研究等業績 - 原著論文 - 柴田 浩行
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Curcumin affects function of Hsp90 and drug efflux pump of Candida albicans
Yean Sheng Lee, Xinyue Chen, Tria Widiasih Widiyanto, Kanami Orihara, Hiroyuki Shibata, Susumu Kajiwara
Frontiers in Cellular and Infection Microbiology ( Frontiers in Cellular and Infection Microbiology ) 12 2022年09月 [査読有り]
研究論文（学術雑誌） 国内共著
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TGF-β and Cancer Immunotherapy
Takashi MaruYama, WanJun Chen, Hiroyuki Shibata
Biological and Pharmaceutical Bulletin ( Biological and Pharmaceutical Bulletin ) 45 ( 2 ) 155 - 161 2022年02月 [査読有り]
研究論文（学術雑誌） 国際共著
<p>The cytokine, transforming growth factor beta (TGF-β), has a history of more than 40 years. TGF-β is secreted by many tumor cells and is associated with tumor growth and cancer immunity. The canonical TGF-β signaling pathway, SMAD, controls both tumor metastasis and immune regulation, thereby regulating cancer immunity. TGF-β regulates multiple types of immune cells in tumor microenvironment, including T cells, natural killer (NK) cells, and macrophages. One of the main roles of TGF-β in the tumor microenvironment is the generation of regulatory T cells, which contribute to the suppression of anti-tumor immunity. Because cancer is one of the highest causes of death globally, the discovery of immune checkpoint inhibitors by Honjo and Allison in cancer immunotherapy earned a Nobel Prize in 2018. TGF-β also regulates the levels of immune checkpoints inhibitory receptors on immune cells. Immune checkpoints inhibitors are now being developed along with anti-TGF-β antibody and/or TGF-β inhibitors. More recently, chimeric antigen receptors (CARs) were applied to cancer immunity and tried to combine with TGF-β blockers.</p>
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Two Cases of ALK-Altered Cancers of Unknown Primary Diagnosed by Immunohistochemistry
Yoriko Kato, Kazuhiro Shimazu, Koji Fukuda, Taichi Yoshida, Daiki Taguchi, Hanae Shinozaki, Hiroshi Nanjyo, Hiroyuki Shibata
Case Reports in Oncology ( Case Reports in Oncology ) 15 ( 1 ) 21 - 26 2022年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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A novel Lynch syndrome pedigree bearing germ-line MSH2 missense mutation c.1808A>T (Asp603Val)
Risako Sekine, Kazuhiro Shimazu, Daisuke Nakano, Tatsuro Yamaguchi, Yusato Suzuki, Koji Fukuda, Taichi Yoshida, Daiki Taguchi, Katsunori Iijima, Hiroshi Nanjyo, Hiroyuki Shibata
Japanese journal of clinical oncology ( Japanese journal of clinical oncology ) 52 ( 1 ) 81 - 85 2022年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Hidekazu Shirota, Keigo Komine, Masanobu Takahashi, Shin Takahashi, Eisaku Miyauchi, Hidetaka Niizuma, Hiroshi Tada, Muneaki Shimada, Tetsuya Niihori, Yoko Aoki, Ikuko Sugiyama, Maako Kawamura, Jun Yasuda, Shuhei Suzuki, Takeshi Iwaya, Motonobu Saito, Tsuyoshi Saito, Hiroyuki Shibata, Toru Furukawa, Chikashi Ishioka
Cancer Medicine ( Cancer Medicine ) 12 ( 5 ) 6170 - 6181 2022年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Sudden and severe cardiotoxicity induced with pembrolizumab, its clinical course, therapeutic intervention, and outcome
Tomohiro Matsumoto, Koji Fukuda, Taichi Yoshida, Kazuhiro Shimazu, Daiki Taguchi, Hanae Shinozaki, Katsuhito Seki, Takayuki Yamanaka, Mako Ootaka, Hiroshi Nanjyo, Hiroyuki Watanabe, Hiroyuki Shibata
International Cancer Conference Journal 2022年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Cohort study of consistency between the compliance with guidelines for chemotherapy-induced nausea and vomiting and patient outcome.
