Research Achievements - Original paper -

Attitudes and Difficulties Associated with Benzodiazepine Discontinuation

Masahiro Takeshima, Yumi Aoki, Kenya Ie, Eiichi Katsumoto, Eichi Tsuru, Takashi Tsuboi, Ken Inada, Morito Kise, Koichiro Watanabe, Kazuo Mishima, and Yoshikazu Takaesu

International Journal of Environmental Research and Public Health   19 ( 23 ) 15990   2022.11  [Refereed]

Research paper (journal)   Single author

Satisfaction with web-based courses on clinical practice guidelines for psychiatrists: Findings from the "Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)" project.

Iida Hitoshi, Okada Tsuyoshi,...., Takeshima Masahiro,..., Ryota Hashimoto

Neuropsychopharmacol Reports     2022.11  [Refereed]

Research paper (journal)   Domestic Co-author

DOI PubMed

Second-Generation Antipsychotic Monotherapy Contributes to the Discontinuation of Anticholinergic Drugs in Hospitalized Patients With Schizophrenia.

Tsuyoshi Okada, Hikaru Hori,..., Masahiro Takeshima,..., Ryota Hashimoto

Journal of Clinical Psychopharmacology     2022.11  [Refereed]

Research paper (journal)   Domestic Co-author

DOI PubMed

Effects of electroconvulsive therapy on the use of anxiolytics and sleep medications: a propensity score-matched analysis.

Takashi Tsuboi, Yoshikazu Takaesu,..., Masahiro Takeshima,..., Ryota Hashimoto

Psychiatry and Clinical Neurosciences ( Psychiatry and Clinical Neurosciences )  77 ( 1 ) 30 - 37   2022.10  [Refereed]

Research paper (journal)   Domestic Co-author

DOI PubMed

Changes in psychotropic polypharmacy and high-potency prescription following policy change: Findings from a large scale Japanese claims database.

Masahiro Takeshima, Minori Enomoto, Masaya Ogasawara, Mizuki Kudo, Yu Itoh, Kazuhisa Yoshizawa, Dai Fujiwara, Yoshikazu Takaesu, Kazuo Mishima

Psychiatry and Clinical Neurosciences   76 ( 9 ) 475 - 477   2022.09  [Refereed]

Research paper (journal)   Domestic Co-author

DOI PubMed

Development and acceptability of a decision aid for chronic insomnia considering discontinuation of benzodiazepine hypnotics.

Yumi Aoki, Yoshikazu Takaesu,..., Masahiro Takeshima,..., Kazuo Mishima

Neuropsychopharmacol Reports ( Neuropsychopharmacology Reports )  42 ( 1 ) 10 - 20   2022.03  [Refereed]

Research paper (journal)   Domestic Co-author

DOI PubMed

Hypotic medication use among inpatients with schizophrenia and major depressive disorder: results of a nationwide study

Furihata R.

Sleep Medicine ( Sleep Medicine )  89   23 - 30   2022.01  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Patterns of hypnotic prescribing for residual insomnia and recurrence of major depressive disorder: a retrospective cohort study using a Japanese health insurance claims database

Yamato K.

BMC Psychiatry ( BMC Psychiatry )  21 ( 1 ) 1 - 12   2021.12  [Refereed]

Research paper (journal)  

DOI

Daytime nap and nighttime breastfeeding are associated with toddlers’ nighttime sleep

Nakagawa M.

Scientific Reports ( Scientific Reports )  11 ( 1 ) 15921   2021.12  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Association between sleep habits/disorders and emotional/behavioral problems among Japanese children

Takeshima M.

Scientific Reports ( Scientific Reports )  11 ( 1 ) 11438   2021.12  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Sleep maturation influences cognitive development of preterm toddlers

Ando A.

Scientific Reports ( Scientific Reports )  11 ( 1 ) 15921   2021.12  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Characteristics of discharge prescriptions for patients with schizophrenia or major depressive disorder: Real-world evidence from the Effectiveness of Guidelines for Dissemination and Education (EGUIDE) psychiatric treatment project

Hashimoto N.

