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Okabe M.
Reproductive Medicine and Biology ( Reproductive Medicine and Biology ) 22 ( 1 ) 2023年01月 [査読有り]
研究論文（学術雑誌）
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Fujishima A.
Tohoku Journal of Experimental Medicine ( Tohoku Journal of Experimental Medicine ) 259 ( 4 ) 327 - 333 2023年
研究論文（学術雑誌）
<p>Gestational diabetes mellitus (GDM) is a state of pre-diabetic impaired glucose tolerance initially occurring during pregnancy. Although abnormalities in glucose metabolism normally resolve rapidly after delivery, women with GDM have a higher lifetime risk of developing diabetes mellitus than those without GDM; thus, postpartum healthcare is essential. Of all GDM patients, 5%-10% test positive for diabetes-related autoantibodies, which increase the risk of developing type 1 diabetes mellitus (T1DM). Autoantibody measurement in GDM screening remains debatable; however, it may be useful for the postnatal follow-up of GDM patients at high risk of developing T1DM. We treated a 29-year-old woman who was GDM positive for anti-glutamic acid decarboxylase antibody (GADA) requiring high-dose insulin therapy during pregnancy. As the patient tested positive for GADA, she received judicious postpartum management, allowing for early diagnosis of T1DM and resumption of treatment. Her insulin secretory capacity was preserved at 1 year after parturition, suggesting either slowly progressive insulin-dependent T1DM or latent autoimmune diabetes in adults. This was a rare case of slowly progressive insulin-dependent T1DM or latent autoimmune diabetes in adults in the early postpartum period, but the fact that GADA was positive during pregnancy enabled early treatment without overlooking it. Measuring diabetes-related autoantibodies in patients considered to be at a high risk for T1DM, such as those who are of slim build, young, or suffering from autoimmune thyroid disorders, may be important for appropriate individualized follow-up.</p>
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藤嶋明子, 前田恵理, 菊地麻里, 水田圭, 菅原香織, 大木春菜, 佐藤高輝, 寺田幸弘
産科と婦人科 ( (株)診断と治療社 ) 90 ( 7 ) 799 - 806 2023年07月 [査読有り]
＜文献概要＞晩産化時代の今,妊娠を願う人々の希望を実現し,安全な妊娠・出産を増やすには,「妊娠前からのヘルスケア(プレコンセプションケア)」を地域で展開する必要がある.プレコンセプションケアの対象は前思春期から生殖可能年齢の男女と幅広く,周知を進めるためには多様なアプローチが必要である.2021年より美術大学やNPO法人らとともに秋田県内へのプレコンセプションケア普及啓発活動を開始した.1年間の活動内容について報告する.
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総説 秋田県内へのプレコンセプションケア周知に向けた活動
藤嶋 明子, 前田 恵理, 菊地 麻里, 水田 圭, 菅原 香織, 大木 春菜, 佐藤 高輝, 寺田 幸弘
産科と婦人科 ( 診断と治療社 ) 90 ( 7 ) 799 - 806 2023年07月
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2波長性電解質インジケーターを用いた哺乳動物胚盤胞内の電解質濃度変化の解析
藤島 綾香, 高橋 和政, 岩澤 卓也, 藤嶋 明子, 白澤 弘光, 佐藤 亘, 熊澤 由紀代, 寺田 幸弘
日本生殖医学会雑誌 ( (一社)日本生殖医学会 ) 67 ( 4 ) 364 - 364 2022年10月
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A Survey of Genetic Counseling for Non-invasive Prenatal Testing Examinees in Akita
Onodera Yohei, Miura Hiroshi, Fujishima Akiko, Notomi Rie, Noguchi Atsuko, Takahashi Ikuko, Sato Akira, Takahashi Tsutomu, Terada Yukihiro
JMA Journal ( 公益社団法人 日本医師会 / 日本医学会 ) 5 ( 3 ) 349 - 355 2022年07月
<p><b>Introduction</b>: In recent years, there has been an increase in noninvasive prenatal testing (NIPT), where maternal blood samples are used to extract fetal cell-free DNA. Despite this being offered in several facilities in urban areas, NIPT remains to be scarcely unavailable in rural areas. Moreover, there is lacking information with regard to how pregnant women in rural areas perceive NIPT. Thus, in this study, we conducted a survey among pregnant women who came to our clinic for NIPT and examined their views on NIPT and genetic counseling.</p><p><b>Methods</b>: A questionnaire survey was administered to pregnant women who requested NIPT and underwent genetic counseling at our hospital between November 2016 and February 2020. The questionnaire was administered twice, once after completing the genetic counseling and once after explaining the NIPT results. The number of genetic counseling and NIPT sessions and positive test results, as well as anxiety about the test and evaluation of genetic counseling and NIPT, were assessed.</p><p><b>Results</b>: In total, 115 patients received genetic counseling, of which 109 underwent NIPT. The test results were found to be positive in six patients. As per our findings, 103 patients (93%) indicated they needed genetic counseling for NIPT, whereas 99 (93%) were satisfied with the counseling they received from a genetic medicine specialist. On the other hand, 82 patients (77%) requested for more testing facilities.</p><p><b>Conclusions</b>: The enhancement of genetic counseling systems is essential to expand the environment in which NIPT is performed. Therefore, we need to consider the need to make the NIPT testing environment more conducive and inform clients of the importance of genetic counseling in NIPT.</p>
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Hirakawa T.
Human Reproduction ( Human Reproduction ) 37 ( 7 ) 1423 - 1430 2022年07月
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科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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タイムラプス蛍光ライブセルイメージングで検証するヒト第一細胞分裂
基盤研究(B)
研究期間: 2021年04月 - 2024年03月 代表者: 寺田 幸弘, 藤嶋 明子, 白澤 弘光, 高橋 和政
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ヒト胚発育動態と細胞内外の電解質の時間的・空間的変化との関連
基盤研究(C)
研究期間: 2021年04月 - 2024年03月 代表者: 熊澤 由紀代, 藤嶋 明子, 寺田 幸弘, 高橋 和政
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PGT-AおよびniPGT-Aのヒト胚診断における意義：長期胚培養系を用いた検討
基盤研究(C)
研究期間: 2021年04月 - 2024年03月 代表者: 佐藤 亘, 藤嶋 明子, 寺田 幸弘, 高橋 和政
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低侵襲である経会陰超音波を用いた新しい分娩評価方法の創出
若手研究
研究期間: 2020年04月 - 2023年03月 代表者: 藤嶋 明子