Research Achievements - Original paper -
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Diagnostic accuracy of ultrasonography for occult femoral neck fracture
Tsukamoto H.
Journal of Clinical Orthopaedics and Trauma ( Journal of Clinical Orthopaedics and Trauma ) 36 2023.01
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Distal sacral nerve roots severed by a fragility fracture of the sacrum: a case report
Igarashi S.
Journal of Medical Case Reports ( Journal of Medical Case Reports ) 16 ( 1 ) 2022.12
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Akagawa M.
Journal of Experimental Orthopaedics ( Journal of Experimental Orthopaedics ) 9 ( 1 ) 2022.12
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Emori M.
BMC Musculoskeletal Disorders ( BMC Musculoskeletal Disorders ) 23 ( 1 ) 378 - 378 2022.12
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BACKGROUND: The aim of the present study was to evaluate the prevalence of non-ossifying fibroma (NOF) and fibrous cortical defect (FCD) in a Japanese pediatric population and the association between the lesion size and pain. METHODS: This retrospective study, conducted across 10 Japanese institutions, included patients aged 5-15 years who had undergone standard antero-posterior and lateral view radiography of the knee. Using these radiographs, we diagnosed the lesion as a NOF or FCD. Patient demographics, including age, sex, the size and location of the NOF, and chief complaint were recorded. The lesion size was determined using radiographs. Student's t-test was used to compare the associations between the lesion size and spontaneous pain. RESULTS: A total of 6222 subjects (3567 boys and 2455 girls) were included in this study. The number of NOF and FCD cases was 143 and 437, respectively, and the prevalence of NOF and FCD was 2.3% and 7.0%, respectively. The average size of NOF and FCD was 22.1 mm (range: 4-102 mm) and 13.2 mm (range: 5-21 mm), respectively. Three patients (2.1%) had pathological fractures due to NOF. Of the 140 NOFs and 437 FCDs, we obtained complaints from the medical records of 126 and 393 patients, respectively. The number of patients with spontaneous pain or other problems with NOF was 68 (54%) and 58 (46%), respectively, that of patients with FCD was 195 (50%) and 198 (50%) patients, respectively. The lesion size was not associated with spontaneous pain in either lesion (p = 0.67 and p = 0.27, respectively). CONCLUSION: The prevalence of NOF and FCD around the knee was lower than that reported in previous studies. The prevalence of NOF increased and that of FCD decreased with advancing age. In both lesions, the lesion size may not be associated with pain.
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Suzuki N.
Medicine (United States) ( Medicine (United States) ) 101 ( 48 ) 2022.12
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Miura T.
International Journal of Environmental Research and Public Health ( International Journal of Environmental Research and Public Health ) 19 ( 24 ) 2022.12
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Shoji R.
Anticancer Research ( Anticancer Research ) 42 ( 11 ) 5357 - 5363 2022.11
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Komatsu M.
Journal of Clinical Orthopaedics and Trauma ( Journal of Clinical Orthopaedics and Trauma ) 34 2022.11
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Horikawa A.
Medicine (United States) ( Medicine (United States) ) 101 ( 43 ) 2022.10
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Hirota R.
Spine ( Spine ) 47 ( 19 ) 1391 - 1398 2022.10
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STUDY DESIGN: Retrospective analysis of prospectively collected multicenter observational data. OBJECTIVE: The aim was to examine the preoperative factors affecting postoperative satisfaction following posterior lumbar interbody fusion (PLIF) and microendoscopic muscle-preserving interlaminar decompression (ME-MILD) in patients with degenerative lumbar spondylolisthesis (DLS). SUMMARY OF BACKGROUND DATA: The technique involved in DLS surgery may either be decompression alone or decompression-fixation. Poor performance may occur after either of these surgical treatments. The author hypothesized that evaluating the correlation between preoperative quality of life and postoperative performance would aid in determining the optimal procedure. MATERIALS AND METHODS: This study included 138 patients who underwent surgery for 1-level mild DLS. The authors performed PLIF for 79 patients and ME-MILD for 59 patients. When the satisfaction subscale of the Zurich Claudication Questionnaire exceeded 2 points, postoperative satisfaction was considered poor. The clinical characteristics were investigated. Responses to preoperative health-related quality of life questionnaires, such as the Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ), short form-36 health survey (SF-36), and visual analog scale, were compared between the satisfied and unsatisfied groups. RESULTS: In the PLIF group, no endogenous factors influenced postoperative satisfaction. The ME-MILD cohort's satisfied and unsatisfied patients differed significantly in terms of preoperative lumbar spine dysfunction ( P <0.001) items of the JOABPEQ, role physical ( P =0.03), and role emotional ( P =0.03) items of the SF-36. A strong correlation ( r =-0.609 P =0.015) was found between preoperative lumbar spine dysfunction and postoperative satisfaction. CONCLUSIONS: In the ME-MILD group, preoperative lumbar spine function was correlated with postoperative satisfaction. Decompression alone may be ineffective in cases with decreased lumbar spine function prior to surgery. The degree of low back pain on movement should be considered before selecting the surgical method. LEVEL OF EVIDENCE: 3.
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Risk Factors of Early Distant Metastasis after Primary Tumor Treatment in Soft Tissue Sarcoma
Tsuchie H.
In Vivo ( In Vivo ) 36 ( 5 ) 2260 - 2264 2022.09
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Miura T.
Medicina (Lithuania) ( Medicina (Lithuania) ) 58 ( 8 ) 1058 - 1058 2022.08
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Background and Objectives: Adequate initial fixation of the uncemented acetabular component in total hip arthroplasty is necessary to achieve long-term survival. Although screw fixation contributes to improved cup stability, there is currently no consensus on the use of this method. This study aimed to assess the existing randomized controlled trials (RCTs) on the efficacy and safety of cup fixation in total hip arthroplasty without screws. Materials and Methods: We searched the EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials, World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov databases to identify RCTs published before February 2022. Primary outcomes were reoperation, cup migration, and Harris Hip Score. Secondary outcomes were the presence of a radiolucent line in the acetabular region, translation and rotation movement, and polyethylene wear. We conducted meta-analyses using the random-effects models. The revised Cochrane risk-of-bias tool was used to assess the risk of bias for outcomes of interest; the Grading of Recommendations, Assessment, Development, and Evaluation approach was used to summarize the body of evidence. Results: We included six reports from four studies. Total hip arthroplasty without screw fixation to the acetabular cup had little to no effect on reoperation (pooled relative risk, 0.98; 95% confidence interval, 0.14–6.68; I2 = 0%), cup migration (pooled relative risk, 1.72; 95% confidence interval, 0.29–10.33; I2 = 1%), Harris Hip Score (mean difference, 1.19; 95% confidence interval, −1.31–3.70; I2 = 0%), radiolucent line (pooled relative risk, 5.91; 95% confidence interval, 0.32–109.35), translation and rotation of all axes, and polyethylene wear (mean difference, 0.01; 95% confidence interval, −0.01–0.04; I2 = 0%), with very low certainty of evidence on all measures. Conclusions: The efficacy of acetabular cups without screw fixation in total hip arthroplasty remains uncertain, suggesting the need for prudent clinical application. Further large-scale, well-designed studies with low risk of bias are required.
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Earlier appearance of Risser sign on ultrasound versus radiograph in adolescent idiopathic scoliosis
Hongo M.
Journal of Clinical Imaging Science ( Journal of Clinical Imaging Science ) 12 2022.07
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Horikawa A.
Journal of Bone and Mineral Metabolism ( Journal of Bone and Mineral Metabolism ) 40 ( 4 ) 670 - 676 2022.07
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Kasukawa Y.
Applied Sciences (Switzerland) ( Applied Sciences (Switzerland) ) 12 ( 9 ) 2022.05
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Causes and Clinical Outcomes of Patellar Post Impingement
Tomite T.
Arthroplasty Today ( Arthroplasty Today ) 14 48 - 52 2022.04
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Vertebral Osteomyelitis and Infective Endocarditis Co-Infection
Morimoto T.
Journal of Clinical Medicine ( Journal of Clinical Medicine ) 11 ( 8 ) 2022.04
Research paper (journal)
Many cases of vertebral osteomyelitis (VO) and infective endocarditis (IE) co-infection have been reported, and it has been recognized that attention should be paid to the possibility of both diseases co-existing during diagnosis and treatment. However, the incidence, clinical status, and outcomes of IE in patients with VO remain unclear. For this study, the eligibility criteria for patient recruitment included all cases of VO at the five medical university hospitals. Patients with a history of spinal surgery were excluded from this study. Echocardiography was routinely performed for all patients with VO. IE was diagnosed according to the modified Duke criteria for definite endocarditis. We analyzed demographic data, underlying conditions, clinical features, laboratory data, echocardiography, radiologic images, treatments, and outcomes. VO was diagnosed in 59 patients and IE was diagnosed in seven patients (12%). There were no significant differences in the clinical features, microorganisms, or radiographic status between the VO-IE co-infection and VO-only groups. In this study, using routine echocardiography for VO, the IE prevalence was 12%. The lack of specific clinical features and laboratory findings may hamper the diagnosis of IE. Therefore, clinicians are always required to suspect IE in patients with VO.
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Shoji R.
In vivo (Athens, Greece) ( In vivo (Athens, Greece) ) 36 ( 2 ) 667 - 671 2022.03
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Chronic atlantoaxial rotatory fixation with neurofibromatosis type I: A case report
Ono Y.
Surgical Neurology International ( Surgical Neurology International ) 13 2022
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Abe K.
Journal of Bone and Mineral Metabolism ( Journal of Bone and Mineral Metabolism ) 2022
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Aphasia testing (auditory comprehension domain) using a new eye-tracking system in healthy participants
Sakai Risa, Koike Yasuharu, Saito Kimio, Matsunaga Toshiki, Shimada Yoichi, Miyakoshi Naohisa
Japanese Journal of Comprehensive Rehabilitation Science ( 一般社団法人 回復期リハビリテーション病棟協会 ) 13 ( 0 ) 31 - 35 2022
Research paper (journal)
<p>Sakai R, Koike Y, Saito K, Matsunaga T, Shimada Y, Miyakoshi N. Aphasia testing (auditory comprehension domain) using a new eye-tracking system in healthy participants. Jpn J Compr Rehabil Sci 2022; 13: 31‒35.</p><p><b>Objective</b>: We administered a conventional pointingmethod test with eye-tracking to evaluate items associated with auditory comprehension and examined the concordance between the obtained results.</p><p><b>Methods</b>: The enrolled participants were 10 healthy volunteers. We performed tests after extracting auditory comprehension items from the SLTA, the WAB, and the Supplementary tests for the SLTA using the eye-tracking system and the pointing method.</p><p><b>Results</b>: The mean test duration was 9 min 51 s ± 1 min 41 s (mean ± SD), and the percentage of correct answers was 100% and in perfect agreement for the pointing method and the eye-tracking system. The mean response time was 0.96 ± 0.36 s for the pointing method and −0.39 ± 0.21 s for the eye-tracking system. Hence, the latter was faster than the former, and examinees completed their responses before listening to the end of the questions.</p><p><b>Conclusion</b>: The new eye-tracking system makes it possible to perform aphasia tests (auditory comprehension items) comparable to the conventional pointing method.</p>
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Contralaterally controlled functional electrical stimulation immediately improves hand function
Murata Shohei, Koike Yasuharu, Kasukawa Yuji, Saito Kimio, Okada Koki, Kudo Daisuke, Shimada Yoichi, Miyakoshi Naohisa
Japanese Journal of Comprehensive Rehabilitation Science ( 一般社団法人 回復期リハビリテーション病棟協会 ) 13 ( 0 ) 26 - 30 2022
Research paper (journal)
<p>Murata S, Koike Y, Kasukawa Y, Saito K, Okada K, Kudo D, Shimada Y, Miyakoshi N. Contralaterally controlled functional electrical stimulation immediately improves hand function. Jpn J Compr Rehabil Sci 2022; 13: 26-30.</p><p><b>Objective</b>: The purpose of this study was to investigate the immediate effects of contralaterally controlled functional electrical stimulation (CCFES) on upper limb function in stroke patients.</p><p><b>Methods</b>: CCFES and mirror therapy (MT) exercises were conducted for 13 stroke patients at least 4 weeks post-onset. A sufficient interval of at least 24 hours was left between the two types of rehabilitation exercises. Before treatment and immediately after each training session, grip strength, Fugl-Meyer Assessment for Upper Extremity (FMA-UE) score and FMA-UE subscores for the shoulder/elbow/forearm, wrist, hand, and coordination were evaluated.</p><p><b>Results</b>: Grip strength, FMA-UE and FMA-UE shoulder/elbow/forearm, wrist, and coordination did not differ significantly after CCFES and MT compared to before therapy. FMA-UE hand did not change significantly after MT compared to before therapy, but it improved significantly after CCFES (<i>p</i> = 0.013).</p><p><b>Conclusion</b>: CCFES for the upper extremities immediately improves hand function and may be effective in maintaining and improving patients' motivation for rehabilitation treatment.</p>
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Tsuchie H.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 2022
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Akagawa M.
