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大学院医学系研究科（医学専攻等） 附属感染制御総合センター |
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松永 哲郎 (マツナガ テツロウ)
MATSUNAGA Tetsuro
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職務経歴（学内） 【 表示 ／ 非表示 】
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2025年04月-継続中
秋田大学 大学院医学系研究科（医学専攻等） 附属感染制御総合センター 教授
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2024年04月-2025年03月
秋田大学 感染統括制御・疫学・分子病態研究センター 教授
職務経歴（学外） 【 表示 ／ 非表示 】
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2025年04月-継続中
秋田大学 大学院医学系研究科附属 感染制御総合センター 感染分子病態研究部門（改組） 教授
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2025年02月-継続中
島津製作所×東北大学 超硫黄生命科学共創研究所, 特任教授（兼任） Research Professor
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2024年04月-継続中
東北大学 大学院医学系研究科 環境医学分野 非常勤講師
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2024年04月-継続中
秋田大学 感染統括制御・疫学・分子病態研究センター 感染分子病態研究部門 教授
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2024年03月
東北大学 大学院医学系研究科 環境医学分野 講師
研究分野 【 表示 ／ 非表示 】
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ライフサイエンス / 応用微生物学
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ライフサイエンス / ウイルス学
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ライフサイエンス / 細菌学
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ライフサイエンス / 医化学
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ライフサイエンス / 細菌学
研究等業績 【 表示 ／ 非表示 】
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Supersulfides contribute to joint homeostasis and bone regeneration
Maemura M.
Redox Biology ( Redox Biology ) 81 103545 - 103545 2025年04月 [査読有り]
研究論文（学術雑誌）
The physiological functions of supersulfides, inorganic and organic sulfides with sulfur catenation, have been extensively studied. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulfide synthase. This study aimed to investigate the role of supersulfides in joint homeostasis and bone regeneration. Using Cars2AINK/+ mutant mice, in which the KIIK motif of CARS2 essential for supersulfide production was replaced with AINK, we evaluated the role of supersulfides in fracture healing and cartilage homeostasis during osteoarthritis (OA). Tibial fracture surgery was performed on the wild-type (Cars2+/+) and Cars2AINK/+ mice littermates. Bulk RNA-seq analysis for the osteochondral regeneration in the fracture model showed increased inflammatory markers and reduced osteogenic factors, indicative of impaired bone regeneration, in Cars2AINK/+ mice. Destabilization of the medial meniscus (DMM) surgery was performed to produce the mouse OA model. Histological analyses with Osteoarthritis Research Society International and synovitis scores revealed accelerated OA progression in Cars2AINK/+ mice compared with that in Cars2+/+ mice. To assess the effects of supersulfides on OA progression, glutathione trisulfide (GSSSG) or saline was periodically injected into the mouse knee joints after the DMM surgery. Thus, supersulfides derived from CARS2 and GSSSG exogenously administered significantly inhibited inflammation and lipid peroxidation of the joint cartilage, possibly through suppression of ferroptosis, during OA development. This study represents a significant advancement in understanding anti-inflammatory and anti-oxidant functions of supersulfides in skeletal tissues and may have a clinical relevance for the bone healing and OA therapeutics.
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Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases
Tianli Zhang, Touya Toyomoto, Tomohiro Sawa, Takaaki Akaike, Tetsuro Matsunaga
Microbiology and Immunology 2025年02月 [査読有り]
研究論文（学術雑誌）
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Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer.
Seji Asamitsu, Yohei Ozawa, Hiroshi Okamoto, Seiryo Ogata, Tetsuro Matsunaga, Jun Yoshitake, Kazuki Fusegawa, Yusuke Taniyama, Chiaki Sato, Hirotaka Ishida, Takaaki Abe, Hozumi Motohashi, Takaaki Akaike, Takashi Kamei
Cancer science 2025年02月 [査読有り]
研究論文（学術雑誌）
Early detection of esophageal cancer is essential for esophagogastroduodenoscopy and histopathological diagnosis. However, endoscopic examinations are sometimes invasive, which limits their clinical application and compliance, and traditional blood tumor markers are unsuitable for cancer screening. The current study aimed to evaluate the usefulness of sulfur metabolites as new biomarkers for esophageal cancer using blood samples and exhaled breath condensate (EBC), which can be readily obtained and is non-invasive. We collected EBC and plasma samples from 50 patients with esophageal cancer and 30 healthy controls. Sulfur metabolome analysis using tandem mass spectrometry was performed to compare the metabolic profile between the two groups. Supersulfide metabolic profiles were different between the two cohorts. Supersulfide metabolome analysis showed that cysteine hydropersulfide (CysSSH) and homocysteine hydropersulfide (HomoCysSSH) were increased in the plasma of patients with esophageal cancer. Elevated levels of HomoCysSSH could distinguish patients with esophageal cancer from healthy subjects (area under the curve [AUC]: 0.93, sensitivity: 89%, specificity: 96%). Interestingly, we also detected an elevation of supersulfides in the EBC analysis. CysSSH levels significantly increased in the EBC recovered from patients with esophageal cancer (AUC: 0.71, sensitivity: 60%, specificity: 96%). In addition, the observed level was correlated with that of HomoCysSSH in the plasma (r = 0.27). Supersulfides, such as CysSSH and HomoCysSSH, are potential biomarkers for detecting esophageal cancer. CysSSH from EBC may serve as a valuable non-invasive biomarker with similar detection ability but with superior precision and convenience compared with the currently available blood biomarkers.
