研究等業績 - 原著論文 - 鄭 松伊
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Kinoshita F.
PLoS ONE ( PLoS ONE ) 18 ( 10 October ) 2023年10月 [査読有り]
研究論文（学術雑誌） 国内共著
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Relationship between lower urinary tract symptoms and frailty.
Yusuke Ozaki, Shingo Hatakeyama, Atsushi Imai, Jung Songee, Osamu Soma, Kai Ozaki, Naoki Fujita, Teppei Okamoto, Hiromichi Iwamura, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama
International journal of urology : official journal of the Japanese Urological Association 2023年04月 [査読有り]
研究論文（学術雑誌） 国内共著
OBJECTIVE: To elucidate the relationship between frailty and lower urinary tract symptoms (LUTS). METHODS: We longitudinally evaluated the temporal changes and the relationships between frailty and LUTS in 247 community-dwelling adults (45 years or older) at baseline and at a 5-year follow-up. We used the Fried phenotype (phenotype-based frailty), 5-item modified frailty index (5i-mFI; comorbidity-based frailty), and frailty discriminant score (comprehensive frailty assessment) to evaluate frailty. LUTS were evaluated using the international prostate symptom score (IPSS) and overactive bladder symptom score (OABSS). RESULTS: We analyzed 247 participants with a median age of 60 years. The median IPSS and OABSS were significantly increased over the 5 years. The proportion of frail individuals did not increase significantly over the 5 years. Of the three frailty assessment tools, the 5i-mFI score significantly increased between 2014 and 2019. Multiple linear regression analyses showed that the 5i-mFI score was significantly associated with the severity of LUTS in 2014 to 5i-mFI in 2019 but not with 5i-mFI in 2014 to the severity of LUTS in 2019. CONCLUSION: The effect of LUTS on frailty might be greater than the effect of frailty on LUTS. Further large-scale studies are needed to elucidate the relationship between LUTS and frailty.
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Body Compression Corrective Garment and Eating Behavioural Change for Weight Reduction: The Mutsu City Randomised Controlled Trial.
Akira Kanda, Yoshikuni Sugimura, Hideki Ohishi, Satoru Tatebayashi, Kaori Sawada, Kyi Mar Wai, Kei Nishiguchi, Asano Tanabu, Songee Jung, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara
Healthcare (Basel, Switzerland) 11 ( 7 ) 2023年03月 [査読有り]
研究論文（学術雑誌） 国内共著
Affordable and accessible behaviour-based interventions that do not overwhelm or demoralise overweight/obese individuals are needed. Combining clothing with behaviour change techniques might be an option. This is because clothing is a social norm, and clothing and motivation for weight loss are associated with the common desire to look better. Therefore, we conducted a single-blind randomised controlled trial to examine the effect of an intervention that combined behaviour change techniques, including simplified goal setting and self-monitoring, with a body compression corrective garment (BCCG), which exerts continuous but minimal tactile pressure on the hips and abdomen. We enrolled healthy community-dwelling adults with a body mass index ≥ 25 kg/m2 and assigned 35 and 34 participants to the intervention and control groups, respectively. The reduction in body weight was 1.3 kg more in the intervention group than in the control group after the 12-week intervention period (p < 0.05, repeated-measures mixed model). In addition, eating behaviour and body appreciation showed significant improvement in the intervention group compared with the control group. Our newly developed intervention improved eating behaviour and body appreciation and reduced the body weight of overweight/obese participants. Wearing a BCCG seems to facilitate behavioural changes and lead to weight loss.
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Nobuo Fuke, Takahiro Yamashita, Sunao Shimizu, Mai Matsumoto, Kaori Sawada, Songee Jung, Itoyo Tokuda, Mina Misawa, Shigenori Suzuki, Yusuke Ushida, Tatsuya Mikami, Ken Itoh, Hiroyuki Suganuma
Metabolites ( MDPI AG ) 13 ( 2 ) 250 - 250 2023年02月 [査読有り]
研究論文（学術雑誌） 国内共著
The influx of intestinal bacteria-derived lipopolysaccharide (LPS) into the blood has attracted attention as a cause of diseases. The aim of this study is investigating the associations between the influx of LPS, dietary factors, gut microbiota, and health status in the general adult population. Food/nutrient intake, gut microbiota, health status and plasma LPS-binding protein (LBP; LPS exposure indicator) were measured in 896 residents (58.1% female, mean age 54.7 years) of the rural Iwaki district of Japan, and each correlation was analyzed. As the results, plasma LBP concentration correlated with physical (right/left arms’ muscle mass [β = −0.02, −0.03]), renal (plasma renin activity [β = 0.27], urine albumin creatinine ratio [β = 0.50]), adrenal cortical (cortisol [β = 0.14]), and thyroid function (free thyroxine [β = 0.05]), iron metabolism (serum iron [β = −0.14]), and markers of lifestyle-related diseases (all Qs < 0.20). Plasma LBP concentration were mainly negatively correlated with vegetables/their nutrients intake (all βs ≤ −0.004, Qs < 0.20). Plasma LBP concentration was positively correlated with the proportion of Prevotella (β = 0.32), Megamonas (β = 0.56), and Streptococcus (β = 0.65); and negatively correlated with Roseburia (β = −0.57) (all Qs < 0.20). Dietary factors correlated with plasma LBP concentration correlated with positively (all βs ≥ 0.07) or negatively (all βs ≤ −0.07) the proportion of these bacteria (all Qs < 0.20). Our results suggested that plasma LBP concentration in the Japanese general adult population was associated with various health issues, and that dietary habit was associated with plasma LBP concentration in relation to the intestinal bacteria.