Acta Medica Okayama ( Acta Medica Okayama ) 76 ( 3 ) 333 - 338 2022
Research paper (journal)
We report a case of atypical femoral fracture achieving early fracture union with combination therapy comprising contralateral nail and immediate teriparatide injection. Fracture union of atypical fractures is often delayed due to bowing deformity and bone metabolic disorders. Combination treatment that takes both problems into consideration represents a useful treatment option for atypical femoral fracture.
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Study of surgical intervention for quadriceps tendon rupture
ASAKA Yasuhito, KIMURA Ryota, KOBAYASHI Takashi, SAITO Hidetomo, MIYAKOSHI Naohisa
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 34 ( 2 ) 116 - 118 2022
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10 cases of spinal cord ischemia in our hospital
KAWARAGI Takashi, KINOSHITA Hayato, KOBAYASHI Takashi, ISHIKAWA Yoshinori, KIKUCHI Kazuma, MIYAKOSHI Naohisa
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 34 ( 2 ) 98 - 102 2022
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Association of the bioimpedance phase angle and quality of life in postmenopausal osteoporosis
Ono Y.
Medical Principles and Practice ( Medical Principles and Practice ) 2022
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Development and evaluation of upper limb rehabilitation robot using VR or AR
SAKURAI Takahiro, IWAMI Takehiko, KIZAWA Satoru, SAITOU Kimio, SHIMADA Youiti, MIYAKOSHI Naohisa
The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec) ( The Japan Society of Mechanical Engineers ) 2022 ( 0 ) 2A2-E09 2022
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Impact of a specialized outpatient clinic on bone metastasis and its burden on spine surgeons
Tsuchie H.
In Vivo ( In Vivo ) 35 ( 6 ) 3575 - 3579 2021.12
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Tsuchie H.
In Vivo ( In Vivo ) 35 ( 6 ) 3467 - 3473 2021.12
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Analysis of bone in adenine-induced chronic kidney disease model rats.
Hikaru Saito, Naohisa Miyakoshi, Yuji Kasukawa, Koji Nozaka, Hiroyuki Tsuchie, Chiaki Sato, Kazunobu Abe, Ryo Shoji, Yoichi Shimada
Osteoporosis and sarcopenia 7 ( 4 ) 121 - 126 2021.12
Research paper (journal)
OBJECTIVES: The purpose of this study is to investigate the stage of chronic kidney disease (CKD) in adenine-induced CKD model rats by serum analyses, and to examine bone mineral density (BMD), bone strength, and microstructure of trabecular and cortical bone in these rats. METHODS: Eight-week-old, male Wistar rats (n = 42) were divided into 2 groups: those fed a 0.75% adenine diet for 4 weeks until 12 weeks of age to generate CKD model rats (CKD group); and sham rats. The CKD and sham groups were sacrificed at 12, 16, and 20 weeks of age (n = 7 in each group and at 12, 16, and 20 weeks), and various parameters were evaluated, including body weight, renal wet weight, muscle wet weight, renal histology, biochemical tests, BMD, biomechanical testing, and micro-computed tomography (CT). The parameters were compared between the 2 groups at the various time points. RESULTS: In the CKD model rats, at 20 weeks of age, serum creatinine, phosphorus, and intact-PTH levels were elevated, and serum calcium levels were normal, indicating that the CKD was stage IV and associated with secondary hyperparathyroidism. Decreased BMDs of the whole body and the femur were observed as bone changes, and micro-CT analysis showed deterioration of bone microstructure of the cortical bone that resulted in decreased bone strength in the cortical and trabecular bone. CONCLUSIONS: These CKD model rats showed stage IV CKD and appear appropriate for evaluating the effects of several treatments for CKD-related osteoporosis and mineral bone disorder.
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Guideline-based Treatment of Glucocorticoid-induced Osteoporosis in Patients with Rheumatoid Arthritis: A Retrospective Study with the AORA Registry.
Tetsuya Kawano, Naohisa Miyakoshi, Hiroyuki Tsuchie, Takeshi Kashiwagura, Moto Kobayashi, Hiroshi Aonuma, Yusuke Sugimura, Yoichi Shimada
Acta medica Okayama 75 ( 6 ) 699 - 704 2021.12
Research paper (journal)
Glucocorticoid-induced osteoporosis (GIOP) is one of the side effects associated with glucocorticoid (GC) therapy. In 2014, the Japanese Society for Bone and Mineral Research (JSBMR) provided new guidelines for the management and treatment of GIOP. The aim of the present study was to clarify the prevalence of patients with rheumatoid arthritis (RA) requiring treatment according to the new guidelines and to identify risk factors associated with lack of treatment in these patients. Patients in the 2018 Akita Orthopedic group on Rheumatoid Arthritis (AORA) database were enrolled. Of 2,234 patients with RA in the database, 683 (30.6%) met the 2014 JSBMR guideline treatment criteria, and 480 (70.3%) had been treated. The untreated group included a larger number of males, younger patients, and patients treated in clinics rather than hospital (p<0.001, p=0.015, and p<0.001, respectively). Multivariate analyses found that male sex, younger age, and clinic-based RA care were significant risk factors associated with lack of treatment (p<0.001, p=0.013, and p<0.001, respectively). Thus, male sex, younger age, and clinic-based care were identified as risk factors.
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Tomite T.
Knee ( Knee ) 32 121 - 130 2021.10
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Miura T.
PLoS ONE ( PLoS ONE ) 16 ( 10 October ) 2021.10
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Evaluation of the Nature and Etiologies of Risk Factors for Diaphyseal Atypical Femoral Fractures
Tsuchie H.
Medical Principles and Practice ( Medical Principles and Practice ) 30 ( 5 ) 430 - 436 2021.10
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Mita M.
Trauma Case Reports ( Trauma Case Reports ) 34 2021.08
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Saito H.
Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology ( Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology ) 24 9 - 13 2021.04
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Pediatric spinal infection with epidural abscess: A report of two cases
Shoji R.
Surgical Neurology International ( Surgical Neurology International ) 12 2021.04
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Tsuchie H.
Bone ( Bone ) 143 2021.02
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Miura T.
Journal of Orthopaedics ( Journal of Orthopaedics ) 23 78 - 82 2021.01
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Ishikawa Y.
World Neurosurgery ( World Neurosurgery ) 145 83 - 88 2021.01
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Sato C.
Journal of Bone and Mineral Metabolism ( Journal of Bone and Mineral Metabolism ) 2021
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Tsukamoto Hiroaki, Shimada Yoichi, Saito Kimio, Matsunaga Toshiki, Iwami Takehiro, Saito Hidetomo, Kijima Hiroaki, Akagawa Manabu, Komatsu Akira, Miyakoshi Naohisa
Progress in Rehabilitation Medicine ( 公益社団法人 日本リハビリテーション医学会 ) 6 ( 0 ) 2021
Research paper (journal)
<p><b>Objectives: </b>The purpose of this study was to clarify the diagnostic accuracy of the mobile assessment of varus thrust using inertial measurement units (IMUs).</p><p><b>Methods: </b>A total of 80 knees in 49 patients were enrolled in this study. On visual analysis of gait to determine the presence or absence of varus thrust, 23 knees were assigned to the Present group, 17 to the Ambiguous group, and 40 to the Absent group. The peak knee varus angular velocities (PVVs), measured by quantitative gait analysis using nine-axis IMUs, were compared between these three groups. A receiver operating characteristic curve for the relationship between the visual assessment of varus thrust (Present and Ambiguous) and the measured PVV was created, and the cut-off PVV for visualized varus thrust was determined as the highest point for both sensitivity and specificity.</p><p><b>Results: </b>The mean PVVs were significantly different between the three groups (Present, 47.7 ± 8.2 degree/s, Ambiguous, 34.1 ± 10.5 degree/s, and Absent, 28.1 ± 8.3 degree/s, respectively, ANOVA P=0.000). The PVV cut-off value for visualized varus thrust was 28.1 degree/s, yielding a sensitivity of 0.957 and a specificity of 0.579.</p><p><b>Conclusions: </b>A PVV <28.1 degree/s is useful for ruling out varus thrust during gait. This quantitative varus thrust assessment method using IMUs has clinical utility as a screening test.</p>
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Iida J.
Surgical Neurology International ( Surgical Neurology International ) 12 2021
Research paper (journal)
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Tomioka T.
Advances in Orthopedics ( Advances in Orthopedics ) 2021 2021
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Kijima H.
Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders ( Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders ) 14 2021
Research paper (journal)
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The Effects of Trends in Osteoporosis Treatment on the Incidence of Fractures
Horikawa A.
Journal of Osteoporosis ( Journal of Osteoporosis ) 2021 2021
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Inoue G.
Spine Surgery and Related Research ( Spine Surgery and Related Research ) 5 ( 4 ) 252 - 263 2021
Research paper (journal)
<p>Introduction: Chronic low back pain (CLBP) is a leading cause of disability, yet there is limited high-quality evidence to identify the most suitable pharmacological therapy. The purpose of this Japanese nationwide, multicenter, prospective study was to compare the effectiveness of four representative drug therapies-acetaminophen, celecoxib, loxoprofen, and a tramadol and acetaminophen (T+A) combination drug-to establish evidence for a drug of choice for CLBP.</p><p>Methods: Patients with CLBP (N=471) received one of the four treatments and were evaluated, prospectively and comprehensively, once every month for six months using a visual analog scale (VAS) for LBP, the Japanese Orthopedic Association (JOA) score, the JOA Back Pain Evaluation Questionnaire (JOABPEQ), the Roland-Morris Disability Questionnaire (RDQ), the EuroQol five-dimensions three-levels (EQ-5D-3L), and the Short Form-8 item health survey (SF-8). We conducted multivariable linear regression analyses of the four drugs at 1 and 6 months after drug allocation. Differences with <i>P</i><0.05 were considered statistically significant.</p><p>Results: Patients who received acetaminophen showed a significant improvement from baseline in the mental health subscale of the JOABPEQ at one month (<i>P</i>=0.02) and the JOA score at six months (<i>P</i><0.01). None of the other outcome measures among the four drugs differed significantly. Across groups, all outcome measures, except the mental component summary (MCS) score of the SF-8, improved equivalently, although most measurements showed no obvious cumulative effect over six months. The MCS score of the SF-8 decreased gradually over six months in all groups.</p><p>Conclusions: Most of the outcome measures among the treated groups were not significantly different, indicating similar treatment effects of the four drugs for CLBP. Our study indicated the limit of each outcome measure for evaluating the patient status, suggesting that a single outcome measure is insufficient to reflect treatment effectiveness.</p>
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Tsuchie H.
Acta Medica Okayama ( Acta Medica Okayama ) 75 ( 4 ) 533 - 538 2021
Research paper (journal)
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Deep Angiomyxoma of the Thigh That Is Difficult to Diagnose: A Case Report and Literature Review
Tsuchie H.
Acta Medica Okayama ( Acta Medica Okayama ) 75 ( 5 ) 653 - 657 2021
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Kawano T.
Acta Medica Okayama ( Acta Medica Okayama ) 75 ( 6 ) 699 - 704 2021
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Ishikawa Y.
Surgical Neurology International ( Surgical Neurology International ) 12 2021
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Deep Angiomyxoma of the Thigh That Is Difficult to Diagnose: A Case Report and Literature Review.