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The Therapeutic Potential of Supersulfides in Oxidative Stress-Related Diseases
Yuexuan Pan, Tetsuro Matsunaga, Tianli Zhang, Takaaki Akaike
Biomolecules ( Biomolecules ) 15 ( 2 ) 2025年01月 [査読有り]
研究論文（学術雑誌）
Oxidation-reduction (redox) reactions are fundamental to sustaining life, with reactive oxygen and nitrogen species playing pivotal roles in cellular signaling and homeostasis. However, excessive oxidative stress disrupts redox balance, contributing to a wide range of diseases, including inflammatory and pulmonary disorders, neurodegeneration, and cancer. Although numerous antioxidant therapies have been developed and tested for oxidative stress-related diseases, their clinical efficacy remains limited. Here, we introduce the emerging concept of 'supersulfides', a class of redox molecule species with unique antioxidant and nucleophilic properties, which have recently been recognized as crucial regulators of cellular redox homeostasis. Unlike traditional antioxidants, supersulfides offer novel mechanisms of action that directly target the underlying processes of oxidative stress. This review summarizes current knowledge on supersulfides, highlighting their roles in oxidative stress and associated diseases, as well as the mechanisms underlying oxidative stress-related pathology. The therapeutic potential of synthetic supersulfides for treating oxidative stress-related diseases is also discussed. A comprehensive understanding of the molecular and cellular basis of redox biology can help to guide the development of innovative redox-based therapeutic strategies aimed at preventing and treating diseases associated with disturbed redox regulation.
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Supersulfide formation in the sinus mucosa of chronic rhinosinusitis
Suzuki J.
Laryngoscope Investigative Otolaryngology ( Laryngoscope Investigative Otolaryngology ) 9 ( 4 ) e1261 2024年08月 [査読有り]
研究論文（学術雑誌）
OBJECTIVES: Disruption of the oxidative stress defense system is involved in developing various diseases. Sulfur compounds such as glutathione (GSH) and cysteine (CysSH) are representative antioxidants in the body. Recently, supersulfides, including reactive persulfide and polysulfide species, have gained attention as potent antioxidants regulating oxidative stress and redox signaling. However, their involvement in the pathogenesis of chronic rhinosinusitis (CRS) remains unclear. METHODS: To clarify the changes in sulfur compounds within the sinus mucosa of each CRS subtype, we measured sulfur compound levels in the sinus mucosa of control individuals (n = 9), patients with eosinophilic CRS (ECRS) (n = 13), and those with non-ECRS (nECRS) (n = 11) who underwent sinus surgery using mass spectrometry. RESULTS: GSH and CysSH levels were significantly reduced, and the glutathione disulfide (GSSG)/GSH ratio, an oxidative stress indicator, was increased in patients with ECRS. Despite the absence of notable variations in supersulfides, patients with ECRS and nECRS exhibited a significant reduction in glutathione trisulfide (GSSSG), which serves as the precursor for supersulfides. CONCLUSIONS: This study is the first quantitative assessment of supersulfides in normal and inflamed sinus mucosa, suggesting that sulfur compounds contribute to the pathogenesis of CRS. LEVEL OF EVIDENCE: N/A.
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Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases
Zhang T.
Microbiology and Immunology ( Microbiology and Immunology ) 69 ( 4 ) 191 - 202 2025年04月 [査読有り]
Supersulfides are molecular species characterized by catenated sulfur moieties, including low-molecular-weight and protein-bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein stabilization, and antiviral defense. Recent studies highlight their regulatory effects on pattern-recognition receptors (PRRs) and associated signaling pathways-such as nucleotide oligomerization domain-like receptor signaling, toll-like receptor signaling, and type I interferon receptor signaling-critical for innate immunity and inflammatory responses. Dysregulation of these pathways is implicated in a heterogeneous group of autoinflammatory diseases, including inflammasomopathies, relopathies, and type I interferonopathies, respectively. Notably, both endogenous and synthetic supersulfide donors have recently shown promising inhibitory effects on PRR signaling, offering their potential as targeted therapies for managing autoinflammatory conditions. This review summarizes the fundamental biology of supersulfides and typical autoinflammatory diseases, focusing on their roles in innate immune and inflammatory responses, while exploring their therapeutic potential in these diseases.
