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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Department of Thoracis Surgery |
IMAI Kazuhiro
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Research Interests 【 display / non-display 】
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lung cancer
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immunology
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oncology
Graduating School 【 display / non-display 】
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-2001.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2009.03
Akita University Graduate School,Division of Medicine Chest Surgery Doctor's Course Completed
Campus Career 【 display / non-display 】
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2018.10-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Associate Professor
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2014.04-2018.09
Akita University Hospital SurgeryⅡ Lecturer
Thesis for a degree 【 display / non-display 】
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Accuracy of helical computed tomography for the identification of lymph node metastasis in resectable non-small cell lung cancer.
Imai K
Surgery Today 38 ( 12 ) 1083 - 1090 2009.03
Domestic Co-author
Research Achievements 【 display / non-display 】
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Extracorporeal Membrane Oxygenation-Assisted Thoracic Surgery: A Series of 10 Cases
Harata Yuzu, Imai Kazuhiro, Takashima Shinogu, Kuriyama Shoji, Iwai Hidenobu, Suzuki Haruka, Demura Ryo, Shibano Sumire, Minamiya Yoshihiro
Surgical Case Reports ( 一般社団法人 日本外科学会 ) 11 ( 1 ) n/a 2025
<p><b>INTRODUCTION:</b> Extracorporeal membrane oxygenation (ECMO) is a type of extracorporeal circulation used to divert blood from and deliver blood to peripheral blood vessels. Recently, the use of ECMO has been reported in various non-transplant surgeries. Particularly in tracheal surgeries, ECMO provides an unobstructed surgical field and enables safe induction of general anesthesia in difficult intubation cases. Here, we report on 10 cases of thoracic surgery in which ECMO was employed at our institution.</p><p><b>CASE PRESENTATION:</b> These 10 cases comprise 4 tracheal cancer surgeries, 2 lung cancer surgeries, and 1 case each of surgery for thyroid cancer, mediastinal cancer, tracheomalacia, and tracheobronchial injury. Veno-venous (VV)-ECMO is most often selected, but veno-arterial (VA)-ECMO is chosen when recirculation with VV-ECMO is unacceptable, when pulmonary artery bleeding needs to be controlled, or when cardiac support is necessary. Among the 10 presented cases, VV-ECMO was used in 8, while VA-ECMO was employed in 2. Three of these cases involved ECMO bailout due to dyspnea caused by airway stenosis. Six of the patients did not receive heparin maintenance. Of those, 1 was maintained on nafamostat mesilate, 2 were maintained on nafamostat mesilate after receiving a single dose of heparin, and 3 received only a single dose of heparin. In none of those cases did ECMO fail to maintain flow due to thrombus formation. A postoperative hemothorax occurred as one of the ECMO-related complications in Case 4. There were no perioperative cardiopulmonary complications, in-hospital deaths, or deaths within 30 days after surgery. One patient died from metastatic recurrence of non-small cell lung cancer 5 months after surgery, another from progression of disease in mediastinal anaplastic cancer 4 months after surgery, and the 3rd from upper gastrointestinal bleeding 2 years after surgery. The other 7 patients remain alive.</p><p><b>CONCLUSIONS:</b> ECMO is useful in tracheal surgery and in cases where intubation is difficult or dangerous, because it facilitates safe and accurate surgery. We also believe that individualized anticoagulant strategies can be safely implemented.</p>