Hiroyuki Tsuchie, Naohisa Miyakoshi, Hiroyuki Nagasawa, Hiroshi Nanjo, Yoichi Shimada
Acta medica Okayama 75 ( 5 ) 653 - 657 2021
Research paper (journal)
We present an extremely rare case of deep angiomyxoma (DAM) in the thigh that was misdiagnosed as desmoid-type fibromatosis. A 40-year-old Japanese woman presented with a mass on the left thigh. The histological diagnosis by needle biopsy was desmoid-type fibromatosis; the tumor grew slowly and was resected 4 years later. The histological diagnosis from the resected tumor was DAM. As of 16 months post-surgery, the patient has not noticed any local recurrence. Although DAM in a lower extremity is extremely rare, clinicians must be aware of its possible occurrence in areas relatively close to the pelvis.
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Impact of a Specialized Outpatient Clinic on Bone Metastasis and Its Burden on Spine Surgeons
HIROYUKI TSUCHIE, NAOHISA MIYAKOSHI, MICHIO HONGO, HIROYUKI NAGASAWA, YUJI KASUKAWA, DAISUKE KUDO, RYOTA KIMURA
In Vivo ( Anticancer Research USA Inc. ) 35 ( 6 ) 3575 - 3579 2021
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Kimura R.
Spinal Cord Series and Cases ( Spinal Cord Series and Cases ) 6 ( 1 ) 2020.12
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Growing Rod Surgery for Early-Onset Scoliosis in an Osteogenesis Imperfecta Patient
Ono Y.
World Neurosurgery ( World Neurosurgery ) 144 178 - 183 2020.12
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Ishikawa Y.
World Neurosurgery ( World Neurosurgery ) 144 82 - 87 2020.12
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Saito H.
Journal of Experimental Orthopaedics ( Journal of Experimental Orthopaedics ) 7 ( 1 ) 2020.12
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Abe K.
Surgical Neurology International ( Surgical Neurology International ) 11 2020.12
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Ultrasound-guided total dorsal ramus block for the treatment of chronic low back pain
Kimura R.
Journal of Orthopaedics, Trauma and Rehabilitation ( Journal of Orthopaedics, Trauma and Rehabilitation ) 27 ( 2 ) 128 - 132 2020.12
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Yamada K.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 25 ( 6 ) 1084 - 1092 2020.11
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Okudera Y.
Journal of Orthopaedics ( Journal of Orthopaedics ) 22 220 - 224 2020.11
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Miyakoshi N.
World Neurosurgery ( World Neurosurgery ) 142 239 - 245 2020.10
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Murahashi Y.
European Radiology ( European Radiology ) 30 ( 10 ) 5768 - 5776 2020.10
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Nozaka K.
BMC Musculoskeletal Disorders ( BMC Musculoskeletal Disorders ) 21 ( 1 ) 2020.09
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Impact of acridine orange in patients with local recurrent soft tissue sarcoma
Tsuchie H.
In Vivo ( In Vivo ) 34 ( 5 ) 2745 - 2750 2020.09
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Prognostic significance of histological subtype in soft tissue sarcoma with distant metastasis
Tsuchie H.
In Vivo ( In Vivo ) 34 ( 4 ) 1975 - 1980 2020.08
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Osteochondritis dissecans of the glenoid in a 13-year-old baseball player: A case report
Seki N.
Sports Orthopaedics and Traumatology ( Sports Orthopaedics and Traumatology ) 36 ( 2 ) 155 - 162 2020.06
Research paper (journal)
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Tsukamoto H.
Knee ( Knee ) 27 ( 3 ) 838 - 845 2020.06
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Effectiveness of circular external fixator in periprosthetic fractures around the knee
Nozaka K.
BMC Musculoskeletal Disorders ( BMC Musculoskeletal Disorders ) 21 ( 1 ) 2020.05
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Hatakeyama Y.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 25 ( 3 ) 503 - 506 2020.05
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Recurrent dysphagia after lower posterior cervical fusion
Ishikawa Y.
Surgical Neurology International ( Surgical Neurology International ) 11 ( 114 ) 2020.05
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Yuasa Y.
Journal of Bone and Mineral Metabolism ( Journal of Bone and Mineral Metabolism ) 38 ( 2 ) 179 - 187 2020.03
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Factors affecting continuation of weekly teriparatide administration in rural areas
Tsuchie H.
Journal of Bone and Mineral Metabolism ( Journal of Bone and Mineral Metabolism ) 38 ( 2 ) 248 - 253 2020.03
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Nozaka K.
BMC Musculoskeletal Disorders ( BMC Musculoskeletal Disorders ) 21 ( 1 ) 2020.03
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Effectiveness of distal tibial osteotomy with distraction arthroplasty in varus ankle osteoarthritis
Nozaka K.
BMC Musculoskeletal Disorders ( BMC Musculoskeletal Disorders ) 21 ( 1 ) 2020.01
Research paper (journal)
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Miyakoshi N.
Spine Surgery and Related Research ( Spine Surgery and Related Research ) 4 ( 3 ) 208 - 215 2020.01
Research paper (journal)
<p>Introduction: Chronic low back pain (CLBP) is a major health burden worldwide and requires patient satisfaction with treatment. Consultation length can be an important factor in patient satisfaction, but few studies have investigated the impact of consultation length on satisfaction in patients with CLBP. This study tried to elucidate the impact of consultation length on clinical outcomes in patients with CLBP.</p><p>Methods: This study is part of an analysis using the database of the nationwide, multicenter cohort for CLBP performed by the Project Committee of the Japanese Society for Spine Surgery and Related Research. A total of 427 patients aged 20-85 years (median age, 73.0 years; female, 58.6%) with CLBP were prospectively followed-up monthly for 6 months. Multivariable nonlinear regression analyses were performed to assess the effect of consultation length on outcome measures including subjective satisfaction score, EuroQol 5-dimension, Japanese Orthopaedic Association (JOA) score, Roland-Morris Disability Questionnaire, JOA Back Pain Evaluation Questionnaire, visual analog scale (VAS) and Medical Outcome Survey short-form 8-item health survey that evaluated at the next phase. Furthermore, we assessed whether the effect of consultation length on patient satisfaction was modified by the baseline Brief Scale for Psychiatric Problems in Orthopaedic Patients (BS-POP) score for patient and physician versions.</p><p>Results: VAS for CLBP was the only score that correlated significantly with consultation length (P = 0.018). Satisfaction score showed a significant positive correlation with consultation length in patients with the highest baseline BS-POP scores (P < 0.2). Moreover, consultation lengths more than 7.6 min and 15.1 min offered increase of satisfaction if patients show the highest BS-POP scores on patient and physician versions, respectively.</p><p>Conclusions: These findings suggest that a sufficiently long consultation is an important factor for subjective satisfaction in the patients with CLBP, particularly in patients with psychological problems.</p>
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Murata S.
International Journal of Surgery Case Reports ( International Journal of Surgery Case Reports ) 77 510 - 514 2020.01
Research paper (journal)
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Treatment of spontaneous osteonecrosis of the knee by daily teriparatide: A report of 3 cases
Horikawa A.
Medicine ( Medicine ) 99 ( 5 ) 2020.01
Research paper (journal)
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Kawano T.
Advances in Orthopedics ( Advances in Orthopedics ) 2020 2020
Research paper (journal)
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Miyakoshi N.
Spinal Cord ( Spinal Cord ) 2020
Research paper (journal)
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Miyakoshi N.
Surgical Neurology International ( Surgical Neurology International ) 11 2020
Research paper (journal)
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Fujii M.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 2020
Research paper (journal)
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Inoue Gen, Taguchi Toshihiko, Haro Hirotaka, Taneichi Hiroshi, Yamazaki Masashi, Nishida Kotaro, Yamada Hiroshi, Kabata Daijiro, Shintani Ayumi, Iwasaki Motoki, Ito Manabu, Kaito Takashi, Miyakoshi Naohisa, Murakami Hideki, Yonenobu Kazuo, Takura Tomoyuki, Mochida Joji, Matsuyama Yukihiro, Yamashita Toshihiko, Kawakami Mamoru, Takahashi Kazuhisa, Yoshida Munehito, Imagama Shiro, Ohtori Seiji
Spine Surgery and Related Research ( 一般社団法人 日本脊椎脊髄病学会 ) 2020
Research paper (journal)
<p><b>Introduction: </b>Chronic low back pain (CLBP) is a leading cause of disability, yet there is limited high-quality evidence to identify the most suitable pharmacological therapy. The purpose of this Japanese nationwide, multicenter, prospective study was to compare the effectiveness of four representative drug therapies—acetaminophen, celecoxib, loxoprofen, and a tramadol and acetaminophen (T+A) combination drug—to establish evidence for a drug of choice for CLBP.</p><p><b>Methods: </b>Patients with CLBP (N = 471) received one of the four treatments and were evaluated, prospectively and comprehensively, once every month for six months using a visual analog scale (VAS) for LBP, the Japanese Orthopedic Association (JOA) score, the JOA Back Pain Evaluation Questionnaire (JOABPEQ), the Roland–Morris Disability Questionnaire (RDQ), the EuroQol five-dimensions three-levels (EQ-5D-3L), and the Short Form-8 item health survey (SF-8). We conducted multivariable linear regression analyses of the four drugs at 1 and 6 months after drug allocation. Differences with P < 0.05 were considered statistically significant.</p><p><b>Results: </b>Patients who received acetaminophen showed a significant improvement from baseline in the mental health subscale of the JOABPEQ at one month (<i>P</i> = 0.02) and the JOA score at six months (<i>P</i> < 0.01). None of the other outcome measures among the four drugs differed significantly. Across groups, all outcome measures, except the mental component summary (MCS) score of the SF-8, improved equivalently, although most measurements showed no obvious cumulative effect over six months. The MCS score of the SF-8 decreased gradually over six months in all groups.</p><p><b>Conclusions: </b>Most of the outcome measures among the treated groups were not significantly different, indicating similar treatment effects of the four drugs for CLBP. Our study indicated the limit of each outcome measure for evaluating the patient status, suggesting that a single outcome measure is insufficient to reflect treatment effectiveness.</p>
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Miyakoshi Naohisa, Masutani Norimitsu, Kasukawa Yuji, Kudo Daisuke, Saito Kimio, Matsunaga Toshiki, Shimada Yoichi
Progress in Rehabilitation Medicine ( 公益社団法人 日本リハビリテーション医学会 ) 5 ( 0 ) 2020
Research paper (journal)
<p><b>Objectives: </b>Previous studies have suggested that the effects of vitamin D in preventing osteoporotic fractures result in part from its influence on fall prevention. However, the effects of vitamin D on dynamic balance as a contributor to fall prevention have not been fully evaluated. Moreover, few studies have compared the effects of native and active forms of vitamin D. The objective of this preliminary randomized prospective study was to compare the effects of native vitamin D and eldecalcitol on muscular strength and dynamic balance in postmenopausal patients undergoing denosumab treatment for osteoporosis.</p><p><b>Methods: </b>A total of 30 women with postmenopausal osteoporosis were randomly assigned to a native D group (administered denosumab and native vitamin D with calcium) or an ELD group (administered denosumab and eldecalcitol) and were followed up for 6 months. The following parameters were compared: the strengths of the back extensor and lower extremity muscles; static balance evaluated using the one-leg standing test; and dynamic balance evaluated using the 10-m walk test, the functional reach test, the timed up and go test, and the total length of the trajectory of the center of gravity (LNG) measured using a dynamic sitting balance measurement device.</p><p><b>Results: </b>Compared to baseline measurements, back extensor and knee extensor strengths had significantly increased after 6 months of treatment in the native D group (P<0.05) but not in the ELD group. In contrast, LNG significantly improved in both groups after 6 months (P<0.05). No significant differences between the two groups were seen in any of these measured parameters after treatment.</p><p><b>Conclusions: </b>Both native vitamin D + denosumab and eldecalcitol + denosumab were effective for improving dynamic sitting balance in postmenopausal women with osteoporosis.</p>
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Diagnosis of presarcopenia using body height and arm span for postmenopausal osteoporosis
Ono Y.
