研究等業績 - その他 - 髙須賀　俊輔

Dysfunction of type 1 and type 2 immune cells: A lesson from exhausted-like ILC2s and their activation-induced cell death

Ebihara T.

International Immunology ( International Immunology )  36 ( 11 ) 585 - 594   2024年11月

DOI

FoxD1 expression identifies a distinct subset of hepatic stellate cells involved in liver fibrosis

Yamagata K.

Biochemical and Biophysical Research Communications ( Biochemical and Biophysical Research Communications )  734   2024年11月

DOI

TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy

Yamada T.

The Journal of experimental medicine ( The Journal of experimental medicine )  220 ( 7 )   2023年07月

DOI CiNii Research

2型自然リンパ球の訓練免疫

海老原 敬, 立松 恵, 高須賀 俊輔

【COPDと気管支喘息、その周辺疾患-病態・診断・治療の最新動向-】喘息病態up-to-date   80   586 - 590   2022年

CiNii Research

Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning

Takemasu S.

Journal of Deaf Studies and Deaf Education ( Journal of Deaf Studies and Deaf Education )  25 ( 1 ) 175 - 185   2020年01月

DOI

Trained innate lymphoid cells in allergic diseases

Ebihara T.

Allergology International ( Allergology International )    2020年

DOI

Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression

Koizumi A.

Scientific Reports ( Scientific Reports )  9 ( 1 )   2019年12月

DOI

Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca²⁺ oscillations in macrophages

Takemasu S.

Genes to Cells ( Genes to Cells )  24 ( 5 ) 366 - 376   2019年05月

DOI

PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca ²⁺ channel

Isobe Y.

Journal of Biochemistry ( Journal of Biochemistry )  165 ( 1 ) 75 - 84   2019年01月

DOI

Sac1 phosphoinositide phosphatase regulates foam cell formation by modulating SR-A expression in macrophages

Nigorikawa K.

Biological and Pharmaceutical Bulletin ( Biological and Pharmaceutical Bulletin )  42 ( 6 ) 923 - 928   2019年

<p>Macrophages endocytose modified low-density lipoproteins (LDL) vigorously <i>via</i> scavenger receptor A (SR-A) to become foam cells. In the present study, we found that Sac1, a member of the Sac family of phosphoinositide phosphatases, increases the protein level of SR-A and upregulates foam cell formation. Mouse macrophages (RAW264.7) were transfected with short hairpin RNAs (shRNAs) against Sac1. Sac1 knockdown decreased cell surface SR-A levels and impaired acetylated LDL-induced foam cell formation. Transfection of Sac1-knockdown cells with shRNA-resistant flag-Sac1 effectively rescued the expression of SR-A. Glycosylation of SR-A was largely attenuated by Sac1 knockdown, but neither mRNA expression nor protein degradation of SR-A were affected. These results suggest that Sac1 maintains SR-A protein levels by modulating SR-A glycosylation.</p>

DOI

The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis

Kimura H.

Modern Rheumatology ( Modern Rheumatology )  28 ( 3 ) 530 - 541   2018年05月

DOI

PIKfyve regulates melanosome biogenesis

Liggins M.

PLoS Genetics ( PLoS Genetics )  14 ( 3 )   2018年03月

DOI

TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis

Morioka S.

Journal of Cell Science ( Journal of Cell Science )  131 ( 5 )   2018年03月

DOI

Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages

Morioka S.

Experimental Cell Research ( Experimental Cell Research )  357 ( 2 ) 252 - 259   2017年08月

DOI

Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy

Kimura H.

JCI Insight ( JCI Insight )  2 ( 1 )   2017年

DOI