TAKAHASHI Tsutomu

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Organ Function-Oriented Medicine  Department of Pediatrics
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Research Interests 【 display / non-display 】

  • 先天代謝異常症

  • 小児内分泌学

  • 小児科学

  • 小児遺伝学

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Graduating School 【 display / non-display 】

  • 1979.04
    -
    1986.03

    Akita University   Faculty of Medicine   Graduated

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Graduate School 【 display / non-display 】

  • 　
    -
    1993.03

    Akita University  Graduate School, Division of Medical Science  Doctor's Course  Completed

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Campus Career 【 display / non-display 】

  • 2009.04
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Organ Function-Oriented Medicine   Professor  

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Research Achievements 【 display / non-display 】

    ◆Original paper【 display / non-display 】

  • Evidence for the association of ultraviolet-C and H(2)O(2)-induced apoptosis with acid sphingomyelinase activation

    Komatsu M, Takahashi T, Abe T, Takahashi I, Ida H, Takada G

    Biochim Biophys Acta   1533 ( 1 ) 47 - 54   2001.01  [Refereed]

    Research paper (journal)  

  • A new locus for a dominant form of multinodular goiter on 3q26.1-q26.3

    Takahashi T， et al.

    BBRC   284   2001.01  [Refereed]

    Research paper (journal)   Domestic Co-author

  • Active hypothalamus-pituitary-gonadal axis in an infant with adrenal hypoplasia congenita

    Takahashi T， et al.

    J Pediatr   130   1997.01  [Refereed]

    Research paper (journal)   Domestic Co-author

  • Identification and expression of five mutations in the human acid sphingomyelinase gene causing types A and B Niemann-Pick disease. Molecular evidence for genetic heterogeneity in the neuronopathic and non-neuronopathic forms.

    Takahashi T, Suchi M, Desnick RJ, Takada G, Schuchman EH

    J Biol Chem   267 ( 18 ) 12552 - 8   1992.01  [Refereed]

    Research paper (journal)  

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    ◆Other【 display / non-display 】

  • Development of a Diagnostic Screening Strategy for Niemann–Pick Diseases Based on Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analyses of <i>N</i>-Palmitoyl-<i>O</i>-phosphocholine-serine and Sphingosylphosphorylcholine

    Biological and Pharmaceutical Bulletin ( The Pharmaceutical Society of Japan )  43 ( 9 ) 1398 - 1406   2020.09

    DOI PubMed CiNii Research

  • Neonatal meningitis and ventriculitis caused by <i>Enterobacter cloacae</i> after surgery for jejunal atresia

    Takahashi Kiichi, Adachi Hiroyuki, Ito Masato, Kato Akie, Hebiguchi Taku, Takahashi Tsutomu

    Journal of Japan Society of Perinatal and Neonatal Medicine ( Japan Society of Perinatal and Neonatal Medicine )  56 ( 2 ) 335 - 342   2020

    <p> <i>Enterobacter cloacae</i>, a gram-negative bacillus, is a member of the normal gut microbiota; however, it is often highly virulent in neonates. Notably, neurological sequelae of meningitis may occur despite the administration of systemic antibiotics. We describe a female neonate weighing 2,309 g born at 33 weeks and 4 days of gestation who developed <i>E. cloacae</i> meningitis and ventriculitis after undergoing surgery for jejunal atresia. She developed severe cerebral necrosis despite treatment with high-dose carbapenem. We speculated that bacterial translocation of <i>E. cloacae</i> secondary to surgical injury caused meningitis and ventriculitis. <i>E. cloacae</i> can rapidly colonize the gut in neonates soon after birth; therefore, early identification of this highly pathogenic organism is important to initiate prompt and optimal infection control measures, particularly in neonates undergoing gastrointestinal surgery.</p>

    DOI CiNii Research

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