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附属病院 第二外科 |
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REG Iαactivates c-Jun through MAPK pathways to enhance the radiosensitivity of squamous esophageal cancer cells
Wakita A, Motoyama S (Corresponding author), Sato Y, Koyota S, Usami S, Yoshino K, Sasaki T, Imai K, Saito H, Minamiya Y
Tumor Biol 2015年04月 [査読有り]
単著
研究等業績 【 表示 ／ 非表示 】
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Okura K.
Journal of Surgical Oncology ( Journal of Surgical Oncology ) 128 ( 8 ) 1259 - 1267 2023年12月
研究論文（学術雑誌）
OBJECTIVE: We examined whether preoperative inspiratory muscle weakness (IMW) is a risk factor for postoperative pulmonary complications (PPCs) in patients with esophageal cancer who underwent subtotal esophagectomy. METHODS: This single-center retrospective cohort study enrolled patients with esophageal cancer who underwent a scheduled subtotal esophagectomy between June 2020 and May 2022. Maximal inspiratory pressure (MIP) was measured as inspiratory muscle strength using a respiratory dynamometer, and we defined IMW as MIP < 80% of the predicted value. Our primary outcome comprised overall PPCs. We investigated the relationship between IMW and PPCs using the Bayesian logistic regression model. RESULTS: After exclusion, 72 patients were included in this study. IMW was identified in 26 patients (36%), and PPCs developed in 28 patients (39%). Among patients with IMW, 15 (58%) developed PPCs. Preoperative IMW was associated with PPCs (mean odds ratio [OR]: 3.58; 95% credible interval [95% CrI]: 1.29, 9.73) in the unweighted model. A similar association was observed in the weighted model adjusted for preoperative and intraoperative contributing factors (mean OR: 4.15; 95% CrI: 2.04, 8.45). CONCLUSIONS: Preoperative IMW was associated with PPCs in patients with esophageal cancer who underwent subtotal esophagectomy. This association remained after adjusting for preoperative and intraoperative contributing factors.
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Sato Y.
Current Oncology ( Current Oncology ) 30 ( 5 ) 4724 - 4735 2023年05月
研究論文（学術雑誌）
Most so-called "beneficial bacteria" in gut microbiota are Gram-positive, and TLR6 recognizes the peptidoglycan (PGN) present in their cell walls. We hypothesized that a high TLR6 expression status predicts a more favorable prognosis after esophagectomy. We used an ESCC tissue microarray (TMA) to examine TLR6 expression status in ESCC patients and to determine whether TLR6 expression status correlates with prognosis after curative esophagectomy. We also examined whether PGN influences the cell proliferation activity of ESCC lines. Clinical ESCC samples from 177 patients tested for the expression of TLR6 were categorized as 3+ (n = 17), 2+ (n = 48), 1+ (n = 68), or 0 (n = 44). High TLR6 expression (3+ and 2+) correlated with significantly more favorable 5-year overall survival (OS) and disease-specific survival (DSS) after esophagectomy than a lower TLR6 expression (1+ and 0). Univariate and multivariate analyses showed that TLR6 expression status is an independent prognostic factor that affects 5-year OS. PGN significantly inhibited the cell proliferation activity of ESCC lines. This is the first study to show that high TLR6 expression status predicts a more favorable prognosis in locally advanced thoracic ESCC patients after curative esophagectomy. PGN released from "beneficial bacteria" seems to have potential to inhibit the cell proliferation activity of ESCC.
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Motoyama S.
Anticancer Research ( Anticancer Research ) 42 ( 12 ) 6105 - 6112 2022年12月 [査読有り]
研究論文（学術雑誌）
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Changes in Serum Trace Element Concentrations before and after Surgery in Resectable Breast Cancer
Takahashi E.
Anticancer Research ( Anticancer Research ) 42 ( 11 ) 5323 - 5334 2022年11月 [査読有り]
研究論文（学術雑誌）
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Motoyama S.
