|
Affiliation |
Hospital Neurosurgery |
Research Interests 【 display / non-display 】
-
nuclear medicine
-
glioma
-
molecular biology
-
脳神経外科
Graduating School 【 display / non-display 】
-
-2009.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
-
-2015.03
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Studying abroad experiences 【 display / non-display 】
-
2015.11-2017.06
Germany Guest Researcher, Department of Neuropathology, Institute of Pathology, University Heidelberg
Campus Career 【 display / non-display 】
-
2023.04-Now
Akita University Hospital Neurosurgery Lecturer
-
2017.07-2023.03
Akita University Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Assistant Professor
External Career 【 display / non-display 】
-
2023.04
Akita University Graduate School of Medicine Department of Neurosurgery Assistant Professor
-
2017.07
Akita University Graduate Scholol of Medicine Department of Neurosurgery Assistant Professor
-
2015.11-2017.06
University Heidelberg Institute of Pathology, Department of Neuropathology Guest Researcher
Research Areas 【 display / non-display 】
-
Life Science / Neurosurgery / brain tumor
Research Career 【 display / non-display 】
-
Refinement of IDH-mutated glioma classification and grading
International Joint Research Projects
Periods of research：
2015.11-2017.10Classification of research form：International Collaboration
-
Diagnostic significance of amino acid tracers for evaluation of temozolomide therapy with interferon-beta and bevacizumab in temozolomide-resistant malignant glioma
Grant-in-Aid for Scientific Research
Periods of research：
2011.04-2015.03Classification of research form：Collaboration within Japan
Research Achievements 【 display / non-display 】
-
Shape of the first mitotic spindles impacts multinucleation in human embryos
Ono Yuki, Shirasawa Hiromitsu, Takahashi Kazumasa, Goto Mayumi, Ono Takahiro, Sakaguchi Taichi, Okabe Motonari, Hirakawa Takeo, Iwasawa Takuya, Fujishima Akiko, Sugawara Tae, Makino Kenichi, Miura Hiroshi, Fukunaga Noritaka, Asada Yoshimasa, Kumazawa Yukiyo, Terada Yukihiro
Akita journal of medicine 52 ( 2 ) 21 - 24 2025.08 [Refereed]
Research paper (journal)
-
Comparative molecular analysis of primary and recurrent pleomorphic xanthoastrocytoma with BRAF mutation treated with combination therapy with dabrafenib and trametinib: a case report and literature review
Shoto Tateoka, Takahiro Ono, Junta Moroi, Hajime Miyata, Takuya Furuta, Mayuko Moritsubo, Hiroshi Nanjo, Yoshitaka Narita, Hiroaki Shimizu
International Cancer Conference Journal 2025.08 [Refereed]
Research paper (journal)
-
Hamasaki Ryo, Abe Takatsugu, Ono Takahiro, Bando Yoshio, Shimizu Hiroaki
AKITA JOURNAL OF MEDICINE ( AKITA MEDICAL SOCIETY ) 52 ( 1 ) 1 - 7 2025.03 [Refereed]
Research paper (journal)
OBJECTIVE: This study aimed to investigate the temporal changes in cerebral blood flow（ CBF） upon
superior sagittal sinus（ SSS） occlusion in a novel rat model.
METHODS: A gelatin sponge was inserted into the SSS to obtain immediate and complete SSS occlusion.
A laser speckle flowmetry （LSF） was employed to monitor the CBF of the parasagittal cortex for 100
minutes post-procedure, and on days 1-3 after occlusion. Regions of interests for CBF were placed in an
area between the two occluded bridging veins（ 2VOA）, or an area adjacent to only one occluded bridging
vein（ 1VOA）. Histopathological evaluation was performed 3 days following SSS occlusion.
RESULT: The CBF in the parasagittal cortices following the SSS occlusion acutely decreased to approximately
70% and 80% in the 2VOA and 1VOA compared to the pre-occlusion levels, respectively. Development
of collateral anastomosis between the bridging veins was observed by 60 minutes following occlusion,
and CBF recovered on day 1. Pathologically, edematous changes were more evident in the 2VOA
than the 1VOA.
Conclusions: CBF reduction in the parasagittal cortices depended on the severity of adjacent venous occlusion.
