研究等業績 - その他 - 栗山 正
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新規クルクミン類縁体を用いた血管新生抑制効果の検討(Anti-angiogenic potential of newly synthesized curcumin analog)
杉山 俊輔, 吉野 優樹, 田中 正光, 栗山 正, 岩渕 好治, 石岡 千加史, 柴田 浩行
日本癌学会総会記事 ( 日本癌学会 ) 72回 315 - 315 2013年10月
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Lipoma Preferred Partnerは肺がんの転移においてMMP15を介してN-cadherinの切断を制御する(Lipoma Preferred Partner regulates N-cadherin shedding by MMP15 during lung adenocarcinoma metastasis)
栗山 正, 矢野 聖二, 後藤 明輝, 田中 正光
日本癌学会総会記事 ( 日本癌学会 ) 72回 128 - 128 2013年10月
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PLEKHN1とガン細胞におけるEMT(上皮間葉系移行)の関連性について
辻正博, 栗山正, 本田耕平, 田中正光, 石川和夫
日本耳鼻咽喉科学会会報 116 ( 4 ) 2013年
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Ohta Kunimasa, Ito Ayako, Kuriyama Sei, Lupo Giuseppe, Nakayama Rika, Ohshima Naoko, Kosaka Mitsuko, Ohnuma Shin-ichi, Nakagawa Shinichi, Tanaka Hideaki
Mechanisms of Development ( ELSEVIER SCIENCE BV ) 126 S273 - S273 2009年 [査読有り]
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Molecular function of Tsukushi on neuronal stem cells
Ohta Kunimasa, Ito Ayako, Kuriyama Sei, Lupo Giuseppe, Nakayama Rika, Ohshima Naoko, Kosaka Mitsuko, Ohnuma Shin-ichi, Nakagawa Shinichi, Tanaka Hideaki
Neuroscience Research ( ELSEVIER IRELAND LTD ) 65 S91 - S91 2009年 [査読有り]
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Molecular analysis of neural crest migration
Sei Kuriyama, Roberto Mayor
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES ( ROYAL SOC ) 363 ( 1495 ) 1349 - 1362 2008年04月
The neural crest (NC) cells have been called the 'explorers of the embryos' because they migrate all over the embryo where they differentiate into a variety of diverse kinds of cells. In this work, we analyse the role of different molecules controlling the migration of NC cells. First, we describe the strong similarity between the process of NC migration and metastasis in tumour cells. The epithelial-mesenchymal transition process that both kinds of cells undergo is controlled by the same molecular machinery, including cadherins, connexins, Snail and Twist genes and matrix metalloproteases. Second, we analysed the molecular signals that control the patterned migration of the cephalic and trunk NC cells. Most of the factors described so far, such as Eph/ephrins, semaphorins/neuropilins and Slit/Robo, are negative signals that prohibit the migration of NC cells into target areas of the embryo. Finally, we analyse how the direction of migration is controlled by regulation of cell polarity and how the planar cell polarity or non-canonical Wnt signalling is involved in this process.
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Ohta Kunimasa, Ito Ayako, Kuriyama Sei, Nakayama Rika, Oshima Naoko, Kosaka Mitsuko, Ohnuma Shinichi, Nakagawa Shinichi, Tanaka Hideaki
Neuroscience Research 61 S42 2008年 [査読有り]
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Role of Wnt signaling in neural crest development: from induction to migration
Roberto Mayor, Helen Matthews, Lorena Marchant, Carlos Carmona-Fontaine, Sei Kuriyama
DEVELOPMENTAL BIOLOGY ( ACADEMIC PRESS INC ELSEVIER SCIENCE ) 306 ( 1 ) 318 - 319 2007年06月
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Tsukushi inhibits the proliferation of retinal stem/progenitor cells
Ohta Kunimasa, Ito Ayako, Kuriyama Sei, Ohnuma Shinichi, Kosaka Mitsuko, Nakagawa Shinichi, Tanaka H
Developmental Biology 306 ( 1 ) 391 2007年 [査読有り]
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Tsukushi inhibits proliferation of retinal stem cells by Wnt signalling inhibition
Ohta Kunimasa, Ito Ayako, Kuriyama Sei, Ohnuma Shin-Ichi, Kosaka Mitsuko, Nakagawa Shin-Ichi, Tanaka Hideaki
Neuroscience Research ( ELSEVIER IRELAND LTD ) 58 S56 - S56 2007年 [査読有り]
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The molecular function of Tsukushi in retinal progenitor cells
Kunimasa Ohta, Ayako Ito, Ryu Gejima, Sei Kuriyama, Mitsuyo Kosaka, Shin-ichi Nakagawa, Hideaki Tanaka
NEUROSCIENCE RESEARCH ( ELSEVIER IRELAND LTD ) 55 S53 - S53 2006年
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Tsukushi is involved in the primitive streak formation in cooperation with Vg1
K. Ohta, S. Kuriyama, T. Okafuji, R. Gejima, S. Ohnuma, H. Tanaka
MECHANISMS OF DEVELOPMENT ( ELSEVIER SCIENCE BV ) 122 S78 - S78 2005年09月
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Molecular cloning and characterization of equarin, a novel soluble molecule expressed with polarity at chick embryonic lens equator
H Mu, K Ohta, S Kuriyama, H Tanihara, H Tanaka
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE ( ASSOC RESEARCH VISION OPHTHALMOLOGY INC ) 44 U294 - U294 2003年05月
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水晶体発生に関連する新規な分泌型因子(Equarin)の遺伝子クローニングと機能解析
穆 紅, 太田 訓正, 栗山 正, 安田 邦雄, 谷原 秀信, 田中 英明
日本眼科学会雑誌 ( (公財)日本眼科学会 ) 107 ( 臨増 ) 338 - 338 2003年03月
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Xerl: a novel secretory protein expressed in eye and brain of Xenopus embryo
S Kuriyama, S Miyatani, T Kinoshita
MECHANISMS OF DEVELOPMENT ( ELSEVIER SCIENCE BV ) 93 ( 1-2 ) 233 - 237 2000年05月
A novel gene, Xerl (Xenopus EGF-like repeat with laminin-G domain protein) was isolated from a Xenopus head cDNA library prepared from tailbud. This gene encoded 779 amino acids including a potential signal sequence, twelve EGF-like repeats, a laminin-a domain, a RGD sequence and a VWF motif. In the EGF-like repeat and the laminin-G domain, Xerl showed similarity to those of Drosophila Crumbs, respectively. Zygotic expression of Xerl began at late gastrula, and increased through neurula up to the tailbud stage. In adult organs, Xerl was detected in brain and eye. Whole-mount in situ hybridization showed that Xerl expression occurred first in the anterior bilateral region of neurula and gradually localized to retina and forebrain and boundaries of midbrain and hindbrain. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.