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Kyota Ishibashi, Eiji Sasaki, Daisuke Chiba, Tetsushi Oyama, Seiya Ota, Hikaru Ishibashi, Yuji Yamamoto, Eiichi Tsuda, Kaori Sawada, Songee Jung, Yasuyuki Ishibashi
BMC Musculoskeletal Disorders ( Springer Science and Business Media LLC ) 23 ( 1 ) 2022年11月 [査読有り]
研究論文（学術雑誌） 国内共著
Abstract
Background
Knee osteoarthritis (OA) has enormous medical and socioeconomic burdens, which early diagnosis and intervention can reduce. We investigated the influence of knee effusion on the progression of knee OA in patients with early knee OA.
Methods
A total of 404 participants without radiographic knee OA were assessed from a 3-year longitudinal analysis. Participants were classified into non-OA and early knee OA groups. The effusion area (mm<sup>2</sup>) was quantified using ultrasonography. Receiver operating characteristic and logistic regression analyses were performed.
Results
At the 3-year follow-up, 114 of 349 knees (32%) had progressed from non-OA and 32 of 55 knees (58%) had progressed from early knee OA to radiographic knee OA. Logistic regression analysis showed that female sex (odds ratio [OR] 3.36, 95% confidence interval [CIs] 2.98–5.42), early knee OA (OR 2.02, 95% CI 1.08–3.75), body mass index (OR 1.11, 95% CI 1.02–1.19), and effusion area (OR 1.01, 95% CI 1.01–1.02) were significantly correlated with knee OA progression. Women who were overweight (body mass index ≥ 25 kg/m<sup>2</sup>) with more severe effusion had a higher risk of OA progression (area under the curve = 0.691, OR = 6.00) compared to those not overweight (area under the curve = 0.568, OR = 1.91).
Conclusion
Knee effusion may be an indicator of the progression of early-stage knee OA. -
Tetsushi Oyama, Kanichiro Wada, Kazushige Koyama, Gentaro Kumagai, Sunao Tanaka, Toru Asari, Atsushi Imai, Teppei Okamoto, Shingo Hatakeyama, Songee Jung, Yoshikuni Sugimura, Chikara Ohyama, Yasuyuki Ishibashi
PLOS ONE ( Public Library of Science (PLoS) ) 17 ( 8 ) e0271479 - e0271479 2022年08月 [査読有り]
研究論文（学術雑誌） 国内共著
This study aimed to investigate the relationship between the cross-sectional area of the dural sac (DCSA) and lower urinary tract symptoms (LUTS). This study included 270 Japanese participants from a community health check-up in 2016. Overactive bladder (OAB) was diagnosed during the assessment of LUTS. The smallest DCSA of each participant was defined as the minimum DCSA (mDCSA). The cutoff size of the mDCSA in OAB was evaluated using receiver operating characteristic analysis. Multiple logistic regression analyses were performed to identify the independent risk factors for OAB, and a scoring system was developed for estimating these. The prevalence of OAB was 11.1%. Age and low back pain visual analogue scale (LBP VAS) scores were significantly higher, and the mean mDCSA was significantly lower in participants with OAB than in those without. The cutoff size of mDCSA in OAB was 69 mm<sup>2</sup>. There were significant correlations between OAB and age, LBP VAS score, and mDCSA<70 mm<sup>2</sup>. Lumbar spinal stenosis (LSS) should be considered a cause of LUTS when mDCSA is <69 mm<sup>2</sup>. Assessing the mDCSA with age and LBP VAS score was more valuable in detecting LUTS in LSS than the mDCSA alone.
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The influence of gut microbiome on progression of overactive bladder symptoms: a community-based 3-year longitudinal study in Aomori, Japan.
