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Affiliation |
Hospital Division of Infection Control and Prevention |
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Laboratory Address |
44-2, Hasunuma Hiroomote, Akita-shi, Akita, 010-8543, Japan |
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Laboratory Phone number |
+81-18-884-6248 |
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Laboratory Fax number |
+81-18-884-6566 |
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Mail Address |
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SAGA Tomoo
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Research Interests 【 display / non-display 】
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Infection Control
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Travel Medicine
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Infection Diseases
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Clinical Microbiology
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Clincal Laboratory Medicine
Graduating School 【 display / non-display 】
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1994.04-2000.03
Tohoku University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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2003.04-2007.03
Tohoku University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2024.04-Now
Akita University Advisor to the President for Infection Control
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2022.04-Now
Akita University Hospital Division of Infection Control and Prevention Hospital Professor
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2020.08-Now
Akita University Hospital Division of Infection Control and Prevention Associate Professor
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2020.09-Now
Akita University Hospital Division of Infection Control and Prevention Director
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2018.04-2020.07
Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Assistant Professor
Research Areas 【 display / non-display 】
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Others / Others
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Life Science / Infectious disease medicine
Qualification acquired 【 display / non-display 】
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Doctor
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Radiation Protection Supervisor(first and second kind)
Thesis for a degree 【 display / non-display 】
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First detection of the plasmid-mediated quinolone resistance determinant qnrA in Enterobacteriaceae clinical isolates in Japan.
Saga T (Corresponding), Akasaka T, Takase H, Tanaka M, Sato K, Kaku M.
International Journal of Antimicrobial Agents 29 ( 6 ) 738 - 739 2007.03
Domestic Co-author
Epub 2007 Mar 19.
PMID:17374476
Research Achievements 【 display / non-display 】
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Characterization of a qnrB-like Genes in Citrobacter species of the American Type Culture Collection (ATCC).
Saga T(corresponding), Sabtcheva S, Mitsutake K, Ishii Y, Tateda K, Yamaguchi K, Kaku M
Antimicrobial Agents and Chemotherapy 57 ( 6 ) 2863 - 2866 2013.06 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2013 Mar 25.
PMID:23529729 -
First detection of the plasmid-mediated quinolone resistance determinant qnrA in Enterobacteriaceae clinical isolates in Japan.
Saga T (Corresponding), Akasaka T, Takase H, Tanaka M, Sato K, Kaku M.
International Journal of Antimicrobial Agents 29 ( 6 ) 738 - 739 2007.06 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2007 Mar 19.
PMID:17374476 -
Sohei Harada,Kohji Komori,Kenya Yukawa,Brian Hayama,Kazumi Takehana,Kageto Yamada,Asako Doi,Tomoo Saga,Masakazu Sasaki,Yoshiro Hadano,Masahiro Suzuki,Kyoko Yokota,Jun Suzuki,Koki Kikuchi,Yohei Doi,Kazuhiro Tateda
Journal of Clinical Microbiology ( ASM ) 63 ( 8 ) e0050025 2025.08 [Refereed]
Research paper (journal) Domestic Co-author
Genomic characteristics and optimal treatment of Corynebacterium jeikeium remain largely unknown. We collected clinical information and performed whole-genome sequencing analysis of the causative strains of six cases of C. jeikeium infection at a single hospital over a 9-year period. Additionally, whole-genome sequencing analysis was performed on 33 C. jeikeium strains from cases of bloodstream infection at eight hospitals. Antimicrobial susceptibility testing was performed, and the results were compared to the resistance genes identified. Publicly available genome data of strains of C. jeikeium complex, consisting of C. jeikeium sensu stricto, Corynebacterium macclintockiae, and Corynebacterium evansiae, worldwide, were combined with the data from this study to determine the distribution of genomic species. In the single-center study, cases of prosthetic osteoarticular infection, postoperative intra-abdominal infection, and catheter-related bloodstream infection were identified, and the causative strains were genomically identified as C. macclintockiae. All but one