IMAI Kazuhiro



Graduate School of Medicine  Doctorial Course in Medicine  Oncoregulatory Medicine  Department of Thoracis Surgery

Research Fields, Keywords

lung cancer, immunology, oncology

Graduating School 【 display / non-display


    Akita University   Faculty of Medicine   Graduated

Graduate School 【 display / non-display


    Akita University  Graduate School,Division of Medicine  Chest Surgery  Doctor's Course  Completed

Campus Career 【 display / non-display

  • 2018.10

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Oncoregulatory Medicine   Associate Professor  

  • 2014.04

    Akita University   Hospital   SurgeryⅡ   Lecturer  


Thesis for a degree 【 display / non-display

  • Accuracy of helical computed tomography for the identification of lymph node metastasis in resectable non-small cell lung cancer.

    Imai K 

    Surgery Today  38 ( 12 ) 1083 - 1090   2009.03

    Domestic Co-author


Published Papers 【 display / non-display

  • Successful Osimertinib Rechallenge After Osimertinib-induced Interstitial Lung Disease in a Patient with Postoperative Recurrence of Lung Cancer

    Matsuo Tsubasa, Imai Kazuhiro, Takashima Shinogu, Atari Maiko, Watanabe Shin-nosuke, Minamiya Yoshihiro

    Haigan ( The Japan Lung Cancer Society )  59 ( 7 ) 1184 - 1189   2019.12

    <p><b><i>Introduction. </i></b>Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has shown significant efficacy and prolongation of the overall survival in patients with EGFR mutation-positive non-small cell lung cancer. However, drug-induced lung injury is recognized as one of the most severe adverse events. <b><i>Case. </i></b>A 58-year-old woman was diagnosed with pulmonary adenocarcinoma harboring an EGFR exon 19 deletion. After receiving her informed consent, left upper lobectomy and systemic lymph node dissection were performed. Three years after the surgery, the patient received gefitinib for multiple pulmonary metastases, and she experienced a partial response (PR); however, the disease progressed further. A computed tomography (CT)-guided percutaneous needle biopsy for pulmonary metastasis revealed an EGFR T790M mutation. The patient received osimertinib. A light cough without sputum appeared a year after osimertinib initiation, and CT showed a ground-glass shadow localized in the right middle lobe. Based on these findings, we diagnosed the patient with drug-induced lung injury. The patient discontinued osimertinib and started treatment with prednisolone immediately, but her pulmonary metastasis was re-enhanced. Although the patient switched to platinum-doublet chemotherapy, she was unable to maintain a PR. Eventually, we attempted rechallenge with osimertinib with 5 mg prednisolone daily. The patient is now receiving osimertinib treatment without disease progression or recurrence of drug-induced lung injury. <b><i>Conclusion. </i></b>This is a successful osimertinib rechallenge in a case with a history of steroid therapy osimertinib-induced lung injury.</p>

    DOI CiNii

  • Intraoperative diagnosis with novel rapid-immunohistochemistry (R-IHC)

    NANJO Hiroshi, AKAGAMI Yoichi, NAKAMURA Rhuta, HIROSHIMA Yuko, TERADA Kaori, IMAI Kazuhiro, Minamiya Yoshihiro

    The Proceedings of Mechanical Engineering Congress, Japan ( The Japan Society of Mechanical Engineers )  2019 ( 0 )   2019

    <p>Immunohistochemistry (IHC) is the most common application of immunostaining. It is widely used in the disgnosis of abnormal cells such as those found in cancerous tumors. Intraoperative pathological diagnosis is also important in selecting suitable surgery for cancer patients. We performed intraoperative diagnosis of 830 cases in Akita University Hospital., with a novel method of rapid-immunohistochemistory (R-IHC) using an alternating current electric field. The results were very good, R-IHC detected an objective evidence that were undetected using conventional HE staining. So we can diagnose degree of malignancy, histological type of cancer, and lymph node metastasis more accurately.</p>

    DOI CiNii

  • Current Status of Sentinel Node Navigation Surgery in Lung Cancer

    Minamiya Y., Imai K., Konno H., Kurihara N., Atari M.

    Nihon Kikan Shokudoka Gakkai Kaiho ( The Japan Broncho-esophagological Society )  70 ( 2 ) 85 - 86   2019

    DOI CiNii

  • Prevention of Evaporation Caused by a Rapid Immunohistochemistry Method Applying Non-contact Alternating-Current Electric-Field Mixing

    HOSHINO Iku, SATO Yusuke, MOTOYAMA Satoru, NANJO Hiroshi, AKAGAMI Yoichi, MINAMIYA Yoshihiro, IMAI Kazuhiro, NAKAMURA Ryuta, SAITO Yoshitaro, FUJISHIMA Satoshi, KURIHARA Nobuyasu, Wakamatsu Yuki, SAITO Hajime, TERATA Kaori

    Journal of the Japan Society for Precision Engineering ( The Japan Society for Precision Engineering )  84 ( 4 ) 383 - 387   2018

    <p>It is widely recognized that pathology is the most important factor for staging and selecting effective chemotherapy for patients with cancer. Immunohistochemistry (IHC) is a reliable screening method, but intra-operative diagnosis by frozen section with IHC is not possible because IHC takes approximately 6 hours. We recently developed a rapid-IHC method that makes use of an alternating current (AC) electric field to facilitate the antigen-antibody reaction, and reported its usefulness for detection of lung cancer and breast cancer. The antibody is mixed within microdroplets as the voltage is switched on and off at specific intervals. The resultant Coulomb force stirs the diluted solution on the sections, which increases the opportunity for contact. The rapid-IHC device reduces the time required for IHC as well as the amount of antibody required for analyses. The device may also be applied for in situ hybridization (ISH); however, ISH requires a warm temperature, such as 37℃, and a longer processing time than the rapid-IHC method. Consequently, evaporation can be a problem during ISH. The aim of the present study was to evaluate the utility and reliability of an oil cover and cover cap made of polyethylene terephthalate (PET) for preventing evaporation due to the AC electric field applied to facilitate the antigen-antibody reaction. We have shown that both the oil cover and PET cover cap prevented evaporation when using the rapid-IHC device.</p>

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