Asian Journal of Psychiatry ( Asian Journal of Psychiatry )  63   102744   2021.09  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review

Ishikawa H.

Neuropsychopharmacology Reports ( Neuropsychopharmacology Reports )  41 ( 3 ) 434 - 439   2021.09  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Effect of residual insomnia and use of hypnotics on relapse of depression: a retrospective cohort study using a health insurance claims database

Inada K.

Journal of Affective Disorders ( Journal of Affective Disorders )  281   539 - 546   2021.02  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Severity of depressive symptoms is associated with venous thromboembolism in hospitalized patients with a major depressive episode

Yoshizawa K.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  17   2955 - 2963   2021  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Does cognitive behavioral therapy for anxiety disorders assist the discontinuation of benzodiazepines among patients with anxiety disorders? A systematic review and meta-analysis

Takeshima M.

Psychiatry and Clinical Neurosciences ( Psychiatry and Clinical Neurosciences )  74 ( 4 ) 247 - 256   2021  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Improvements in the degree of understanding the treatment guidelines for schizophrenia and major depressive disorder in a nationwide dissemination and implementation study

Numata S.

Neuropsychopharmacology Reports ( Neuropsychopharmacology Reports )  41 ( 2 ) 199 - 206   2021  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

The usefulness of the combination of d-dimer and soluble fibrin monomer complex for diagnosis of venous thromboembolism in psychiatric practice: a prospective study

Takeshima M.

Vascular Health and Risk Management ( Vascular Health and Risk Management )  17   239 - 246   2021  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Efficacy and safety of bright light therapy for manic and depressive symptoms in patients with bipolar disorder: A systematic review and meta-analysis

Takeshima M.

Psychiatry and Clinical Neurosciences ( Psychiatry and Clinical Neurosciences )  74 ( 4 ) 247 - 256   2020.04  [Refereed]

Research paper (journal)   International Co-author

DOI

Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia

Takahashi Y.

Neuropsychopharmacology Reports ( Neuropsychopharmacology Reports )  40 ( 1 ) 10 - 15   2020.03  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Ramelteon for Delayed Sleep-wake Phase Disorder: A Case Report.

Takeshima M, Shimizu T, Ishikawa H, Kanbayashi T.

Clinical psychopharmacology and neuroscience   18 ( 1 ) 167 - 169   2020.02  [Refereed]

Research paper (journal)   Domestic Co-author

Prevalence of asymptomatic venous thromboembolism in depressive inpatients

Takeshima M.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  16   579 - 587   2020.02  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

A Multi-center Questionnaire Survey on the Management and Treatment of Epilepsy in Akita

Shibata Ken-ichi, Yano Tamami, Okawa Satoshi, Takeshima Masahiro, Shimizu Hiroaki

Journal of the Japan Epilepsy Society ( JAPAN EPILEPSY SOCIETY )  37 ( 3 ) 779 - 787   2020.01  [Refereed]

Research paper (journal)   Domestic Co-author

<p>There are few epilepsy specialists in Akita, and non-specialists manage and treat most of the epilepsy patients. This study surveyed the actual state of the management and treatment for epilepsy in Akita. We conducted a questionnaire survey of 97 medical doctors in four different departments at 35 institutions. The questionnaire contained 24 items regarding the number of patients, type of the tests and treatments conducted, and issues regarding the management and treatment for epilepsy. Completed surveys were obtained from 47 medical doctors. Symptomatic localization-related epilepsy was common. Cerebrovascular disease was the most frequent cause. Evaluation of electroencephalography and magnetic resonance imaging performed in more than 90% of patients contributed to diagnosis of epilepsy. Seizures were well controlled by antiepileptic drugs in 90% of patients. Levetiracetam was selected most often for localization-related epilepsy, followed by carbamazepine and lamotrigine. Valproic acid was selected most often for generalized epilepsy, followed by levetiracetam and lamotrigine. Issues in the management and treatment for epilepsy included difficulties in the interpretation of electroencephalography and the lack of local epilepsy specialists.</p>

DOI

Long-term use of hypnotics: Analysis of trends and risk factors

Enomoto M.

