Research Achievements - Original paper -

Ramelteon for Delayed Sleep-wake Phase Disorder: A Case Report.

Takeshima M, Shimizu T, Ishikawa H, Kanbayashi T.

Clinical psychopharmacology and neuroscience   18 ( 1 ) 167 - 169   2020.02  [Refereed]

Research paper (journal)   Domestic Co-author

Prevalence of asymptomatic venous thromboembolism in depressive inpatients

Takeshima M.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  16   579 - 587   2020.02  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

A Multi-center Questionnaire Survey on the Management and Treatment of Epilepsy in Akita

Shibata Ken-ichi, Yano Tamami, Okawa Satoshi, Takeshima Masahiro, Shimizu Hiroaki

Journal of the Japan Epilepsy Society ( JAPAN EPILEPSY SOCIETY )  37 ( 3 ) 779 - 787   2020.01  [Refereed]

Research paper (journal)   Domestic Co-author

<p>There are few epilepsy specialists in Akita, and non-specialists manage and treat most of the epilepsy patients. This study surveyed the actual state of the management and treatment for epilepsy in Akita. We conducted a questionnaire survey of 97 medical doctors in four different departments at 35 institutions. The questionnaire contained 24 items regarding the number of patients, type of the tests and treatments conducted, and issues regarding the management and treatment for epilepsy. Completed surveys were obtained from 47 medical doctors. Symptomatic localization-related epilepsy was common. Cerebrovascular disease was the most frequent cause. Evaluation of electroencephalography and magnetic resonance imaging performed in more than 90% of patients contributed to diagnosis of epilepsy. Seizures were well controlled by antiepileptic drugs in 90% of patients. Levetiracetam was selected most often for localization-related epilepsy, followed by carbamazepine and lamotrigine. Valproic acid was selected most often for generalized epilepsy, followed by levetiracetam and lamotrigine. Issues in the management and treatment for epilepsy included difficulties in the interpretation of electroencephalography and the lack of local epilepsy specialists.</p>

DOI

Long-term use of hypnotics: Analysis of trends and risk factors

Enomoto M.

General Hospital Psychiatry ( General Hospital Psychiatry )  62   49 - 55   2020.01  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Current state of hypnotic use disorders: Results of a survey using the Japanese version of Benzodiazepine Dependence Self-Report Questionnaire

Yamamoto M.

Neuropsychopharmacology Reports ( Neuropsychopharmacology Reports )  41 ( 1 ) 14 - 25   2020  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Clinical characteristics of symptomatic narcolepsy or hypersomnia: an analysis of 182 consecutive cases with neurological disorders associated with hypersomnolence

Ono H.

Sleep and Biological Rhythms ( Sleep and Biological Rhythms )  17 ( 1 ) 123 - 140   2019.01  [Refereed]

Research paper (journal)  

DOI

Gabapentin enacarbil for antipsychotic induced akathisia in schizophrenia patients: a pilot open-labeled study.

Takeshima M, Ishikawa H, Kanbayashi T, Shimizu T.

Neuropsychiatric disease and treatment   14   3179 - 3184   2018.11  [Refereed]

Research paper (journal)   Domestic Co-author

Repository

Inpatient phase-advance therapy for delayed sleep-wake phase disorder: a retrospective study.

Takeshima M, Shimizu T, Echizenya M, Ishikawa H, Kanbayashi T.

Nature and science of sleep   10   327 - 333   2018.10  [Refereed]

Research paper (journal)   Domestic Co-author

Successful management of clozapine-induced akathisia with gabapentin enacarbil: A case report

Takeshima M.

Clinical Psychopharmacology and Neuroscience ( Clinical Psychopharmacology and Neuroscience )  16 ( 3 ) 346 - 348   2018.08  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

A case of perampanel-induced delirium in a patient with symptomatic epilepsy.

Takeshima M, Ishikawa H, Ono T, Kanbayashi T, Shimizu T.

Seizure     2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

A case of perampanel-induced delirium in a patient with symptomatic epilepsy

Takeshima M.