Yoshiharu Okuyama, Teppei Okamoto, Daichi Sasaki, Kai Ozaki, Jung Songee, Shingo Hatakeyama, Tatsuya Mikami, Chikara Ohyama
International urology and nephrology 54 ( 1 ) 9 - 16 2022年01月 [査読有り]
研究論文（学術雑誌） 国内共著
PURPOSE: To assess the influence of gut microbiome on overactive bladder (OAB) symptoms progression. METHODS: This was a 3-year longitudinal study, Hirosaki in Japan. We assessed OAB symptoms and reviewed the medication records of each subject in 2016. We extracted 16S rRNA genes from fecal samples and analyzed gut microbiomes via next-generation sequencing. We evaluated the changes in urinary urgency (UU) and/or urgent urinary incontinence (UUI) from 2016 to 2019. We defined UU/UUI-progression as exacerbation of UU and/or UUI. We compared the clinical backgrounds and microbiota structure between UU/UUI-progression subjects and non-progression (controls). We assessed the impact of gut microbiome on the UU/UUI-progression via multivariate logistic regression analyses. RESULTS: Of 669 subjects, 126 were UU/UUI-progression subjects. These subjects had a higher age and prevalence of proton pump inhibitor (PPI) use (14% vs. 5.4%, P = 0.003), irritable bowel syndrome, sleep disturbance, and metabolic syndrome than those without. We found the different microbiota structures between subjects with UU/UUI-progression and those without. A higher relative abundance of genus Streptococcus (harmful bacterial genus for human health) appeared in UU/UUI-progression subjects (3.8% vs. 2.3%, P < 0.001). Multivariate analysis revealed that age ≥ 65 years, current smoking, sleep disturbance, metabolic syndrome, and genus Streptococcus (Odds ratio: 1.05, P = 0.029) were independent risk factors for UU/UUI-progression. PPI use turned to be a significant risk factor on a multivariate analysis without including genus Streptococcus. CONCLUSIONS: Gut microbiome might be associated with a risk for OAB symptoms progression. PPI use might cause gut dysbiosis and increase this risk.
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Shiori Miura, Akira Sasaki, Shuya Kasai, Takayuki Sugawara, Yasunori Maeda, Shinichi Goto, Takashi Kasai, Nami Shimizume, Songee Jung, Takuro Iwane, Ken Itoh, Atsushi Matsubara
Journal of Human Genetics ( Springer Science and Business Media LLC ) 67 ( 6 ) 369 - 375 2022年01月 [査読有り]
研究論文（学術雑誌） 国内共著
Abstract
Age-related hearing loss (ARHL) is a complex multifactorial disorder. Studies in animals, including mitochondria-mutator mice, and in human suggest that oxidative stress and mitochondrial disturbance play an important role in the pathoetiology of ARHL. Mitochondrial DNA (mtDNA) haplogroups are populations with genetically similar traits, and they have been reported to affect the mitochondrial function of oxidative phosphorylation. To gain further insights into the relationships between mitochondrial haplotypes and the susceptibility to cochlear aging, in this study, we aimed to elucidate how the differences in mtDNA haplogroups may affect ARHL development in Japanese general population. We focused on early onset ARHL, as the same mtDNA haplogroup can show either a negative or positive effect on systemic co-morbidities of ARHL that appear later in life. A total of 1167 participants of the Iwaki Health Promotion Project were surveyed in 2014, and 12 major haplotype groups (D4a, D4b, D5, G1, G2, M7a, M7b, A, B4, B5, N9, and F) were selected for the analysis. A total of 698 subjects aged 30 to 65 years were included in the statistical analysis, and the hearing loss group consisted of 112 males (40.3%) and 111 females (26.4%). Multiple logistic regression analysis showed that the male subjects belonging to haplogroup A had a significantly increased risk of hearing loss, whereas the female subjects belonging to haplogroup N9 had a significantly decreased risk of hearing loss. These results suggested that the mtDNA haplogroup may be an indicator for future risk of morbidity associated with ARHL. -
Application of state-space model with skew-t measurement noise to blood test value prediction
Takanori Hasegawa, Rui Yamaguchi, Masanori Kakuta, Masataka Ando, Jung Songee, Itoyo Tokuda, Koichi Murashita, Seiya Imoto
Applied Mathematical Modelling ( Elsevier BV ) 100 365 - 378 2021年12月 [査読有り]
研究論文（学術雑誌） 国内共著
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Association between Visceral Fat and Brain Structural Changes or Cognitive Function
Naoki Ozato, Shinnichiro Saitou, Tohru Yamaguchi, Mitsuhiro Katashima, Mina Misawa, Songee Jung, Kenta Mori, Hiromitsu Kawada, Yoshihisa Katsuragi, Tatsuya Mikami, Shigeyuki Nakaji
Brain Sciences ( {MDPI} {AG} ) 11 ( 8 ) 1036 - 1036 2021年08月 [査読有り]
研究論文（学術雑誌） 国内共著
Visceral fat accumulation is an independent risk factor for cardiovascular disease and mortality. Visceral fat is a causal risk factor for hypertension and type 2 diabetes, which was reported as one of the risk factors for dementia. Visceral fat areas (VFA) might be clinically important to prevent dementia; however, the association between VFA and cognitive function in the elderly remains unknown. We aimed to evaluate the association between brain structural abnormalities using magnetic resonance imaging (MRI) and VFA, and the association between cognitive function and VFA, in the elderly. A total of 2364 healthy individuals were enrolled, and we excluded those diagnosed with dementia. Participants were divided into a high-VFA and a low-VFA group based on median VFA. The high-VFA group had significantly lower cognitive function than the low-VFA group (p = 0.025), after adjustment for related factors using a linear regression model. Regarding brain structure in MRI, VFA remained significantly associated with white matter lesions (odds ratio (OR), 1.90; 95% confidence interval (1.33-2.70); adjusted p < 0.001) and perivascular space (OR, 1.28; 95% confidence interval (1.02-1.61); adjusted p = 0.033). Further follow-up studies are needed, but reducing visceral fat might be important, not only to prevent cardiovascular disease but also to prevent dementia.