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Fundamental study of Electric Field Mixing Technique in accelerating Nucleic Acid hybridization
Okubo Yoshinobu, Nakamura Ryuta, Akagami Yoichi, Wakamatsu Yuki, Imai Kazuhiro, Minamiya Yoshihiro, Kusumi Takayuki
Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering ) 2024A ( 0 ) 567 - 568 2024.08
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Harata Yuzu, Imai Kazuhiro, Takashima Shinogu, Kurihara Nobuyasu, Kuriyama Shoji, Minamiya Yoshihiro
The Journal of the Japanese Association for Chest Surgery ( The Japanese Association for Chest Surgery ) 38 ( 2 ) 99 - 105 2024.03
<p>The patient was a 74-year-old female diagnosed with primary hyperparathyroidism, due to elevated serum levels of calcium and intact parathyroid hormone. CT and <sup>99m</sup>Tc-MIBI SPECT indicated the presence of an ectopic mediastinal parathyroid adenoma, which prompted her referral to our department for its surgical resection. Based on CT, the nodule was buried within the mediastinal fat and would be difficult to identify during surgery. Therefore, radio-guidance with <sup>99m</sup>Tc-MIBI and monitoring of intact-PTH were used as intraoperative guides. The operation was performed by hybrid video-assisted thoracic surgery with a 6-cm incision in the 3<sup>rd</sup> intercostal space, and we resected the nodule buried in the superior mediastinal fat. The nodule showed high <sup>99m</sup>Tc accumulation, and the intact-PTH level decreased after 10 minutes following resection. This led us to conclude that complete resection had been achieved. The final pathological diagnosis was ectopic mediastinal parathyroid adenoma, and there has been no recurrence to date. This outcome suggests that intraoperative guidance using a radioisotope technique along with intact-PTH monitoring may enable more precise excision of mediastinal ectopic parathyroid adenoma, and that accurate identification of the position of the nodule may reduce the rate of recurrence.</p>
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Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses
白石 航也, 高橋 篤, 桃沢 幸秀, 醍醐 弥太郎, 金子 修三, 川口 喬久, 國頭 英夫, 松本 慎吾, 堀之内 秀仁, 後藤 明輝, 本多 隆行, 清水 公裕, 虎澤 匡洋, 高柳 大輔, 齋藤 元伸, 斎藤 聡, 大江 裕一郎, 渡辺 俊一, 後藤 功一, 坪井 正博, 土原 一哉, 髙田 定暁, 碧井 智美, 高野 淳, 小林 正嗣, 宮城 洋平, 田中 和美, 鈴木 弘行, 前田 大地, 山浦 匠, 松田 麻衣子, 島田 陽子, 水野 孝昭, 坂本 裕美, 吉田 輝彦, 後藤 悌, 吉田 達哉, 山地 太樹, 園部 誠, 豊岡 伸一, 米田 和恵, 真砂 勝泰, 田中 文啓, 原 めぐみ, 布施 昇男, 西塚 哲, 元井 紀子, 澤田 典絵, 西田 裕一郎, 熊田 和貴, 竹内 研時, 丹野 高三, 谷田部 恭, 角南 久仁子, 菱田 智之, 宮崎 泰成, 伊藤 秀美, 雨宮 光宏, 戸塚 裕彦, 中山 治彦, 横瀬 智之, 石垣 和慶, 永島 宗晃, 大瀧 容一, 今井 一博, 高澤 建, 南谷 佳弘, 小林 和馬, 大久保 憲一, 若井 建志, 清水 厚志, 山本 雅之, 岩崎 基, 松田 浩一, 稲澤 譲治, 白石 友一, 西川 博嘉, 村上 善則, 久保 充明, 松田 文彦, 鎌谷 洋一郎, 浜本 隆二, 松尾 恵太郎, 河野 隆志
Cancer Communications ( Wiley ) 44 ( 2 ) 287 - 293 2024.02
非喫煙者に多いEGFR変異肺腺がんへのかかりやすさを解明 肺腺がんの予防・早期発見にむけた手がかりとして期待. 京都大学プレスリリース. 2023-11-09.
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Fundamental study of Electric Field Mixing Technique in accelerating Nucleic Acid hybridization
Ohkubo Yoshinobu, Nakamura Ryuta, Akagami Yoichi, Wakamatsu Yuki, Imai Kazuhiro, Kusumi Takayuki, Minamiya Yoshihiro
Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering ) 2023A ( 0 ) 741 - 742 2023.08