Clinical Interventions in Aging ( Clinical Interventions in Aging ) 15 357 - 361 2020
Research paper (journal)
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Effectiveness of Ilizarov external fixation in elderly patients with pilon fractures
Nozaka K.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 2020
Research paper (journal)
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Okuyama K.
Acta Orthopaedica et Traumatologica Turcica ( Acta Orthopaedica et Traumatologica Turcica ) 54 ( 6 ) 647 - 650 2020
Research paper (journal)
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Imagama S.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 2020
Research paper (journal)
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Kudo D.
Journal of Back and Musculoskeletal Rehabilitation ( Journal of Back and Musculoskeletal Rehabilitation ) 33 ( 2 ) 263 - 268 2020
Research paper (journal)
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Initial Rotational Instability of the Tapered Wedge-Shaped Type Cementless Stem
Iwamoto Y.
Advances in Orthopedics ( Advances in Orthopedics ) 2020 2020
Research paper (journal)
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Kasukawa Yuji, Miyakoshi Naohisa, Hongo Michio, Ishikawa Yoshinori, Kudo Daisuke, Kimura Ryota, Ono Yuichi, Shimada Yoichi
Progress in Rehabilitation Medicine ( 公益社団法人 日本リハビリテーション医学会 ) 5 ( 0 ) 2020
Research paper (journal)
<p><b>Objectives: </b>The extent to which locomotive syndrome is associated with low back pain (LBP), health-related quality of life (HRQOL), and impairment of activities of daily living among elderly men and women remains poorly documented. This study evaluated associations between locomotive syndrome and both HRQOL and LBP as assessed using a questionnaire completed by elderly individuals, including some >80 years old.</p><p><b>Methods: </b>We conducted a survey assessing locomotive syndrome using the loco-check, HRQOL using the Short-Form 36 questionnaire (SF-36), and LBP using the Roland-Morris Disability Questionnaire (RDQ) among individuals >60 years old. SF-36 and RDQ scores were compared between 253 subjects with and without locomotive syndrome.</p><p><b>Results: </b>Fifty-seven men (48%) and 71 women (53%) were diagnosed with locomotive syndrome. Subjects of both sexes with locomotive syndrome scored significantly lower for eight items from SF-36. Physical and mental component summary scores were significantly worse in women with locomotive syndrome in their 60s and 70s. RDQ scores were significantly higher in participants with locomotive syndrome for men in their 60s and for both men and women in their 70s.</p><p><b>Conclusions: </b>Locomotive syndrome was associated with impaired HRQOL and worse LBP among men and women >60 years old. Differences in HRQOL and LBP between subjects with and without locomotive syndrome were significant for both men and women in their 60s and 70s, but not in their 80s. Locomotive syndrome should be prevented to maintain HRQOL, particularly for men and women in their 60s and 70s.</p>
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Tsuchie H.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre ( Medical principles and practice : international journal of the Kuwait University, Health Science Centre ) 29 ( 6 ) 538 - 543 2020
Research paper (journal)
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Kikuchi K.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 2020
Research paper (journal)
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Relationship between Dynamic Trunk Balance and the Balance Evaluation Systems Test in Elderly Women
Takahashi Yasuhiro, Saito Kimio, Matsunaga Toshiki, Iwami Takehiro, Kudo Daisuke, Tate Kengo, Miyakoshi Naohisa, Shimada Yoichi
Progress in Rehabilitation Medicine ( 公益社団法人 日本リハビリテーション医学会 ) 5 ( 0 ) 2020
Research paper (journal)
<p><b>Objective</b>: Falls are major contributors to elderly subjects becoming bedridden. Consequently, it is important to evaluate and minimize the risk of falls in the elderly. Trunk stability is important for balance function and is related to fall prevention in elderly women. We developed a balance-measuring device that uses a dynamic sitting position to safely measure balance function. The Balance Evaluation Systems Test (BESTest) is useful method to assess balance function, a recently developed balance evaluation test that can detect minor balance problems not captured by previous tests. The purpose of the present study was to examine the relationship between dynamic trunk balance and findings of the BESTest in elderly women. <b>Methods</b>: Thirty-one healthy women aged 60 years or more participated in this study. The evaluation items were the BESTest total score, scores for each of the six elements of the BESTest, dynamic sitting balance, static postural balance, and muscle strength. <b>Results</b>: The mean total BESTest score was 85.4 points. The mean total trajectory length of the center of gravity (COG) during the dynamic sitting balance test was 1447.5 mm. A negative correlation (r=–0.481, P= 0.006) was observed between the total COG trajectory length and the BESTest score. A negative correlation was also found between the total COG trajectory length and biomechanical constraints (r=–0.492, P=0.005) and anticipatory postural adjustments (r=–0.532, P=0.002). There were no correlations between the dynamic sitting balance total COG trajectory length and the stationary standing COG trajectory length or muscle strength. <b>Conclusions</b>: In elderly women, the total COG trajectory length during dynamic sitting was negatively correlated with the BESTest total score.</p>
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Spinal Cord Compression with Occult Bony Fragment in Osteoporotic Vertebral Fracture: A Case Report
Ishikawa Yoshinori, Miyakoshi Naohisa, Hongo Michio, Kasukawa Yuji, Kudo Daisuke, Shimada Yoichi
Spine Surgery and Related Research ( 一般社団法人 日本脊椎脊髄病学会 ) 2020
Research paper (journal)
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The Differences in Imaging Findings Between Painless and Painful Osteoarthritis of the Hip
Kijima H.
Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders ( Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders ) 13 2020
Research paper (journal)
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Cohort Study of Rheumatoid Arthritis in Japan
Kashiwagura Takeshi, Aonuma Hiroshi, Kawano Tetsuya, Miyakoshi Naohisa, Shimada Yoichi
The Japanese Journal of Rehabilitation Medicine ( The Japanese Association of Rehabilitation Medicine ) 57 ( 11 ) 1054 - 1061 2020
Research paper (journal)
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Post-operative outcomes of distal radius fractures for the late-stage elderly patients
YUASA Yusuke, SENMA Seietsu, NARITA Yuichiro, ITO Hiroki, MIYAKOSHI Naohisa, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 32 ( 4 ) 570 - 573 2020
Research paper (journal)
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MIURA Takanori, EBINA Toshihito, TANI Takayuki, CHIDA Shuichi, MIYAKOSHI Naohisa, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 32 ( 1 ) 112 - 116 2020
Research paper (journal)
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The Role of Exercise and Sports Activity for Elderly Patients with Spinal Disorders
Hongo Michio, Miyakoshi Naohisa, Shimada Yoichi
Japanese Journal of Orthopaedic Sports Medicine ( Japanese Orthopaedic Socety for Sports Medicine ) 40 ( 2 ) 135 - 140 2020
Research paper (journal)
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Miyakoshi N.
World Neurosurgery ( World Neurosurgery ) 132 63 - 66 2019.12
Research paper (journal)
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Hagino H.
Journal of Bone and Mineral Metabolism ( Journal of Bone and Mineral Metabolism ) 37 ( 6 ) 1013 - 1023 2019.11
Research paper (journal)
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Miyakoshi N.
World Neurosurgery ( World Neurosurgery ) 131 38 - 42 2019.11
Research paper (journal)
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Kimura R.
Clinical Spine Surgery ( Clinical Spine Surgery ) 32 ( 8 ) E380 - E385 2019.10
Research paper (journal)
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Kaito T.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 24 ( 5 ) 805 - 811 2019.09
Research paper (journal)
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Tsuchie H.
Medical Principles and Practice ( Medical Principles and Practice ) 28 ( 5 ) 425 - 431 2019.09
Research paper (journal)
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Unoki E.
Spine ( Spine ) 44 ( 17 ) E1024 - E1030 2019.09
Research paper (journal)
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Kobayashi T.
Journal of Medical Case Reports ( Journal of Medical Case Reports ) 13 ( 1 ) 2019.08
Research paper (journal)
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Ishikawa Y.
European Spine Journal ( European Spine Journal ) 28 ( 7 ) 1670 - 1677 2019.07
Research paper (journal)
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An epidemiological study of traumatic spinal cord injuries in the fastest aging area in Japan
Kudo D.
Spinal Cord ( Spinal Cord ) 57 ( 6 ) 509 - 515 2019.06
Research paper (journal)
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Miyakoshi N.
Journal of Bone and Mineral Metabolism ( Journal of Bone and Mineral Metabolism ) 37 ( 3 ) 411 - 418 2019.05
Research paper (journal)
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Quantitative measurements of hip abduction strength in lumbar surgery patients
Hatakeyama Y.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 24 ( 3 ) 400 - 403 2019.05
Research paper (journal)
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Kinoshita H.
BMC Surgery ( BMC Surgery ) 19 ( 1 ) 2019.04
Research paper (journal)
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Horikawa A.
Medicine (United States) ( Medicine (United States) ) 98 ( 6 ) 2019.02
Research paper (journal)
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Hirota R.
Spine ( Spine ) 44 ( 4 ) E211 - E218 2019.02
Research paper (journal)
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Tomite T.
Journal of Orthopaedics ( Journal of Orthopaedics ) 16 ( 1 ) 25 - 30 2019.01
Research paper (journal)
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Urayama Masakazu, Iwamoto Yosuke, Abe Hidekazu, Suzuki Norio, Kamo Keiji, Sugimura Yusuke, Kawano Tetuya, Miyakoshi Naohisa, Shimada Yoichi, AORA(Akita Orthopedic group on Rheumatoid Arthritis), Aonuma Hiroshi, Kashiwagura Takeshi, Konishi Natuo, Ito Hiroki, Kobayashi Moto, Sakuraba Tsutomu, Tani Takayuki, Aizawa Toshiaki
Clinical Rheumatology and Related Research ( The Japanese Society for Clinical Rheumatology and Related Research ) 31 ( 3 ) 217 - 223 2019
Research paper (journal)
<p>[Purpose] We investigated the efficacy and safety of tocilizumab(TCZ)therapy in patients older than 65 years of age with rheumatoid arthritis(RA).</p><p>[Methods] We investigated the clinical backgrounds, drug retention rates, disease activity score(DAS)with 28-ESR, and EULAR responses of 47 RA patients aged ≥65 years(elderly group)and 102 patients aged <65 years(young group)who were listed in the Akita Orthopedic Group on RA registry.</p><p>[Results] In the elderly vs. young groups, the drug retention rate was 91% vs. 93% at 1 year, and 82% vs. 80% at 3 years(p≥0.05), respectively, whereas the mean DAS28-ESR score decreased at 24 weeks from 4.55 to 2.53 vs. 4.73 to 2.49(p<0.01), respectively. At 52 weeks 74% vs. 72% of the patients achieved low disease activity criteria(p≥0.05), as assessed by DAS28-ESR. Notably, 87% of the patients in both groups achieved a good or moderate response at 52 weeks. By study completion in 2017, 8 vs. 24 patients had dropped out because of adverse events or loss of efficacy(p≥0.05).</p><p>[Conclusion] Based on the efficacy and safety, TCZ therapy was compatible for RA patients aged ≥ 65 and < 65 years. Thus, TCZ therapy was useful in elderly RA patients.</p>
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Current status of treatment for glucocorticoid-induced osteoporosis in AORA registry 2017
KAWANO Tetsuya, KASHIWAGURA Takeshi, AIZAWA Toshiaki, MIYAKOSHI Naohisa, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 31 ( 2 ) 171 - 176 2019
Research paper (journal)
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Costal osteomyelitis as a side reaction of Bacillus Calmette-Guérin vaccination: A case report
WAKABAYASHI Rena, MIYAKOSHI Naohisa, TSUCHIE Hiroyuki, NAGASAWA Hiroyuki, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 31 ( 4 ) 483 - 486 2019
Research paper (journal)
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Early Lymph Node Metastasis May Predict Poor Prognosis in Soft Tissue Sarcoma
Emori M.
International Journal of Surgical Oncology ( International Journal of Surgical Oncology ) 2019 2019
Research paper (journal)
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Impact of acridine orange in patients with soft tissue sarcoma treated with marginal resection
Tsuchie H.