Inoue M, Shoji M, Shindo N, Otsuka K, Miura M, Shibata H.
BMC Pharmacology & Toxicology 2015年03月 [査読有り]
研究論文（学術雑誌） 国内共著
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Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo.
Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hoshi Y, Kanda H, Oshima M, Iwabuchi Y, Shibata H.
Gastric Cancer 2014年10月 [査読有り]
研究論文（学術雑誌） 国内共著
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Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer.
Imai H, Soeda H, Komine K, Otsuka K, Shibata H.
BMC Palliative Care 2013年10月 [査読有り]
研究論文（学術雑誌） 国内共著
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Utility of Measuring Circulating Tumor Cell Counts to Assess the Efficacy of Treatment for Carcinomas of Unknown Primary Origin.
Komine K, Inoue M, Otsuka K, Fukuda K, Nanjo H, Shibata H.
ANTICANCER RESEARCH 2013年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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A Phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients.
Kanai M, Otsuka K, SatoM, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S, Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H.
Cancer Chemotherapy and Pharmacology 71 ( 6 ) 1521 - 1530 2013年03月 [査読有り]
研究論文（学術雑誌） 国内共著
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Outcomes of patients with stage ⅣA esophageal cancer (Japanese classification) treated with definitive chemoradiotherapy.
Anbai A, Koga M, Motoyama S, Jin M, Shibata H.
Japanese journal of radiology 31 ( 4 ) 270 - 276 2013年02月 [査読有り]
研究論文（学術雑誌） 国内共著
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Practical Utility of Circulating Tumour Cells as Biomarkers in Cancer Chemotherapy for Advanced Colorectal Cancer.
Otsuka K, Imai H, Soeda H, Komine K, Ishioka C, Shibata H.
ANTICANCER RESEARCH 33 ( 2 ) 625 - 629 2013年02月 [査読有り]
研究論文（学術雑誌） 国内共著
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The effect of XELOX plus bevacizumab on rectal hepatoid adenocarcinoma.
Otsuka K, Nanjo H, Soeda H, Shibata H.
International Cancer Conference Journal 2012年08月 [査読有り]
研究論文（学術雑誌） 国内共著
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The effect of XELOX plus bevacizumab on rectal hepatoid adenocarcinoma.
Otsuka K, Nanjo H, Soeda H, Shibata H.
International Cancer Conference Journal 2012年08月 [査読有り]
研究論文（学術雑誌） 国内共著
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Challenges in Establishing Potent Cancer Chemotherapy using Newly Synthesized 1,5-Diaryl-3-Oxo-1,4-Pentadiene Analogs of Curcumin.
Shibata H, Iwabuchi Y.
Medicinal Uses and Health Benefits 177 - 191 2012年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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Challenges in Establishing Potent Cancer Chemotherapy using Newly Synthesized 1,5-Diaryl-3-Oxo-1,4-Pentadiene Analogs of Curcumin.
Shibata H, Iwabuchi Y.
Medicinal Uses and Health Benefits 177 - 191 2012年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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Acquired/intratumor mutation of KRAS during metastatic progression of colorectal carcinogenesis.
Kazunori Otsuka*, Rika Satoyoshi*, Hiroshi Nanjo, Hideaki Miyazawa, Yuki Abe, Masamitsu Tanaka, Yuzo Yamamoto, Hiroyuki Shibata.
Oncology Letter 2012年03月 [査読有り]
研究論文（学術雑誌） 国内共著
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Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents for multiple myeloma with enhanced abilities.
Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata.
Anticancer Research 2011年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Curcumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis.
Atsuko Sato, Chieko Kudo, Hiroyuki Yamakoshi, Yoshihiko Uehara, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata.
Cancer Science 2011年02月 [査読有り]
研究論文（学術雑誌） 国内共著