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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Department of Pediatrics |
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Laboratory Address |
1-1-1 Hondo, Akita |
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Laboratory Fax number |
+81-18-836-2620 |
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Mail Address |
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TOYONO Manatomo
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Graduating School 【 display / non-display 】
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-1993.03
Akita University Faculty of Medicine Graduated
Studying abroad experiences 【 display / non-display 】
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2006.04-2008.06
Cleveland Clinic Research Fellow
Campus Career 【 display / non-display 】
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2014.02-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Associate Professor
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2009.10-2014.01
Akita University Hospital Pediatrics Lecturer
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2008.07-2009.09
Akita University Hospital Pediatrics Assistant Professor
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2001.04-2006.04
Akita University Hospital Pediatrics Medical Staff
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1996.10-1997.03
Akita University Hospital Pediatrics Medical Staff
Academic Society Affiliations 【 display / non-display 】
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2001.06-Now
United States
American Society of Echocardiography
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2008.08-Now
United States
American Heart Association
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2011.01-Now
United States
American College of Cardiology
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2015.04-Now
Japan
Asian Society of Pediatric Research
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2016.11-Now
Japan
The Japan Spciety of Ultrasonic Medicine
Research Areas 【 display / non-display 】
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Life Science / Embryonic medicine and pediatrics
Thesis for a degree 【 display / non-display 】
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Morphological adaptation of the cardiovascular system in fetal rats during late gestation
Toyono M, Ito T, Harada K, Tamura M, Takada G
Tohoku J Exp Med 188 299 - 309 2001.03
Domestic Co-author
Research Achievements 【 display / non-display 】
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Maturational changes in left ventricular contractile state
Toyono M, Harada K, Takahashi Y, Takada G
Int J Cardiol 15 247 - 252 1998.05 [Refereed]
Research paper (journal) Domestic Co-author
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Effects of carvedilol on left ventricular function, mass, and scintigraphic findings in isolated left ventricular non-compaction
Toyono M, Kondo C, Nakajima Y, Nakazawa M, Momma K, Kusakabe K
Heart 86 E4 2001.07 [Refereed]
Research paper (journal) Domestic Co-author
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Persistent tricuspid regurgitation and its predictor in adults after percutaneous and isolated surgical closure of secundum atrial septal defect
Toyono M, Krasuski RA, Pettersson GB, Matsumura Y, Yamano T, Shiota T
Am J Cardiol 104 ( 6 ) 856 - 861 2009.09 [Refereed]
Research paper (journal) Domestic Co-author
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Myocardial acceleration during isovolumic contraction as a new index of right ventricular contractile function and its relation to pulmonary regurgitation in patients after repair of tetralogy of Fallot
Toyono M, Harada K, Tamura M, Yamamoto F, Takada G
J Am Soc Echocardiogr 17 ( 4 ) 332 - 337 2004.04 [Refereed]
Research paper (journal) Domestic Co-author
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Different determinants of residual tricuspid regurgitation after tricuspid annuloplasty: comparison of atrial septal defect and mitral valve prolapse
Toyono M, Fukuda S, Gillinov AM, Pettersson GB, Matsumura Y, Wada N, Yamano K, Takasaki K, Shiota T
J Am Soc Echocardiogr 22 ( 8 ) 899 - 903 2009.08 [Refereed]
Research paper (journal) Domestic Co-author
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Journal of Clinical Echocardiography
Manatomo Toyono
27 ( 6 ) 552 - 556 2017.06
Introduction and explanation (commerce magazine) Single author
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Pulmonary arterial hypertension in adults with atrial septal defect
Toyono M
J Cardiol Cases ( Elsevier ) 6 e32 - e33 2012.08
Introduction and explanation (scientific journal) Single author
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Diagnostic value of left ventricular outflow area in patients with hypertrophic cardiomyopathy: a real-time three-dimensional echocardiographic study
Fukuda S, Lever HM, Stewart WJ, Tran H, Song JM, Shin MS, Greenberg NL, Wada N, Matsumura Y, Toyono M, Smedira NG, Thomas JD, Shiota T
J Am Coll Cardiol 49 127A - 127A 2007.03 [Refereed]
