA, Zarkovic K, Sawa Y, Salvayre R, Nègre-Salvayre A.

Circ Res.   104 ( 3 ) 328 - 336   2009.02  [Refereed]

Research paper (journal)   Domestic Co-author

Differential changes in axonal conduction following CNS demyelination in two mouse models.

Bando Y, Takakusaki K, Ito S, Terayama R, Kashiwayanagi M, Yoshida S.

Eur J Neurosci   28 ( 9 ) 1731 - 1742   2008.11  [Refereed]

Research paper (journal)   Domestic Co-author

Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells.

Sanson M, Ingueneau C, Vindis C, Thiers JC, Glock Y, Rousseau H, Sawa Y, Bando Y, Mallat Z, Salvayre R, Nègre-Salvayre A.

Cell Death Differ.   15 ( 8 ) 1255 - 1265   2008.08  [Refereed]

Research paper (journal)   Domestic Co-author

Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.

Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL.

J Immunol.   180 ( 11 ) 7327 - 7337   2008.06  [Refereed]

Research paper (journal)   Domestic Co-author

HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA.

Manabe T, Ohe K, Katayama T, Matsuzaki S, Yanagita T, Okuda H, Bando Y, Imaizumi K, Reeves R, Tohyama M, Mayeda A.

Genes Cells.   12 ( 10 ) 1179 - 1191   2007.10  [Refereed]

Research paper (journal)   Domestic Co-author

CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis.

Zhu B, Bando Y, Xiao S, Yang K, Anderson AC, Kuchroo VK, Khoury SJ.

J Immunol.   179 ( 8 ) 5228 - 5237   2007.10  [Refereed]

Research paper (journal)   Domestic Co-author

Phosphorylated PKR contributes the induction of GRP94 under ER stress.

Ito M, Onuki R, Bando Y, Tohyama M, Sugiyama Y.

Biochem Biophys Res Commun.   360 ( 3 ) 615 - 620   2007.08  [Refereed]

Research paper (journal)   Domestic Co-author

Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury.

Terayama R, Bando Y, Murakami K, Kato K, Kishibe M, Yoshida S.

Neuroscience.   148 ( 1 ) 175 - 187   2007.08  [Refereed]

Research paper (journal)   Domestic Co-author

Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins.

Kishibe M, Bando Y, Terayama R, Namikawa K, Takahashi H, Hashimoto Y, Ishida-Yamamoto A, Jiang YP, Mitrovic B, Perez D, Iizuka H, Yoshida S.

J Biol Chem.   282 ( 8 ) 5834 - 5841   2007.02  [Refereed]

Research paper (journal)   Domestic Co-author

Novel interaction between HMGA1a and StIP1 in murine terminally differentiated retina.

Okuda H, Manabe T, Yanagita T, Matsuzaki S, Bando Y, Katayama T, Wanaka A, Tohyama M.

Mol Cell Neurosci.   33 ( 1 ) 81 - 87   2006.09  [Refereed]

Research paper (journal)   Domestic Co-author

Regeneration of the abdominal postganglionic sympathetic system.

Yamada M, Terayama R, Bando Y, Kasai S, Yoshida S.

Neurosci Res.   54 ( 4 ) 261 - 268   2006.04  [Refereed]

Research paper (journal)   Domestic Co-author

Implications of protease M/neurosin in myelination during experimental demyelination and remyelination.

Bando Y, Ito S, Nagai Y, Terayama R, Kishibe M, Jiang YP, Mitrovic B, Takahashi T, Yoshida S.

Neurosci Lett.   54 ( 4 ) 261 - 268   2006.04  [Refereed]

Research paper (journal)   Domestic Co-author

Involvement of neuropsin in the pathogenesis of experimental autoimmune encephalomyelitis.

Terayama R, Bando Y, Yamada M, Yoshida S.

GLIA   52 ( 2 ) 108 - 118   2005.11  [Refereed]

Research paper (journal)   Domestic Co-author

Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis.

Terayama R, Bando Y, Jiang YP, Mitrovic B, Yoshida S.

Neurosci Lett.   382 ( 1-2 ) 82 - 87   2005.07  [Refereed]

Research paper (journal)   Domestic Co-author

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.

Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, Tsujimoto Y, Tohyama M.

J Cell Biol.   165 ( 3 ) 347 - 356   2005.05  [Refereed]

Research paper (journal)   Domestic Co-author

150-kDa oxygen-regulated protein attenuates myocardial ischemia-reperfusion injury in rat heart.

Aleshin AN, Sawa Y, Kitagawa-Sakakida S, Bando Y, Ono M, Memon IA, Tohyama M, Ogawa S, Matsuda H.

J Mol Cell Cardiol.   38 ( 3 ) 517 - 525   2005.03  [Refereed]

Research paper (journal)   Domestic Co-author

Possible involvement of the expression and phosphorylation of N-Myc in the induction of HMGA1a by hypoxia in the human neuroblastoma cell line.

Yanagita T, Manabe T, Okuda H, Matsuzaki S, Bando Y, Katayama T, Tohyama M.

Neurosci Lett.   374 ( 1 ) 47 - 52   2005.02  [Refereed]

Research paper (journal)   Domestic Co-author

RA410/Sly1 suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells.

Bando Y, Katayama T, Taniguchi M, Ishibashi T, Matsuo N, Ogawa S, Tohyama M.

Neurobiol Dis.   18 ( 1 ) 143 - 151   2005.02  [Refereed]

Research paper (journal)   Domestic Co-author

Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease.

Bando Y, Onuki R, Katayama T, Manabe T, Kudo T, Taira K, Tohyama M.

Neurochem Int.   46 ( 1 ) 11 - 18   2005.01  [Refereed]

Research paper (journal)   Domestic Co-author

GRP94 reduces cell death in SH-SY5Y cells perturbated calcium homeostasis.

Bando Y, Katayama T, Aleshin AN, Manabe T, Tohyama M.

Apoptosis.   9 ( 4 ) 501 - 508   2004.07  [Refereed]

Research paper (journal)   Domestic Co-author

Novel function of PS2V: change in conformation of tau proteins.

Nishikawa A, Manabe T, Katayama T, Kudo T, Matsuzaki S, Yanagita T, Okuda H, Bando Y, Tohyama M.

Biochem Biophys Res Commun.   318 ( 2 ) 435 - 438   2004.05  [Refereed]

Research paper (journal)   Domestic Co-author

An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease.

Onuki R, Bando Y, Suyama E, Katayama T, Kawasaki H, Baba T, Tohyama M, Taira K.

EMBO J.   23 ( 4 ) 959 - 968   2004.02  [Refereed]

Research paper (journal)   Domestic Co-author

GRP94 (94 kDa glucose-regulated protein) suppresses ischemic neuronal cell death against ischemia/reperfusion injury.

Bando Y, Katayama T, Kasai K, Taniguchi M, Tamatani M, Tohyama M.

Eur J Neurosci.   18 ( 4 ) 829 - 840   2003.08  [Refereed]

Research paper (journal)   Domestic Co-author

Hypothermic treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain.

Aoki M, Tamatani M, Taniguchi M, Yamaguchi A, Bando Y, Kasai K, Miyoshi Y, Nakamura Y, Vitek MP, Tohyama M, Tanaka H, Sugimoto H.

Brain Res Mol Brain Res.   95 ( 1-2 ) 117 - 128   2001.11  [Refereed]

Research paper (journal)   Domestic Co-author

150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells.

Bando Y, Ogawa S, Yamauchi A, Kuwabara K, Ozawa K, Hori O, Yanagi H, Tamatani M, Tohyama M.

Am J Physiol Cell Physiol.   278 ( 6 ) C1172 - 1182   2000.06  [Refereed]

Research paper (journal)   Domestic Co-author

Exposure of cultured primary rat astrocytes to hypoxia results in intracellular glucose depletion and induction of glycolytic enzymes.

Niitsu Y, Hori O, Yamaguchi A, Bando Y, Ozawa K, Tamatani M, Ogawa S, Tohyama M.

Brain Res Mol Brain Res.   74 ( 1-2 ) 26 - 36   1999.12  [Refereed]

Research paper (journal)   Domestic Co-author