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松永 哲郎 (マツナガ テツロウ)
MATSUNAGA Tetsuro
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職務経歴（学内） 【 表示 ／ 非表示 】
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2025年04月-継続中
秋田大学 大学院医学系研究科（医学専攻等） 附属感染制御総合センター 教授
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2024年04月-2025年03月
秋田大学 感染統括制御・疫学・分子病態研究センター 教授
職務経歴（学外） 【 表示 ／ 非表示 】
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2025年04月-継続中
秋田大学 大学院医学系研究科附属 感染制御総合センター 感染分子病態研究部門（改組） 教授
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2025年02月-継続中
島津製作所×東北大学 超硫黄生命科学共創研究所, 特任教授（兼任） Research Professor
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2024年04月-継続中
東北大学 大学院医学系研究科 環境医学分野 非常勤講師
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2024年04月-継続中
秋田大学 感染統括制御・疫学・分子病態研究センター 感染分子病態研究部門 教授
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2024年03月
東北大学 大学院医学系研究科 環境医学分野 講師
研究分野 【 表示 ／ 非表示 】
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ライフサイエンス / 応用微生物学
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ライフサイエンス / ウイルス学
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ライフサイエンス / 細菌学
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ライフサイエンス / 医化学
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ライフサイエンス / 細菌学
研究等業績 【 表示 ／ 非表示 】
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Kabongo A.T.
Free Radical Biology Medicine ( Free Radical Biology Medicine ) 246 646 - 659 2026年03月
研究論文（学術雑誌）
Adults of Schistosoma mansoni reside in the mesenteric veins, where they are naturally exposed to high levels of hydrogen sulfide (H2S). S. mansoni and other intestinal parasites have adapted to this sulfide-rich environment, but the evolved mechanisms to metabolize sulfide remain unelucidated. Here we reveal that the putative sulfide:quinone oxidoreductase (SQOR) encoded by S. mansoni is indeed an SQOR, catalyzing the first step of sulfide metabolism. We demonstrated that S. mansoni SQOR (SmSQOR) is expressed in eggs, cercaria and adult stages and localized in the mitochondria. The reaction catalyzed by SmSQOR was investigated using sulfane sulfur probe 4 (SSP4) and shown to require the co-presence of sulfide, quinone, and a sulfur acceptor, indicating a quaternary complex-mediated mechanism. Unlike human and bacterial SQORs, purified SmSQOR could not reduce quinones in the presence of sulfide alone unless sulfite, cyanide, or L-cysteine (but not coenzyme A or glutathione) was provided as the sulfur acceptor. In the presence of these sulfur acceptors, SmSQOR formed a long-lived charge-transfer (CT) complex, a transient electronically coupled association between electron donor and acceptor, as indicated by a broad band around 637-755 nm in the spectrum, which was associated with a partial loss of enzyme activity. Moreover, residues critical for CT complex formation and SQOR catalysis were identified. Using SSP4, we also demonstrated that SQOR was active in S. mansoni adult, egg, and cercaria stages. Taken together, these features suggest that metabolism of sulfide proceeds differently in S. mansoni than in humans.
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Takamori S.
Antioxidants ( Antioxidants ) 15 ( 1 ) 2026年01月
研究論文（学術雑誌）
Hepatic ischemia-reperfusion injury (IRI) is a critical clinical condition associated with liver transplantation and acute liver injury. This study investigated the role of sulfide quinone oxidoreductase (SQOR) and its downstream product, supersulfides, in hepatic IRI. C57BL/6NJ mice were subjected to 45 min of partial hepatic ischemia, followed by reperfusion lasting 4 h. Control of shRNA mediated knockdown of SQOR expressing adeno-associated viral vectors were administered 3 weeks prior to liver ischemia. In the shRNA-mediated knockdown of SQOR group, the hydro-trisulfide donor sodium trisulfide was administered daily for 1 week prior to the induction of liver ischemia. SQOR played a crucial protective role during hepatic IRI by facilitating electron transport to the mitochondrial respiratory chain and maintaining the oxidized and reduced nicotinamide adenine dinucleotide ratio. Administration of sodium trisulfide, exhibited protective effects against hepatic IRI. Sodium trisulfide restored the oxidized and reduced nicotinamide adenine dinucleotide ratio, reduced oxidative stress, and preserved the expression of key enzymes involved in the sulfide oxidation pathway. SQOR and supersulfides contribute to hepatic protection against IRI, likely through their potent antioxidative and redox-regulating functions, and highlight sodium trisulfide as a potential therapeutic agent.
