|
Affiliation |
Advanced Research Center for Geriatric Medicine |
Graduating School 【 display / non-display 】
-
-2008.03
Akita University Faculty of Medicine Graduated
Campus Career 【 display / non-display 】
-
2018.02-Now
Akita University Advanced Research Center for Geriatric Medicine Specially-appointed Assistant Professor
Thesis for a degree 【 display / non-display 】
-
Low Plasma Concentration of Gefitinib in Patients with EGFR Exon 21 L858R Point Mutations Shortens Progression-Free Survival
Yuji Okuda, Kazuhiro Sato, Kazuhisa Sudo, Yukiyasu Hasegawa, Mariko Asano, Hajime Miura, Masahide Takeda, Masaaki Sano, Hiroyuki Watanabe, Hiroyuki Kobayashi, Takenori Niioka, Masatomo Miura, Hiroshi Ito
Cancer Chemotherapy and Pharmacology. 2018.03
Domestic Co-author
Research Achievements 【 display / non-display 】
-
Case report of QT interval prolongation induced by anamorelin in an obese patient with non-small cell lung cancer.
Hayato Yokota, Ruriko Asahi, Yumiko Akamine, Mizuki Kobayashi, Hiyu Wakabayashi, Sho Sakamoto, Yuji Okuda, Kazuhiro Sato, Katsutoshi Nakayama, Masafumi Kikuchi
Journal of pharmaceutical health care and sciences 10 ( 1 ) 33 - 33 2024.06
Research paper (journal)
BACKGROUND: Anamorelin, a drug to treat cancer cachexia, binds to ghrelin receptors and improves body weight and appetite. In clinical trials in Japan, patients experienced a 10.7% frequency of stimulant conduction system depression as a severe side effect. Although rare, anamorelin sometimes causes fatal arrhythmias. Because patients with cancer cachexia are often underweight, data on the safety of anamorelin in obese patients are lacking. We report a case of QT interval prolongation after anamorelin administration to an obese patient with non-small cell lung cancer. CASE PRESENTATION: A female patient with a body mass index of 30 kg/m2 underwent immunotherapy for lung adenocarcinoma. She presented with severe weight loss, anorexia, and fatigue. She had no history of heart disease. On day 12, after administration of anamorelin 100 mg once daily, the patient developed nausea, diarrhea, and anorexia, which were considered cancer immunotherapy-induced immune-related adverse events, and she was admitted to the hospital. An electrocardiogram (ECG) on admission showed a QTc interval of 502 ms. On admission, her hepatic function was Child-Pugh class B, and anamorelin was discontinued the next day. On day 3 after anamorelin discontinuation, the QTc interval was prolonged by up to 557 ms, then decreased to 490 ms on day 6, and improved to 450 ms on day 16. Re-administration of anamorelin was avoided. CONCLUSIONS: When administering anamorelin to obese patients, we should be aware of the potential for stimulatory conduction system depression, as in underweight patients. Therefore, we should monitor patients by ECG from the early stages of anamorelin administration. Anamorelin is lipophilic, and its volume of distribution is increased in obese patients. Consequently, obese patients may continue to have QT interval prolongation after discontinuation of anamorelin, requiring long-term side-effect monitoring.
-
Yuji Okuda, Kazuhiro Sato, Mariko Asano, Kentaroh Kudoh, Eiki Omoto, Yuka Izumiya, Sho Sakamoto, Masahide Takeda, Tatsunori Shimizu, Hidetaka Ota, Hirokazu Kurokawa, Yoshihiro Minamiya, Katsutoshi Nakayama
Geriatrics & gerontology international ( Geriatrics and Gerontology International ) 23 ( 8 ) 622 - 627 2023.07
Research paper (journal)
AIM: Akita Prefecture has the largest proportion of older inhabitants and the highest cancer mortality rate in Japan. Lung cancer is one of the biggest killers, and early detection is critical. Chest X-ray examinations are the main screening method for lung cancer; however, the COVID-19 pandemic has affected the screening system. Here, we evaluate how COVID-19 has affected lung cancer screening in Akita Prefecture. METHODS: Using the Akita General Health Corporation database, the average annual number of chest X-ray screening tests, close examinations and lung cancer diagnoses (stratified by sex and age) was evaluated during 2016-2019, and compared with the 2020 values. Furthermore, data on lung cancer registrations from 2018 to 2020 were obtained from the Collaborative Akita Prefecture Hospital-Based Cancer Registration System and analyzed. RESULTS: The average annual number of screening tests, close examinations and lung cancer diagnoses declined (by >50%) between 2016 to 2019 and 2020, especially among older people (aged ≥65 years). Furthermore, by stage, the number of patients with early-stage lung cancer (stage 0-I) decreased, and the number with advanced-stage cancer (stage IV) increased. CONCLUSIONS: The COVID-19 pandemic reduced lung cancer screening participation, especially among the older adult population in Akita Prefecture, resulting in a decrease in lung cancer diagnoses through screening. This might have reduced the number of early-stage cancer registrations. It is necessary to improve health education among the public regarding the importance of chest X-ray screening. Geriatr Gerontol Int 2023; ••: ••-••.