Seizure ( Seizure )  58   154 - 155   2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Anorexia nervosa-associated pancytopenia mimicking idiopathic aplastic anemia: A case report

Takeshima M.

BMC Psychiatry ( BMC Psychiatry )  18 ( 1 )   2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Incidence of venous thromboembolism in psychiatric inpatients: A chart review

Takeshima M.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  14   1363 - 1370   2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: An open-labeled clinical observation

Omori Y.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  14   1281 - 1286   2018.05  [Refereed]

Research paper (journal)   International Co-author

DOI

Successful management of clozapine-induced restless legs syndrome with gabapentin enacarbil.

Hosoya T, Takeshima M, Ishikawa H, Kanbayashi T, Shimizu T.

Clinical Neuropsychopharmacology and Therapeutics.   9   1 - 2   2018.03  [Refereed]

Research paper (journal)   Domestic Co-author

Orexin/hypocretin levels in the cerebrospinal fluid and characteristics of patients with myotonic dystrophy type 1 with excessive daytime sleepiness

Omori Y.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  14   451 - 457   2018.02  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Effects of aripiprazole for prolonged nocturnal sleep and delayed sleep phase disorder

Kanbayashi Takashi, Shimizu Tetsuo, Omori Yuki, Imanishi Aya, Takaki Manabu, Sagawa Youhei, Tsutsui Ko, Takeshima Masahiro, Ono Taisuke, Shiomi Toshiaki

Neurological Therapeutics ( Japanese Society of Neurological Therapeutics )  34 ( 4 ) 406 - 410   2018  [Refereed]

Research paper (journal)   Domestic Co-author

<p>Delayed sleep phase disorder (DSPD) comprises a persistent or recurrent pattern of sleep disturbances, sleep disruption that leads to insomnia and/or excessive daytime sleepiness, and impaired functioning in social, occupational, or other spheres. Three techniques are typically used to treat DSPD : chronotherapy, phototherapy, and exogenous melatonin administration. Antipsychotics have not been reported in the treatment of DSPD, aripiprazole (APZ), which is a second generation antipsychotic, manifests a novel mechanism of action by serving as a partial agonist of D2 receptors. Depression is reported to be the most common psychopathology associated with DSPD, and APZ is reported to be effective in major depressive disorder as adjunctive therapy. Therefore, we speculated that APZ might be effective to treat DSPD, and we observed how APZ works for the treatment of DSPD.</p><p>Methods : 18 subjects (including 7 women) who are 14–48–year–old (the average is 31.6) were included. The patients were prescribed 0.75–4.5mg APZ at once a day.</p><p>Results : We prescribed 1.5–3.0mg/day of APZ, all subject reduced total sleep time (9.6 +/− 2.3h → 7.8 +/− 2.0h, p=0.03), many cases got up earlier (9.1 +/− 1.9h → 6.7 +/− 1.4h, p=0.005) in the morning and advanced their sleep phase within one week. The sleep onset was not significantly changed (23.5 +/− 2.0h → 22.9 +/− 1.9h, n.s.).</p><p>Conclusion : Low dose of APZ would reduce nocturnal sleep time in the subjects who had prolonged sleep time and DSPD symptoms. The mechanism of action would be dopaminergic up regulation due to dopamine D3 agonistic activity. Since it is difficult for physicians to treat prolonged sleep time and DSPD symptoms, this medication would become a new therapeutic tool for these patients.</p>

DOI

Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study

Takahashi J.

Sleep and Biological Rhythms ( Sleep and Biological Rhythms )  15 ( 3 ) 235 - 241   2017.07  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Acute Respiratory Distress Syndrome and Lamotrigine: A Case Report

Takeshima M.

Psychosomatics ( Psychosomatics )  58 ( 3 ) 313 - 316   2017.05  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Lamotrigine-Induced Disseminated Intravascular Coagulation With Anticonvulsant Hypersensitivity Syndrome: A Case Report.

Takeshima M, Ishikawa H, Shimizu T, Toyoshima A, Manabe M.

Psychosomatics   57 ( 5 ) 540 - 542   2016.09  [Refereed]

Research paper (journal)   Domestic Co-author