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Kazuo Umezawa, Satomi Asai, Ryosuke Tanitsu, Tetsuro Matsunaga, Masayoshi Hashimoto, Dai Yoshizawa, Kentaro Wakamatsu, Toshio Kawahara, Takaaki Akaike, Kyoko Hayashi
All Life ( Informa UK Limited ) 18 ( 1 ) 2025年09月 [査読有り]
研究論文（学術雑誌）
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Supersulfides contribute to joint homeostasis and bone regeneration
Maemura M.
Redox Biology ( Redox Biology ) 81 103545 - 103545 2025年04月 [査読有り]
研究論文（学術雑誌）
The physiological functions of supersulfides, inorganic and organic sulfides with sulfur catenation, have been extensively studied. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulfide synthase. This study aimed to investigate the role of supersulfides in joint homeostasis and bone regeneration. Using Cars2AINK/+ mutant mice, in which the KIIK motif of CARS2 essential for supersulfide production was replaced with AINK, we evaluated the role of supersulfides in fracture healing and cartilage homeostasis during osteoarthritis (OA). Tibial fracture surgery was performed on the wild-type (Cars2+/+) and Cars2AINK/+ mice littermates. Bulk RNA-seq analysis for the osteochondral regeneration in the fracture model showed increased inflammatory markers and reduced osteogenic factors, indicative of impaired bone regeneration, in Cars2AINK/+ mice. Destabilization of the medial meniscus (DMM) surgery was performed to produce the mouse OA model. Histological analyses with Osteoarthritis Research Society International and synovitis scores revealed accelerated OA progression in Cars2AINK/+ mice compared with that in Cars2+/+ mice. To assess the effects of supersulfides on OA progression, glutathione trisulfide (GSSSG) or saline was periodically injected into the mouse knee joints after the DMM surgery. Thus, supersulfides derived from CARS2 and GSSSG exogenously administered significantly inhibited inflammation and lipid peroxidation of the joint cartilage, possibly through suppression of ferroptosis, during OA development. This study represents a significant advancement in understanding anti-inflammatory and anti-oxidant functions of supersulfides in skeletal tissues and may have a clinical relevance for the bone healing and OA therapeutics.
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Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases
Tianli Zhang, Touya Toyomoto, Tomohiro Sawa, Takaaki Akaike, Tetsuro Matsunaga
Microbiology and Immunology 2025年02月 [査読有り]
研究論文（学術雑誌）
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Cyclo-octa-sulfur contributes to energy metabolism in mitochondria
Tetsuro Matsunaga, Uladzimir Barayeu, Masanobu Morita, Seiryo Ogata, Minkyung Jung, Tianli Zhang, Tsuyoshi Takata, Michito Yoshizawa, Hozumi Motohashi, Takaaki Akaike
FREE RADICAL BIOLOGY AND MEDICINE 233 2025年06月
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Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases
Zhang T.
Microbiology and Immunology ( Microbiology and Immunology ) 69 ( 4 ) 191 - 202 2025年04月 [査読有り]
Supersulfides are molecular species characterized by catenated sulfur moieties, including low-molecular-weight and protein-bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein stabilization, and antiviral defense. Recent studies highlight their regulatory effects on pattern-recognition receptors (PRRs) and associated signaling pathways-such as nucleotide oligomerization domain-like receptor signaling, toll-like receptor signaling, and type I interferon receptor signaling-critical for innate immunity and inflammatory responses. Dysregulation of these pathways is implicated in a heterogeneous group of autoinflammatory diseases, including inflammasomopathies, relopathies, and type I interferonopathies, respectively. Notably, both endogenous and synthetic supersulfide donors have recently shown promising inhibitory effects on PRR signaling, offering their potential as targeted therapies for managing autoinflammatory conditions. This review summarizes the fundamental biology of supersulfides and typical autoinflammatory diseases, focusing on their roles in innate immune and inflammatory responses, while exploring their therapeutic potential in these diseases.
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Supersulfide donors and their therapeutic targets in inflammatory diseases
Zhang T.