Research paper (international conference proceedings) Domestic Co-author
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Geometric deformity of the mitral annulus in patients with hypertrophic obstructive cardiomyopathy: real-time three-dimensional echocardiographic study
Wada N, Fukuda S, Toyono M, Matsumura Y, Thomas JD, Watanabe N, Yoshida K, Shiota T
J Am Coll Cardiol 49 163A - 163A 2007.03 [Refereed]
Research paper (international conference proceedings) Domestic Co-author
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Plasma levels of natriuretic peptide can reflect pulmonary vascular resistance in patients of ventricular septal defect with pulmonary hypertension
Toyono M, Harada K, Tamura M, Okazaki-Aoki M, Ishii H, Shimada S, Takada G
Cardiol Young 15 ( S2 ) 17 - 17 2005.05 [Refereed]
Research paper (international conference proceedings) Domestic Co-author
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Tissue Doppler imaging combined with pulsed Doppler echocardiography estimates mean left atrial pressure in patients with left-to-right shunt
Toyono M, Harada K, Tamura M, Okazaki-Aoki M, Ishii H, Shimada S, Takada G
Cardiol Young 15 ( S2 ) 36 - 37 2005.05 [Refereed]
Research paper (international conference proceedings) Domestic Co-author
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Tissue Doppler imaging combined with pulsed Doppler echocardiography estimates mean left atrial pressure in patients with left-to-right shunt
Toyono M, Harada K, Tamura M, Okazaki-Aoki M, Ishii H, Shimada S, Takada G
J Am Soc Echocardiogr 18 501 - 501 2005.05 [Refereed]
Research paper (international conference proceedings) Domestic Co-author
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Paradox
Toyono Manatomo
Pediatric Cardiology and Cardiac Surgery ( Japanese Society of Pediatric Cardiology and Cardiac Surgery ) 38 ( 1 ) 1 - 2 2022.02
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Tsubura Masahiro, Yoshimoto Jun, Kim Sung-Hae, Mitsushita Norie, Sakamoto Kisaburo, Tanaka Yasuhiko, Nii Masaki, Takahashi Ken, Takigiku Kiyohiro, Toyono Manatomo, Iwashima Satoru, Inoue Nao, Ishigaki Mizuhiko, Sato Keisuke
Pediatric Cardiology and Cardiac Surgery ( Japanese Society of Pediatric Cardiology and Cardiac Surgery ) 35 ( 1 ) 30 - 37 2019
<p><b>Background:</b> Atrioventricular valve regurgitation (AVVR) has a notable impact on the prognosis of patients with hypoplastic left heart syndrome (HLHS) and right atrial isomerism (RAI).</p><p><b>Methods:</b> The study population comprised two groups: (1) HLHS and RAI group: n=32 (HLHS=15, RAI=17), and (2) normal control group: n=53. X-plane images of apical four-chamber view and orthogonal plane cutting through the center of annulus were acquired using transthoracic matrix array probe. Speckle-tracking of the two opposing points on the annulus in four-chamber plane and orthogonal plane was performed, and the distances of respective opposing points were consecutively measured along the cardiac cycle. Atrioventricular valve (AVV) area dynamics were classified into three categories according to the areal change pattern during systole in the normal group: Type-1: area decreases during systole; Type-2: area increases during systole; and Type-3: no significant areal change. The HLHS and RAI groups were subdivided into two subgroups according to the grade of AVVR: low-grade AVVR and high-grade AVVR, and the annular dynamics were compared between the groups.</p><p><b>Results:</b> Normal group was classified into the subgroups as follows: Type-1=22 (42%); Type-2=24 (45%); and Type-3=7 (13%). HLHS and RAI group was classified into the following subgroups: Type-1=4 (13%), Type-2=7 (24%), and Type-3=21 (65%). Type-3 was predominant in the HLHS and RAI groups (<i>p</i><0.01). The subdivided groups were similarly classified into low-grade AVVR group (n=16) and high-grade AVVR group (n=16). Type-3 was predominant in the high-grade AVVR group (<i>p</i><0.01).</p><p><b>Conclusions:</b> In patients with single ventricle associated with tricuspid valve or common AVV, significant valve incompetence was observed in those with reduced annular dynamics, suggesting the importance of annular function in the patients.</p>
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Echocardiography in congenital heart disease with left-to-right shunting
TOYONO Manatomo
Choonpa Igaku ( The Japan Society of Ultrasonics in Medicine ) 45 ( 5 ) 481 - 490 2018
Congenital heart disease is a common disorder. Ventricular septal defect and atrial septal defect are the most common pathology, comprising approximately 40% of cases of congenital heart disease. As in most types of congenital heart disease, echocardiography has become the keystone for precise diagnosis and determination of the direction of clinical care and approach to therapeutic intervention in these disorders. Thus, although the presence of ventricular septal defect or atrial septal defect is often easily detected, ideal echocardiographic evaluation and interpretation require that one has a detailed understanding of septal anatomy, the relationships of defects to other cardiovascular structures, and the impact of these defects on hemodynamics.
