研究等業績 - 原著論文 - 長岐　雄志

Neoadjuvant Chemoradiotherapy Upregulates the Immunogenicity of Cold to Hot Tumors in Esophageal cancer Patients

Nagaki Y, Motoyama S, Sato Y, Wakita A, Fujita H, Kemuriyama K, Sasamori R, Nozaki S, Nomura K, Minamiya Y.

Annals of Surgery Open   5 ( 1 ) 385 - 385   2024年02月  [査読有り]

研究論文（学術雑誌）   単著

Objective: To test the hypothesis that neoadjuvant chemoradiotherapy (NACRT) is more effective against hot esophageal squamous cell carcinoma (ESCC) and that it may upregulate tumor immunogenicity.

Background: There have been several recent reports showing the efficacy of immune check-point inhibitors (ICIs) against esophageal cancer, especially immunologically hot tumors. In addition, several studies have suggested that chemotherapy and radiotherapy may convert cold tumors to hot tumors.

Methods: Of 105 ESCC patients who underwent surgery after NACRT between 2010 and 2018 at our hospital, 99 whose biopsy tissue samples were obtained were enrolled. Based on immunohistochemical analysis, tumors that were FOXA1 (+) and/or EYA2 (+) were defined as hot tumors, others were cold tumors. We then investigated the association between tumor immunogenicity and clinicopathological features.

Results: The 29 patients with hot tumors before NACRT had a significantly better 5-year disease-specific survival (DSS) rate than the remaining 70 patients with cold tumors (85% vs 64%; P = 0.036). In a multivariate analysis, tumor immunogenicity was a significant independent predictor of DSS. Of 68 patients without a pathological complete response (non-pCR) in their primary tumor, 51 (75%) had hot tumors after NACRT. Moreover, 75% (36/48) of tumors that were cold before NACRT were converted to hot tumors after NACRT.

Conclusions: Patients with hot ESCC tumors treated with NACRT plus esophagectomy had a better prognosis than those with cold tumors. NACRT upregulated cold tumor immunogenicity to hot tumors, suggesting NACRT may increase the sensitivity of ESCC to adjuvant ICIs.

DOI PubMed

PET-Uptake Reduction into Lymph Nodes After Neoadjuvant Therapy is Highly Predictive of Prognosis for Patients Who have Thoracic Esophageal Squamous Cell Carcinoma Treated with Chemoradiotherapy Plus Esophagectomy

Nagaki Y.

Annals of Surgical Oncology ( Annals of Surgical Oncology )  29 ( 2 ) 1336 - 1346   2022年02月

研究論文（学術雑誌）   国内共著

DOI

Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression

Jianbo An, Yushi Nagaki, S. Motoyama, Yuta Kuze, Midori Hoshizaki, Kohei Kemuriyama, Tomokazu Yamaguchi, T. Ebihara, Y. Minamiya, Yutaka Suzuki, Y. Imai, K. Kuba

Oncogene ( Oncogene )    2022年  [査読有り]

研究論文（学術雑誌）   国内共著

DOI

m⁶A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis

Nagaki Y.

Genes to Cells ( Genes to Cells )  25 ( 8 ) 547 - 561   2020年08月  [査読有り]

研究論文（学術雑誌）  

DOI

SUV<inf>max</inf> reduction predicts long-term survival in patients of non-pCR both in the tumor and lymph nodes after neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma

Nagaki Y.

World Journal of Surgical Oncology ( World Journal of Surgical Oncology )  19 ( 1 )   2021年12月

研究論文（学術雑誌）   国内共著

DOI

Patterns and timing of recurrence in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiotherapy plus esophagectomy

Nagaki Y.

BMC Cancer ( BMC Cancer )  21 ( 1 )   2021年12月  [査読有り]

研究論文（学術雑誌）   国内共著

DOI

Does Esophagectomy Provide a Survival Advantage to Patients Aged 80 Years or Older? Analyzing 5066 Patients in the National Database of Hospital-based Cancer Registries in Japan

Motoyama S.

Annals of Surgery ( Annals of Surgery )  276 ( 1 ) E16 - E23   2022年07月

研究論文（学術雑誌）  

DOI

Association between ABCC2 polymorphism and hematological toxicity in patients with esophageal cancer receiving platinum plus 5-fluorouracil therapy

Fujita K.