Frontiers in Immunology ( Frontiers in Immunology ) 16 1581385 - 1581385 2025年
Inflammation is one defense mechanism of the body that has multiple origins, ranging from physical agents to infectious agents including viruses and bacteria. The resolution of inflammation has emerged as a critical endogenous process that protects host tissues from prolonged or excessive inflammation, which can become chronic. Failure of the inflammation resolution is a key pathological mechanism that drives the progression of numerous inflammatory diseases. Owing to the various side effects of currently available drugs to control inflammation, novel therapeutic agents that can prevent or suppress inflammation are needed. Supersulfides are highly reactive and biologically potent molecules that function as antioxidants, redox regulators, and modulators of cell signaling. The catenation state of individual sulfur atoms endows supersulfides with unique biological activities. Great strides have recently been made in achieving a molecular understanding of these sulfur species, which participate in various physiological and pathological pathways. This review mainly focuses on the anti-inflammatory effects of supersulfides. The review starts with an overview of supersulfide biology and highlights the roles of supersulfides in both immune and inflammatory responses. The various donors used to generate supersulfides are assessed as research tools and potential therapeutic agents. Deeper understanding of the molecular and cellular bases of supersulfide-driven biology can help guide the development of innovative therapeutic strategies to prevent and treat diseases associated with various immune and inflammatory responses.
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New aspects of redox signaling mediated by supersulfides in health and disease
Akaike T.
Free Radical Biology and Medicine ( Free Radical Biology and Medicine ) 222 539 - 551 2024年09月 [査読有り]
Oxygen molecules accept electrons from the respiratory chain in the mitochondria and are responsible for energy production in aerobic organisms. The reactive oxygen species formed via these oxygen reduction processes undergo complicated electron transfer reactions with other biological substances, which leads to alterations in their physiological functions and cause diverse biological and pathophysiological consequences (e.g., oxidative stress). Oxygen accounts for only a small proportion of the redox reactions in organisms, especially under aerobic or hypoxic conditions but not under anaerobic and hypoxic conditions. This article discusses a completely new concept of redox biology, which is governed by redox-active supersulfides, i.e., sulfur-catenated molecular species. These species are present in abundance in all organisms but remain largely unexplored in terms of redox biology and life science research. In fact, accumulating evidence shows that supersulfides have extensive redox chemical properties and that they can be readily ionized or radicalized to participate in energy metabolism, redox signaling, and oxidative stress responses in cells and in vivo. Thus, pharmacological intervention and medicinal modulation of supersulfide activities have been shown to benefit the regulation of disease pathogenesis as well as disease control.
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A persulfide shield: An endogenous reactive sulfur species in the forefront in the electrophile detoxification pathway
Hisyam Abdul Hamid, Tsuyoshi Takata, Tetsuro Matsunaga, Takaaki Akaike
Sulfurtransferases ( Elsevier ) 101 - 117 2023年01月 [査読有り]
The research area of persulfides and polysulfides has piqued the interest of many scientists worldwide. Numerous attempts have been made to understand the nature of reactive sulfur species particularly biological polysulfides and supersulfides (RSnSH). Appreciable amounts of the endogenous RSnSH cysteine hydropersulfide were discovered in various organisms. The moonlighting function of mitochondrial cysteinyl-tRNA synthetase as a persulfide synthase was also discovered. This enzyme was thought to be the major player in the biogenesis of endogenous low-molecular-weight RSnSH, and, as one important function, it integrates RSnSH into proteins. Several studies indicated that RSnSH is highly relevant to various biological functions, from cell signaling to electrophilic regulation. In this review, we focus on highlighting the potential roles of endogenous RSnSH as part of the critical biological detoxification mechanism.
