ZHOU Ming

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Bioregulatory Medicine  Department of Anatomy

Graduate School 【 display / non-display

  • 1993.02
    -
    1996.04

    Showa University  Graduate School, Division of Medicine  Doctor's Course  Completed

Campus Career 【 display / non-display

  • 2009.04
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Bioregulatory Medicine   Assistant Professor  

 

Published Papers 【 display / non-display

  • Different localization of ATP sensitive K+ channel subunits in rat testis.

    周 明、賀 恵経、田中 理、関口雅樹、河原克雅、阿部 寛

    The Anatomical Record   294 ( 4 ) 729 - 737   2011.04  [Refereed]

    Domestic Co-author

    ATP sensitive K+ (KATP) channels are important linkage for cell membrane excitability with the cellular bioenergetic state. These channels are in vivo composed of pore-forming subunits and regulatory subunits. The present study was focused on the cellular expression and localization of these subunits in rat testis. RT-PCR analysis showed that rat testis contains five KATP channel subunits, Kir6.1, Kir6.2, SUR1, SUR2A and SUR2B. Immunoblot assay showed that proteins of Kir6.1, Kir6.2, SUR2A and SUR2B were expressed in rat testis. Immunohistochemistry revealed that the spermatogenic cells, Sertoli cells and Leydig cells show positive staining for these KATP channel subunits with different localizations, implying these subunits play roles during spermatogenesis. A double immunofluorescence labeling study demonstrated that Kir6.1 does not colocalize with SUR2A or SUR2B, but Kir6.2 colocalizes with SUR2B in the head cap or acrosome of spermatids, suggesting that the KATP channel in spermatids is formed by Kir6.2 and SUR2B.

    DOI

  • Localization of ATP sensitive K+ channel subunits in rat submandibular gland

    周 明、賀 恵経、平野真紀、関口雅樹、田中 理、河原克雅、阿部 寛

    Journal of Histochemistry & Cytochemistry   58 ( 6 ) 499 - 507   2010.06  [Refereed]

    Domestic Co-author

    ATP sensitive K+ (KATP) channel subunits were investigated in rat submandibular gland (SMG). RT-PCR detected the presence of mRNA transcripts of the Kir6.1, Kir6.2, SUR2A and SUR2B in the SMG, while SUR1 mRNA was barely detected. Western blot analysis provided the evidence that these four KATP channel subunits expressed in rat SMG. Immunostaining detected that these four KATP channel subunits are widely distributed in myoepithelial cells, epithelial cells of intercalated ducts, granular convoluted tubules, striated ducts, and excretory ducts with different intensities. Immunofluorescence double staining showed that Kir6.1 or Kir6.2 colocalized with SUR2A in the myoepithelial cells, granular convoluted tubule, striated duct, and excretory duct. Kir6.1 or Kir6.2 also colocalized with SUR2B mainly in the duct system such as the granular convoluted tubules, striated ducts, and excretory ducts. Taken together with these results, the KATP channels in SMG may be consisted of Kir6.1, Kir6.2, SUR2A and SUR2B, with various combinations of colocalization with each other, and may play important roles in rat SMG during the salivary secretion.

    DOI

  • Localization of the sulphonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epithelium

    周 明、賀 恵経、田中 理、鈴木良地、関口雅樹、安岡由紀子、河原克雅、伊藤英晃、阿部 寛

    The Tohoku Journal of Experimental Medicine   214 ( 3 ) 247 - 256   2008.03  [Refereed]

    Single author

  • Localization of sulphonylurea receptor subunits, SUR2A and SUR2B, in rat heart

    周 明、賀 恵経、鈴木良地、柳 克祥、田中 理、関口雅樹、伊藤英晃、河原克雅、阿部 寛

    Journal of Histochemistry and Cytochemistry   55 ( 8 ) 795 - 804   2007.08  [Refereed]

    Domestic Co-author

    DOI

  • Expression of ATP sensitive K+ channel subunit Kir6.1 in rat kidney

    周、明、 賀、恵経、鈴木良地、田中、理 関口雅樹、安岡由紀子、河原克雅、伊藤英晃、阿部 寛 

    European Journal of Histochemistry   51 ( 1 ) 43 - 52   2007.03  [Refereed]

    Domestic Co-author

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