研究等業績 - 原著論文 - 永澤 博幸
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Zeniya T.
Acta Orthopaedica Belgica ( Acta Orthopaedica Belgica ) 90 ( 4 ) 731 - 737 2024年12月 [査読有り]
研究論文（学術雑誌） 国内共著
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Michinobu Umakoshi, Yukitsugu Kudo-Asabe, Hiroyuki Tsuchie, Zhuo Li, Kei Koyama, Ken Miyabe, Makoto Yoshida, Hiroyuki Nagasawa, Hiroshi Nanjo, Kyoji Okada, Daichi Maeda, Naohisa Miyakoshi, Masamitsu Tanaka, Akiteru Goto
Pathobiology : journal of immunopathology, molecular and cellular biology ( Pathobiology ) 92 ( 1 ) 2024年07月 [査読有り]
研究論文（学術雑誌） 国内共著
INTRODUCTION: The tumor microenvironment of sarcomas has not been studied in detail; in particular, little is known about cancer-associated fibroblasts (CAFs). Sarcoma cells are difficult to distinguish from CAFs, either histomorphologically or immunohistochemically. METHODS: We scored expression of individual CAF markers (fibroblast activating protein (FAP), CD10, and podoplanin) in the intratumoral and marginal areas of 133 sarcomas. We also examined the association between these markers, as well as the number of CD163-positive macrophages (i.e., tumor-associated macrophages), and clinical outcome. RESULTS: In all cases, the log-rank test revealed that those with high marker scores and macrophage counts (except for marginal CD10+ CAFs) showed significantly worse disease-free survival (DFS). Grade 2/3 cases with high CAF scores (excluding the marginal FAP and CD10 scores) showed significantly worse DFS, whereas those with high intratumoral FAP/CD10 and marginal podoplanin scores showed significantly worse metastasis-free survival (MFS), and those with a high intratumoral CD10 score showed significantly worse local recurrence-free survival (LFS). Multivariate analysis identified intratumoral CD10/podoplanin scores and marginal FAP/podoplanin scores as independent prognostic factors for DFS, intratumoral FAP/CD10 and marginal FAP/podoplanin/CD163-positive macrophage scores as independent prognostic factors for MFS, and the intratumoral podoplanin score as an independent prognostic factor for LFS. There was a weak-to-moderate correlation between each score and CD163-positive macrophage counts. CONCLUSION: Patients with high CAF marker expression in the intratumoral and marginal areas have a poorer outcome.
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Effect of Acridine Orange and Zoledronic Acid on Bone Metastasis in Renal Cell Carcinoma
Oya K.
Anticancer research ( Anticancer research ) 44 ( 6 ) 2487 - 2495 2024年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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Development of a New Focal Mouse Model of Bone Metastasis in Renal Cell Carcinoma
Oya K.
In vivo (Athens, Greece) ( In vivo (Athens, Greece) ) 38 ( 3 ) 1074 - 1078 2024年05月 [査読有り]
研究論文（学術雑誌） 国内共著
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Development of a New Focal Mouse Model of Bone Metastasis in Renal Cell Carcinoma
OYA KEITA, TSUCHIE HIROYUKI, NAGASAWA HIROYUKI, HONGO MICHIO, KASUKAWA YUJI, KUDO DAISUKE, SHOJI RYO, KASAMA FUMIHITO, KAWARAGI TAKASHI, WATANABE MANABU, TOMINAGA KENTA, MIYAKOSHI NAOHISA
In Vivo ( International Institute of Anticancer Research ) 38 ( 3 ) 1074 - 1078 2024年
研究論文（学術雑誌） 国内共著
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Macrophage numbers in the marginal area of sarcomas predict clinical prognosis
Umakoshi M.