General Hospital Psychiatry ( General Hospital Psychiatry )  62   49 - 55   2020.01  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Current state of hypnotic use disorders: Results of a survey using the Japanese version of Benzodiazepine Dependence Self-Report Questionnaire

Yamamoto M.

Neuropsychopharmacology Reports ( Neuropsychopharmacology Reports )  41 ( 1 ) 14 - 25   2020  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Clinical characteristics of symptomatic narcolepsy or hypersomnia: an analysis of 182 consecutive cases with neurological disorders associated with hypersomnolence

Ono H.

Sleep and Biological Rhythms ( Sleep and Biological Rhythms )  17 ( 1 ) 123 - 140   2019.01  [Refereed]

Research paper (journal)  

DOI

Gabapentin enacarbil for antipsychotic induced akathisia in schizophrenia patients: a pilot open-labeled study.

Takeshima M, Ishikawa H, Kanbayashi T, Shimizu T.

Neuropsychiatric disease and treatment   14   3179 - 3184   2018.11  [Refereed]

Research paper (journal)   Domestic Co-author

Repository

Inpatient phase-advance therapy for delayed sleep-wake phase disorder: a retrospective study.

Takeshima M, Shimizu T, Echizenya M, Ishikawa H, Kanbayashi T.

Nature and science of sleep   10   327 - 333   2018.10  [Refereed]

Research paper (journal)   Domestic Co-author

Successful management of clozapine-induced akathisia with gabapentin enacarbil: A case report

Takeshima M.

Clinical Psychopharmacology and Neuroscience ( Clinical Psychopharmacology and Neuroscience )  16 ( 3 ) 346 - 348   2018.08  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

A case of perampanel-induced delirium in a patient with symptomatic epilepsy.

Takeshima M, Ishikawa H, Ono T, Kanbayashi T, Shimizu T.

Seizure     2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

A case of perampanel-induced delirium in a patient with symptomatic epilepsy

Takeshima M.

Seizure ( Seizure )  58   154 - 155   2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Anorexia nervosa-associated pancytopenia mimicking idiopathic aplastic anemia: A case report

Takeshima M.

BMC Psychiatry ( BMC Psychiatry )  18 ( 1 )   2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Incidence of venous thromboembolism in psychiatric inpatients: A chart review

Takeshima M.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  14   1363 - 1370   2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: An open-labeled clinical observation

Omori Y.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  14   1281 - 1286   2018.05  [Refereed]

Research paper (journal)   International Co-author

DOI

Successful management of clozapine-induced restless legs syndrome with gabapentin enacarbil.

Hosoya T, Takeshima M, Ishikawa H, Kanbayashi T, Shimizu T.

Clinical Neuropsychopharmacology and Therapeutics.   9   1 - 2   2018.03  [Refereed]

Research paper (journal)   Domestic Co-author

Orexin/hypocretin levels in the cerebrospinal fluid and characteristics of patients with myotonic dystrophy type 1 with excessive daytime sleepiness

Omori Y.

Neuropsychiatric Disease and Treatment ( Neuropsychiatric Disease and Treatment )  14   451 - 457   2018.02  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Effects of aripiprazole for prolonged nocturnal sleep and delayed sleep phase disorder

Kanbayashi Takashi, Shimizu Tetsuo, Omori Yuki, Imanishi Aya, Takaki Manabu, Sagawa Youhei, Tsutsui Ko, Takeshima Masahiro, Ono Taisuke, Shiomi Toshiaki

Neurological Therapeutics ( Japanese Society of Neurological Therapeutics )  34 ( 4 ) 406 - 410   2018  [Refereed]

