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Affiliation |
Hospital Pediatrics Surgery |
Graduating School 【 display / non-display 】
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-1999.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2010.03
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Studying abroad experiences 【 display / non-display 】
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2013.04-2015.03
University of Toronto Postdoctoral Fellowships
Campus Career 【 display / non-display 】
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2011.06-Now
Akita University Hospital Pediatrics Surgery Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / General surgery and pediatric surgery
Thesis for a degree 【 display / non-display 】
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Onset of apoptosis in the cystic duct during metamorphosis of a Japanese Lamprey, Lethenteron reissneri.
Morii M, Mezaki Y, Yamaguchi N, Yoshikawa K, Miura M, Imai K, Yoshino H, Hebiguchi T, Hebiguchi T, Senoo H.
Anat Rec, 293 1155 - 1166 2011.03
Domestic Co-author
Research Achievements 【 display / non-display 】
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Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.
Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R.
J Clin Invest. 120 4525 - 45242 2018.08
Research paper (journal) Domestic Co-author
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Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats.
Hebiguchi T, Mezaki Y, Morii M, Watanabe R, Yoshikawa K, Miura M, Imai K, Senoo H, Yoshino H.
Int J Mol Med. 35 ( 3 ) 724 - 730 2015.01
Research paper (journal) Domestic Co-author
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Intestinal absorption of Vitamin A and Short bowel syndrome
Hebiguchi,T, Mezaki Y, Morii M, Watanabe R, Yoshino H, Senoo Y.
JSM Cell. 2 ( 2 ) 1012 - 1015 2014.01
Research paper (journal) Domestic Co-author
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Uptake and storage of vitamin A as lipid droplets in the cytoplasm of cells in the lamina propria mucosae of the rat intestine.
Senoo H, Mezaki Y, Morii M, Hebiguchi T, Miura M, Imai K.
Cell Biol Int. 37 ( 11 ) 1171 - 1180 2013.11
Research paper (journal) Domestic Co-author
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Differential increases in the expression of intermediate filament proteins and concomitant morphological changes of transdifferentiating rat hepatic stellate cells observed in vitro.
3) Mezaki Y, Morii M, Hebiguchi T, Yoshikawa K, Yamaguchi N, Miura M, Imai K, Yoshino H, Senoo H.
Acta Histochem Cytochem. 46 ( 5 ) 137 - 143 2013.10
Research paper (journal) Domestic Co-author
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Involvement of apotosis in biliary atresia. BILIARY ATRESIA,
Morii M, Yoshino, H Hebiguchi T, Mezaki Y, Yamaguchi N, Yoshikawa K, Miura M, Imai K, Senoo H, Hebiguchi T
Proceedings of the 35th Conference of the Japanese Biliary Atresia Society, ( Kodansha Shuppan Service Center ) 2009.01
Introduction and explanation (bulletin of university, research institution) Domestic Co-author
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Mesenteric Lipoma in a Child: An Unusual Cause of Recurrent Abdominal Pain and Failure to Thrive
Suganuma Rie, Yoshino Hiroaki, Morii Mayako, Hebiguchi Taku, Watanabe Ryo, Azuma Saya, Yamagata Kenki, Hayashi Kaito, Mizuno Masaru, Ohtsuka Mihoko
Journal of the Japanese Society of Pediatric Surgeons ( The Japanese Society of Pediatric Surgeons ) 56 ( 7 ) 1150 - 1155 2020
<p>Mesenteric lipomas are relatively rare, benign tumors in children. We present a case of mesenteric lipoma in a child with symptoms of partial bowel obstruction, diagnosed preoperatively via abdominal ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI). A 7-year-old boy with a history of recurrent abdominal pain and failure to thrive presented with symptoms of vomiting over the last four days. Physical examination revealed slight abdominal distention without a palpable mass. Plain abdominal radiography revealed small bowel loop distention, with a flat, dilated junction segment, indicating mechanical intestinal obstruction. Ultrasonography revealed a heterogenous echogenic mass lesion within the pelvic cavity. CT revealed a well-encapsulated nonenhancing mass with nodular organization and negative attenuation values. T1- and T2-weighted MRI sequences revealed that the mass showed hypersignal intensities and was mobile, which are indicative of mesenteric lipoma. Laparotomy revealed a smooth, round, soft, yellow mass measuring approximately 8.5×8.0×3.0 cm, arising from the mesentery, 80 cm proximal to the ileocecal valve. Resection of the affected segment of the ileum and end-to-end ileal anastomosis were performed. Histopathological analysis showed that the tumor was composed of mature adipocytes without atypia, confirming the diagnosis of mesenteric lipoma. The findings were negative for malignancy. No recurrence was observed during the two-year postoperative follow-up. The clinical presentation of the case was indicative of partial obstruction due to compression with spontaneous detorsion. Mesenteric lipoma should be considered a possible differential diagnosis in children with recurrent abdominal pain and failure to thrive.</p>
