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大学院医学系研究科(医学専攻等) 医学専攻 病態制御医学系 形態解析学・器官構造学講座 |
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Morphologic observation for anomalous patterns of the flexor carpi radialis muscle and atypical insertions: a proposal for a new classification
Zhou M, Ishizawa A, Akashi H, Suzuki R, Bando Y
Anatomical Science International ( Springer Japan ) 2022年07月 [査読有り]
研究論文(学術雑誌) 国内共著
In the present study, four types of variations of the flexor carpi radialis with accessory muscular bundles were classified depending on the origin of the accessory muscular bundle and relationships with the bicipital aponeurosis, biceps brachii, pronator teres, and coracobrachialis. Six types of insertions of the tendon of the flexor carpi radialis were also divided according to their inserted positions on the carpal and metacarpal bones. An accessory muscular bundle of the flexor carpi radialis was found in 4 (1 female and 3 males) of 68 cadavers (5.88%), with five examples in 136 arms (3.68%). It was bilateral in one cadaver and unilateral (two on the right and one on the left) in three. The insertion of the flexor carpi radialis tendon was not only on the proximal surface of the base of the second metacarpal bone but also on the third metacarpal bone, the tubercle of the trapezium, and the scaphoid. These findings and classifications are important in anatomical education, and have important significances in clinical diagnosis and therapies.
Keywords: Accessory muscular bundle; Flexor carpi radialis muscle; Human anatomy; Tendon of flexor carpi radialis muscle; Variation. -
Different localization of ATP sensitive K+ channel subunits in rat testis.
周 明、賀 恵経、田中 理、関口雅樹、河原克雅、阿部 寛
The Anatomical Record 294 ( 4 ) 729 - 737 2011年04月 [査読有り]
研究論文(学術雑誌) 国内共著
ATP sensitive K+ (KATP) channels are important linkage for cell membrane excitability with the cellular bioenergetic state. These channels are in vivo composed of pore-forming subunits and regulatory subunits. The present study was focused on the cellular expression and localization of these subunits in rat testis. RT-PCR analysis showed that rat testis contains five KATP channel subunits, Kir6.1, Kir6.2, SUR1, SUR2A and SUR2B. Immunoblot assay showed that proteins of Kir6.1, Kir6.2, SUR2A and SUR2B were expressed in rat testis. Immunohistochemistry revealed that the spermatogenic cells, Sertoli cells and Leydig cells show positive staining for these KATP channel subunits with different localizations, implying these subunits play roles during spermatogenesis. A double immunofluorescence labeling study demonstrated that Kir6.1 does not colocalize with SUR2A or SUR2B, but Kir6.2 colocalizes with SUR2B in the head cap or acrosome of spermatids, suggesting that the KATP channel in spermatids is formed by Kir6.2 and SUR2B.
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Localization of ATP sensitive K+ channel subunits in rat submandibular gland
周 明、賀 恵経、平野真紀、関口雅樹、田中 理、河原克雅、阿部 寛
Journal of Histochemistry & Cytochemistry 58 ( 6 ) 499 - 507 2010年06月 [査読有り]
研究論文(学術雑誌) 国内共著
ATP sensitive K+ (KATP) channel subunits were investigated in rat submandibular gland (SMG). RT-PCR detected the presence of mRNA transcripts of the Kir6.1, Kir6.2, SUR2A and SUR2B in the SMG, while SUR1 mRNA was barely detected. Western blot analysis provided the evidence that these four KATP channel subunits expressed in rat SMG. Immunostaining detected that these four KATP channel subunits are widely distributed in myoepithelial cells, epithelial cells of intercalated ducts, granular convoluted tubules, striated ducts, and excretory ducts with different intensities. Immunofluorescence double staining showed that Kir6.1 or Kir6.2 colocalized with SUR2A in the myoepithelial cells, granular convoluted tubule, striated duct, and excretory duct. Kir6.1 or Kir6.2 also colocalized with SUR2B mainly in the duct system such as the granular convoluted tubules, striated ducts, and excretory ducts. Taken together with these results, the KATP channels in SMG may be consisted of Kir6.1, Kir6.2, SUR2A and SUR2B, with various combinations of colocalization with each other, and may play important roles in rat SMG during the salivary secretion.
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周 明、賀 恵経、田中 理、鈴木良地、関口雅樹、安岡由紀子、河原克雅、伊藤英晃、阿部 寛
The Tohoku Journal of Experimental Medicine 214 ( 3 ) 247 - 256 2008年03月 [査読有り]
研究論文(学術雑誌) 単著
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Localization of sulphonylurea receptor subunits, SUR2A and SUR2B, in rat heart
周 明、賀 恵経、鈴木良地、柳 克祥、田中 理、関口雅樹、伊藤英晃、河原克雅、阿部 寛
Journal of Histochemistry and Cytochemistry 55 ( 8 ) 795 - 804 2007年08月 [査読有り]
研究論文(学術雑誌) 国内共著
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An anomalous case of the flexor carpi radialis with an excessive muscular bundle
Zhou M.
Anatomical Science International ( Anatomical Science International ) 95 ( 2 ) 293 - 296 2020年03月