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附属病院 耳鼻咽喉科 |
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TIGIT mediates activation-induced cell death of ILC2sduring chronic airway allergy
Yamada T.
Journal of Experimental Medicine ( Journal of Experimental Medicine ) 220 ( 7 ) 2023年07月
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特集 花粉症診療は変わったか? 花粉症治療に関する最近の話題 非鎮静性抗ヒスタミン薬の役割
山田 武千代, 宮部 結, 富澤 宏基, 山田 俊樹
JOHNS ( 東京医学社 ) 38 ( 1 ) 41 - 46 2022年01月
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Trained innate lymphoid cells in allergic diseases
Ebihara T.
Allergology International ( Allergology International ) 70 ( 2 ) 174 - 180 2021年04月
<p>Group 2 innate lymphoid cells (ILC2s) reside in peripheral tissues such as the lungs, skin, nasal cavity, and gut and provoke innate type 2 immunity against allergen exposure, parasitic worm infection, and respiratory virus infection by producing T<sub>H</sub>2 cytokines. Recent advances in understanding ILC2 biology revealed that ILC2s can be trained by IL-33 or allergic inflammation, are long-lived, and mount memory-like type 2 immune responses to any other allergens afterwards. In contrast, IL-33, together with retinoic acid, induces IL-10-producing immunosuppressive ILC2s. In this review, we discuss how the allergic cytokine milieu and other immune cells direct the generation of trained ILC2s with immunostimulatory or immunosuppressive recall capability in allergic diseases and infections associated with type 2 immunity. The molecular mechanisms of trained immunity by ILCs and the physiological relevance of trained ILC2s are also discussed.</p>
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A case of rhinogenic ophthalmic artery pseudoaneurysm
Yamada T.
Practica Oto-Rhino-Laryngologica ( Practica Oto-Rhino-Laryngologica ) 112 ( 1 ) 25 - 31 2019年01月
<p>Ophthalmic artery pseudoaneurysm is a rare vascular lesion. Herein, we describe a rare case of an infectious pseudoaneurysm caused by a frontal sinus cyst. An 87-year-old man diagnosed as having orbital cellulitis was admitted to our hospital. Paranasal sinus CT imaging showed a frontal sinus cyst and subperiosteal abscess. Emergency endoscopic sinus surgery was performed under local anesthesia. The frontal sinus was filled with viscous pus and the dura mater was exposed. Thereafter, although the fever resolved, the patient continued to have persistent left-sided exophthalmos, and a residual subperiosteal abscess was suspected. Direct orbital puncture of the subperiosteal abscess was performed, but arterial blood was drawn instead of pus. At this point, a pseudoaneurysm was suspected and a contrast-enhanced CT confirmed ophthalmic artery pseudoaneurysm. Intravascular treatment, including arterial embolization was considered, but endovascular treatment of a pseudoaneurysm carries a high risk if the ophthalmic artery is involved. Therefore, the ophthalmic artery pseudoaneurysm was treated conservatively, and the exophthalmos gradually improved. A repeat CT conducted about 3 months after the onset confirmed disappearance of the pseudoaneurysm.</p>
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科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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アレルギー性鼻炎患者における活性化2型自然リンパ球細胞死の影響に関する研究
基盤研究(C)
研究期間: 2023年04月 - 2025年03月
鼻アレルギーにおいて2型自然リンパ球(ILC2)の関与が指摘されている。ILC2は、組織に常在し、IL-5やIL-13を産生することによりアレルギー
炎症を誘導するが一度活性化したILC2の運命決定機構は不明である。我々は、独自の細胞系譜解析により、過剰な活性化により免疫チェックポ
イント分子の一つであるTIGITを発現したILC2は細胞死へと向かうという現象を発見した。また、慢性アレルギー炎症においてTIGITを阻害する
と、ILC2の細胞死が抑制され、アレルギー炎症が増悪することがわかった。本研究では、活性化ILC2細胞死の作用機序と慢性アレルギー疾患に
おける意義を明らかにする。