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New aspects of redox signaling mediated by supersulfides in health and disease
Akaike T.
Free Radical Biology and Medicine ( Free Radical Biology and Medicine ) 222 539 - 551 2024年09月 [査読有り]
Oxygen molecules accept electrons from the respiratory chain in the mitochondria and are responsible for energy production in aerobic organisms. The reactive oxygen species formed via these oxygen reduction processes undergo complicated electron transfer reactions with other biological substances, which leads to alterations in their physiological functions and cause diverse biological and pathophysiological consequences (e.g., oxidative stress). Oxygen accounts for only a small proportion of the redox reactions in organisms, especially under aerobic or hypoxic conditions but not under anaerobic and hypoxic conditions. This article discusses a completely new concept of redox biology, which is governed by redox-active supersulfides, i.e., sulfur-catenated molecular species. These species are present in abundance in all organisms but remain largely unexplored in terms of redox biology and life science research. In fact, accumulating evidence shows that supersulfides have extensive redox chemical properties and that they can be readily ionized or radicalized to participate in energy metabolism, redox signaling, and oxidative stress responses in cells and in vivo. Thus, pharmacological intervention and medicinal modulation of supersulfide activities have been shown to benefit the regulation of disease pathogenesis as well as disease control.
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A persulfide shield: An endogenous reactive sulfur species in the forefront in the electrophile detoxification pathway
Hisyam Abdul Hamid, Tsuyoshi Takata, Tetsuro Matsunaga, Takaaki Akaike
Sulfurtransferases ( Elsevier ) 101 - 117 2023年01月 [査読有り]
The research area of persulfides and polysulfides has piqued the interest of many scientists worldwide. Numerous attempts have been made to understand the nature of reactive sulfur species particularly biological polysulfides and supersulfides (RSnSH). Appreciable amounts of the endogenous RSnSH cysteine hydropersulfide were discovered in various organisms. The moonlighting function of mitochondrial cysteinyl-tRNA synthetase as a persulfide synthase was also discovered. This enzyme was thought to be the major player in the biogenesis of endogenous low-molecular-weight RSnSH, and, as one important function, it integrates RSnSH into proteins. Several studies indicated that RSnSH is highly relevant to various biological functions, from cell signaling to electrophilic regulation. In this review, we focus on highlighting the potential roles of endogenous RSnSH as part of the critical biological detoxification mechanism.
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新興感染症菌Helicobacter cinaediの骨髄内の潜伏感染と細胞内寄生性の分子機構の解明
松永 哲郎, 西村 明, 守田 匡伸, 井田 智章, 津々木 博康, 澤 智裕, 河村 好章, 赤池 孝章
日本細菌学雑誌 ( 日本細菌学会 ) 74 ( 1 ) 104 - 104 2019年03月
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新興感染症菌Helicobacter cinaediの骨髄内における潜伏感染と細胞内寄生性の解析
松永哲郎, 西村明, 守田匡伸, 藤井重元, 井田智章, 澤智裕, 河村好章, 赤池孝章
日本細菌学雑誌(Web) ( 日本細菌学会 ) 73 ( 1 ) 117(J‐STAGE) - 117 2018年02月
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Book（書籍） 【 表示 ／ 非表示 】
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呼吸器ウイルス感染症と呼気オミックス
松永哲郎, 張田力, 赤池孝章 ( 担当： その他 )
臨床免疫・アレルギー科 2024年09月
その他
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呼吸器ウイルス感染症と呼気オミックス
松永哲郎, 張 田力, 赤池孝章 ( 担当： その他 )