Research paper (journal)   Domestic Co-author

<p>Delayed sleep phase disorder (DSPD) comprises a persistent or recurrent pattern of sleep disturbances, sleep disruption that leads to insomnia and/or excessive daytime sleepiness, and impaired functioning in social, occupational, or other spheres. Three techniques are typically used to treat DSPD : chronotherapy, phototherapy, and exogenous melatonin administration. Antipsychotics have not been reported in the treatment of DSPD, aripiprazole (APZ), which is a second generation antipsychotic, manifests a novel mechanism of action by serving as a partial agonist of D2 receptors. Depression is reported to be the most common psychopathology associated with DSPD, and APZ is reported to be effective in major depressive disorder as adjunctive therapy. Therefore, we speculated that APZ might be effective to treat DSPD, and we observed how APZ works for the treatment of DSPD.</p><p>Methods : 18 subjects (including 7 women) who are 14–48–year–old (the average is 31.6) were included. The patients were prescribed 0.75–4.5mg APZ at once a day.</p><p>Results : We prescribed 1.5–3.0mg/day of APZ, all subject reduced total sleep time (9.6 +/− 2.3h → 7.8 +/− 2.0h, p=0.03), many cases got up earlier (9.1 +/− 1.9h → 6.7 +/− 1.4h, p=0.005) in the morning and advanced their sleep phase within one week. The sleep onset was not significantly changed (23.5 +/− 2.0h → 22.9 +/− 1.9h, n.s.).</p><p>Conclusion : Low dose of APZ would reduce nocturnal sleep time in the subjects who had prolonged sleep time and DSPD symptoms. The mechanism of action would be dopaminergic up regulation due to dopamine D3 agonistic activity. Since it is difficult for physicians to treat prolonged sleep time and DSPD symptoms, this medication would become a new therapeutic tool for these patients.</p>

DOI

Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study

Takahashi J.

Sleep and Biological Rhythms ( Sleep and Biological Rhythms )  15 ( 3 ) 235 - 241   2017.07  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Acute Respiratory Distress Syndrome and Lamotrigine: A Case Report

Takeshima M.

Psychosomatics ( Psychosomatics )  58 ( 3 ) 313 - 316   2017.05  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Lamotrigine-Induced Disseminated Intravascular Coagulation With Anticonvulsant Hypersensitivity Syndrome: A Case Report.

Takeshima M, Ishikawa H, Shimizu T, Toyoshima A, Manabe M.

Psychosomatics   57 ( 5 ) 540 - 542   2016.09  [Refereed]

Research paper (journal)   Domestic Co-author

Comparison of sleep estimation using wrist actigraphy and waist actigraphy in healthy young adults.

Takeshima M, Echizenya M, Inomata Y, Shimizu K, Shimizu T.

Sleep and biological rhythms   12 ( 1 ) 767 - 769   2016.07  [Refereed]

Research paper (journal)   Domestic Co-author

Validity and reliability of the Japanese version of the Morningness-Eveningness Questionnaire evaluated from actigraphy.

Inomata Y, Echizenya M, Takeshima M, Shimizu K, Shimizu T.

Sleep and biological rhythms.   12 ( 4 ) 289 - 296   2016.07  [Refereed]

Research paper (journal)   Domestic Co-author

Scurvy in an alcohol-dependent patient with a severely unbalanced diet.

Takeshima M, Echizenya M, Inomata Y, Shimizu T.

Psychiatry Clin Neurosci   68 ( 3 ) 242 - 243   2014.03  [Refereed]

Research paper (journal)   Domestic Co-author

Total sleep deprivation followed by sleep phase advance and bright light therapy in drug-resistant mood disorders.

Echizenya M, Suda H, Takeshima M, Inomata Y, Shimizu T.

Journal of affective disorders.   144 ( 1-2 ) 28 - 33   2013.01  [Refereed]

Research paper (journal)   Domestic Co-author

Core body temperature rhythms in circadian rhythm sleep disorder, irregular sleep-wake type.

Narita E, Echizenya M, Takeshima M, Inomata Y, Shimizu T.

Psychiatry Clin Neuroscience   65 ( 7 ) 679 - 679   2011.12  [Refereed]

Research paper (journal)   Domestic Co-author