Research Achievements - Original paper -

Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.

Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T

Sci Rep.   9 ( 1 ) 13257   2019.09  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning.

Takemasu S, Nigorikawa K, Yamada M, Tsurumi G, Kofuji S, Takasuga S, Hazeki K

J Biochem.   166 ( 2 ) 175 - 185   2019.08  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages.

Nigorikawa K, Matsumura T, Sakamoto H, Morioka S, Kofuji S, Takasuga S, Hazeki K

Biol Pharm Bull.   42 ( 6 ) 923 - 928   2019.06  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca(2+) oscillations in macrophages.

Takemasu S, Ito M, Morioka S, Nigorikawa K, Kofuji S, Takasuga S, Eguchi S, Nakanishi H, Matsuoka I, Sasaki J, Sasaki T, Hazeki K

Genes Cells.   24 ( 5 ) 366 - 376   2019.05  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel.

Isobe Y, Nigorikawa K, Tsurumi G, Takemasu S, Takasuga S, Kofuji S, Hazeki K

J Biochem.   165 ( 1 ) 75 - 84   2018.03  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

PIKfyve regulates melanosome biogenesis.

Liggins MC, Flesher JL, Jahid S, Vasudeva P, Eby V, Takasuga S, Sasaki J, Sasaki T, Boissy RE, Ganesan AK

PLoS Genet.   14 ( 3 ) e1007290   2018.03  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis.

Morioka S, Nigorikawa K, Okada E, Tanaka Y, Kasuu Y, Yamada M, Kofuji S, Takasuga S, Nakanishi H, Sasaki T, Hazeki K

J Cell Sci.   131 ( 5 ) jcs213272   2018.03  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis.

Kimura H, Matsuyama Y, Araki S, Koizumi A, Kariya Y, Takasuga S, Eguchi S, Nakanishi H, Sasaki J, Sasaki T

Mod Rheumatol.   28 ( 3 ) 530 - 541   2018.03  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages.

Morioka S, Nigorikawa K, Hazeki K, Ohmura M, Sakamoto H, Matsumura T, Takasuga S, Hazeki O

Exp Cell Res.   357 ( 2 ) 252 - 259   2017.08  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.

Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T

JCI Insight.   2 ( 1 ) e89462   2017.01  [Refereed]

Research paper (journal)   Domestic Co-author

DOI