Scientific Reports ( Scientific Reports ) 13 ( 1 ) 1290 - 1290 2023年12月
研究論文（学術雑誌）
Even when treated comprehensively by surgery, chemotherapy, and radiotherapy, soft-tissue sarcoma has an unfavorable outcome. Because soft-tissue sarcoma is rare, it is the subject of fewer clinicopathological studies, which are important for clarifying pathophysiology. Here, we examined tumor-associated macrophages in the intratumoral and marginal areas of sarcomas to increase our knowledge about the pathophysiology. Seventy-five sarcoma specimens (not limited to a single histological type), resected at our institution, were collected, and the number of CD68-, CD163-, and CD204-positive macrophages in the intratumoral and marginal areas was counted. We then performed statistical analysis to examine links between macrophage numbers, clinical factors, and outcomes. A high number of macrophages positive for all markers in both areas was associated with worse disease-free survival (DFS). Next, we divided cases according to the FNCLCC classification (Grade 1 and Grades 2/3). In the Grade 1 group, there was no significant association between macrophage number and DFS. However, in the Grade 2/3 group, high numbers of CD163- and CD204-positive macrophages in the marginal area were associated with poor DFS. By contrast, there was no significant difference between the groups with respect to high or low numbers of CD68-, CD163-, or CD204-positive macrophages in the intratumoral area. Multivariate analysis identified the number of CD163- and CD204-positive macrophages in the marginal area as an independent prognostic factor. Macrophage numbers in the marginal area of soft-tissue sarcoma may better reflect clinical behavior.
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Effects of Soft Tissue Sarcoma and Doxorubicin on Bone Metabolism in Mice
Kasama F.
In vivo (Athens, Greece) ( In vivo (Athens, Greece) ) 37 ( 4 ) 1532 - 1539 2023年07月 [査読有り]
研究論文（学術雑誌） 国内共著
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Emori M.
Skeletal Radiology ( Skeletal Radiology ) 53 ( 4 ) 657 - 664 2023年 [査読有り]
研究論文（学術雑誌） 国内共著
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Emori M, Tsuchie H, Teramoto A, Shimizu J, Mizushima E, Murahashi Y, Nagasawa H, Miyakoshi N, Yamashita T
BMC Musculoskeletal Disorders ( BMC Musculoskeletal Disorders ) 23 ( 1 ) 378 - 378 2022年12月 [査読有り]
研究論文（学術雑誌） 国際共著
BACKGROUND: The aim of the present study was to evaluate the prevalence of non-ossifying fibroma (NOF) and fibrous cortical defect (FCD) in a Japanese pediatric population and the association between the lesion size and pain. METHODS: This retrospective study, conducted across 10 Japanese institutions, included patients aged 5-15 years who had undergone standard antero-posterior and lateral view radiography of the knee. Using these radiographs, we diagnosed the lesion as a NOF or FCD. Patient demographics, including age, sex, the size and location of the NOF, and chief complaint were recorded. The lesion size was determined using radiographs. Student's t-test was used to compare the associations between the lesion size and spontaneous pain. RESULTS: A total of 6222 subjects (3567 boys and 2455 girls) were included in this study. The number of NOF and FCD cases was 143 and 437, respectively, and the prevalence of NOF and FCD was 2.3% and 7.0%, respectively. The average size of NOF and FCD was 22.1 mm (range: 4-102 mm) and 13.2 mm (range: 5-21 mm), respectively. Three patients (2.1%) had pathological fractures due to NOF. Of the 140 NOFs and 437 FCDs, we obtained complaints from the medical records of 126 and 393 patients, respectively. The number of patients with spontaneous pain or other problems with NOF was 68 (54%) and 58 (46%), respectively, that of patients with FCD was 195 (50%) and 198 (50%) patients, respectively. The lesion size was not associated with spontaneous pain in either lesion (p = 0.67 and p = 0.27, respectively). CONCLUSION: The prevalence of NOF and FCD around the knee was lower than that reported in previous studies. The prevalence of NOF increased and that of FCD decreased with advancing age. In both lesions, the lesion size may not be associated with pain.
