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Affiliation |
Hospital SurgeryⅡ |
Graduating School 【 display / non-display 】
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-2008.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2015.03
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2016.04-Now
Akita University Hospital SurgeryⅡ Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Digestive surgery / 食道外科
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Life Science / Digestive surgery / Esophageal surgery
Thesis for a degree 【 display / non-display 】
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REG Iαactivates c-Jun through MAPK pathways to enhance the radiosensitivity of squamous esophageal cancer cells
Wakita A, Motoyama S (Corresponding author), Sato Y, Koyota S, Usami S, Yoshino K, Sasaki T, Imai K, Saito H, Minamiya Y
Tumor Biol 2015.04 [Refereed]
Single author
Research Achievements 【 display / non-display 】
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Imai K.
Cancer Imaging ( Cancer Imaging ) 24 ( 1 ) 2024.12 [Refereed]
Research paper (journal) Domestic Co-author
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Takahashi Y.
Physiotherapy Research International ( Physiotherapy Research International ) 29 ( 4 ) e2138 2024.10 [Refereed]
Research paper (journal) Domestic Co-author
INTRODUCTION: Frailty is significantly correlated with a higher incidence of medical complications during hospitalization after esophagectomy. As frailty is thought to be a reversible condition, improving the reserve capacity through preoperative physical therapy is expected to reduce the risk of postoperative pulmonary complications (PPCs). Herein, we report our experience with preoperative physical therapy in a patient with esophageal cancer who was considered to have inadequate fitness for surgery owing to poor physical performance. CASE PRESENTATION: A 72-year-old man (height: 169.5 cm, weight: 54.7 kg, body mass index: 18.9 kg/m2) with esophagogastric junction tumors (cStage IIIA) was hospitalized and scheduled to undergo surgery based on preoperative screening. He was categorized as frail according to the revised Japanese version of the Cardiovascular Health Study criteria and the Mini Nutritional Assessment Short-Form indicated severe malnutrition. We focused on physical therapy to improve exercise tolerance and prevent PPCs and devised a short-term intensive physical therapy program comprising minimal exercises that the patient could perform efficiently. The program consisted of only inspiratory muscle training and aerobic exercises. His maximal inspiratory pressure (MIP) and 6-min walking distance improved by 30 cm H2O and 145 m, respectively, on the day before surgery compared with those on day 8. The percentage predicted value of the MIP improved from 56.6% at the start of physical therapy to 102.9% on the day before surgery. On day 43, the patient underwent subtotal esophagectomy and was able to ambulate on postoperative day 5 without respiratory complications. CONCLUSION: We conducted a short-term, intensive, and minimal preoperative physical therapy program for a patient with esophageal cancer who had physical frailty. Preoperative physical therapy to increase the reserve capacity may result in a favorable postoperative course even in patients with physical frailty.
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Sato Y.
Current Oncology ( Current Oncology ) 30 ( 5 ) 4724 - 4735 2023.05 [Refereed]
Research paper (journal) Domestic Co-author
Most so-called "beneficial bacteria" in gut microbiota are Gram-positive, and TLR6 recognizes the peptidoglycan (PGN) present in their cell walls. We hypothesized that a high TLR6 expression status predicts a more favorable prognosis after esophagectomy. We used an ESCC tissue microarray (TMA) to examine TLR6 expression status in ESCC patients and to determine whether TLR6 expression status correlates with prognosis after curative esophagectomy. We also examined whether PGN influences the cell proliferation activity of ESCC lines. Clinical ESCC samples from 177 patients tested for the expression of TLR6 were categorized as 3+ (n = 17), 2+ (n = 48), 1+ (n = 68), or 0 (n = 44). High TLR6 expression (3+ and 2+) correlated with significantly more favorable 5-year overall survival (OS) and disease-specific survival (DSS) after esophagectomy than a lower TLR6 expression (1+ and 0). Univariate and multivariate analyses showed that TLR6 expression status is an independent prognostic factor that affects 5-year OS. PGN significantly inhibited the cell proliferation activity of ESCC lines. This is the first study to show that high TLR6 expression status predicts a more favorable prognosis in locally advanced thoracic ESCC patients after curative esophagectomy. PGN released from "beneficial bacteria" seems to have potential to inhibit the cell proliferation activity of ESCC.
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Wakita A.
Annals of Gastroenterological Surgery ( Annals of Gastroenterological Surgery ) 7 ( 6 ) 904 - 912 2023 [Refereed]
Research paper (journal) Domestic Co-author
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Kemuriyama K.