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Echocardiography in congenital heart disease with left-to-right shunting
TOYONO Manatomo
Choonpa Igaku ( The Japan Society of Ultrasonics in Medicine ) 45 ( 5 ) 481 - 490 2018
Congenital heart disease is a common disorder. Ventricular septal defect and atrial septal defect are the most common pathology, comprising approximately 40% of cases of congenital heart disease. As in most types of congenital heart disease, echocardiography has become the keystone for precise diagnosis and determination of the direction of clinical care and approach to therapeutic intervention in these disorders. Thus, although the presence of ventricular septal defect or atrial septal defect is often easily detected, ideal echocardiographic evaluation and interpretation require that one has a detailed understanding of septal anatomy, the relationships of defects to other cardiovascular structures, and the impact of these defects on hemodynamics.
◆Original paper【 display / non-display 】
◆Introduction and explanation【 display / non-display 】
◆International conference proceedings【 display / non-display 】
◆Other【 display / non-display 】
Books 【 display / non-display 】
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Congenital Heart Disease: Morphological and Functional Assessment
Senzaki H, Yasukochi S, Toyono M
Springer 2015.02 ISBN: 978-4-431-54355-8
Academic Awards Received 【 display / non-display 】
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Akita Medical School Award for Excellent Educator
2018.07.09
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2017.04 - 2020.03
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Grant-in-Aid for Scientific Research(S)
Project Year： 1997.04 - 1999.03
Presentations 【 display / non-display 】
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Mitral annulus velocities in children with left ventricular volume overload
Toyono M, Harada K, Yasuoka K
American Society of Echocardiography 11th Annual Scientific Sessions (Chicago) 2000.06 - 2000.06 American Society of Echocardiography
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The effects of supine bicycle exercise on the change of right ventricular pressure and function in children late after repair of tetralogy of Fallot
Toyono M, Harada K, Tamura M, Yasuoka K, Takada G
American College of Cardiology 50th Annual Scientific Session (Orlando) 2001.03 - 2001.03 American College of Cardiology
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Noninvasive assessment of the left anterior descending coronary artery flow reserve in Kawasaki disease during supine bicycle Doppler echocardiography
Toyono M, Harada K, Tamura M, Yasuoka K, Takada G
American College of Cardiology 50th Annual Scientific Session (Orlando) 2001.03 - 2001.03 American College of Cardiology
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Persistent ductal constriction during uterine life and left ventricular remodeling in neonatal rats by maternally administered indomethacin
Toyono M, Harada K, Oyama T, Tamura M, Yasuoka K, Takada G
American College of Cardiology 50th Annual Scientific Session (Orlando) 2001.03 - 2001.03 American College of Cardiology
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Noninvasive visualization and measurement of great cardiac vein flow by transthoracic Doppler echocardiography in normal children and children with left ventricular volume overload
Toyono M, Harada K, Tamura M, Yasuoka K, Takada G
American Society of Echocardiography 12th Annual Scientific Sessions (Seattle) 2001.06 - 2001.06 American Society of Echocardiography
Academic Activity 【 display / non-display 】
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2015.08-Now
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2015.08-Now
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2015.08-Now
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2013.08-Now
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2013.06-Now