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A Case of Generalized Lymphatic Anomaly After 17 Years of Sclerotherapy for Lymphatic Malformation
Watanabe Ryo, Yoshino Hiroaki, Morii Mayako, Hebiguchi Taku, Azuma Saya, Yamagata Kenki
Journal of the Japanese Society of Pediatric Surgeons ( The Japanese Society of Pediatric Surgeons ) 55 ( 5 ) 988 - 992 2019
<p>The patient was a 17-year-old male. A congenital giant cystic lesion on the neck was detected prenatally, and he was diagnosed as having cervical cystic lymphatic malformation postnatally. Two rounds of sclerotherapy were performed during infancy. The cyst size was markedly reduced. At 4 years of age, he underwent surgical removal of the excess skin at the Department of Plastic Surgery, and the swelling in the neck improved. Thereafter, he discontinued outpatient visits on his own and no follow-up was conducted. When he had a fracture of the cervical spine during baseball practice at 17 years of age, multiple cystic lesions in the bone were detected. MRI indicated no recurrence of the cervical cystic lesion but multiple cystic lesions in the cervical spine, thorax, ribs, iliac bone, and spleen were detected; thus, he was diagnosed as having generalized lymphatic anomaly (GLA). Bone union occurred later at the fracture site of the cervical spine. No pleural effusion, cardiac effusion, or ascites were noted, and blood analysis showed no abnormality. Therefore, he is currently under follow-up with no treatment. Cystic lymphangioma is currently defined as lymphatic malformation due to developmental disorders of lymphatic vessels. The present case was classified as a macrocystic-type lymphatic malformation and considered to belong to a disease group different from GLA, which is a systemic disease. However, GLA may develop during the course, as in this case, and long-term follow-up in addition to diagnosis and treatment may be warranted.</p>
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Congenital Cervical Salivary Fistula From the Submandibular Gland
Morii Mayako, Hebiguchi Taku, Watanabe Ryo, Azuma Saya, Yamagata Kenki, Yoshino Hiroaki
Journal of the Japanese Society of Pediatric Surgeons ( The Japanese Society of Pediatric Surgeons ) 53 ( 7 ) 1316 - 1319 2017
<p>An otherwise healthy two-year-old boy was referred to our department with intermittent mucous drainage from the fistula in the middle of the inside margin of the sternocleidomastoid muscle after birth. Fistulography revealed that the fistula was branched and limited to the submandibular triangle. This tract originated from the normal left submandibular gland. The lesion was explored surgically by spindle incision surrounding the orifice and the fistula was dissected up to the submandibular gland. Wharton's duct was opened normally at the sublingual caruncle. The postoperative course was uneventful. Histological examination revealed a sero-mucinous salivary gland with the ducts lined by stratified squamous epithelium consistent with congenital salivary fistula.</p>
◆Original paper【 display / non-display 】
◆Introduction and explanation【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2018.04 - Now
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Grant-in-Aid for Young Scientists (Start-up)
Project Year： 2015.04 - 2017.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2011.04 - 2013.03
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Grant-in-Aid for Young Scientists(B)
Project Year： 2011.04 - 2012.03
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Grant-in-Aid for Young Scientists(B)
Project Year： 2008.04 - 2009.03
Presentations 【 display / non-display 】
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Postoperative Anorectal Motor Function following Transanal Endorectal Pull-through and Duhamel Procedure
Mayako Moriia, Hiroyuki Kayabab, Taku Hebiguchia, Ryo Watanabea, Kenki Yamagataa, Rie Suganumac, Hiroaki Yoshinoa
BAPS Congress 2019 2019.07 - 2019.07
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Reversibility of periductal fibrosis during biliary atresia in the lamprey
Morii, M., Yoshino, H., Hebiguchi, T., Mezaki, Y., Yamaguchi, N., Yoshikawa, K., Miura, M., Imai, K., Senoo, H., and Hebiguchi, T
16th International Symposium on Cells of Hepatic Sinusoid 2011.09 - 2011.09
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Apoptosis in the biliary epitherial cells during metamorphosis of a Japanese lamprey - model system for the human biliary atresia ? -
Morii, M., Mezaki, Y., Yamaguchi, N. et al.
The 15th ISCHS meeting 2010.08 - 2010.09
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Onset of apoptosis in the porta hepatis during metamorphosis of a Japaneselamprey- model system for the human biliary atresia ?
Morii, M., Yoshino, H., Hebiguchi,T
43rd Pacific associstionof pediatric surgeons 2010.05 - 2010.05
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Long-term outcome of high jejunal atresia: wing-shaped end-to-end anastomosis.
morii,yosshino,hebiguchi ,hebigutchi,yamaguti,yosshikawa, mezaki,imai,miura,senoo,katou
Congress of Asian Association of Pediatric Surgeons、 2008.11 - 2008.11