-
Association Between Endothelial Progenitor Cells and Treatment Response in Non-Squamous Non-small Cell Lung Cancer Treated with Bevacizumab.
Kazuhisa Sudo, Kazuhiro Sato, Sho Sakamoto, Yukiyasu Hasegawa, Mariko Asano, Yuji Okuda, Masahide Takeda, Masaaki Sano, Hiroyuki Watanabe, Takanobu Shioya, Hiroshi Ito
Anticancer research 37 ( 10 ) 5565 - 5571 2017.10
Research paper (journal)
BACKGROUND/AIM: To investigate the association between the number of circulating endothelial progenitor cells (EPCs) in non-squamous non-small cell lung cancer (NSCLC) and disease outcome, in combination chemotherapy with and without bevacizumab. MATERIALS AND METHODS: We retrospectively identified 25 non-squamous NSCLC cases, and divided them into high-EPC and low-EPC groups. Within each group, we compared disease outcomes, with or without the administration of bevacizumab. RESULTS: In the high-EPC group, chemotherapy with bevacizumab produced a significantly higher tumor reduction rate and objective response rate, with significantly longer progression-free survival, compared to chemotherapy without bevacizumab (p<0.001, p=0.010, and p<0.001, respectively). However, in the low-EPC group, there were no significant differences in disease outcomes in groups with versus those without bevacizumab. CONCLUSION: The number of EPCs may be a useful biomarker to guide decision-making in the use of bevacizumab in non-squamous NSCLC.
-
Shimizu Tatsunori, Kodama Ayuto, Sugawara Kaoru, Asano Mariko, Okuda Yuji, Ota Hidetaka
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics ( The Japan Geriatrics Society ) 59 ( 4 ) 543 - 550 2022
<p><b>Aim: </b>To consider what is necessary to ensure the efficient performance of dementia community support coordinators.</p><p><b>Methods: </b>In Akita Prefecture, we conducted a simple questionnaire survey of dementia community support coordinators in 25 municipalities to clarify the current status of their activities and examine what needs to be done to develop their projects more efficiently.</p><p><b>Results: </b>It became clear that residents were not aware of the existence of these coordinators, underscoring the need to publicize their existence and activities. The lack of tools to improve the public's understanding of social resources for sharing information on building a support system was also demonstrated. In terms of cooperation, it was found that, despite the establishment of cooperation with IPIST and the medical center for dementia, cooperation with dementia support coordinators was insufficient. Furthermore, we confirmed that support coordinators were not very involved in the creation and activities of dementia care paths.</p><p><b>Conclusions: </b>Based on the above findings, we propose five points to support further efficient development. 1. Disseminate information to inform local residents about dementia community support coordinators, 2. Collaborate with dementia support coordinators and the welfare commissioner, 3. Create social resource maps and facilitate their understanding and establish dementia care path activities, 4. Create a work environment where dementia community support coordinators do not have to work concurrently, and 5. Create learning opportunities to improve understanding of the overall dementia policy.</p>
-
Kodama Ayuto, Asano Mariko, Okuda Yuji, Ota Hidetaka
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics ( The Japan Geriatrics Society ) 58 ( 2 ) 266 - 271 2021
<p>The purpose of this study was to clarify the trends in the activity of the initial-phase intensive support teams in Akita Prefecture and to, clarify the factors contributing to the more efficient promotion of future projects. A survey was conducted by questionnaire among 46 initial-phase intensive support team member for dementia. The results indicated that it is mostly maintained cooperation medical center for dementia and community support promoter for dementia. However, the question was insufficient cooperation with family doctor including visit the home. These findings suggest that it is important to disseminate information and improve awareness among the community as well as foster relationships of trust by families.</p>
-
Association between plasma concentration of gefitinib and polymorphisms related to the pharmacokinetics
坂本祥, 佐藤一洋, 横田隼人, 赤嶺由美子, 奥田佑道, 浅野真理子, 竹田正秀, 三浦昌朋, 中山勝敏
日本呼吸器学会誌(Web) 10 2021
-
An examination for efficient project promotion of the initial-phase intensive support team for dementia in Akita Prefecture
小玉鮎人, 浅野真理子, 奥田佑道, 大田秀隆
日本老年医学会雑誌 58 ( 2 ) 2021
-
Eosinophil ETosis in BALF of patients with chronic eosinophilic pneumonia
竹田正秀, 坂本祥, 佐藤一洋, 植木重治, 宮部結, 佐野正明, 奥田佑道, 浅野真理子, 長谷川幸保, 熊谷奈保, 廣川誠, 中山勝敏
日本呼吸器学会誌(Web) 9 2020