Annals of Surgery ( Annals of Surgery ) 276 ( 1 ) E16 - E23 2022年07月 [査読有り]
研究論文（学術雑誌）
OBJECTIVE: To determine whether esophagectomy provides a survival advantage in octogenarians with resectable thoracic esophageal cancer. SUMMARY BACKGROUND DATA: Elderly patients with thoracic esophageal cancer do not always receive the full standard treatment; however, advanced age alone should not preclude the use of effective treatment that could meaningfully improve survival. METHODS: We retrieved the 2008 to 2011 data from the National Database of Hospital-based Cancer Registries from the National Cancer Centerin Japan, divided the patients into a ≥75 group (75-79 years; n = 2935) and a ≥80 group (80 years or older; n = 2131), and then compared the patient backgrounds and survival curves. A multivariable Cox proportional hazards regression model was developed to compare the effects of esophagectomy and chemoradiotherapy in the 2 groups. RESULTS: A significantly greater percentage of patients were treated with esoph-agectomy in the ≥75 group (34.6%) than the ≥80 group (18.4%). Among patients who received esophagectomy, the 3-year survival rate was 51.1% in the ≥ 75 group and 39.0% in the ≥80 group (P < 0.001). However, among patients who received chemoradiotherapy, there was no difference in survival curve between the 2 groups (P = 0.17). Multivariable Cox proportional hazard analysis revealed that esoph-agectomy for clinical Stage ii-iii patients was significantly associated to better survival (adjusted HR: 0.731) (95%CI: 0.645-0.829, P < 0.001) in the ≥75 group but not the ≥ 80 group when compared with chemoradiotherapy. CONCLUSIONS: Many octogenarians do not necessarily get a survival benefit from esophagectomy. However, patients should be evaluated based on their overall health before ruling out surgery based on age alone.
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Nozaki S.
Esophagus ( Esophagus ) 2024年
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Wakita A.
Annals of Gastroenterological Surgery ( Annals of Gastroenterological Surgery ) 7 ( 6 ) 904 - 912 2023年
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Kemuriyama K.
Genes to Cells ( Genes to Cells ) 28 ( 8 ) 573 - 584 2023年
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Ikeda T.
Acta Medica Okayama ( Acta Medica Okayama ) 77 ( 2 ) 193 - 197 2023年
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周術期口腔機能管理は有用か 食道癌患者は重度歯周病罹患率が高く、周術期口腔機能管理は術後重症肺炎発生率を低減する
佐藤 雄亮, 脇田 晃行, 長岐 雄志, 煙山 紘平, 笹森 凌平, 野崎 崇, 南谷 佳弘
日本外科感染症学会雑誌 ( (一社)日本外科感染症学会 ) 19 ( 1 ) 182 - 182 2022年10月
研究発表要旨（全国大会，その他学術会議）
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◆その他【 表示 ／ 非表示 】
科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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高精度遺伝子解析および遺伝子編集技術を用いた放射線感受性中心因子の検索
若手研究
研究期間: 2021年04月 - 継続中
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MAPKシグナル経路操作による新規放射線感受性増強剤の開発
若手研究
研究期間: 2018年04月 - 2023年03月 代表者: 脇田 晃行
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高精度遺伝子解析および遺伝子編集技術を用いた放射線感受性中心因子の検索
若手研究
研究期間: 2021年04月 - 2024年03月 代表者: 脇田 晃行
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食道扁平上皮癌に対するTLR3アゴニストを用いた新規免疫療法の確立
基盤研究(C)
研究期間: 2019年04月 - 2022年03月 代表者: 佐藤 雄亮, 脇田 晃行, 本山 悟
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MAPKシグナル経路操作による新規放射線感受性増強剤の開発
若手研究
研究期間: 2018年04月 - 継続中 代表者: 脇田晃行
学会等発表 【 表示 ／ 非表示 】
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当科における術者移行に伴うロボット支援下胸腔鏡下食道切除術の治療成績
脇田晃行, 本山悟, 佐藤雄亮, 藤田啓, 煙山紘平, 林健次郎, 南谷佳弘
第75回日本胸部外科学会定期学術集会 2022年10月 - 2022年10月
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Borderline resectable 局所進行胸部食道癌 (cT3.5) に対する術前化学放射線療法の成績
脇田晃行, 本山悟, 佐藤雄亮, 藤田啓, 煙山紘平, 林健次郎, 南谷佳弘
第76回日本食道学会学術集会 2022年09月 - 2022年09月
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Role of preoperative neoadjuvant chemoradiotherapy for locally advanced borderline resectable thoracic esophageal cancer
Akiyuki Wakita, Motoyama Satoru, Yusuke Sato, Hiromu Fujita, Kohei Kemuriyama, Kenjiro Hayashi, Yoshihiro Minamiya
18th ISDE World Congress for Esophageal Diseases 2022年09月 - 2022年09月
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Optimal reconstruction method for McKeown esophagectomy
Akiyuki Wakita, Satoru Motoyama, Yusuke Sato, Hiromu Fujita, Kohei Kemuriyama, Kenjiro Hayashi, Yoshihiro Minamiya.
第77 回日本消化器外科学会総会 2022年07月 - 2022年07月
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地域格差を考慮した高齢食道癌患者における至適治療戦略の検討
脇田晃行, 本山悟, 佐藤雄亮, 藤田啓, 煙山紘平, 南塚祐介, 南谷佳弘
第122回日本外科学会定期学術集会 2022年04月 - 2022年04月