isolate (32/33, 97.0%) in the eight-center study identified as C. jeikeium by matrix-assisted laser desorption ionization-time of flight mass spectrometry were also genomically identified as C. macclintockiae. Nosocomial transmission was suggested in three strain pairs by core-genome single nucleotide polymorphism analysis. C. macclintockiae strains were generally multidrug-resistant, but all anti-methicillin-resistant Staphylococcus aureus agents, including teicoplanin, had favorable activity, and the strains without the tet(W) gene (22/38, 57.9%) were susceptible to tetracyclines. Genome analysis of 66 C. jeikeium complex strains collected worldwide, consisting mainly of clinical strains, re-identified 51 strains (77.3%) as C. macclintockiae. This study demonstrates that C. macclintockiae is the major genomic species of the C. jeikeium complex causing human infections.IMPORTANCERecent widespread use of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has facilitated the identification of Corynebacterium spp. in microbiology laboratories, thereby raising awareness of the clinical importance of these organisms. Nevertheless, the accumulation of information on genomic characteristics of Corynebacterium jeikeium has been significantly limited compared to other pathogenic organisms thus far. In this study, we analyzed causative strains of infections identified as C. jeikeium by MALDI-TOF MS, collected from multiple institutions throughout Japan, and found that most of these strains were genomically identified as Corynebacterium macclintockiae, a species that has been newly described recently. Collection of clinical information on selected cases showed that C. macclintockiae indeed caused invasive infections that required intravenous or long-term oral antimicrobial therapy. Additional analyses using genomic data of C. jeikeium complex strains registered in public databases suggest that C. macclintockiae is of global clinical importance.
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Vibrio parahaemolyticus chromosomal qnr homologue VPA0095: demonstration by transformation with a mutated gene of its potential to reduce quinolone susceptibility in Escherichia coli.
Saga T, Kaku M, Onodera Y, Yamachika S, Sato K, Takase H.
Antimicrobial agents and chemotherapy 49 ( 5 ) 2144 - 2145 2005.05 [Refereed]
Research paper (journal) Domestic Co-author
PMID:15855551
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Cholinergic urticaria improved by daily hot bath : The analysis of its etiology
55 ( 1 ) 9 - 12 2001.01 [Refereed]
Research paper (journal) Domestic Co-author
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History of Antimicrobial Agents and Resistant Bacteria.
Saga T, Yamaguchi K.
Japan Medical Association Journal ( 日本医師会 ) 52 ( 2 ) 103 - 108 2009.03
Introduction and explanation (others) Domestic Co-author
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Administration route, prevention and management of adverse events following pneumococcal vaccination in adults.
Saga T, Hirokawa M
Nihon Naika Gakkai Zasshi ( Japanese Society of Internal Medicine ) 104 ( 11 ) 2336 - 2342 2015.11
Introduction and explanation (others) Domestic Co-author
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New mechanisms of quinolone resistance among Enterobacteriaceae: focused on plasmid-mediated quinolone resistance
Tomoo SAGA
Nihon Rinsho 70 ( 2 ) 333 - 338 2012.02
Introduction and explanation (commerce magazine) Single author
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Viewpoint: Skill Certifications for Japanese Medical Technologists
Rinsho Byori ( Japanese Society of Laboratory Medicine ) 64 ( 1 ) 89 - 95 2016.01
Introduction and explanation (others) Domestic Co-author
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Diagnostic Challenges in Pulmonary Embolism in Young Adults: Thrombosis Associated With Cytomegalovirus and Mycoplasma pneumoniae.
Haruka Hikichi, Ryo Hasegawa, Akiko Saga, Tomoo Saga, Shigeharu Ueki
Cureus 14 ( 12 ) e32757 2022.12
A 23-year-old man presented with a fever, shaking chills, headaches, nausea, and a dry cough. Investigations showed lymphocytic leukocytosis with atypical lymphocytes in a blood smear. Liver function test results, D-dimer concentrations, and fibrin degradation product concentrations were greatly elevated. Computed tomography of the whole body with contrast showed hepatosplenomegaly with splenic infarction and bilateral pulmonary embolism without deep vein thrombosis. Cytomegalovirus (CMV) immunoglobulin M, and serum CMV pp65 antigenemia were positive, and serum Mycoplasma pneumoniae (M. pneumoniae) antibody was also highly positive. These results suggested the diagnosis of co-infection of CMV and M. pneumoniae complicated by systemic arteriovenous thrombosis, which resulted in pulmonary embolism and splenic infarction. After he started edoxaban tosilate hydrate for the thrombosis, his symptoms resolved in a few days. To the best of our knowledge, this is the first case of co-infection of CMV and M. pneumoniae leading to pulmonary embolism and splenic infarction.
