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Funasaka H.
Eneurologicalsci ( Eneurologicalsci ) 40 2025年09月
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Sanpei Y.
Internal Medicine ( Internal Medicine ) 64 ( 12 ) 1906 - 1910 2025年
<p>We herein report a 48-year-old man with neurosyphilis manifesting as limbic encephalitis, initially suspected to be autoimmune limbic encephalitis. The patient exhibited rapid behavioral changes, and magnetic resonance imaging showed high-intensity lesions in both medial temporal lobes. The diagnosis was based on symptoms, cerebrospinal fluid abnormalities, and positive serum tests for syphilis. Notably, the cerebrospinal fluid immunoglobulin G index was markedly elevated (4.91). This case highlights the diagnostic challenges in differentiating neurosyphilis from autoimmune limbic encephalitis, given the increasing atypical presentation. A markedly elevated immunoglobulin G index may serve as a valuable diagnostic indicator for neurosyphilis in such cases. </p>
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Sanpei Y.
Muscle and Nerve ( Muscle and Nerve ) 70 ( 4 ) 761 - 765 2024年10月
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Hanazono A.
Eneurologicalsci ( Eneurologicalsci ) 36 2024年09月
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Matsuda M.
Brain and Development ( Brain and Development ) 46 ( 1 ) 73 - 74 2024年01月