Anticancer Research ( Anticancer Research ) 39 ( 11 ) 6365 - 6372 2019
Research paper (journal)
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Impact of spinal kyphosis on gastric myoelectrical activity in elderly patients with osteoporosis
Tsuchie H.
Biomedical Research (Japan) ( Biomedical Research (Japan) ) 40 ( 6 ) 215 - 223 2019
Research paper (journal)
<p>An association between spinal kyphosis and gastroesophageal reflux disease (GERD) was reported in recent years. However, it remains unclear whether spinal kyphosis affects gastric motility. We evaluated the changes in myoelectrical activity measured by electrogastrography (EGG) in elderly osteoporosis patients. A total of 18 patients scheduled for the treatment of osteoporosis were included in this study. They were analyzed by recording EGG to assess myoelectrical activity and heart rate variability (HRV) to evaluate the autonomic nervous system function before and after meals. Dominant power (DP) representing the strength of gastric electrical activity and dominant frequency (DF) representing its frequency were analyzed in blocks with a 5-minute duration. We divided the patients into 2 groups, thoracolumbar kyphosis (TLK) and non-TLK groups, and compared them. There were no significant differences between the 2 groups in background data. In the non-TLK group, DPs post 0–5 min were significantly higher than those during pre 5–0 min in channels 1 and 3 (<i>P</i> < 0.05 and <i>P</i> < 0.01). DF deviation in the TLK group was significantly higher than that in the non-TLK group at 10 to 15 postprandial minutes (<i>P</i> < 0.05). Low frequency/high frequency activity measured by HRV, reflecting the activity of the sympathetic nervous system, in the TLK group was significantly lower than that in the non-TLK group while eating (<i>P</i> < 0.01). The EGG of patients with spinal kyphotic deformity showed a similar change to that of patients with GERD; the spinal kyphotic deformity itself may affect gastric electrical activity.</p>
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Tani T.
Advances in Orthopedics ( Advances in Orthopedics ) 2019 2019
Research paper (journal)
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Kasukawa Y.
Clinical Interventions in Aging ( Clinical Interventions in Aging ) 14 1399 - 1405 2019
Research paper (journal)
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Ono Y.
Biomedical Research (Japan) ( Biomedical Research (Japan) ) 40 ( 5 ) 197 - 205 2019
Research paper (journal)
<p>We investigated the effects of ibandronate, a bisphosphonate; eldecalcitol, an active vitamin D3 analogue; and combination treatment with both agents on secondary osteoporosis and arthritis using rats with adjuvant-induced arthritis. Arthritis was induced in 8-week-old male Lewis rats. Rats were randomized into four treatment groups and an untreated normal control group: ibandronate, eldecalcitol, ibandronate + eldecalcitol, vehicle, and control. Paw thickness was measured to evaluate arthritis. Joint destruction was evaluated histomorphometrically by the ankle joint stained with Fast Green and safranin O. The femur and lumbar spine were scanned using dual-energy X-ray absorptiometry, and the distal femur was scanned using micro-computed tomography for bone mineral density (BMD) and trabecular microstructural evaluations. Ibandronate and/or eldecalcitol increased BMD in both the lumbar vertebrae and femur and improved several microstructural parameters (bone volume/total volume, structure model index, trabecular number, and trabecular separation of the distal femur). In addition, there was an additive effect of combination treatment compared with single treatments for most trabecular parameters, including BMD and bone volume. However, ibandronate and/or eldecalcitol did not inhibit arthritis and joint destruction. Combination treatment with ibandronate and eldecalcitol may be effective for secondary osteoporosis associated with arthritis.</p>
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Prognostic impact of CD44 expression in patients with myxofibrosarcoma
Tsuchie H.
In Vivo ( In Vivo ) 33 ( 6 ) 2095 - 2102 2019
Research paper (journal)
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Kasukawa Y.
Asian Spine Journal ( Asian Spine Journal ) 13 ( 5 ) 832 - 841 2019
Research paper (journal)
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Kamo K.
Advances in Orthopedics ( Advances in Orthopedics ) 2019 2019
Research paper (journal)
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Matsunaga Toshiki, Miyakoshi Naohisa, Kudo Daisuke, Saito Kimio, Kimura Ryota, Inoue Junichi, Chida Satoaki, Hatakeyama Kazutoshi, Shimada Yoichi
The Japanese Journal of Rehabilitation Medicine ( The Japanese Association of Rehabilitation Medicine ) 56 ( 7 ) 555 - 559 2019
Research paper (journal)
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A case of lymphangiomatosis causing cervical vertebral fracture
MITA Motoki, MIYAKOSHI Naohisa, TSUCHIE Hiroyuki, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 31 ( 4 ) 468 - 472 2019
Research paper (journal)
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Osteoporosis and Therapeutic Exercise
Miyakoshi Naohisa
The Japanese Journal of Rehabilitation Medicine ( The Japanese Association of Rehabilitation Medicine ) 56 ( 5 ) 367 - 370 2019
Research paper (journal)
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MIURA Takanori, TANI Takayuki, KIJIMA Hiroaki, EBINA Toshihito, MIYAKOSHI Naohisa, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 31 ( 1 ) 66 - 69 2019
Research paper (journal)
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Posterior spinal fusion using a unilateral C1 posterior arch screw and a C2 laminar screw for atlantoaxial fracture dislocation.
Yuichi Ono, Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Yoshinori Ishikawa, Daisuke Kudo, Ryota Kimura, Jumpei Iida, Yoichi Shimada
SAGE open medical case reports 7 2050313X19849276 2019
Research paper (journal)
INTRODUCTION: C1 lateral mass screws and C2 pedicle screws are usually chosen to fix atlantoaxial (C1-C2) instability. However, there are a few situations in which these screws are difficult to use, such as in a case with a fracture line at the screw insertion point and bleeding from the fracture site. A new technique using a unilateral C1 posterior arch screw and a C2 laminar screw combined with a contralateral C1 lateral mass screws-C2 pedicle screws procedure for upper cervical fixation is reported. CASE REPORT: A 24-year-old woman had an irreducible C1-C2 anterior dislocation with a type III odontoid fracture on the right side due to a traffic accident. The patient underwent open reduction and posterior C1-C2 fixation. On the left side, a C1 lateral mass screws and a C2 pedicle screws were placed. Because there was bleeding from the fracture site and a high-riding vertebral artery was seen on the right side, a C1 posterior arch screw and a C2 laminar screw were chosen. Eight months after the surgery, computed tomography scans showed healing of the odontoid fracture with anatomically correct alignment. CONCLUSIONS: Although there have been few comparable studies, fixation with unilateral C1 posterior arch screw-C2 laminar screw could be a beneficial choice for surgeries involving the upper cervical region in patients with fracture dislocation or arterial abnormalities.
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Age-related prevalence of periodontoid calcification and its associations with acute cervical pain
Kobayashi T.
Asian Spine Journal ( Asian Spine Journal ) 12 ( 6 ) 1117 - 1122 2018.12
Research paper (journal)
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Tsuchie H.
Osteoporosis International ( Osteoporosis International ) 29 ( 12 ) 2659 - 2665 2018.12
Research paper (journal)
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Saito H.
Knee Surgery and Related Research ( Knee Surgery and Related Research ) 30 ( 4 ) 293 - 302 2018.12
Research paper (journal)
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Traumatic intratumoral hemorrhage of schwannoma of the cauda equina: A report of two cases
Kimura R.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 23 ( 6 ) 1105 - 1109 2018.11
Research paper (journal)
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Akagawa M.
PLoS ONE ( PLoS ONE ) 13 ( 10 ) e0204857 2018.10
Research paper (journal)
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Suzuki N.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 23 ( 5 ) 849 - 852 2018.09
Research paper (journal)
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Tsuchie H.
International Journal of Clinical Oncology ( International Journal of Clinical Oncology ) 23 ( 4 ) 775 - 782 2018.08
Research paper (journal)
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Miyakoshi N.
BMC Surgery ( BMC Surgery ) 18 ( 1 ) 38 2018.06
Research paper (journal)
Background: Safe excision of spinal cord tumors depends on sufficient visualization of the tumor and surrounding structures. In patients with spinal cord tumor adjacent to a stenotic spinal canal, extensive bony decompression proximal and distal to the tumor should be considered for safer excision of the tumor. Extensive wide laminectomy is one choice for such cases, but postoperative problems such as kyphotic deformity remain a concern. Case presentation: A 76-year-old man and a 60-year-old woman presented with symptomatic intradural extramedullary spinal cord tumors in the cervical spine. Both patients showed a combination of spondylotic changes in the cervical spine and stenotic condition at the level of the tumor. Both tumors were successfully resected through open-door laminoplasty with hydroxyapatite (HA) spacers, with the tumor located on the side of the laminoplasty. Histological diagnosis was schwannoma for both tumors. HA spacers completely bonded to the host bone and did not interfere with postoperative magnetic resonance imaging (MRI) of the inside of the spinal canal. Cervical spine alignment was maintained at the final follow-up of 6 years in both cases. Conclusion: Laminoplasty with HA spacers enabled successful tumor extirpation, reliable MRI follow-up after surgery, and maintenance of normal cervical spine alignment. Laminoplasty with HA spacers represents a good option for the treatment of cervical spinal cord tumor in patients combined with spinal stenosis.
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Kasukawa Y.
Pain Practice ( Pain Practice ) 18 ( 5 ) 625 - 630 2018.06
Research paper (journal)
Purpose: We aimed to evaluate the incidence of (and risk factors for) postoperative pregabalin and/or limaprost to treat persistent numbness and/or pain of the lower extremities after lumbar spinal stenosis (LSS) surgery. Methods: Medical records of 329 patients (168 men, 161 women
average age 70 years) were retrospectively reviewed for data on the duration of LSS diagnosis
LSS disease
preoperative medication (limaprost, pregabalin, or combined limaprost/pregabalin
duration)
symptoms
preoperative/postoperative intermittent claudication (IC)
operation type
and postoperative medication and period. Results: Limaprost, pregabalin, and combined limaprost/pregabalin were prescribed preoperatively for 43%, 7%, and 5% of patients, respectively. At an average of 21 months postoperatively, limaprost, pregabalin, and combined therapy were prescribed in 11%, 8%, 4% of patients, respectively. Medication requirement was significantly lower postoperatively than preoperatively (P <
0.0001). Significant risk factors for required postoperative medication were required preoperative medication (odds ratio [OR] 3.088, 95% confidence interval [CI] 1.679 to 5.681]
postoperative period (OR 1.063, 95% CI 1.031 to 1.096)
and postoperative IC (OR 3.868, 95% CI 1.481 to 10.103). A negative impact from postoperative medication was seen in patients who had undergone decompression surgery (OR 0.589, 95% CI 0.377 to 0.918). Conclusions: Overall, 23% of LSS patients required medication for pain and/or numbness at 21 months postoperatively. Significant factors portending required postoperative medication were preoperative medication, longer postoperative period, and postoperative IC. A negative influence from postoperative medication was seen in patients who had undergone decompression surgery without fusion. -
Reconstruction of a chronically ruptured Achilles tendon using an internal brace: A case report
Chida S.
Journal of Medical Case Reports ( Journal of Medical Case Reports ) 12 ( 1 ) 54 2018.03
Research paper (journal)
Background: We reconstructed a chronically ruptured Achilles tendon and the associated scar tissue using braided polyblend polyethylene sutures (FiberWire
Arthrex Inc.
Naples, FL, USA) and anchors. Case presentation: A 68-year-old Japanese man, who was being treated for right Achilles tendinosis, felt pain in his Achilles tendon when walking and started to find plantar flexion of his ankle joint difficult. As his symptoms persisted, he visited us after 4 weeks. Surgery and orthotic therapy were recommended, but he did not want to undergo these treatments. However, he began to find walking difficult and so underwent surgery 6 months after suffering the injury. The interior of the tendon was curetted, and the ruptured region was subjected to plication using the surrounding scar tissue. Using the percutaneous Achilles repair system (Arthrex Inc.), FiberWire sutures were inserted, and two skin incisions were made on the medial and lateral sides of his calcaneus in the region surrounding the Achilles tendon attachment. SutureLasso (Arthrex Inc.) was passed through, and the proximal FiberWire suture was relayed and fixed with 4.75-mm SwiveLock (Arthrex Inc.). After surgery, his foot was fixed in plaster at 20° plantar flexion of his ankle joint. The plaster was removed 1 week after surgery, and after-treatment was initiated with active dorsiflexion training. No orthosis was used after surgery. As of 16 postoperative months, no re-rupture had occurred. Conclusions: This method might allow post-treatment rehabilitation, and so on, to occur earlier, and, hence, could become an option for the reconstruction of chronically ruptured Achilles tendons. -
Kijima H.