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好酸球のETosisと,シャルコー・ライデン結晶の形成
齋藤 秀和, 植木 重治, 徳永 貴裕, 本田 耕平, 竹田 正秀, 福地 峰世, 宮部 結, 面川 歩, 嵯峨 知生, 守時 由起, 今野 泰典, 廣川 誠, 藤枝 重治, 山田 武千代
耳鼻咽喉科免疫アレルギー ( 日本耳鼻咽喉科免疫アレルギー学会 ) 37 ( 2 ) 204 - 205 2019.06
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免疫担当細胞 in vitroにおけるシャルコー・ライデン結晶の形成機構
竹田 正秀, 植木 重治, 福地 峰世, 宮部 結, 面川 歩, 嵯峨 知生, 守時 由起, 佐藤 一洋, 佐野 正明, 中山 勝敏, 廣川 誠
アレルギー ( (一社)日本アレルギー学会 ) 68 ( 4-5 ) 517 - 517 2019.05
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好酸球増多疾患・好酸球性肺炎 著明な組織内シャルコー・ライデン結晶を認めた好酸球増多症候群患者
福地 峰世, 植木 重治, 山本 洋平, 奈良 美保, 今野 泰典, 面川 歩, 嵯峨 知生, 守時 由起, 大森 泰文, 高橋 直人, 廣川 誠
アレルギー ( (一社)日本アレルギー学会 ) 68 ( 4-5 ) 529 - 529 2019.05
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市中病院の臨床分離ESBL産生大腸菌におけるST131-fimH30の検出
谷岡 友則, 佐賀, 加藤 純, 嵯峨 知生, 植木 重治, 廣川 誠, 面川 歩, 長谷川 諒
日本化学療法学会雑誌 ( (公社)日本化学療法学会 ) 67 ( Suppl.A ) 279 - 279 2019.03
◆Original paper【 display / non-display 】
◆Introduction and explanation【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2027.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2020.04 - 2024.03
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Grant-in-Aid for Young Scientists(B)
Project Year： 2010.04 - 2012.03
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Grant-in-Aid for Young Scientists(B)
Project Year： 2008.04 - 2010.03
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Use of molecular epidemiological evidence for pre-travel education to reduce potential health risks for travelling students
Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2027.03
Presentations 【 display / non-display 】
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Development of a Scalable Pre-travel Education Program for Students Doing Fieldwork Abroad and Establishment of a Travel Clinic at a University Located in Rural Japan.
Tomoo Saga, Akiko Saga, Ayumi Omokawa, Shigeharu Ueki, Tomomi Suda, Haruka Hikichi, Ken Watanabe, Ryo Hasegawa, Yuki Fujioka, Yuki Moritoki, Hitoshi Hasegawa
CISTM18 (18th Conference of the International Society for Travel Medicine) (Basel, Switzerland) 2023.05 - 2023.05 ISTM(International Society for Travel Medicine)
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Development of an Audio-visual-assisted Staff-aiding System and a Prompter and Checkbox System for Managing Viral Hemorrhagic Fever Patients.
Saga T, Nakamura M, Omokawa A, Hirokawa M
ASM Microbe 2019 (San Francisco, CA, USA) 2019.06 - 2019.06 ASM
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Comparison of the number of genome-wide single nucleotide polymorphisms (SNPs) among epidemiologically-related and -unrelated methicillin-resistant Staphylococcus aureus (MRSA) isolates of indistinguishable genotype by PCR-based open-reading frame typing (POT) kit.
Saga T, Tatsuko R, Aoki K, Omokawa A, Moritoki Y, Shimizu-Saga A, Kobayashi N, Ueki S, Ishii Y, Tateda K, Hirokawa.
IDWeek™2016 2016.10 - 2016.10
Academic Activity 【 display / non-display 】
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2025.09-Now
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2021.04-Now
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2025.09-2026.10
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2012.05-Now
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2015.02-Now