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Shoji R, Tsuchie H, Nagasawa H, Hongo M, Kasukawa Y, Nozaka K, Kudo D, Saito H, Abe K, Igarashi S, Harata S, Kasama F, Miyakoshi N
Anticancer Research ( Anticancer Research ) 42 ( 11 ) 5357 - 5363 2022年11月 [査読有り]
研究論文（学術雑誌） 国際共著
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Risk Factors of Early Distant Metastasis after Primary Tumor Treatment in Soft Tissue Sarcoma
Tsuchie H, Emori M, Nagasawa H, Murahashi Y, Mizushima E, Shimizu J, Yamashita T, Miyakoshi N
In Vivo ( In Vivo ) 36 ( 5 ) 2260 - 2264 2022年09月 [査読有り]
研究論文（学術雑誌） 国際共著
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Shoji R, Tsuchie H, Nagasawa H, Hongo M, Kasukawa Y, Kudo D, Miyakoshi N
In vivo (Athens, Greece) ( In vivo (Athens, Greece) ) 36 ( 2 ) 667 - 671 2022年03月 [査読有り]
研究論文（学術雑誌） 国内共著
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Tsuchie H, Umakoshi M, Hasegawa T, Nagasawa H, Okada K, Nanjo H, Goto A, Miyakoshi N
Journal of Orthopaedic Science ( Journal of Orthopaedic Science ) 29 ( 1 ) 374 - 378 2022年 [査読有り]
研究論文（学術雑誌） 国際共著
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Tsuchie H, Emori M, Nagasawa H, Murahashi Y, Mizushima E, Shimizu J, Yamashita T, Miyakoshi N
In Vivo ( In Vivo ) 35 ( 6 ) 3467 - 3473 2021年12月 [査読有り]
研究論文（学術雑誌） 国内共著
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Impact of a specialized outpatient clinic on bone metastasis and its burden on spine surgeons
Tsuchie H, Miyakoshi N, Hongo M, Nagasawa H, Kasukawa Y, Kudo D, Kimura R
In Vivo ( In Vivo ) 35 ( 6 ) 3575 - 3579 2021年12月 [査読有り]
研究論文（学術雑誌） 国内共著
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Tumor Lysis Syndrome due to Eribulin Administration for Metastatic Undifferentiated Pleomorphic Sarcoma of the Buttock.
Hiroyuki Tsuchie, Naohisa Miyakoshi, Hiroyuki Nagasawa, Yoichi Shimada
Acta medica Okayama 75 ( 4 ) 533 - 538 2021年08月 [査読有り]
研究論文（学術雑誌） 国際共著
Tumor lysis syndrome (TLS) is a complication of cancer treatment that requires urgent intervention. It is extremely rare in the treatment of soft tissue sarcoma (STS) of the limbs or trunk, and there are currently no reports of TLS occurrence from eribulin therapy. We report the case of a 78-year-old woman with an undiffer-entiated pleomorphic sarcoma on the right buttock. We initiated chemotherapy with intravenous eribulin mesylate. Deterioration of renal function, mild hyperkalemia, hyperuricemia, hypocalcemia, and hyperphos-phatemia were confirmed on examination, suggesting the presence of TLS. We present an extremely rare case of TLS from eribulin for STS.
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Tsuchie H, Miyakoshi N, Nagasawa H, Shimada Y
Acta Medica Okayama ( Acta Medica Okayama ) 75 ( 4 ) 533 - 538 2021年 [査読有り]
研究論文（学術雑誌）
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Deep Angiomyxoma of the Thigh That Is Difficult to Diagnose: A Case Report and Literature Review.
Hiroyuki Tsuchie, Naohisa Miyakoshi, Hiroyuki Nagasawa, Hiroshi Nanjo, Yoichi Shimada
Acta medica Okayama 75 ( 5 ) 653 - 657 2021年 [査読有り]
研究論文（学術雑誌） 国内共著
We present an extremely rare case of deep angiomyxoma (DAM) in the thigh that was misdiagnosed as desmoid-type fibromatosis. A 40-year-old Japanese woman presented with a mass on the left thigh. The histological diagnosis by needle biopsy was desmoid-type fibromatosis; the tumor grew slowly and was resected 4 years later. The histological diagnosis from the resected tumor was DAM. As of 16 months post-surgery, the patient has not noticed any local recurrence. Although DAM in a lower extremity is extremely rare, clinicians must be aware of its possible occurrence in areas relatively close to the pelvis.
