Research Achievements - Original paper -

Galectin-3 plays a role in neuroinflammation in the visual pathway in experimental optic neuritis.

Funaki M., Nio-Kobayashi J., Suzuki R., Bando Y.

Cells ( MDPI )  13   612   2024.03  [Refereed]  [Invited]

Research paper (journal)   Domestic Co-author

Expression levels of KATP channel subunits and morphological changes in the mouse liver after exposure to radiation

Ming Zhou, Tao-Sheng Li, Hiroshi Abe, Hideo Akashi, Ryoji Suzuki, Yoshio Bando

World Journal of Experimental Medicine     2024.03  [Refereed]

Research paper (journal)  

Mechanism of Demyelination and Remyelination in Multiple Sclerosis

Bando Y.

Clinical and Experimental Neuroimmunology   in press   2020.01  [Refereed]  [Invited]

Research paper (journal)   Single author

Localization of ATP-sensitive K+ channel subunits in rat liver.

Zhou M., Yoshikawa K., Akashi H., Miura M., Suzuki R., Sheng T., Abe H., Bando Y.

World Journal of Experimental Medicine.   9 ( 2 ) 14 - 31   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

An anomalous case of the flexor carpi radialis with an excessive muscular bundle.

Zhou M, Ishizawa A, Akashi H, Suzuki R, Kanatsu Y, Abe H, Bando Y

Anat Sci Int.   Dec 17   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

Disease modifying mitochondrial uncouplers, MP101, and a slow release ProDrug, MP201, in models of Multiple Sclerosis.

Bando Y, Geisler JG.

Neurochem Int   131   104561   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

Potential of Adult Endogenous Neural Stem/Progenitor Cells in the Spinal Cord to Contribute to Remyelination in Experimental Autoimmune Encephalomyelitis.

Maeda Y, Nakagomi N, Nakano-Doi A, Ishikawa H, Tatsumi Y, Bando Y, Yoshikawa H, Matsuyama T, Gomi F, Nakagomi T.

Cells   8 ( 9 ) E1025   2019.09  [Refereed]

Research paper (journal)   Domestic Co-author

Potential of Adult Endogenous Neural Stem/Progenitor Cells in the Spinal Cord to Contribute to Remyelination in Experimental Autoimmune Encephalomyelitis.

Maeda Y, Nakagomi N, Nakano-Doi A, Ishikawa H, Tatsumi Y, Bando Y, Yoshikawa H, Matsuyama T, Gomi F, Nakagomi T.

Cells.   8 ( (9) ) E1025   2019.09  [Refereed]

Research paper (journal)   Domestic Co-author

Dataset on the effect of knockout of KLK8 in social memory.

Nakazawa H, Suzuki Y, Ishikawa Y, Bando Y, Yoshida S, Shiosaka S.

Data Brief.   26   104458   2019.08  [Refereed]

Research paper (journal)   Domestic Co-author

Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse.

Nakazawa H, Suzuki Y, Ishikawa Y, Bando Y, Yoshida S, Shiosaka S.

Neurobiol Learn Mem.   162   47 - 58   2019.07  [Refereed]

Research paper (journal)   Domestic Co-author

Pathological changes in mice with long term cuprizone administration.

Nomura T, Bando Y, Nakazawa H, Kanemoto S, Yoshida S.

Neurochem Int.   126   229 - 238   2019.06  [Refereed]

Research paper (journal)   Domestic Co-author

Cell- and stage-specific localization of galectin-3, a β-galactoside-binding lectin, in a mouse model of experimental autoimmune encephalomyelitis.

Itabashi T, Arima Y, Kamimura D, Higuchi K, Bando Y, Takahashi-Iwanaga H, Murakami M, Watanabe M, Iwanaga T, Nio-Kobayashi J.

Neurochem Int.   118   176 - 184   2018.09  [Refereed]

Research paper (journal)   Domestic Co-author

Alterations of Both Dendrite Morphology and Weaker Electrical Responsiveness in the Cortex of Hip Area Occur Before Rearrangement of the Motor Map in Neonatal White Matter Injury Model.

Ueda Y, Bando Y, Misumi S, Ogawa S, Ishida A, Jung CG, Shimizu T, Hida H.