Esophagus ( Esophagus )  19 ( 1 ) 146 - 152   2022年01月

研究論文（学術雑誌）  

DOI

Lower local recurrence rate after robot-assisted thoracoscopic esophagectomy than conventional thoracoscopic surgery for esophageal cancer

Motoyama S.

Scientific Reports ( Scientific Reports )  11 ( 1 )   2021年12月

研究論文（学術雑誌）  

DOI

Differences in treatment and survival between elderly patients with thoracic esophageal cancer in metropolitan areas and other areas

Motoyama S.

Cancer Science ( Cancer Science )  112 ( 10 ) 4281 - 4291   2021年10月

研究論文（学術雑誌）  

DOI

Approaches to resection of recurrent solitary mediastinal lymph nodes after esophagectomy

Motoyama S.

Esophagus ( Esophagus )  18 ( 3 ) 700 - 703   2021年07月

研究論文（学術雑誌）  

DOI

Robot-assisted thoracoscopic enucleation for a large esophageal leiomyoma: a case report.

Kemuriyama K, Motoyama S, Sato Y, Wakita A, Nagaki Y, Fujita H, Sasamori R, Imai K, Aokawa M, Minamiya Y.

Surgical Case Reports     2021年05月  [査読有り]

研究論文（学術雑誌）   単著

Verification of the Optimal Interval Before Esophagectomy After Preoperative Neoadjuvant Chemoradiotherapy for Locally Advanced Thoracic Esophageal Cancer

Wakita A.

Annals of Surgical Oncology ( Annals of Surgical Oncology )  28 ( 4 ) 2101 - 2110   2021年04月

研究論文（学術雑誌）  

DOI

IGF2BP3 Expression Correlates With Poor Prognosis in Esophageal Squamous Cell Carcinoma

Wakita A.

Journal of Surgical Research ( Journal of Surgical Research )  259   137 - 144   2021年03月

研究論文（学術雑誌）  

DOI

Neoadjuvant chemoradiotherapy followed by esophagectomy with three-field lymph node dissection for thoracic esophageal squamous cell carcinoma patients with clinical stage iii and with supraclavicular lymph node metastasis

Sato Y.

Cancers ( Cancers )  13 ( 5 ) 1 - 14   2021年03月

研究論文（学術雑誌）  

DOI

Effects of SLC31A1 and ATP7B polymorphisms on platinum resistance in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiotherapy

Fujita K.

Medical Oncology ( Medical Oncology )  38 ( 1 )   2021年01月

研究論文（学術雑誌）  

DOI

Salvage Robotic-Assisted Thoracoscopic Esophagectomy after Definitive Chemoradiotherapy for Clinical T4b Esophageal Cancer: A Case Report

Sasamori Ryohei, Motoyama Satoru, Sato Yusuke, Wakita Akiyuki, Nagaki Yushi, Imai Kazuhiro, Minamiya Yoshihiro

Annals of Thoracic and Cardiovascular Surgery ( Annals of Thoracic and Cardiovascular Surgery 編集委員会 )  advpub ( 0 )   2021年

研究論文（学術雑誌）  

<p>The advantages of salvage esophagectomy through robotic-assisted surgery for patients with clinically diagnosed tumor invasion of adjacent vital organs (cT4b) or patients with scar tissue from definitive chemoradiotherapy (dCRT) are still only rarely reported. A man in his 60s with middle thoracic esophageal cancer (cT4b [left main bronchus] N1 M0 cStage IIIC) received dCRT (60 Gy). After the chemoradiotherapy, upper gastrointestinal endoscopy revealed a residual primary tumor, and we performed robotic-assisted thoracoscopic subtotal esophagectomy and gastric tube reconstruction via a retrosternal route with three-field lymphadenectomy. Although it was difficult to dissect the tumor from adjacent organs, especially the left main bronchus and left inferior pulmonary vein, due to loss of the dissecting layer and scarring, R0 surgery was achieved. With robot-assisted thoracoscopic surgery, the high-magnification, high-resolution, and three-dimensional images; the stable surgical field with full countertraction made with the robotic arm forceps, which were readily adjusted; and the stable motion of the robotic arm without physiological tremor are considerable advantages for salvage esophagectomy for cT4b tumors. It goes without saying that sufficient experience with robot-assisted surgery and sufficient understanding and surgical skill in esophageal cancer surgery under suitable surgical indications and timing are required to make use of these advantages.</p>

DOI CiNii Research

Comparison of the incidences of anastomotic leakage when PDSII or LACLON are used in esophago-gastric conduit handsewn anastomosis after esophagectomy

Sato Y.