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Book（書籍） 【 表示 ／ 非表示 】
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呼気および空間オミックスによる無侵襲な新興再興感染症検知システムの開発
松永哲郎, 張田力, 赤池孝章 ( 担当： その他 )
アレルギーリウマチ性疾患 2026年01月
その他
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呼気および空間オミックスによる無侵襲な新興再興感染症検知システムの開発
松永哲郎, 張田力, 赤池孝章 ( 担当： その他 )
「BIO Clinica」11月臨時増刊・北隆館 2025年11月
その他
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呼吸器ウイルス感染症と呼気オミックス
松永哲郎, 張 田力, 赤池孝章 ( 担当： その他 )
臨床免疫・アレルギー科 2024年09月
その他
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呼吸器ウイルス感染症と呼気オミックス
松永哲郎, 張田力, 赤池孝章 ( 担当： その他 )
臨床免疫・アレルギー科 2024年09月
その他
産業財産権 【 表示 ／ 非表示 】
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空気中の微粒子捕集装置および空気中の微粒子捕集方法
特許
特願 特願2023-037618
出願日： 2023年03月10日
高奈 秀匡, 中嶋 智樹, 太田 信, 赤池 孝章, 安西 眸, 松永 哲郎
科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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呼気および空間オミックスによる無侵襲な新興再興感染症検知システムの開発
基盤研究(B)
研究期間: 2025年04月 - 2028年03月 代表者: 松永 哲郎
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呼気および空間オミックスによる無侵襲な新興再興感染症検知システムの開発
基盤研究(B)
研究期間: 2025年04月 - 2028年03月 代表者: 松永 哲郎
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呼気および空間オミックスによる無侵襲な新興再興感染症検知システムの開発
基盤研究(B)
研究期間: 2025年04月 - 2028年03月 代表者: 松永 哲郎
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超硫黄分子によるエネルギー代謝と酸化ストレスシグナル機能の解明
基盤研究(S)
研究期間: 2024年04月 - 2029年03月 代表者: 赤池 孝章, 三木 裕明, 村上 一馬, 松永 哲郎
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超硫黄分子によるエネルギー代謝と酸化ストレスシグナル機能の解明
基盤研究(S)
研究期間: 2024年04月 - 2029年03月 代表者: 赤池 孝章, 三木 裕明, 村上 一馬, 松永 哲郎
学会等発表 【 表示 ／ 非表示 】
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Supersulfides-mediated mitochondrial energy metabolism and breath omics analysis
Tetsuro Matsunaga
第99回日本薬理学会年会（仙台） スポンサードシンポジウム１ 学術変革領域（A）「新興硫黄生物学が拓く生命原理変革」共催 カルコゲン超分子の生理機能とその医療応用 2026年03月 - 2026年03月
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呼気および空間オミックスによる無侵襲な新興再興感染症検知システムの開発
松永哲郎, 井田智章, 緒方星陵, 張 田力, 守田匡伸, 本橋ほづみ, 赤池孝章
第99回日本細菌学会総会（広島） 2026年03月 - 2026年03月
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呼気および空間オミックスによる無侵襲な新興•再興感染症検知システムの開発と応用
松永哲郎, 井田智章, 緒方星陵, Jung Minkyung, 高田 剛, 田, 守田匡伸, 本橋ほづみ, 赤池孝章
第25回分子予防環境医学研究会（東京） 2026年02月 - 2026年02月
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環化超硫黄分子 (S8) の選択的な生体内生成とミトコンドリアエネルギー代謝機構の解明
松永 哲郎
学術変革領域(A)「硫黄生物学」第5回領域会議（宮城蔵王） 2026年01月 - 2026年01月
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超硫黄分子の高感度質量分析技術の開発と定量解析（分担代理発表）
松永 哲郎, 赤池孝章
CREST「多細胞」FY2025 領域会議（名古屋） 2025年12月 - 2025年12月
担当経験のある授業科目(学外) 【 表示 ／ 非表示 】
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微生物学
2013年学校法人加寿美学園 熊本中央高等学校
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微生物学
2013年熊本労災看護専門学校
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微生物学
2012年学校法人 有明学園 有明高等学校（熊本県）
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ISTU環境保健医学（1単元、日本語）
東北大学・医学系研究科
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ISTU環境保健医学（1単元、英語）
東北大学・医学系研究科
メディア報道 【 表示 ／ 非表示 】
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超硫黄分子の新知見！ 超硫黄分子が拓く 骨再生・変形性関節症の新たな治療戦略
2025年02月27日
昭和大学プレスリリース・研究成果
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高い抗酸化作用を持つ超硫黄分子の特性解明へ、老化を防ぐ医薬品・食品の開発に貢献 「島津製作所×東北大学 超硫黄生命科学共創研究所」を設置
2024年03月13日
東北大学プレスリリース・研究成果
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「超硫黄分子」の寿命延長効果を発見 ～新たなサプリメントや健康法の開発に期待～
2024年01月19日
東北大学プレスリリース・研究成果
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東北大学流体科学研究所とMeiji Seikaファルマ 空気中のウイルス捕集・計数に関する共同実証試験を開始
2023年10月05日
東北大学プレスリリース・研究成果
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超硫黄分子による心機能の制御メカニズムを解明 虚血性心疾患や難治性心不全などの診断・治療への応用に期待
2023年08月21日
東北大学プレスリリース・研究成果