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Impact of a Specialized Outpatient Clinic on Bone Metastasis and Its Burden on Spine Surgeons
HIROYUKI TSUCHIE, NAOHISA MIYAKOSHI, MICHIO HONGO, HIROYUKI NAGASAWA, YUJI KASUKAWA, DAISUKE KUDO, RYOTA KIMURA
In Vivo ( Anticancer Research USA Inc. ) 35 ( 6 ) 3575 - 3579 2021年 [査読有り]
研究論文（学術雑誌） 国際共著
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Murahashi Y, Emori M, Shimizu J, Anzai K, Tanaka T, Naka N, Tsuchie H, Nagasawa H, Miyakoshi N, Shimada Y, Yamashita T
European Radiology ( European Radiology ) 30 ( 10 ) 5768 - 5776 2020年10月 [査読有り]
研究論文（学術雑誌） 国内共著
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Impact of acridine orange in patients with local recurrent soft tissue sarcoma
Tsuchie H, Emori M, Miyakoshi N, Okada K, Nagasawa H, Murahashi Y, Mizushima E, Shimizu J, Yamashita T, Shimada Y
In Vivo ( In Vivo ) 34 ( 5 ) 2745 - 2750 2020年09月 [査読有り]
研究論文（学術雑誌） 国内共著
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TKA周囲骨折おけるイリザロフ創外固定の有用性
高橋 靖博, 野坂 光司, 永澤 博幸, 齊藤 英知, 木島 泰明, 土江 博幸, 斉藤 公男, 藤井 昌, 宮腰 尚久, 島田 洋一
日本創外固定・骨延長学会雑誌 ( 日本創外固定・骨延長学会 ) 31 250 - 250 2020年03月 [査読有り]
研究論文（学術雑誌） 国内共著
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Early lymph node metastasis may predict poor prognosis in soft tissue sarcoma
Emori M, Tsuchie H, Nagasawa H, Sonoda T, Tsukamoto A, Shimizu J, Murahashi Y, Mizushima E, Takada K, Murase K, Iesato K, Igarashi K, Hori T, Yamamoto M, Sugita S, Miyakoshi N, Hasegawa T, Shimada Y, Yamashita T
International Journal of Surgical Oncology 2019年12月 [査読有り]
研究論文（学術雑誌） 国内共著
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Impact acridine orange in patients with soft tissue sarcoma treated with marginal resection
Tsuchie H, Emori M, Miyakoshi N, Nagasawa H, Okada K, Murahashi Y, Mizushima E, Shimizu J, Yamashita T, Shimada Y
Anticancer Reserch 39 ( 11 ) 6365 - 6372 2019年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Prognostic impact of CD44 expression in patients with myxofibrosarcoma
Tsuchie H, Emori M, Miyakoshi N, Nagasawa H, Okada K, Nanjyo H, Murahashi Y, Mizushima E, Shimizu J, Yamashita T, Shimada Y
In Vivo 33 2095 - 2102 2019年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Ilizarov創外固定を依頼される足関節周辺骨折の特徴
野坂 光司, 山田 晋, 永澤 博幸, 齊藤 英知, 木島 泰明, 土江 博幸, 水谷 嵩, 益谷 法光, 尾野 祐一, 宮腰 尚久, 島田 洋一, 柏倉 剛, 富岡 立, 千田 秀一, 柴田 暢介
日本創外固定・骨延長学会雑誌 ( 日本創外固定・骨延長学会 ) 28 159 - 159 2017年02月 [査読有り]
研究論文（学術雑誌） 国内共著