Scientific Reports ( Scientific Reports )  10 ( 1 )   2020年12月

研究論文（学術雑誌）  

DOI

Does esophagectomy provide a survival advantage to patients aged 80 years or older? Analyzing 5,066 patients in the National Database of Hospi-tal-based Cancer Registries in Japan.

Motoyama S, Maeda E, Iijima K, Sato Y, Koizumi S, Wakita A, Nagaki Y, Fujita H, Yoneya T, Imai K, Terata K, Minamiya Y, Higashi T.

Annals of Surgery     2020年12月

研究論文（学術雑誌）   単著

High TLR4 expression predicts a poor prognosis after esophagectomy for advanced thoracic esophageal squamous cell carcinoma

Sato Y.

Esophagus ( Esophagus )  17 ( 4 ) 408 - 416   2020年10月

研究論文（学術雑誌）  

DOI

Prognostic significance of combined platelet distribution width and c-reactive protein score in esophageal cancer

Kawakita Y.

Anticancer Research ( Anticancer Research )  40 ( 10 ) 5715 - 5725   2020年10月

研究論文（学術雑誌）  

DOI

Decreases in the Psoas Muscle Index Correlate More Strongly with Survival than Other Prognostic Markers in Esophageal Cancer After Neoadjuvant Chemoradiotherapy Plus Esophagectomy

Kawakita Y.

World Journal of Surgery ( World Journal of Surgery )  44 ( 5 ) 1559 - 1568   2020年05月

研究論文（学術雑誌）  

DOI

Evaluation of metastatic lymph nodes in cN0 thoracic esophageal cancer patients with inconsistent pathological lymph node diagnosis

Wakita A.

World Journal of Surgical Oncology ( World Journal of Surgical Oncology )  18 ( 1 )   2020年05月

研究論文（学術雑誌）  

DOI

Extensive lymph node dissection around the left laryngeal nerve achieved with robot-assisted thoracoscopic esophagectomy

Motoyama S.

Anticancer Research ( Anticancer Research )  39 ( 3 ) 1337 - 1342   2019年03月

研究論文（学術雑誌）  

DOI

TLR3 expression status predicts prognosis in patients with advanced thoracic esophageal squamous cell carcinoma after esophagectomy

Sato Y.

American Journal of Surgery ( American Journal of Surgery )  216 ( 2 ) 319 - 325   2018年08月

研究論文（学術雑誌）  

DOI

Efficacy and safety of neoadjuvant chemoradiotherapy following esophagectomy with japanese-style extended 3-field lymphadenectomy for thoracic esophageal cancer

Motoyama S.

Anticancer Research ( Anticancer Research )  37 ( 10 ) 5837 - 5843   2017年10月

研究論文（学術雑誌）  

DOI

CXCL10 Expression Status is Prognostic in Patients with Advanced Thoracic Esophageal Squamous Cell Carcinoma.

Sato Y, Motoyama S, Nanjo H, Wakita A, Yoshino K, Sasaki T, Nagaki Y, Liu J, Imai K, Saito H, Minamiya Y.

Annals of Surgical Oncology     2016年03月  [査読有り]

研究論文（学術雑誌）   単著

Salvage esophagectomy under bilateral thoracotomy after definitive chemoradiotherapy for aorta T4 thoracic esophageal squamous cell carcinoma: Report of a case.

Nagaki Y, Sato Y, Motoyama S, Yoshino K, Sasaki T, Wakita A, Imai K, Saito H, Minamiya Y.

International Journal of Surgery Case Reports     2015年01月  [査読有り]

研究論文（学術雑誌）   単著

REG1A expression status suggests chemosensitivity among advanced thoracic esophageal squamous cell carcinoma patients treated with esophagectomy followed by adjuvant chemotherapy.

Sato Y, Motoyama S, Nanjo H, Ito S, Yoshino K, Sasaki T, Kuribayashi K, Nagaki Y, Imai K, Saito H, Minamiya Y, Ogawa J

Annals of Surgical Oncology     2013年09月

研究論文（学術雑誌）   単著