Genes to Cells ( Genes to Cells ) 28 ( 8 ) 573 - 584 2023 [Refereed]
Research paper (journal) Domestic Co-author
Abstract
Tumor‐derived G‐CSF is a well‐known factor to aggravate disease progression in various types of cancers. In this study, we investigated a role of G‐CSF in squamous cell carcinoma (SCC). High expression of G‐CSF in the tumor tissues of esophageal SCC (ESCC) patients correlated with poor prognosis. Murine SCC NR‐S1M cells produce considerable amount of G‐CSF, which expression is correlated with its metastatic potentials. Deletion of G‐CSF in NR‐S1M cells mitigated tumor growth and metastasis to lymph node and lung of subcutaneous NR‐S1M tumors in the mice. Mechanistically, G‐CSF enhanced cell proliferation in autocrine manner in vitro, whereas in NR‐S1M tumor‐bearing mice, accumulation of plasma G‐CSF was associated with expansion of peripheral neutrophils, which led to a decreased proportion of CD8<sup>+</sup> T cells. Antibody depletion of neutrophils restored the number of CD8+ T cells and modestly suppressed tumor outgrowth, albeit no changes in distant metastasis. We propose that G‐CSF produced by NR‐S1M cells facilitates tumor progression in mice through bi‐functional effects to promote neutrophil recruitment and tumor cell proliferation, which may render poor prognosis to the ESCC patients with high G‐CSF expression. -
食道がん患者における白金製剤+5-FU療法誘発血液毒性に及ぼす関連遺伝子多型の影響
藤田 一馬, 本山 悟, 佐藤 雄亮, 脇田 晃行, 南谷 佳弘, 三浦 昌朋
日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 60回 MSA P69 - 1 2022.10
Research paper (other academic council materials etc.) Domestic Co-author
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食道癌周術期の口腔機能評価と吸気筋トレーニングの有用性
佐藤 雄亮, 高野 裕史, 大倉 和貴, 脇田 晃行, 長岐 雄志, 煙山 紘平, 笹森 凌平, 野崎 崇, 本山 悟, 南谷 佳弘
日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 60回 P32 - 3 2022.10
Research paper (other academic council materials etc.) Domestic Co-author
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A male with primary accessory breast carcinoma in an axilla is strongly suspected of having hereditary breast cancer.
Eriko Takahashi, Kaori Terata, Hiroshi Nanjo, Koichi Ishiyama, Yuko Hiroshima, Ayuko Yamaguchi, Misako Yatsuyanagi, Chiaki Kudo, Akiyuki Wakita, Shinogu Takashima, Yusuke Sato, Kazuhiro Imai, Satoru Motoyama, Yoshihiro Minamiya
International cancer conference journal 10 ( 2 ) 107 - 111 2021.04
We herein report on a male with primary accessory breast cancer in an axilla. A 75-year-old man first noticed a subcutaneous nodule about 2 cm in diameter in the area of his right axilla. The patient underwent extirpation of the mass in a public hospital. Histological examination revealed invasive breast carcinoma of no special type associated with mucinous carcinoma, invasive micropapillary carcinoma and intraductal components. Immunohistochemical analysis showed that the tumor cells were positive for Gross cystic disease fluid protein (GCDFP)-15, mammaglobin and GATA3. Staining for estrogen receptor (ER) and progesterone receptor (PR) was positive, and human epidermal growth factor receptor 2 (HER2) was negative. The Ki67 labeling index (LI) was 33.6%. Imaging revealed no evidence of a primary tumor in any other organ or in the bilateral mammary gland. We performed radical resection of the right axilla, including the scar, and axillary lymph node dissection. The final pathological examination of the surgical specimen showed normal mammary gland tissue that was not connected to the proper mammary gland, and no residual cancer or metastatic lymph nodes. Based on our clinical and pathological findings, this tumor was diagnosed as breast cancer originating from the accessory mammary gland in the right axilla. After surgery, tamoxifen was administered as adjuvant therapy. Since the surgery, 2 years ago, there has been no evidence of recurrence. Hereditary Breast and Ovarian Cancer syndrome was suspected in this case because the patient was a male with breast cancer, and he had two first-degree relatives with breast cancer. This patient had no BRCA mutations on genetic testing. Nonetheless, in cases of male breast cancer, it is necessary to obtain genetic information due to the possibility of hereditary breast cancer, including cancers associated with BRCA gene mutation.
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2027.03
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Grant-in-Aid for Early-Career Scientists
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for Early-Career Scientists
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for Early-Career Scientists
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for Early-Career Scientists
Project Year： 2021.04 - 2024.03
Presentations 【 display / non-display 】
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食道癌扁平上皮癌術後予後のバイオマーカーとしてのToll-like receptor発現
佐藤雄亮,脇田晃行,長岐雄志,笹森凌平,煙山紘平,野崎崇,南谷佳弘
第77回日本食道学会学術集会 2023.06 - 2023.06
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Role of preoperative neoadjuvant chemoradiotherapy for locally advanced borderline resectable thoracic esophageal cancer
Akiyuki Wakita, Motoyama Satoru, Yusuke Sato, Hiromu Fujita, Kohei Kemuriyama, Kenjiro Hayashi, Yoshihiro Minamiya
18th ISDE World Congress for Esophageal Diseases 2022.09 - 2022.09
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Optimal reconstruction method for McKeown esophagectomy
Akiyuki Wakita, Satoru Motoyama, Yusuke Sato, Hiromu Fujita, Kohei Kemuriyama, Kenjiro Hayashi, Yoshihiro Minamiya.
第77 回日本消化器外科学会総会 2022.07 - 2022.07
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Analysis whether esophagectomy provides advantages for elderly patients
脇田晃行,本山悟,佐藤雄亮,藤田啓,煙山紘平,南塚祐介,安倍明,和田優貴,南谷佳弘
第75回日本食道学会学術集会 2021.09 - 2021.09
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Evaluation of the benefits of robot-assisted surgery for thoracic esophageal cancer
Akiyuki Wakita, Satoru Motoyama, Yusuke Sato, Yushi Nagaki, Hiromu Fujita, Kohei Kemuriyama, Yoshihiro Sasaki, Yoshihiro Minamiya
第76回日本消化器外科学会総会 2021.07 - 2021.07