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Association between mild cognitive impairment and lumbar degenerative disease in a Japanese community: A cross-sectional study.
Kazushige Koyama, Kanichiro Wada, Gentaro Kumagai, Hitoshi Kudo, Sunao Tanaka, Toru Asari, Songee Jung, Masataka Ando, Yasuyuki Ishibashi
PloS one 16 ( 10 ) e0258852 2021年 [査読有り]
研究論文（学術雑誌） 国内共著
Lumbar degenerative disease and dementia are increasing in super-aging societies and are both related to physical dysfunction and pain. However, the relationship between these diseases remains unclear. This cross-sectional study aimed to investigate the comorbidity rates of lumbar spinal canal stenosis (LSS) and mild cognitive impairment (MCI) and clarify the association between LSS presence, lumbar symptoms, and quality of life (QOL) related to low back pain and cognitive impairment in the Japanese population. We enrolled 336 participants (men 124; women 212; mean age 72.2 years) from a medical checkup program. LSS was diagnosed using a self-administered questionnaire, and lumbar symptoms were evaluated using the visual analog scale (low back pain, and pain and numbness of the lower limb). QOL related to low back pain was evaluated using the Japanese Orthopedic Association Back-Pain Evaluation Questionnaire (JOABPEQ: pain, and lumbar, and gait function). Radiological lumbar degeneration was classified using Kellgren-Lawrence grading and lateral radiographs of the lumbar spine. Cognitive function was measured using the Mini Mental State Examination (MMSE), and MCI was defined by a summary score of MMSE ≤27. Logistic and multiple linear regression analyses were performed to analyze the association between MCI, summary score of MMSE, and lumbar degenerative disease. The comorbidity rate of MCI and LSS was 2.1%, and the rate of MCI was 41% in participants with LSS. Lumbar function in JOABPEQ was associated with MCI. The presence of LSS and lumbar function in JOABPEQ were associated with MMSE. Over one-third of the people with LSS had MCI. The presence of LSS and deterioration of QOL due to low back pain were related to cognitive impairment. We recommend evaluating cognitive function for patients with LSS because the rate of MCI was high in LSS participants.
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The impact of microalbuminuria on overactive bladders: Results from a community-based four-year longitudinal study in Japan
Teppei Okamoto, Shingo Hatakeyama, Masataka Ando, Jung Songee, Atsushi Imai, Itsuto Hamano, Naoki Fujita, Akiko Okamoto, Hayato Yamamoto, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama
NEUROUROLOGY AND URODYNAMICS ( WILEY ) 39 ( 5 ) 1567 - 1575 2020年06月
研究論文（学術雑誌）
Aims To investigate the longitudinal association of microalbuminuria with overactive bladder (OAB).Methods This longitudinal study investigated 561 participants of the Iwaki Health Promotion Project in both 2015 and 2019 in Japan. Microalbuminuria and OAB symptoms were assessed using the urine albuminuria creatinine ratio (ACR) and the overactive bladder symptom score (OABSS), respectively. Urine ACR was defined as high if >= 9.3 mg/gCr. Differences in OABSS between 2015 and 2019 were evaluated as increment OABSS. Participants were divided into two groups according to Delta OABSS: high (Delta OABSS > 1) and control (<= 1). We used baseline data acquired in 2015, such as urine ACR, the Pittsburgh Sleep Quality Index (PSQI), and arterial stiffness expressed by brachial-ankle pulse wave velocity (baPWV). Predictive factors of a Delta OABSS > 1 were assessed by multivariable logistic regression analysis.Results This study included 332 women and 229 men. Of those, 86 (34 males and 52 females) were classified into the Delta OABSS > 1 group. There were significant group differences in age, renal function, and hemoglobin A1c. Participants in the Delta OABSS > 1 had a higher prevalence of PSQI > 5, baPWV >= 1400 seconds/cm, and urine ACR >= 9.3 mg/gCr (49% vs 20%, P = .001) than those in the control group. Multivariable analysis revealed that PSQI > 5 (odds ratio [OR], 2.57; 95% confidence interval [CI], 1.15-4.60; P = .002) and urine ACR >= 9.3 mg/gCr (OR, 1.93; 95% CI, 1.15-3.23; P = .013) were independent risk factors for Delta OABSS > 1.Conclusions Microalbuminuria may be an independent risk indicator for OAB symptom exacerbation.