HIP International ( HIP International ) 28 ( 2 ) 145 - 147 2018.03
Research paper (journal)
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SAITO Hidetomo, SAITO Kimio, SHIMADA Yoichi, AKAGAWA Manabu, TSUKAMOTO Hiroaki, MIYAKOSHI Naohisa
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 30 ( 2 ) 155 - 163 2018
Research paper (journal)
<p>Around knee osteotomy (AKO), Uni-compartmental Knee Arthroplasty (UKA) and Total Knee Arthroplasty (TKA) were well-established procedure to treat medial osteoarthritis. Physiological joint orientation was re-acquired by Double Level Osteotomy. Depressed medial tibial plateau could be reduced by Tibial Condylar Valgus Osteotomy. Thus, deformity created by medial knee osteoarthritis (OA) could be reduced if use of these procedures even if severely advanced knee OA. We compared the clinical results between TKA and AKO. The subjects were surveyed clinical scores (New KSS, KOOS, Oxford knee score, JOA score) at 36 knees (average age: 71.9 years, follow-up period: 22.4 months) and compared with AKO group (14 knees) and TKA (22 knees). In the New KSS, the AKO group was significantly higher in postoperative functional activity and advanced activity. The subscale pain of KOOS was significantly higher in the TKA group. AKO was supposed to be one of procedures to treat advanced knee OA.</p>
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Analgesic effects of minodronate in a rat chronic pain model
Kasukawa Y.
Biomedical Research (Japan) ( Biomedical Research (Japan) ) 39 ( 5 ) 261 - 268 2018
Research paper (journal)
<p>We evaluated the analgesic effects of minodronate, alendronate and pregabalin on mechanical and thermal allodynia, as well as changes in bone mineral density and skeletal muscle volume caused by chronic constriction injury (CCI) in an ovariectomized rat. Ovariectomy was performed on four-week-old female Wistar rats. Thereafter, at 8-weeks of age, the left sciatic nerve was ligated to create the chronic pain model (CCI limb), and sham surgery was performed on the right hindlimb. In all rats, either minodronate (0.15 mg/kg/week), alendronate (0.15 mg/kg/week), pregabalin (10 mg/kg/week), or their vehicle was administered for 2 weeks starting on the 0th day of CCI. Behavioral evaluations, with von Frey testing and the hot plate test, were performed on days 0, 7 and 14. After 2 weeks, bilateral femurs and tibialis anterior muscles were harvested for bone mineral density and cross sectional area measurements, respectively. Two weeks treatment with minodronate significantly improved mechanical and thermal allodynia evaluated by the von Frey and hot plate tests in the CCI limb (<i>P</i> < 0.05). Minodronate and alendronate treatment for 2 weeks significantly increased total femoral bone mineral density in the CCI limb compared with pregabalin or vehicle treatment (<i>P</i> < 0.01). Cross sectional area of the CCI limb in the minodronate group was significantly larger than that of the alendronate group (<i>P</i> < 0.05) and pregabalin group (<i>P</i> < 0.05). Two-week treatment with minodronate, but not alendronate or pregabalin, improved mechanical and thermal allodynia caused by CCI in ovariectomized rats.</p>
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Urayama Masakazu, Abe Hidekazu, Kamo Keiji, Sugimura Yusuke, Miyakoshi Naohisa, Shimada Yoichi, AORA (Akita Orthopedic group on Rheumatoid Arthritis), Aonuma Hiroshi, Kashiwagura Takeshi, Ito Hiroki, Kobayashi Moto, Sakuraba Tsutomu, Tani Takayuki, Aizawa Toshiaki, Kawano Tetuya
Clinical Rheumatology and Related Research ( The Japanese Society for Clinical Rheumatology and Related Research ) 30 ( 2 ) 114 - 119 2018
Research paper (journal)
<p>Objective: By assessing dropout of rheumatoid arthritis (RA) cases due to inadequate effect of Tocilizumab (TCZ) therapy in the Akita Orthopedic Group on Rheumatoid Arthritis registry, this study aimed to investigate more effective ways to use this drug.Subjects and methods: This study included 177 patients who were treated with TCZ, consisting of 95 treatment-naive patients (group N) and 82 patients switching to TCZ therapy (group S). We retrospectively collected data on patient characteristics, duration of treatment before discontinuation, treatment details after discontinuation, disease activity.Results: TCZ therapy was discontinued due to inadequate effect in 12 patients. Patient mean age was 58 years (range, 44-82 years). Mean disease duration was 120 months (range, 6-366 months). Group N included 4 patients, and group S included 8, all of whom switched from tumor necrosis factor (TNF) inhibitors. The mean duration of TCZ therapy before discontinuation was 30 months (range, 6-67 months). After discontinuation, TCZ was switched to other biopharmaceuticals in 10 patients, consisting of 2 patients who switched to TNF inhibitors and 8 who switched to abatacept (ABT). At the final evaluation, 3 patients switched to TNF inhibitors again. Clinical disease activity index (CDAI) was 20.3 ± 13.4 (mean ± standard deviation) at the start of therapy and 12.4 ± 8.1 at the time of discontinuation. Six patients achieved low disease activity (LDA). CDAI at the final evaluation was 9.5 ± 8.4. LDA was achieved in 8 patients.Conclusion: Dropout cases due to inadequate effect of TCZ for RA included many patients who switched from TNF inhibitors. TNF inhibitors and ABT can equally replace TCZ for dropout cases. TCZ can be more effectively and continuously used, based on comprehensive assessment of its effect.</p>
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Comparison of Atypical and Osteoporotic Femoral Shaft Fractures in the Elderly: A Multicenter Study
Miura T.
Advances in Orthopedics ( Advances in Orthopedics ) 2018 1068053 2018
Research paper (journal)
Background. In atypical femoral fractures, owing to the high rates of complications and delayed healing that accompany the plate fixation, the most favorable treatment is intramedullary nailing. Although there is insufficient evidence, plate fixation is chosen due to anterolateral bowing of the femur. This study compared the bone healing time and rates of complications in atypical femoral shaft fractures and osteoporotic femoral shaft fractures. Methods. We searched the medical records of 3 institutions in Japan for patients with femoral shaft fractures who visited between 1 January 2010 and 31 December 2015. We identified 65 patients and excluded 37 among these due to high-energy injuries or being younger than 65 years. Among the remaining patients, we identified 17 and 11 women with atypical (AFF group) and osteoporotic femoral shaft fractures (OP group), respectively. Results. In surgical method, there were differences in intramedullary nailing (94.1% versus 27.2%) (p <
0.01). The mean bone healing time was 11.1 months versus 6.7 months in 2 groups (p <
0.01). Iatrogenic femoral fractures during intramedullary nail insertion were observed in both groups, and reoperation was only seen in atypical femoral fractures treated with a plate fixation, but there was no difference in the rate of complications (23.5% versus 9.1%). Conclusions. In the atypical femoral fracture group, intramedullary nailing was more chosen, but the bone healing time was delayed and plate fixation cases needed reoperation. There was no significant difference in the rate of complications between the 2 groups. -
Kimura Ryota, Shimada Yoichi, Matsunaga Toshiki, Iwami Takehiro, Kudo Daisuke, Saitoh Kimio, Hatakeyama Kazutoshi, Watanabe Motoyuki, Takahashi Yusuke, Miyakoshi Naohisa
Progress in Rehabilitation Medicine ( 公益社団法人 日本リハビリテーション医学会 ) 3 ( 0 ) 2018
Research paper (journal)
<p><b>Objective:</b> We developed a rehabilitation robot to assist hemiplegics with gait exercises. The robot was combined with functional electrical stimulation (FES) of the affected side and was controlled by a real-time-feedback system that attempted to replicate the lower extremity movements of the non-affected limb on the affected side. We measured the reproducibility of the non-affected limb movements on the affected side using FES in non-disabled individuals and evaluated the smoothness of the resulting motion. <b>Method:</b> Ten healthy men participated in this study. The left side was defined as the non-affected side. The measured hip and knee joint angles of the non-affected side were reproduced on the pseudo-paralytic side using the robot's motors. The right quadriceps was stimulated with FES. Joint angles were measured with a motion capture system. We assessed the reproducibility of the amplitude from the maximum angle of flexion to extension during the walking cycle. The smoothness of the motion was evaluated using the angular jerk cost (AJC). <b>Results:</b> The amplitude reproduction (%) was 87.9 ± 6.2 (mean ± standard deviation) and 71.5 ± 10.7 for the hip and knee joints, respectively. The walking cycle reproduction rate was 99.9 ± 0.1 and 99.8 ± 0.2 for the hip and knee joints, respectively. There were no statistically significant differences between results with FES versus those without FES. The AJC of the robot side was significantly smaller than that of the non-affected side. <b>Conclusions:</b> A master–slave gait rehabilitation system has not previously been attempted in hemiplegic patients. Our rehabilitation robot showed high reproducibility of motion on the affected side.</p>
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AKAGAWA Manabu, SAITO Hidetomo, SAITO Kimio, SASAKI Kana, MIYAKOSHI Naohisa, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 30 ( 1 ) 86 - 88 2018
Research paper (journal)
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Kudo D.
Clinical Interventions in Aging ( Clinical Interventions in Aging ) 13 1633 - 1638 2018
Research paper (journal)
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Pyogenic Spondylitis Caused by Methicillin-Resistant <i>Staphylococcus aureus</i> Associated with Tracheostomy followed by Resection of Ossification of the Anterior Longitudinal Ligament.
Hongo M, Miyakoshi N, Fujii M, Kasukawa Y, Ishikawa Y, Kudo D, Shimada Y
Case reports in orthopedics 2018 9076509 2018
Research paper (journal)
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The relation between bone marrow lesions of knee osteoarthritis and bone strength parameters
FUJII Masashi, KIJIMA Hiroaki, SAITO Hidetomo, NOZAKA Koji, MIYAKOSHI Naohisa, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 30 ( 1 ) 52 - 56 2018
Research paper (journal)
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Cervical arachnoid cyst mimicking the cause of cervical radiculopathy: A case report
Kobayashi T.
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management ( Interdisciplinary Neurosurgery: Advanced Techniques and Case Management ) 10 37 - 39 2017.12
Research paper (journal)
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Kudo D.
European Spine Journal ( European Spine Journal ) 26 ( 12 ) 3156 - 3161 2017.12
Research paper (journal)
Malnutrition is one of the important risk factors for postoperative complications. Transferrin, prealbumin, and retinol-binding protein, so-called rapid turnover proteins (RTPs), may be the better indicators for early detection of nutritional deficits. However, few studies have described the impact of serum RTP levels on postoperative surgical site infection (SSI) in spine surgery. The purpose of this study was to investigate the relationship between preoperative serum RTPs and postoperative SSI.
The data of 105 patients (64 male, 41 female; average age 64.4 years; age range 20-88 years) who underwent spine surgery in a single institution between 2014 and 2015 were retrospectively analyzed. Preoperative total lymphocyte count, serum albumin, transferrin, prealbumin, retinol-binding protein, pre-and postopeartive C-reactive protein (CRP), white blood cell count (WBC), and total lymphocyte count were evaluated. Postoperative CRP, WBC, and total lymphocyte count were repeated two or three times/week until hospital discharge. A broad spectrum penicillin or second generation cephalosporin was administered as a prophylactic antibiotic to each patient. When repeated CRP elevation or lymphopenia (no more than 10% or 1000/mu L) after postoperative day 3 or 4 was observed, possible SSI was diagnosed. Variables between possible SSI group and non-SSI group were compared using Mann-Whitney U or Chi square test. All variables on univariate analysis were included in multiple logistic regression analysis to identify risk factors for possible postoperative SSI.
