Research Achievements - Other -

c-FOSはIKZF1転写活性化複合体の重要な構成要素であり、多発性骨髄腫におけるレナリドマイド耐性を誘導する(c-FOS is an integral component of the IKZF1 transactivator complex and mediates lenalidomide resistance in multiple myeloma)

長田 直希, 菊池 次郎, 安井 寛, 池田 翔, 松岡 紗恵, 高橋 直人, 古川 雄祐

International Journal of Myeloma ( (一社)日本骨髄腫学会 )  13 ( 3 ) 136 - 136   2023.05

Refractory esophageal stricture of esophageal mucous membrane pemphigoid after allogeneic hematopoietic stem cell transplantation

FUJITA Nanako, YAMASHITA Takaya, ABE Fumito, NARA Miho, YOSHIOKA Tomoko, KOGA Hiroshi, ISHII Norito, TAKAHASHI Naoto

Rinsho Ketsueki ( The Japanese Society of Hematology )  64 ( 2 ) 107 - 112   2023

<p>Haploidentical allogeneic hematopoietic stem cell transplantation from her brother was performed on a 41-year-old lady with no prior history of pemphigoid to treat recurrent AML. On day 59 following transplantation, she experienced esophageal stenosis. During immunosuppressive therapy for graft vs. host disease, this condition was controlled with periodic esophageal dilatation (GVHD). Her esophageal stricture, which required periodic dilatation, grew worse after she stopped immunosuppressive therapy because of recurrent AML. The esophageal mucosa was easily hemorrhagic and desquamative. Histologic analysis revealed that the squamous cell layers had been divided. Indirect immunofluorescence was negative for IgG and positive for IgA on the epidermal layers, while direct immunofluorescence showed a linear deposition of IgG on the basement membrane zone. It was determined through immunoblotting utilizing recombinant protein of BP180 C-terminal domain that both IgG and IgA antibodies were present, supporting the diagnosis of mucous membrane pemphigoid with anti-BP180. After allogeneic transplantation, basal epidermal cell destruction by GVHD may result in autoimmune blistering disorders, which expose basement membrane proteins and antigen presentation. A similar mechanism could apply to our situation. For rare GVHD cases, a thorough histological diagnosis is required.</p>

DOI CiNii Research

c-FOS mediates IMiDs resistance acting as a co-activator of IKZF1-target genes in multiple myeloma.

長田直希, 菊池次郎, 松岡紗恵, 安井寛, 池田翔, 高橋直人, 仲宗根秀樹, 古川雄祐

日本癌学会学術総会抄録集(Web)   82nd   2023

J-GLOBAL

Postmortem diagnosis of intravascular large B-cell lymphoma after atraumatic splenic rupture due to splenic infiltration

KUROKI Wataru, KOBAYASHI Takahiro, UMAKOSHI Michinobu, KITADATE Akihiro, IMAIZUMI Chihiro, SAITO Masaya, KOBAYASHI Isuzu, FUJISHIMA Masumi, FUJISHIMA Naohito, YOSHIOKA Tomoko, GOTO Akiteru, TAKAHASHI Naoto

Rinsho Ketsueki ( The Japanese Society of Hematology )  63 ( 6 ) 523 - 529   2022

<p>Atraumatic splenic rupture (ASR) is a rare but fatal complication of malignant lymphoma. However, only one case of intravascular large B-cell lymphoma (IVLBCL)-related ASR (IVLBCL-ASR) has previously been reported, and the mechanism of IVLBCL-ASR is unknown. We present the case of a 78-year-old man who died unexpectedly and was diagnosed with IVLBCL-ASR pathologically by autopsy. A massive intraperitoneal hemorrhage and four lacerations on the splenic surface were discovered during the autopsy. CD20-positive lymphoma cells that infiltrated into small vessels were highly concentrated in the center of the spleen and were only slightly distributed in the lacerations on the splenic surface. Therefore, increased intrasplenic pressure due to lymphoma cell proliferation was identified as the cause of ASR. The patient had undergone ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) for tongue cancer evaluation 3 months earlier, and positive uptake was found in the right adrenal gland, where lymphoma cell infiltration was confirmed by the autopsy. Our findings suggest that clinicians should be aware that the advanced stage of IVLBCL can cause fatal ASR via increased intrasplenic pressure. Therefore, early diagnosis and early treatment intervention are desirable to prevent the onset of IVLBCL-ASR, and ¹⁸F-FDG PET/CT is useful for the early diagnosis of IVLBCL.</p>

DOI PubMed CiNii Research

Long-term complete remission of HIV-negative primary testicular plasmablastic lymphoma treated with bortezomib in combination with EPOCH

FUJISHIMA Takashi, KAWABATA Yoshinari, MICHISHITA Yoshihiro, KITABAYASHI Atushi, TAKAHASHI Naoto

Rinsho Ketsueki ( The Japanese Society of Hematology )  63 ( 10 ) 1386 - 1391   2022

