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Induction of osteoclast-like cells derived from the synovial lavage fluids of patients with temporomandibular joint disorders
Takano H, Ariyoshi W, Kanno T, Fukuhara E, Ichimiya H, Matayoshi T, Goto T and Takahashi T
Osteoarthritis and cartilage. ; 15(3) : 291-299. 2007 15 ( 3 ) 291 - 299 2006年12月
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ニボルマブ投与後に多形紅斑重症型が生じた1例
鈴木 兼一郎, 髙野 裕史, 福地 峰世, 五十嵐 秀光, 今野 泰典, 福田 雅幸
日本口腔科学会雑誌 ( 特定非営利活動法人 日本口腔科学会 ) 72 ( 1 ) 20 - 25 2023年
Nivolumab is an anti-PD-1 antibody that is an immune checkpoint inhibitor that blocks PD-1/PD-L1 signals and exerts an antitumor effect. Immune checkpoint inhibitors including nivolumab are known to cause various immune-related adverse events including skin disorders. We report a case of erythema multiforme major （EM major） after nivolumab administration.
<br>A 66-year-old female with mandibular gingival cancer （cT4aN2cM0） underwent bilateral neck dissection and mandibular segmental resection in January 2019. After postoperative concurrent chemoradiation （cisplatin + radiation）, multiple lung metastases were diagnosed three months postoperatively, and nivolumab 240mg every two weeks was started. Pruritus of the eyes, erythema of the trunk and extremities, and erosion of the oral mucosa occurred after seven doses of nivolumab had been administered. She was referred to a dermatologist and was admitted to the hospital because of suspicion of Stevens–Johnson syndrome. The symptoms improved daily with Prednisolone administration, and she was discharged from the hospital four weeks later. The final diagnosis was EM major.
<br>Nivolumab is effective for head and neck cancers, but adverse events are more diverse than with conventional chemotherapy. Although most of the skin disorders are reported to be mild, it may be necessary to observe them carefully and be important to treat them in the early stage. -
及川 湧基, 五十嵐 秀光, 鈴木 兼一郎, 今野 泰典, 髙野 裕史, 福田 雅幸
日本口腔外科学会雑誌 ( 公益社団法人 日本口腔外科学会 ) 68 ( 2 ) 94 - 98 2022年02月
<p>Angiolipoma is a benign tumor that shows a mixture of adipose tissue and hemangioma-like lesion histologically. It frequently occurs in the trunk and limbs, and it is very rare in the lip. We report a case of angiolipoma of the upper lip. The patient was a 28-year-old woman who was referred to our hospital because of a mass in the right upper lip. A painless elastic-soft tumor was found under the mucosa of the right upper lip. The skin and mucosa just above the swelling was normal. MRI showed an unclearly demarcated lesion measuring 13 × 11 × 5 mm in the right upper lip with a mixed pattern of high and low intensity on T1- and T2-weighted images. An incisional biopsy was performed under local anesthesia, and the histopathological diagnosis was angiolipoma. Based on this diagnosis, the tumor was resected under general anesthesia. Immunohistochemical examination revealed CD31, CD34, α-SMA and VEGF positive cells in the tumor. There has been no recurrence one year after surgery.</p>
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Yusa K.
Applied Sciences (Switzerland) ( Applied Sciences (Switzerland) ) 11 ( 23 ) 2021年12月
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有馬 実咲, 桑島 精一, 福田 雅幸, 福地 峰世, 五十嵐 秀光, 高野 裕史
日本口腔外科学会雑誌 ( 社団法人 日本口腔外科学会 ) 67 ( 5 ) 281 - 285 2021年
<p>Ectopic impacted teeth are considered to be caused by congenital malposition of tooth germs, increased internal pressure from cysts, tumor growth, periodontal ligament traction, and rupture of the gubernacular cord. It often progresses asymptomatic, but has been reported to cause pain and infection. Here, we report a case of ectopic impacted tooth in which the mandibular horizontal impacted wisdom tooth migrated to the vicinity of the mandibular notch over 9 years.</p><p> A 42-year-old woman visited our department with the chief complaint of pain in the left mandible. Upon comparison with past radiographs, the left impacted mandibular wisdom tooth was found to have migrated to the mandibular notch over 9 years. We performed an ectopic impacted wisdom tooth extraction to improve the</p><p>pain.</p><p> Fragile soft tissue was found forward the tooth. Histopathological specimens showed no epithelial structure and numerous plasma cell infiltrates. Immunohistochemical staining was negative for cytokeratin. The cause of the migration was considered to be the gubernacular cord thickened by inflammation. After the operation, the pain disappeared, no relapse was observed, and the patient has shown good progress.</p>
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Igarashi H.
Oral Oncology ( Oral Oncology ) 108 2020年09月