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Relationship between chronic kidney disease without diabetes mellitus and components of frailty in community-dwelling Japanese older adults
Sungchul Lee, Sangyoon Lee, Seongryu Bae, Kazuhiro Harada, Songee Jung, Masakazu Imaoka, Hyuma Makizako, Takehiko Doi, Hiroyuki Shimada
Geriatrics and Gerontology International ( WILEY ) 18 ( 2 ) 286 - 292 2020年02月
研究論文（学術雑誌）
© 2017 Japan Geriatrics Society Aim: To evaluate the relationship between kidney function without diabetes and components of the frailty phenotype in community-dwelling Japanese older adults. Methods: Participants were 8343 residents who completed baseline assessments, classified into four categories according to eGFR. Frailty status was defined using five criteria: (i) slow gait speed; (ii) muscle weakness; (iii) low physical activity; (iv) exhaustion; and (v) unintentional weight loss. Results: After multivariate adjustment, participants with the lowest kidney function were at higher risk of frailty (OR 1.57, 95% CI 1.02–3.50) than those with normal kidney function. In addition, after adjustment for multiple confounders, estimated glomerular filtration rate <30 was associated with a greater risk of the individual frailty components of weight loss (OR 2.14, 95% CI 1.11–4.12), low physical activity (OR 1.35, 95% CI, 1.01–2.54) and slowness (OR 1.82, 95% CI 1.36–3.77) compared with estimated glomerular filtration rate ≥60. Conclusions: Lower kidney function was associated with a higher risk of weight loss, low physical activity and slowness among community-dwelling Japanese older adults. Geriatr Gerontol Int 2018; 18: 286–292.
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Daily Physical Activity and Functional Disability Incidence in Community-Dwelling Older Adults with Chronic Pain: A Prospective Cohort Study
Keitaro Makino, Sangyoon Lee, Sungchul Lee, Seongryu Bae, Songee Jung, Yohei Shinkai, Hiroyuki Shimada
Pain Medicine (United States) ( OXFORD UNIV PRESS ) 20 ( 9 ) 1702 - 1710 2019年09月
研究論文（学術雑誌）
© 2018 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Objective: This study examined the association between daily physical activity and functional disability incidence in community-dwelling older adults with chronic pain. Design: Prospective cohort study. Setting: Japanese community. Subjects: Of the 5,257 participants enrolled for baseline assessment, data on the 693 participants who had chronic lower back or knee pain and underwent daily physical activity assessment using an accelerometer were analyzed. Methods: Participants were assessed for regular physical activity (step counts, moderate- to vigorous-intensity physical activity duration, and light-intensity physical activity duration) using an accelerometer at baseline and were followed up for monthly functional disability incidence, based on the national long-term care insurance system, for approximately two years. We determined the effect of physical activity cutoff points on functional disability incidence using receiver operating characteristic curves and Youden index. Cox proportional hazards regression models were used to analyze associations between the cutoff points and disability incidence. Results: Among the 693 participants with chronic pain, 69 (10.0%) developed functional disability during the follow-up period. Participants with lower physical activity levels showed significantly higher risk of disability. After adjusting for all covariates, functional disability was associated with step counts (hazard ratio [HR] = 1.79, 95% confidence interval [CI] = 1.02-3.14) and moderate- to vigorous-intensity physical activity duration (HR = 2.02, 95% CI = 1.16-3.51) but had no relationship with light-intensity physical activity duration (HR = 1.72, 95% CI = 0.97-3.05). Conclusions: Maintenance of physical activity with at least moderate intensity may be effective in preventing disability even among older adults with chronic pain.
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Pain characteristics and incidence of functional disability among community-dwelling older adults
Keitaro Makino, Sangyoon Lee, Seongryu Bae, Songee Jung, Yohei Shinkai, Ippei Chiba, Hiroyuki Shimada
PLoS ONE ( PUBLIC LIBRARY SCIENCE ) 14 ( 4 ) e0215467 2019年04月
研究論文（学術雑誌）
© 2019 Makino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This study examined the association between pain characteristics and the incidence of functional disability among community-dwelling older adults. This prospective cohort study included 4,365 older adults (mean age 74.7 years, 53.5% female) living in community settings. Pain characteristics, including severity and duration of pain, were assessed in participants who also underwent monthly follow-up assessment of functional disability for 24 months based on the national long-term care insurance system. Among the 4,365 participants, 2,149 (48.7%) reported pain, regardless of severity and duration. Of the 2,149 participants with pain, 950 (44.2%) reported moderate to severe pain and 1,680 (78.2%) reported chronic pain. Based on the univariate analyses, participants with moderate (hazard ratio [95% confidence interval]: 1.48 [1.05–2.09]) or severe (2.84 [1.89–4.27]) pain and chronic pain (1.50 [1.15–1.95]) showed significantly higher risk of disability incidence than did those without pain. After adjusting for covariates, severe pain remained a significant predictor (hazard ratio [95% confidence interval]: 1.66 [1.05–2.62]), but moderate (1.00 [0.69–1.47]) and chronic pain (1.04 [0.77–1.40]) did not. Our results established that moderate to severe pain or chronic pain affects functional disability; in particular, severe pain was independently associated with the incidence of disability. Subjective complaints of pain do not always correspond to physical causes; however, simplified questions regarding pain characteristics could be useful predictors of functional disability in community-dwelling older people.