Development of collateral venous anastomosis seemed to contribute for the CBF recovery. -
Identifying the appropriate measurement environment for laser speckle flowmetry of cerebral blood flow in rats
Ryosei Wakasa, Takahiro Ono, Naomoto Senbokuya, Mikiko Kuwayama, Hiroaki Shimizu
Brain Research ( Elsevier BV ) 149443 - 149443 2025.01 [Refereed]
Research paper (journal)
-
Takahiro Ono, Hayato Suzuki, Hiroshi Nanjo, Hiroaki Shimizu
Journal of neuro-oncology ( Journal of Neuro-Oncology ) 168 ( 3 ) 393 - 404 2024.05 [Refereed]
Research paper (journal)
PURPOSE: It remains unclear whether combining carmustine wafer (CW) implantation with the standard treatment for adult-type diffuse gliomas is safe and has a prognostic impact. This study aimed to investigate the prognostic value and safety of CW implantation. METHODS: Adult patients with IDH-wild-type and -mutant gliomas, grades 3-4 treated with surgical resection, radiotherapy, and temozolomide chemotherapy between 2013 and 2023 were surveyed. CWs were implanted except in cases of intraoperative wide ventricle opening or marked preoperative brain swelling. For survival analyses, a case-matched dataset based on propensity score matching (PSM), including multiple factors (patient background, diagnosis, and extent of resection) was generated. Progression-free survival (PFS), overall survival (OS), and frequency of complications of CW implantation (brain edema, infection, and cerebrospinal fluid leakage) were compared between the CW and non-use groups. RESULTS: In total, 127 patients (75 in the CW use group and 52 in the non-use group) were enrolled. Regardless of stratification, no significant differences in PFS and OS were observed between the CW use and non-use groups. The frequency of postoperative brain edema was significantly higher in the CW use group than in the non-use group. An adjusted dataset containing 41 patients in the CW use and nonuse groups was generated. Even after PSM, CW implantation had no prognostic effect. CONCLUSIONS: CW implantation with standard treatment demonstrated little beneficial effect for the present strategy of CW use.
-
自動迅速免疫染色装置を活かす簡易型自動薄切装置の開発(Development of automatic slice device that utilizes automatic rapid immunostaining device)
南條 博, 廣嶋 優子, 佐藤 寛恭, 吉野 雅彦, 今井 一博, 寺田 かおり, 小野 隆裕, 中村 竜太, 赤上 陽一, 南谷 佳弘
日本病理学会会誌 ( (一社)日本病理学会 ) 113 ( 1 ) 332 - 332 2024.02
-
Outcomes of initial conservative management in patients with acute subdural hematoma
Kuwayama Mikiko, Ono Takahiro, Togashi Shuntaro, Takahashi Masataka, Shimizu Hiroaki
Neurotraumatology ( The Japan Society of Neurotraumatology ) 46 ( 1 ) 12 - 19 2023.06 [Refereed]
-
Automation of novel rapid-immunohistochemistry (R-IHC)
南條博, 廣嶋優子, 今井一博, 寺田かおり, 小野隆裕, 中村竜太, 大久保義真, 赤上陽一, 南谷佳弘
日本病理学会会誌 110 ( 1 ) 2021
-
The REAL-WORLD of Elderly PCNSL Therapy in Tohoku and Niigata Area According to Retrospective Analysis: A Collaborative Investigation of the Tohoku Brain Tumor Study Group
浅野研一郎, 山下洋二, 小野隆裕, 棗田学, 別府高明, 松田憲一朗, 市川優寛, 金森政之, 松坂方士, 黒瀬顕, 齋藤清, 園田順彦, 小笠原邦昭, 藤井幸彦, 清水宏明, 大熊洋揮, 北中千史, 嘉山孝正, 冨永悌二
日本脳腫瘍学会プログラム・抄録集 38th 2020
-
Intracerebral hemorrhage: the role of surgery
鈴木隼士, 鈴木隼士, 小野隆裕, 山口卓, 西野克寛, 清水宏明
脳卒中 41 ( 1 ) 2019
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
-
Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2029.03
-
Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2029.03
-
Grant-in-Aid for Early-Career Scientists
Project Year： 2019.04 - 2023.03
-
Grant-in-Aid for Early-Career Scientists
Project Year： 2019.04 - 2023.03
-
Grant-in-Aid for Early-Career Scientists
Project Year： 2019.04 - 2023.03