臨床免疫・アレルギー科 2024年09月
その他
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超硫黄分子による呼吸器疾患制御と呼気オミックス
緒方星陵, 松永哲郎, 赤池孝章 ( 担当： その他 )
呼吸器疾患最新の治療 2025-2026 2024年
その他
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新型コロナウイルス感染症と酸化ストレス
松永 哲郎 ( 担当： その他 )
酸化ストレスの医学 改訂第３版 2024年
その他
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【環境化学物質と生体応答】環境物質と生命の起源：超硫黄生物学プロローグ
松永 哲郎, 赤池 孝章 ( 担当： その他 )
メディカルサイエンスダイジェスト・ニューサイエンス社 2023年01月
その他
産業財産権 【 表示 ／ 非表示 】
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空気中の微粒子捕集装置および空気中の微粒子捕集方法
特許
特願 特願2023-037618
出願日： 2023年03月10日
高奈 秀匡, 中嶋 智樹, 太田 信, 赤池 孝章, 安西 眸, 松永 哲郎
科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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超硫黄分子によるエネルギー代謝と酸化ストレスシグナル機能の解明
基盤研究(S)
研究期間: 2024年04月 - 2029年03月 代表者: 赤池 孝章, 三木 裕明, 村上 一馬, 松永 哲郎
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超硫黄分子によるエネルギー代謝と酸化ストレスシグナル機能の解明
基盤研究(S)
研究期間: 2024年04月 - 2029年03月 代表者: 赤池 孝章, 三木 裕明, 村上 一馬, 松永 哲郎
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超硫黄分子によるエネルギー代謝と酸化ストレスシグナル機能の解明
基盤研究(S)
研究期間: 2024年04月 - 2029年03月 代表者: 赤池 孝章, 三木 裕明, 村上 一馬, 松永 哲郎
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超硫黄分子の代謝制御メカニズムの解明
基盤研究(C)
研究期間: 2023年04月 - 2026年03月 代表者: 守田 匡伸, 松永 哲郎, 井田 智章
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超硫黄分子の代謝制御メカニズムの解明
基盤研究(C)
研究期間: 2023年04月 - 2026年03月 代表者: 守田 匡伸, 松永 哲郎, 井田 智章
学会等発表 【 表示 ／ 非表示 】
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環化超硫黄分子の生体内大量生成とミトコンドリアエネルギー代謝機能の解明
松永哲郎, Uladimir Barayeu, Minkyung Jung, 緒方星陵, 高田 剛, 守田匡伸, 吉沢道人, 本橋ほづみ, 赤池孝章
第24回分子予防環境医学研究会大会 2025年03月 - 2025年03月
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Supersulfides-mediated mitochondrial energy metabolism in mammals
Tetsuro Matsunaga
Nitric Oxide Gordon Research Conference; Nitric Oxide and Sulfide in Redox Signaling and Medicine (Ventura, California) 2025年02月 - 2025年02月
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環化超硫黄分子 (S8) を介したミトコンドリアエネルギー代謝機構の解明
松永哲郎, Uladzimir Barayeu, Minkyung Jung, Lorenzo Catti, 清水隆之, 緒方星陵, 張 田力, 高田 剛, 守田匡伸, 増田真二, 吉沢道人, 本橋ほづみ, 赤池孝章
学術変革領域研究（A）「新興硫黄生物学が拓く生命原理変革（硫黄生物学）」 第4回領域会議（滋賀） 2024年12月 - 2024年12月
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超硫黄分子の高感度質量分析技術と定量解析
松永哲郎, 赤池孝章
CREST「多細胞」第6回領域会議（分担発表）（沼津） 2024年12月 - 2024年12月
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超硫黄分子に依存した哺乳類のミトコンドリアエネルギー代謝機構の解明
松永 哲郎, 赤池 孝章 [招待有り]
第43回日本認知症学会学術集会（郡山） 2024年11月 - 2024年11月
担当経験のある授業科目(学外) 【 表示 ／ 非表示 】
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微生物学
2013年学校法人加寿美学園 熊本中央高等学校
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微生物学
2013年熊本労災看護専門学校
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微生物学
2012年学校法人 有明学園 有明高等学校（熊本県）
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ISTU環境保健医学（1単元、日本語）
東北大学・医学系研究科
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ISTU環境保健医学（1単元、英語）
東北大学・医学系研究科
メディア報道 【 表示 ／ 非表示 】
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超硫黄分子の新知見！ 超硫黄分子が拓く 骨再生・変形性関節症の新たな治療戦略
2025年02月27日
昭和大学プレスリリース・研究成果
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高い抗酸化作用を持つ超硫黄分子の特性解明へ、老化を防ぐ医薬品・食品の開発に貢献 「島津製作所×東北大学 超硫黄生命科学共創研究所」を設置
2024年03月13日
東北大学プレスリリース・研究成果
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「超硫黄分子」の寿命延長効果を発見 ～新たなサプリメントや健康法の開発に期待～
2024年01月19日
東北大学プレスリリース・研究成果
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東北大学流体科学研究所とMeiji Seikaファルマ 空気中のウイルス捕集・計数に関する共同実証試験を開始
2023年10月05日
東北大学プレスリリース・研究成果
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超硫黄分子による心機能の制御メカニズムを解明 虚血性心疾患や難治性心不全などの診断・治療への応用に期待
2023年08月21日
東北大学プレスリリース・研究成果