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The effect of a multicomponent intervention to promote community activity on cognitive function in older adults with mild cognitive impairment: A randomized controlled trial
Seongryu Bae, Sangyoon Lee, Sungchul Lee, Songee Jung, Keitaro Makino, Kazuhiro Harada, Kenji Harada, Yohei Shinkai, Ippei Chiba, Hiroyuki Shimada
Complementary Therapies in Medicine ( CHURCHILL LIVINGSTONE ) 42 164 - 169 2019年02月
研究論文（学術雑誌）
© 2018 Elsevier Ltd Objectives: This study aimed to examine the effectiveness of a multicomponent intervention combining physical, cognitive, and social activities developed to promote community activity in improving cognitive function in older adults with mild cognitive impairment (MCI). Design: Single-blind randomized controlled trial. Setting: A total of 83 Japanese older adults with MCI participated in the study from April to September 2017. Interventions: Participants were randomly assigned to either the multicomponent intervention group (n = 41), attending 90-minute physical, cognitive, or social activity sessions using community resources twice weekly, or the health education control group (n = 42). Outcomes: The primary outcomes were cognitive functions, and the secondary outcomes were grip strength, walking speed, depressive symptoms, physical activities, number of outdoor activities, and conversation time. Results: Analysis using linear mixed models revealed significantly greater improvements in the intervention group in spatial working memory (p = 0.024) following intervention compared with the control group. Time spent in moderate-to-vigorous physical activity (p = 0.048) and step count (p = 0.059) decreased from the baseline post-intervention in the control group, whereas the baseline was maintained in the intervention group. No significant between-group differences were found post-intervention in the other primary and secondary outcomes. Conclusions: This study showed that a 24-week multicomponent intervention program was effective in improving spatial working memory and maintaining physical activity in older adults with MCI. A follow-up investigation is required to determine whether continuation of physical, cognitive, and social activity can prevent dementia or reverse MCI in older adults.
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Impact of sedentary time on chronic kidney disease and disability incidence in community-dwelling Japanese older adults: A 4-year prospective cohort study
Sungchul Lee, Sangyoon Lee, Seongryu Bae, Kazuhiro Harada, Songee Jung, Keitaro Makino, Hiroyuki Shimada
Journal of Aging and Physical Activity ( HUMAN KINETICS PUBL INC ) 27 ( 2 ) 184 - 190 2019年
研究論文（学術雑誌）
© 2019 Human Kinetics, Inc. This study examined the association between the estimated glomerular filtration rate (eGFR) and disability incidence according to sedentary time in community-dwelling Japanese older adults. This prospective cohort study sampled 5,104 community-dwelling older adults (≥65 years) enrolled in a health promotion study in a general population. The participants (n = 4,457; ≥65 years) were monitored for inclusion in the long-term care insurance system for 4 years. This study used blood samples to assess eGFR. Cox proportional regression analysis was used to determine predictors of disability. In total, 461 participants (10.3%) became newly certified as needing long-term care insurance services.Cox regressionmodelswere adjusted formultiple confounders:eGFR < 45 ml/min/1.73m2 (hazard ratio = 1.741, 95%confidence interval [1.193-2.539]) and eGFR < 45 ml/min/1.73m2 with high sedentary time (≥8 hr) (hazard ratio = 4.367, 95% confidence interval [2.021-9.438]) remained significantly associated with disability incidence. Our findings suggest that in the case of chronic kidney disease, the disability incidence rate may be affected by sedentary time.
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The role of social frailty in explaining the association between hearing problems and mild cognitive impairment in older adults
Seongryu Bae, Sangyoon Lee, Sungchul Lee, Songee Jung, Keitaro Makino, Hyuntae Park, Hiroyuki Shimada
Archives of Gerontology and Geriatrics ( ELSEVIER IRELAND LTD ) 78 45 - 50 2018年09月
研究論文（学術雑誌）
© 2018 Elsevier B.V. Background: We examined the role of social frailty in the association between hearing problems and mild cognitive impairment (MCI), and investigated which cognitive impairment domains are most strongly involved. Methods: Participants were 4251 older adults (mean age 72.5 ± 5.2 years, 46.1% male) who met the study inclusion criteria. Hearing problems were measured using the Hearing Handicap Inventory for the Elderly. Social frailty was identified using responses to five questions. Participants were divided into four groups depending on the presence of social frailty and hearing problems: control, social frailty, hearing problem, and co-occurrence. We assessed memory, attention, executive function, and processing speed using the National Center for Geriatrics and Gerontology-Functional Assessment Tool. Participants were categorized into normal cognition, single- and multiple-domain MCI, depending on the number of impaired cognitive domains. Results: Participants with multiple-domain MCI exhibited the highest odds ratios (OR) of the co-occurrence group (OR: 3.89, 95% confidence intervals [CI]: 1.96–7.72), followed by the social frailty (OR: 2.65, 95% CI: 1.49–4.67), and hearing problem (OR: 1.90, 95% CI: 1.08–3.34) groups, compared with the control group. However, single-domain MCI was not significantly associated with any group. Cognitive domain analysis revealed that impaired executive function and processing speed were associated with the co-occurrence, hearing problem, and social frailty groups, respectively. Conclusions: Social frailty and hearing problems were independently associated with multiple-domain MCI. Comorbid conditions were more strongly associated with multiple-domain MCI. Longitudinal studies are needed to elucidate the causal role of social frailty in the association between hearing impairment and MCI.