Thirty-five patients were diagnosed with possible SSI. The mean operative time of possible SSI group was significantly longer (p = 0.036), preoperative total lymphocyte count and serum prealbumin level of possible SSI group were significantly lower (p = 0.002, p = 0.048, respectively) than that of non-SSI group. On univariate analysis, operative time (p = 0.012), preoperative total lymphocyte count (p = 0.041), serum albumin level (p = 0.038), and serum prealbumin level (p = 0.044) were significant contributors to possible SSI, and multiple logistic regression analysis revealed that operative time was the significant contributor to possible SSI (odds ratio 1.008, 95% confidence interval (CI) 1.001-1.015, p = 0.024).
A low prealbumin level is a possible risk factor for early-stage SSI in spine surgery, though it was not statistically significant; operative time was the most important indicator of SSI on multivariate analysis. -
Miyakoshi N.
Asian Spine Journal ( Asian Spine Journal ) 11 ( 5 ) 756 - 762 2017.10
Research paper (journal)
Study Design: A retrospective comparative study. Purpose: To compare perioperative medical complications after posterior approach spinal instrumentation surgery for osteoporotic vertebral collapse (OVC) between patients with primary osteoporosis and those with secondary osteoporosis. Overview of Literature: With increased aging of society, the demand for instrumentation surgery for an osteoporotic spine has been increasing. However, no studies have compared the rates or severities of perioperative complications after spinal instrumentation surgery between patients with primary osteoporosis and those with secondary osteoporosis. Methods: Ninety-one patients with OVC aged =50 years (23 males and 68 females) who underwent posterior approach vertebral replacement with cages or posterior spinal fusion combined with vertebroplasty were divided into primary (n=56) and secondary (n=35) osteoporosis groups. Bone mineral density (BMD), osteoporosis treatment prior to OVC, operative invasiveness, and perioperative medical complications were compared. Results: Diabetes mellitus (51.4%) was the most common cause of secondary osteoporosis, followed by glucocorticoid use (22.9%). No significant differences were seen in terms of age, gender, BMD, osteoporosis treatment, or operative invasiveness, including the number of levels fused, estimated blood loss, and number of patients requiring transfusion. No significant difference in the incidence of perioperative complications were observed between the primary and secondary osteoporosis groups (16.1% vs. 22.9%). However, surgical site infection (SSI) was significantly more frequently seen in the secondary osteoporosis group (11.4%) than in the primary osteoporosis group (1.8%
p <
0.05). One patient in the secondary osteoporosis group developed methicillin-resistant Staphylococcus aureus infection that ultimately required instrument removal. Conclusions: The overall incidence of perioperative medical complications after posterior approach spinal instrumentation surgery for OVC was comparable between the primary and secondary osteoporosis groups under conditions of similar background characteristics and operative invasiveness. However, SSI (particularly more severe cases) occurred more frequently in patients with secondary osteoporosis. -
Sasaki K.
Asian Spine Journal ( Asian Spine Journal ) 11 ( 4 ) 562 - 569 2017.08
Research paper (journal)
Study Design: In vivo biomechanical study using a three-dimensional (3D) musculoskeletal model for elderly individuals with or without pelvic retroversion. Purpose: To evaluate the effect of pelvic retroversion on the sagittal alignment of the spine, pelvis, and lower limb in elderly females while standing and walking. Overview of Literature: Patients with hip-spine syndrome have concurrent hip-joint and spine diseases. However, the dynamic sagittal alignment between the hip joint and spine has rarely been investigated. We used a 3D musculoskeletal model to evaluate global spinopelvic parameters, including spinal inclination and pelvic tilt (PT). Methods: A total of 32 ambulant females (mean age=78 years) without assistance were enrolled in the study. On the basis of the radiographic measurement for PT, participants were divided into the pelvic retroversion group (R-group
PT=20°) and the normal group (N-group
PT <
20°). A 3D musculoskeletal motion analysis system was used to analyze the calculated value for the alignment of spine, pelvis, and lower limb, including calculated (C)-PT, sagittal vertical axis (C-SVA), pelvic incidence, lumbar lordosis, T1 pelvic angle (CTPA), as well as knee and hip flexion angles while standing and walking. Results: While standing, C-PT and C-TPA in the R-group were significantly larger than those in the N-group. Hip angle was significantly smaller in the R-group than in the N-group, unlike knee angle, which did not show difference. While walking, C-SVA and C-TPA were significantly increased, whereas C-PT decreased compared with those while standing. The maximum hip-flexion angle was significantly smaller in the R-group than in the N-group. There was a significant correlation between the radiographic and calculated parameters. Conclusions: The 3D musculoskeletal model was useful in evaluating the sagittal alignment of the spine, pelvis, and leg. Spinopelvic sagittal alignment showed deterioration while walking. C-PT was significantly decreased while walking in the R-group, indicating possible compensatory mechanisms attempting to increase coverage of the femoral head. The reduction in the hip flexion angle in the R-group was also considered as a compensatory mechanism. -
Kinoshita H.
Modern Rheumatology ( Modern Rheumatology ) 27 ( 4 ) 582 - 586 2017.07
Research paper (journal)
Objectives: This study aimed to investigate the efficacy of denosumab (compared with that of bisphosphonates) for preventing secondary osteoporosis and inflammation caused by excessive bone resorption in Japanese rheumatoid arthritis (RA) patients never previously treated for osteoporosis.
Methods: Ninety-eight patients with coexisting RA and osteoporosis were enrolled. The patients were subdivided by whether they were treated with denosumab (n=49) or traditional bisphosphonates (n=49). RA disease activity, bone turnover markers, and bone mineral density (BMD) were compared between the two groups before treatment, and after 6 and 12 months of treatment.
Results: There was no significant difference between the groups in any of the disease activity indices and BMD at any of the measured time points. With regard to bone metabolism, denosumab significantly reduced bone-specific alkaline phosphatase at 6 and 12 months compared with pretreatment, but had no effect on tartrate-resistant acid phosphatase 5b levels, suggesting an effect on the bone formation rate, but not on the bone resorption rate.
Conclusions: Neither denosumab nor bisphosphonates could suppress inflammation or RA disease activity, but denosumab significantly suppressed a marker of bone metabolism in Japanese RA patients never previously treated for osteoporosis. -
Distant metastasis in patients with myxofibrosarcoma
Tsuchie H.
Upsala Journal of Medical Sciences ( Upsala Journal of Medical Sciences ) 122 ( 3 ) 190 - 193 2017.07
Research paper (journal)
Purpose: A clinical feature of myxofibrosarcoma is local recurrence, but knowledge about distant metastasis is sparse. We evaluated the tendency of clinical and histological features of metastasis in myxofibrosarcoma patients.
Methods: Fifty-eight patients with myxofibrosarcoma were treated in our hospitals, and a total of 16 consecutive patients with distant metastases were included in this retrospective study (9 males and 7 females, with a mean age of 77 years). Because there was no patient complicated by both lung and lymph node metastases, we compared the age, sex, tumor size and location, French Federation of Cancer Centers Sarcoma Group (FNCLCC) grade, American Joint Committee on Cancer (AJCC) stage, and times of the first metastasis from the initial examination between the lung and lymph node groups. In addition, we examined factors affecting the prognosis.
Results: The median follow-up period was 42.9 months (range 8-142). Eleven of 16 patients developed pulmonary metastases. The sites of extra pulmonary metastases were the lymph nodes in 5 patients, bone in 1, subcutaneous in 1, intramuscular in 1, and peritoneum in 1. The median time for patients to develop distant metastases was 17.4 months (range 0-59). The time until the onset of the first metastasis in the lung metastasis group was significantly shorter than in the lymph node group (p < 0.05). Also, the survival rate in the lymph node metastasis group was better than in the lung metastasis group (p < 0.05).
Conclusions: Not only lung metastasis but also lymph node metastasis occurs frequently in myxofibrosarcoma patients. Myxofibrosarcoma with lung metastasis is more aggressive than the type with lymph node metastasis. -
Enhanced bone healing and decreased pain in sacral insufficiency fractures after teriparatide treatment: retrospective clinical-based observational study.
Kasukawa Y, Miyakoshi N, Ebina T, Hongo M, Ishikawa Y, Kudo D, Nozaka K, Shimada Y
Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 14 ( 2 ) 140 - 145 2017.05
Research paper (journal)
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Back Strengthening Exercise for Elderly Patients with Spinal Deformity
30 ( 4 ) 339 - 344 2017.04
Research paper (journal)
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Ishikawa Y.
Gait and Posture ( Gait and Posture ) 53 98 - 103 2017.03
Research paper (journal)
Spinal deformities can affect quality of life (QOL) and risk of falling, but no studies have explored the relationships of spinal mobility and sagittal alignment of spine and the lower extremities simultaneously. Purpose of this study is to clarify the relationship of those postural parameters to QOL and risk of falling. The study evaluated 110 subjects (41 men, 69 women; mean age, 73 years). Upright and flexion and extension angles for thoracic kyphosis, lumbar lordosis, and spinal inclination were evaluated with SpinalMouse. Total-body inclination and hip and knee flexion angles in upright position were measured from lateral photographs. Subjects were divided into Fallers (n= 23, 21%) and Non-fallers (n= 87, 79%) based on past history of falls. QOL was assessed using the Short Form 36 Health Survey (SF-36). Age, total-body inclination, spinal inclination upright and in extension, thoracic kyphosis in flexion, lumbar lordosis upright and in extension, and knee flexion correlated significantly with the SF-36. Multiple regression analysis revealed total-body inclination and knee flexion to have the most significant relationships with the SF-36. SF-36, total-body inclination, spinal inclination in extension, thoracic kyphosis in flexion, lumbar lordosis upright and in extension, and hip and knee flexion angles differed significantly between Fallers and Non-fallers (P<0.05 for all). Multivariate logistic regression analyses revealed lumbar lordosis in extension to be a significant predictor of falling (P= 0.038). Forward-stooped posture and knee-flexion deformity could be important indicator of lower QOL. Moreover, limited extension in the lumbar spine could be a useful screening examination for fall prevention in the elderly. (C) 2017 Elsevier B.V. All rights reserved.
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Age-related changes in muscle strength and spinal kyphosis angles in an elderly Japanese population
Kasukawa Y.
Clinical Interventions in Aging ( Clinical Interventions in Aging ) 12 413 - 420 2017.02
Research paper (journal)
Lumbar kyphosis and the decreased mobility of the lumbar spine increase the risk of falls and impair both the quality of life and the ability to perform activities of daily living. However, in the elderly Japanese population, little is known about the age-related changes and sex-related differences in muscle strength, including of the upper and lower extremities and back extensors. An adequate kyphotic or lordotic angle has also not been determined. In this study, we evaluated the age-related changes in muscle strength and spinal kyphosis in 252 males and 320 females $50 years of age. Grip, back extensor, hip flexor, and knee extensor strength
thoracic and lumbar kyphosis
and spinal inclination in the neutral standing position were assessed, together with the range of motion of the thoracic and lumbar spine and spinal inclination. Grip strength, back extensor strength, and the strength of the hip flexors and knee extensors decreased significantly with aging, both in males (P,0.0001) and in females (P=0.0015 to P,0.0001). The lumbar but not the thoracic kyphosis angle decreased significantly with aging, only in females (P,0.0001). Spinal inclination increased significantly with aging in both males (P=0.002) and females (P,0.0001). Back extensor strength and the thoracic kyphosis angle were significant variables influencing the lumbar kyphosis angle in both sexes. Spinal inclination correlated significantly with both the lumbar kyphosis angle and hip flexor strength in males, as well as with the lumbar kyphosis angle in females. -
Imajo Y.
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 22 ( 1 ) 10 - 15 2017.01
Research paper (journal)
Background: The Japanese Society for Spine Surgery and Related Research USSR) performed a third study on complications in spinal surgery in 2011. The purpose was to present information about surgery and complications in a large amount of elderly patients aged 65 years with lumbar spinal stenosis (LSS) without coexisting spondylolisthesis, spondylolysis, or scoliosis, and to compare patients aged >= 80 years to those aged 65-79 years.