Front Neurol.   9   443   2018.06  [Refereed]

Research paper (journal)   Domestic Co-author

Bando Y, Hagiwara Y, Suzuki Y, Yoshida K, Aburakawa Y, Kimura T, Murakami C, Ono M, Tanaka T, Jiang YP, Mitrovi B, Bochimoto H, Yahara O, Yoshida S.

Bando Y, Hagiwara Y, Suzuki Y, Yoshida K, Aburakawa Y, Kimura T, Murakami C, Ono M, Tanaka T, Jiang YP, Mitrovi B, Bochimoto H, Yahara O, Yoshida S.

GLIA   66 ( 2 ) 359 - 378   2018.02  [Refereed]

Research paper (journal)   Domestic Co-author

Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis.

Yoshio Bando, Yoshiaki Hagiwara, Yasuhiro Suzuki, Kosuke Yoshida, Yoko Aburakawa, Takashi Kimura, Chisato Murakami, Miyuki Ono, Tatsuhide Tanaka, Ying-Ping Jiang, Branka Mitrovi, Hiroki Bochimoto, Osamu Yahara, Shigetaka Yoshida

Glia ( WILEY )  66 ( 2 ) 359 - 378   2018.02  [Refereed]

Research paper (journal)  

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), and experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of the disease. Here, we examined the pathophysiological role of Kallikrein 6 (Klk6), a serine protease produced by oligodendrocytes (OLs), in EAE using Klk6 knockout (Klk6-/-) mice. Compared with Klk6+/+ (wild-type) mice, Klk6-/- mice showed milder EAE symptoms, including delayed onset and milder paralysis. Loss of Klk6 suppressed matrix metalloprotease-9 expression and diminished the infiltration of peripheral inflammatory cells into the CNS by decreasing blood-brain barrier (BBB) permeability and reducing expression levels of inflammatory cytokines, chemokines and their receptors. Scanning electron microscopic analysis revealed demyelination characterized by myelin detachment from the axons in the early phase of EAE progression (days 3-7) in Klk6+/+ mice but not in Klk6-/- mice. Interestingly, anti-MOG (myelin oligodendrocyte glycoprotein) autoantibody was also detected in the cerebrospinal fluid (CSF) and spinal cord on day 3 after MOG immunization. Furthermore, treatment of primary cultured OLs with anti-MOG autoantibody induced oligodendroglial morphological changes and increases in myelin basic protein and Klk6 expression. We also developed a novel enzyme-linked immunoabsorbent assay method for detecting activated KLK6 in human CSF. In human autopsy brain samples, expression of active KLK6 was detected in OLs using an antibody that specifically recognizes the protein's activated form. Taken together, our findings demonstrate that Klk6 secreted by OLs plays a critical role in the pathogenesis of EAE/MS and that it might serve as a potential therapeutic target for MS.

DOI PubMed

Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia.

Nomura T, Bando Y, You H, Tanaka T, Yoshida S.

Neurochem Res.   42 ( 12 ) 3525 - 3536   2017.12  [Refereed]

Research paper (journal)   Domestic Co-author

Microglia support ATF3-positive neurons following hypoglossal nerve axotomy.

Tanaka T, Murakami K, Bando Y, Nomura T, Isonishi A, Morita-Takemura S, Tatsumi K, Wanaka A, Yoshida S.

Neurochem Int.   108   332 - 342   2017.09  [Refereed]

Research paper (journal)   Domestic Co-author

Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism.

Iinuma S, Kishibe M, Saito N, Igawa S, Honma M, Bando Y, Yoshida S, Ishida-Yamamoto A.

Exp Dermatol.   26 ( 3 ) 289 - 291   2017.03  [Refereed]

Research paper (journal)   Domestic Co-author

Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism.

Shin Iinuma, Mari Kishibe, Nao Saito, Satomi Igawa, Masaru Honma, Yoshio Bando, Shigetaka Yoshida, Akemi Ishida-Yamamoto

Experimental dermatology ( WILEY )  26 ( 3 ) 289 - 291   2017.03  [Refereed]

Research paper (journal)  

DOI PubMed

Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells.

Yamashita T, Miyamoto Y, Bando Y, Ono T, Kobayashi S, Doi A, Araki T, Kato Y, Shirakawa T, Suzuki Y, Yamauchi J, Yoshida S, Sato N.

PLoS One.   12 ( 2 ) e0171947   2017.02  [Refereed]

Research paper (journal)   Domestic Co-author