<p>Plasmablastic lymphoma (PBL) is a rare variant of diffuse large B-cell lymphoma that is frequently associated with HIV infection or other immunodeficiencies. We present a case of HIV-negative primary testicular PBL with long-term complete remission (CR) and successful treatment with bortezomib in combination with EPOCH (V-EPOCH). Because of rapidly increasing right testicular swelling, an 86-year-old man without immunodeficiencies was admitted to our hospital. Following that, a right high orchiectomy was performed. Histopathological and immunohistochemical analyses revealed diffuse infiltration of plasmablastic lymphocytes, which were positive for CD38, CD138, CD56, MUM1, lambda, EBER, and MYC respectively, but negative for CD20. The MIB-1 index was 90%. FDG abnormal uptake was discovered on PET/CT at systemic lymph nodes. There was no abnormal cell infiltration in either the bone marrow or cerebral spinal fluid. He was diagnosed with PBL, clinical-stage IIIE-A, IPI high-intermediate risk. He achieved durable CR more than 30 months after the diagnosis after six courses of V-EPOCH, followed by intrathecal prophylaxis (IT) and adjuvant radiation therapy (total 30 Gy). Although PBL shows an aggressive clinical course and poor prognosis, adequate therapeutic approaches for PBL have not been established due to the rarity of this disease. According to our findings, V-EPOCH combined with IT and adjuvant radiotherapy appeared to be feasible and effective as a frontline treatment for elderly patients with primary testicular PBL.</p>

DOI PubMed CiNii Research

R-MPV療法を施行した中枢神経原発悪性リンパ腫の有効性と安全性の解析(The safety and efficacy of R-MPV therapy for untreated primary CNS lymphoma(PCNSL))

亀岡 吉弘, 阿部 滉, 山田 雅浩, 渡部 敦, 茂木 睦仁, 久米 正晃, 波多野 善明, 小笠原 仁, 高橋 直人

日本血液学会学術集会 ( (一社)日本血液学会 )  83回   OS1 - 4   2021.09

ボスチニブ治療における血清クレアチニン値はボスチニブ血中トラフ濃度とSLC22A2遺伝子多型に影響される(Effect of SLC22A2 SNP and bosutinib concentrations on serum creatinine in patients taking bosutinib)

鐙屋 舞子, 高橋 直人, 高橋 さおり, 吉岡 智子, 亀岡 吉弘, 三浦 昌朋

日本血液学会学術集会 ( (一社)日本血液学会 )  83回   OS2 - 5   2021.09

慢性骨髄性白血病急性転化におけるクローン進化および遺伝子異常と予後の解析(Clonal evolution and clinical impact of genetic lesions in blast crisis of chronic myeloid leukemia)

越智 陽太郎, 吉田 健一, 南谷 泰仁, 佐々木 光, 三谷 絹子, 細谷 紀子, 平本 展大, 石川 隆之, 大屋敷 一馬, 高橋 直人, 高久 智生, 土屋 俊, 兼村 信宏, 中村 信彦, 上田 恭典, 吉原 哲, 塩澤 裕介, 趙 蘭英, 竹田 淳恵, 綿谷 陽作, 奥田 瑠璃花, 牧島 秀樹, 白石 友一, 千葉 健一, 田中 洋子, 真田 昌, 高折 晃史, 宮野 悟, Shih Lee-Yung, 小川 誠司

日本血液学会学術集会 ( (一社)日本血液学会 )  83回   OS1 - 1   2021.09

慢性骨髄性白血病急性転化のクローン進化および遺伝子異常と予後

越智 陽太郎, 吉田 健一, 南谷 泰仁, 佐々木 光, 三谷 絹子, 細谷 紀子, 石川 隆之, 大屋敷 一馬, 高橋 直人, 塩澤 裕介, 牧島 秀樹, 白石 友一, 真田 昌, 高折 晃史, 宮野 悟, 小川 誠司

日本癌学会総会記事 ( (一社)日本癌学会 )  80回   [E14 - 1]   2021.09

再発難治性ホジキンリンパ腫に対する免疫チェックポイント阻害薬治療の後方視的解析(Retrospective analysis of ICI therapy for relapsed or refractory classical Hodgkin's lymphoma: THF26)

前田 峻大, 小宅 達郎, 久保 恒明, 高畑 武功, 玉井 佳子, 亀岡 吉弘, 高橋 直人, 宮入 泰郎, 村井 一範, 下瀬川 健二, 吉田 こず恵, 菅原 健, 猪倉 恭子, 福原 規子, 張替 秀郎, 佐藤 諒, 石澤 賢一, 田嶋 克史, 齊藤 宗一, 深津 真彦, 池添 隆之, 角田 三郎, 神林 裕行, 三田 正行, 森 甚一, 古和田 周吾, 伊藤 薫樹

日本血液学会学術集会 ( (一社)日本血液学会 )  83回   OS2 - 2   2021.09

成人初期前駆T細胞性急性リンパ性白血病の臨床的特徴と予後に関する後方視的研究 THF-24(Clinical features and prognosis of adult early T-cell precursor acute lymphoblastic leukemia: THF-24)