Methods: A recordable optical disc for data storage was sent by JSSR in January 2012 to 1105 surgeons certified by the JSSR in order to collect surgical data. Data were returned by the end of May 2012.
Results: Data were accumulated for 8033 patients aged 65 years. The incidence of surgical complications was 10.8%, and did not differ significantly between age groups. The incidence of general complications was 2.7%, and differed significantly between age groups (p < 0.005). The highest incidence of surgical complications was for dural tear (DT) (3.6%), followed by deep wound infection (DWI) (1.4%), neurological complications (1.3%), and epidural hematoma (1.3%). Spinal instrumentation was applied in 30.3%. Incidences of surgical complications in instrumented and noninstrumented surgery were 17.3% and 8.8%. In instrumented surgery, incidences of surgical and general complications were higher in the >= 80 year age group than in the 65-79 year age group. Logistic regression analyses showed patients with microendoscopic surgery at increased risk of DT. Patients with diabetes mellitus and instrumented surgery showed increased risks of DWI.
Conclusions: Incidences of surgical complications did not differ significantly between age groups. Attention should be paid to both surgical and general complications, particularly for postoperative mental disease in instrumented surgery for patients >= 80 years old. (C) 2016 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved. -
Effects of exercise and sports on bone health in pre- and postmenopausal women
Miyakoshi N.
Clinical calcium ( Clinical calcium ) 27 ( 1 ) 107 - 115 2017.01
Research paper (journal)
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Kobayashi T.
Journal of Medical Case Reports ( Journal of Medical Case Reports ) 11 ( 1 ) 1 - 7 2017.01
Research paper (journal)
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[Aging and homeostasis. Prevention and treatment of locomotive syndrome.]
Miyakoshi N
Clinical calcium 27 ( 7 ) 1013 - 1020 2017
Research paper (journal)
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[Effects of exercise and sports on bone health in pre- and postmenopausal women.]
Miyakoshi N
Clinical calcium 27 ( 1 ) 107 - 115 2017
Research paper (journal)
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A Case of Fracture-Redislocation of the Hip Caused by a Depressed Fracture of the Femoral Head Similar to a Hill-Sachs Lesion.
Okudera Y, Kijima H, Yamada S, Konishi N, Kubota H, Tazawa H, Tani T, Suzuki N, Kamo K, Sasaki K, Kawano T, Iwamoto Y, Miyakoshi N, Shimada Y
Case reports in orthopedics 2017 7409153 2017
Research paper (journal)
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Okuyama K.
Spine Surgery and Related Research ( Spine Surgery and Related Research ) 1 ( 3 ) 129 - 134 2017
Research paper (journal)
<p>Study Design: A prospective cohort study was conducted on patients with anterior cervical decompression and fusion (ACDF) with a polyetheretherketone cage (PEEKc).</p><p>Background: Advantages of a PEEKc have been proposed in the study. However, benefits of using a PEEKc in ACDF are still controversial.</p><p>Objective: To investigate the advantages of a PEEKc in ACDF.</p><p>Materials and Methods: A total of 27 patients was enrolled in the study. The mean age of patients was 55±10 years (mean±standard deviation). The mean duration of symptoms was 17±21 months. Surgery was conducted at C3/4 in 1, C4/5 in 3, C5/6 in 11, C6/7 in 9, C7/T1 in 2, and C5/6/7 in 1 patient. The mean follow-up period was 2.1±1.3 years. Clinical outcomes were analyzed by the Japanese Orthopedic Association Scores (JOA scores) and its recovery rate. Perioperative complications were also investigated. Radiologically, studies were conducted on interbody lordotic angle (IBLA), interbody height (IBH), and bone fusion rates.</p><p>Results: The JOA score was 14.7±1.4 preoperatively and 16.3±1.3 at the final follow-up. A significant improvement was observed (p<0.05). The mean recovery rate of JOA scores was 74.0±25.0%. The preoperative IBLA was 0.5±6.1°. The mean IBLA at the final follow-up was 1.9±5.6°. The preoperative IBH was 34.2±3.5 mm. The mean IBH at the final follow-up was 34.3±3.5 mm. No significant improvement in IBLA and IBH was observed. A complete union rate at 1 year and 2.3 years (range, 2.0-6.0) after surgery was 29% (8/28 segments) and 61% (11/18 segments). No major complications were observed.</p><p>Conclusions: Despite an unsatisfactory bone union rate and no significant improvement in IBLA and IBH at the final follow-up, ACDF with a PEEKc clinically provided a stable outcome with less surgical invasion and minor donor-site morbidity.</p>
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Cut-off value of medial meniscal extrusion for knee pain
Kijima H.
Advances in Orthopedics ( Advances in Orthopedics ) 2017 6793026 2017
Research paper (journal)
Purpose. Medial meniscal extrusion (MME) has attracted attention as an index of knee pain in conjunction with clinical symptoms that could be more useful than the diagnosis of knee osteoarthritis on X-ray. However, the size of MME that would cause knee pain has not been clarified. The aim of the present study was to investigate the cut-off value of MME for knee pain. Methods. A total of 318 knees were evaluated. The presence of current or past knee pain was confirmed by interview. Next, MME was measured using vertical sonographic images of the medial joint spaces during weightbearing. Results. Overall, 71 knees were painful (P-group), and 247 knees were not (N-group). MME was 5.9 ± 1.8 mm in the P-group and 2.9 ± 1.5 mm in the N-group (P<
0.0001). Analysis of the receiver operating characteristic curve showed that the cut-off value of MME for knee pain was 4.3 mm, with sensitivity of 0.8451 and specificity of 0.8502. In addition, 64% of knees without pain cases at the time of examination whose MME exceeded this cut-off value had past knee pain. Conclusions. The sensitivity and specificity of MME for knee pain were very high with a cut-off value of 4.3 mm. -
Unoki E.
Spine Surgery and Related Research ( Spine Surgery and Related Research ) 1 ( 2 ) 90 - 95 2017
Research paper (journal)
<p>Introduction: Sacroiliac joint pain (SIJP) after lumbar fusion surgery has recently gained attention as a source of low back pain after lumbar fusion. There are two risk factors for postoperative SIJP, i.e., fusion involving the sacrum and multiple-segment fusion. In this study, we examined whether SIJP could occur more frequently in patients with two risk factors (multiple-segment fusion to sacrum). Further, we examined SIJP after multiple-segment (≥3) lumbar fusion, focusing on the difference between floating fusion (non-fused sacrum) and fixed fusion (fused sacrum).</p><p>Methods: Ninety-one patients who underwent multiple-segment lumbar fusion were included. Patients without preoperative clinical SIJP were considered. Of these, 17 developed new-onset SIJP. We investigated postoperative SIJP development, duration from surgery to SIJP onset, and postoperative treatment outcomes of SIJP patients using Japanese Orthopaedic Association (JOA) scores. We compared the findings between floating fusion group and fixed fusion group.</p><p>Results: The incidence of SIJP was significantly higher with fixed fusion (32.1%) than with floating fusion (12.7%). The mean time of onset of sacroiliac joint pain was at 8.63 (2-13) months after surgery in the floating fusion group and 3.78 (1-10) months after surgery in the fixed fusion group, indicating that incidence occurred significantly earlier in the fixed fusion group. Our treatment outcome indicated that the mean JOA score significantly improved in the floating fusion group from 5.13 at the time of onset to 9.50 at the time of final follow-up; however, in the fixed fusion group, it improved from 5.78 at the time of onset to 7.33 at the time of final follow-up, indicating no significant improvement.</p><p>Conclusions: In multiple-segment lumbar fusion, fixed fusion (fused sacrum) has a very high risk of SIJP. In addition, the onset of SIJP in such cases may occur earlier. This aspect deserves consideration, given the difficulty of pain treatment.</p>
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Imajo Y.
Spine Surgery and Related Research ( Spine Surgery and Related Research ) 1 ( 1 ) 7 - 13 2017
Research paper (journal)
<p>Introduction: Details of surgical and general complications for patients with cervical spondylotic myelopathy (CSM) are still uncertain. The purpose of this study was to describe surgeries and their complications among Japanese patients with CSM. Methods: The Japanese Society for Spine Surgery and Related Research performed a nationwide survey on spine surgery and complications in 2011. Data of patients with 2,961 CSM >40 years old were included. The clinicopathological variables were basic demographic and clinical information, surgical information, and surgical and general complications. To examine the influence of age, variables were compared among three age groups: patients 40-64 (n=1,123), 65-74 (n=966), and ≥75 (n=872) years of age. Results: The study included 1,970 males and 991 females and the mean age was 64.3 years old. There were 168 anterior (5.7%) and 2,770 posterior (94.2%) approach surgeries. The vast majority of patients with CSM were treated using the posterior approach, 89.4% of whom had decompression surgery only. Anterior surgeries were more common in the younger age group, but posterior surgeries were equally distributed. The incidence of total complications including surgical/general complications was similar for the anterior (16/168; 9.5%) and posterior (295/2,770; 10.6%) approaches. No patient died on the operating table, but four patients (0.1%) died within one month after surgery. No association was detected between complications and age, comorbidity, and other surgical factors. The incidence of complications was similar for the different age groups. However general complications were predominantly observed in the older group and those who had instrumented surgery. Conclusions: The results indicate that the indication and surgical performance for patients with CSM is favorable in Japan, despite the super-aging population. Few serious complications were reported in this study. However, more detailed informed consent about surgical and, in particular, general complications is necessary for the older patients with CSM.</p>
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Evaluation of Trunk Stability in the Sitting Position Using a New Device
Saito Kimio, Takahashi Yasuhiro, Chida Satoaki, Hatakeyama Kazutoshi, Watanabe Motoyuki, Ishikawa Junki, Takahashi Yusuke, Suzuki Masamichi, Murata Shu, Shimada Yoichi, Miyakoshi Naohisa, Matsunaga Toshiki, Iwami Takehiro, Hongo Michio, Kasukawa Yuji, Saito Hidetomo, Masutani Norimitsu
The Japanese Journal of Rehabilitation Medicine ( The Japanese Association of Rehabilitation Medicine ) 54 ( 1 ) 31 - 35 2017
Research paper (journal)
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Systemic administration of insulin-like growth factor(IGF)-binding protein-4(IGFBP-4)increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism.
Miyakoshi N, et al.
Endocrinology 142 ( 6 ) 2641 - 2648 2001.01 [Refereed]
Research paper (journal)
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Evaluation of long-term sequential changes in bone mass and strength following withdrawal of incadronate disodium(YM175)in ovariectomized rats.
Miyakoshi N, et al.
J Orthop Sci 6 ( 2 ) 167 - 176 2001.01 [Refereed]
Research paper (journal)
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Evidence that IGF-binding protein-5 functions as a growth factor.
Miyakoshi N, et al.
J Clin Invest 107 ( 1 ) 73 - 81 2001.01 [Refereed]
Research paper (journal)
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Outcome of one-level posterior lumber interbody fusion for spondylolisthesis and postoperative intervertebral disc degeneration adjacent to the fusion.
Miyakoshi N, et al.
Spine 25 ( 14 ) 1837 - 1842 2000.01 [Refereed]
Research paper (journal)
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Anterior decompression with single segmental spinal interbody fusion for lumbar burst fracture.
Miyakoshi N, et al.
Spine 24 ( 1 ) 67 - 73 1999.01 [Refereed]
Research paper (journal)
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Histomorphometric evaluation of the effects of ovariectomy on bone turnover in rat caudal vertebrae.
Miyakoshi N, et al.
Calcif Tissue Int 64 318 - 324 1999.01 [Refereed]
Research paper (journal)
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Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice.
Miyakoshi N, et al.
Endocrinology 140 ( 12 ) 5719 - 5728 1999.01 [Refereed]
Research paper (journal)
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Bone-loss pattern of corticosteroid-induced osteopenia in rats : A node-strut analysis of the tibia.
Miyakoshi N, et al.
J Bone Miner Metab 15 94 - 99 1997.01 [Refereed]
Research paper (journal)
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Preventive effects of intermittent administration of human parathyroid hormone on steroid-induced osteopenia in rats.
Miyakoshi N
J Orthop Sci 1 318 - 328 1996.01 [Refereed]
Research paper (journal)