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Effectiveness of the KENKOJISEICHI local revitalization system on cognitive function change in older adults with mild cognitive impairment: Study protocol for a randomized controlled trial
Songee Jung, Sungchul Lee, Seongryu Bae, Sangyoon Lee, Keitaro Makino, Yohei Shinkai, Hiroyuki Shimada
Trials ( BIOMED CENTRAL LTD ) 19 ( 1 ) 276 - 276 2018年05月
研究論文（学術雑誌）
© 2018 The Author(s). Background: Physical activity is associated with a lower risk of cognitive decline in older adults. However, past studies have demonstrated that older adults tend to relapse into inactivity after completing interventions. This ongoing study employs a randomized controlled trial design to assess the efficacy and efficiency of the KENKOJISEICHI local revitalization system for promoting daily outdoor behaviors to improve cognitive function in community-dwelling older adults with mild cognitive impairment (MCI). Methods/design: This 6-month randomized controlled trial will include 83 community-dwelling older adults aged 65 years or older with MCI. Participants will be randomized to the KENKOJISEICHI experimental group or an educational control group. The KENKOJISEICHI group will receive a 90-minute session twice per week that consists of social, intellectual, and physical activities involving outdoor behaviors intended to support cognitive function. Participants in the educational control group will attend two 120-minute educational classes during the 6-month trial period. Considering a 20-30% dropout rate, a sample size of 35 participants per group is required. Discussion: If the program successfully promotes long-term habitual outdoor behaviors, this will expand knowledge regarding how to support social, intellectual, and physical activities, as well as communication change, among the older population to provide them with cognitive benefits.
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Older Korean adults have lower physical function despite longer exercise times compared to their Japanese counterparts: A Japan-Korea comparative study
Songee Jung, Yoshiro Okubo, Yosuke Osuka, Satoshi Seino, Joonsung Park, Hosung Nho, Kiyoji Tanaka
Geriatrics and Gerontology International ( WILEY ) 18 ( 4 ) 576 - 583 2018年04月
研究論文（学術雑誌）
© 2017 Japan Geriatrics Society Aim: We aimed to compare the level of physical function (PF) and habitual exercise between older Japanese and Korean adults. Methods: A comparative study was carried out on 1069 community-dwelling older Japanese and Korean adults (mean age 73.9 ± 5.2 years). The participants were asked to complete a self-reported questionnaire regarding habitual exercise and covariates. PF age, a composite measure of PF, was derived from the 12 items, using principal component analysis. PF age and habitual exercise were compared between the Japanese and Korean adults, using analysis of covariance (ancova) and multivariable logistic regression analysis adjusted for all covariates using propensity scores. Results: ancova showed that PF age in older Japanese adults was significantly younger than in their Korean counterparts. Older Japanese adults exercised significantly less frequently than their Korean counterparts. Furthermore, older Japanese adults practiced significantly less walking, mountain climbing and bicycling, but more calisthenics, resistance training, ball games and dances than their Korean counterparts. Conclusions: We found that older Korean adults had lower PF (3.7 years older in PF age) than their Japanese counterparts. Although the overall frequency and amount of habitual exercise in older Korean adults were higher than those in their Japanese counterparts, particular types of exercise might have contributed to the higher PF levels among older Japanese adults. Thus, older Korean adults might need to engage more in habitual exercises that are specifically effective in maintaining PF. Geriatr Gerontol Int 2018; 18: 576–583.
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Relationship between physical activity levels and depressive symptoms in community-dwelling older Japanese adults
Songee Jung, Sangyoon Lee, Sungchul Lee, Seongryu Bae, Masakazu Imaoka, Kazuhiro Harada, Hiroyuki Shimada
Geriatrics and Gerontology International ( WILEY ) 18 ( 3 ) 421 - 427 2018年03月
研究論文（学術雑誌）
© 2017 Japan Geriatrics Society Aim: The aim of the present study was to investigate the relationship between physical activity (PA) and depressive symptoms in community-dwelling older Japanese adults. Methods: A cross-sectional study design was used to obtain data from 3191 community-dwelling older Japanese adults aged 70–95 years. Depressive symptoms were assessed using self-reported scores on the Geriatric Depression Scale-15. PA was objectively measured using an accelerometer worn for a maximum of 40 days, and average daily durations of light-intensity PA (LPA), moderate-to-vigorous intensity PA (MVPA) and step count were calculated. PA was compared between participants with and without depressive symptoms by carrying out analysis of covariance and multivariable logistic regression analysis adjusted for all covariates by using propensity scores. Results: Depressive symptoms were present in 598 participants (19.6%). A comparison of propensity-score adjusted PA showed that step count (5059.6 ± 53.7 vs 5003.0 ± 112.1 count/day; P = 0.652) and moderate-to-vigorous intensity PA duration (23.0 ± 0.4 vs 23.8 ± 0.7 min/day; P = 0.358) were not significantly different between participants with and without depressive symptoms, respectively. However, participants without depressive symptoms had a significantly higher LPA duration than those with depressive symptoms (39.4 ± 0.3 vs 37.3 ± 0.7 min/day, respectively; P < 0.01). Conclusions: The present results suggest that individuals with lower LPA have a higher risk of depressive symptoms. These findings imply that PA recommendations, especially for older adults, should emphasize LPA, which appears to be especially effective at preventing depressive symptoms. Geriatr Gerontol Int 2018; 18: 421–427.