古川 瑛次郎, 大西 康, 遠宮 靖雄, 原崎 頼子, 深津 真彦, 池添 隆之, 亀岡 吉弘, 高橋 直人, 八田 俊介, 勝岡 優奈, 濱田 宏之, 村井 一範, 小宅 達郎, 伊藤 薫樹, 甲斐 龍幸, 助川 真純, 中嶌 真治, 柳谷 稜, 石澤 賢一, 山口 公平, 高橋 太郎, 張替 秀郎

日本血液学会学術集会 ( (一社)日本血液学会 )  83回   OS3 - 5   2021.09

濾胞性リンパ腫におけるリツキシマブ維持療法の長期生存 東北血液フォーラム前向き多施設共同研究結果(Long-term survival in patients with follicular lymphoma following Rituximab maintenance in THF-19)

大本 英次郎, 妻沼 りこ, 熊谷 裕昭, 相澤 桂子, 吉田 こず恵, 池田 和彦, 亀岡 吉弘, 石澤 賢一, 張替 秀郎, 高橋 直人

日本血液学会学術集会 ( (一社)日本血液学会 )  83回   BPA - 6   2021.09

Correlation between increased immune checkpoint molecule expression and refractoriness to blinatumomab evaluated by longitudinal T cell analysis

Kobayashi T.

International Journal of Hematology ( International Journal of Hematology )    2021

Domestic Co-author

DOI

Primary breast diffuse large B-cell lymphoma in an elderly man maintaining long-term complete response

NOGUCHI Shinsuke, SAITOH Hirobumi, SASAKI Hideto, KAMATA Shuichi, ENOMOTO Katsuhiko, TAKAHASHI Naoto

Rinsho Ketsueki ( The Japanese Society of Hematology )  62 ( 5 ) 341 - 345   2021

<p>Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin's lymphoma that mostly affects women. Here, we report a case of primary breast DLBCL that affected an older man without any autoimmune disease or drug-related female hormones. The patient was a 65-year-old man whose chief complaints were gradually-increasing lump in the right chest and swelling of the right axillary lymph nodes. He was diagnosed with malignant lymphoma through a needle biopsy on suspicion of right breast cancer with right axillary lymph node metastasis. Since the histological type could not be confirmed, right breast mass resection was performed. The patient was referred to our department for treatment because of the diagnoses of primary breast DLBCL, germinal center B-cell type (Hans classification), and clinical stage IIA. In addition to the six courses of R-CHOP therapy, intrathecal injections were used in combination to prevent CNS infiltration. He has been in complete remission for 5 years. Although rare, breast lymphoma can also occur in men; therefore, early histological diagnosis and response to CNS recurrence prevention are important.</p>

DOI CiNii Research

髄外疾患はヒアルロナン誘導同種親和性骨髄腫細胞-細胞相互作用に由来する【JST・京大機械翻訳】|||

菊池次郎, 小玉信之, 小玉信之, 竹下昌孝, 竹下昌孝, 比島智子, 比島智子, 池田翔, 小林敬宏, 黒田芳明, 内山倫宏, 長田直希, 小山大輔, BOGEN Bjarne, 安井寛, 高橋直人, 三輪哲義, 三輪哲義

日本血液学会学術集会抄録(Web) ( (一社)日本血液学会 )  83rd ( 2 ) OS2 - 1   2021

J-GLOBAL

Phase 2 study of bosutinib in Japanese patients with newly diagnosed chronic phase chronic myeloid leukemia

Hino M.

International Journal of Hematology ( International Journal of Hematology )  112 ( 1 ) 24 - 32   2020.07  [Refereed]

Domestic Co-author

DOI

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia

Ko T.K.

Blood ( Blood )  135 ( 26 ) 2337 - 2353   2020.06  [Refereed]

International Co-author

DOI

好酸球増多疾患・好酸球性肺炎 著明な組織内シャルコー・ライデン結晶を認めた好酸球増多症候群患者

福地 峰世, 植木 重治, 山本 洋平, 奈良 美保, 今野 泰典, 面川 歩, 嵯峨 知生, 守時 由起, 大森 泰文, 高橋 直人, 廣川 誠

アレルギー ( (一社)日本アレルギー学会 )  68 ( 4-5 ) 529 - 529   2019.05

Pharmacokinetics of Tacrolimus Coadministered With Letermovir in Allogeneic Hematopoietic Stem Cell Transplantation Patients.

Guo YM, Abumiya M, Yamashita T, Ubukawa K, Takahashi N

Clinical pharmacology in drug development   8 ( 3 ) 411 - 412   2019.04

DOI PubMed

Different clonal dynamics of chronic myeloid leukaemia between bone marrow and the central nervous system.

Ogawa M, Yokoyama K, Hirano M, Jimbo K, Ochi K, Kawamata T, Ohno N, Shimizu E, Yokoyama N, Yamaguchi R, Imoto S, Uchimaru K, Takahashi N, Miyano S, Imai Y, Tojo A

British journal of haematology   183 ( 5 ) 842 - 845   2018.12

DOI PubMed