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Development of the Nutrition and Functionality Assessment (NFA) among Older Adults in Japan
Y. Okubo, M. Nemoto, Y. Osuka, S. Jung, S. Seino, R. Figueroa, G. Vinyes-Pares, E. A. Offord, M. Shevlyakova, D. Breuille, K. Tanaka
The Journal of frailty & aging 7 ( 3 ) 187 - 192 2018年01月
研究論文（学術雑誌）
OBJECTIVE: Develop and evaluate the feasibility and validity of the Nutrition and Functionality Assessment (NFA) which identifies "target" older adults who could benefit from a personalized program following evaluation of their nutrition status and physical functionality. DESIGN: Cross-sectional study. SETTING: Community and geriatric day-care centers and university in Japan. PARTICIPANTS: 267 older adults aged 65-90. MEASUREMENTS: The "target" individuals were screened based on gait speed (0.6-1.5 m/s). Nutrition (Mini Nutrition Assessment-short form and protein intake), strength (30s chair sit-to-stand and hand-grip strength) and endurance (6-minute walk) were assessed. Physical activity was monitored using a tri-axil accelerometer for a week. Fried frailty phenotype was also assessed. RESULTS: Out of 267 individuals, 185 (69%) had gait speed between 0.6-1.5 m/s, corresponding to our "target" group from which, 184 (95%) completed the nutrition and physical functionality assessments with the physical activity monitoring. The NFA was completed in approximately 30 minutes. No adverse events directly due to the NFA were reported. NFA physical functionality and global scores were significantly related to frailty phenotype but nutrition score was not related to frailty phenotype. CONCLUSION: The study demonstrated that the NFA is a safe and feasible tool to screen target older adults and simultaneously evaluate their nutritional status and physical functionality. Validity of the NFA was partially confirmed by the significant association of the global and physical functionality scores with frailty phenotype. More studies are required to validate and maximize the applicability of the NFA in communities and institutions in Japan and elsewhere.
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Does attending an exercise class with a spouse improve long-term exercise adherence among people aged 65 years and older: A 6-month prospective follow-up study
Yosuke Osuka, Songee Jung, Taeho Kim, Yoshiro Okubo, Eunbi Kim, Kiyoji Tanaka
BMC Geriatrics ( BMC ) 17 ( 1 ) 170 - 170 2017年07月
研究論文（学術雑誌）
© 2017 The Author(s). Background: Family support can help older adults better adhere to exercise routine, but it remains unclear whether an exercise program targeting older married couples would have stronger effects on exercise adherence than would a program for individuals. The purpose of this study was to determine the effects of an exercise program on the exercise adherence of older married couples over a 24-week follow-up period. Methods: Thirty-four older married couples and 59 older adults participated in this study as couple and non-couple groups (CG and NCG, respectively). All participants attended an 8-week supervised program (once a week and a home-based exercise program comprising walking and strength exercises) and then participated in a follow-up measurement (24 weeks after post-intervention measurement). Exercise adherence was prospectively measured via an exercise habituation diary during the follow-up period - specifically, we asked them to record practice rates for walking (≥2 days/week) and strength exercises (≥6 items for 2 days/week). A multivariate logistic regression analysis was conducted to obtain the CG's odds ratios (ORs) and 95% confidence intervals (CIs) for adherence to walking and strength exercise adjusted for potential confounders (with NCG as the reference). Results: Although the adherence rate of walking exercise in the CG was significantly higher than that in the NCG (29.2%; P < 0.001), there was no significant difference in the adherence rate of strength exercise between the two groups (P = 0.199). The multivariate logistic regression analysis showed that CG had significantly higher odds of adherence to walking exercise compared with the NCG (3.68 [1.57-8.60]). However, the odds of adherence to strength exercise did not significantly differ between the two groups (1.30 [0.52-3.26]). Conclusions: These results suggest that an exercise program targeting older married couples may be a useful strategy for maintaining walking adherence, even six months after the supervised program has ceased. A blinded randomized controlled trial will be needed to confirm this conclusion. Trial registration: Retrospectively registered. UMIN Clinical Trials Registry (Registered: 02/11/16) UMIN000024689.