研究等業績 - 原著論文 - 平澤 暢史
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Characteristics of black bear‐related trauma: A retrospective observational study
Hideomi Tsuchida, Kasumi Satoh, Nobuhisa Hirasawa, Manabu Okuyama, Hajime Nakae
Acute Medicine & Surgery ( Wiley ) 11 ( 1 ) 2024年01月
研究論文（学術雑誌）
Abstract
Aim
Bear‐related trauma is a significant concern in Japan. This study identified trauma patterns, outcomes, and therapeutic approaches for bear‐related injuries treated.
Methods
This retrospective observational study used medical records from Akita University Hospital, focusing on patients with bear‐related trauma in 2023. Demographic data, injury details, treatment procedures, and outcomes were extracted.
Results
The study included 20 patients (median age: 74.5 years, 65% males). Most injuries occurred in human habitats, mainly in autumn, with the face being the most affected area (90%). Three patients required emergency transfusions and tracheal intubation. Emergency surgery was performed in 52.6% of patients, and 42.1% were admitted to the intensive care unit. All patients survived with a median hospital stay of 17 days. However, 15.8% of patients had significant sequelae, such as blindness. Despite prophylactic antibiotics, wound infections occurred in 21.1% of patients, particularly in deep wounds that were not adequately washed under general anesthesia.
Conclusions
Bear‐related trauma often results in severe upper‐body injuries that require prompt medical intervention. These findings highlight the need for improved preventive measures and strategies for initial treatment and long‐term care. -
Takuto Yasuda, Kasumi Satoh, Nobuhisa Hirasawa, Manabu Okuyama, Hajime Nakae
Acute Medicine & Surgery ( Wiley ) 11 ( 1 ) 2024年01月
研究論文（学術雑誌）
Abstract
Background
Direct reinfusion of pericardial blood during cardiac surgery triggers a systemic inflammatory response. Although various inflammatory mediators have been identified as triggers, the role of damage‐associated molecular patterns (DAMPs) remains poorly understood. Despite guidelines recommending against this practice owing to its harmful effects, it is sometimes used in emergencies.
Case Presentation
A 72‐year‐old man with atrial fibrillation and cerebral infarction developed cardiac tamponade during catheter ablation. He underwent pericardial drainage and direct blood reinfusion. He was transferred to our ICU, where he developed acute respiratory distress syndrome (ARDS) and disseminated intravascular coagulation (DIC). Despite aggressive management, the patient died 41 days after admission.
Conclusion
This case highlights severe adverse events following direct reinfusion of pericardial blood. These findings suggest a significant role for DAMPs in mediating these inflammatory responses. Direct reinfusion of pericardial drainage blood should be avoided during emergencies to prevent life‐threatening complications. -
Suzuki Y.
Therapeutic Apheresis and Dialysis ( Therapeutic Apheresis and Dialysis ) 27 ( 6 ) 1028 - 1034 2023年12月 [査読有り]
研究論文（学術雑誌）
INTRODUCTION: Coronavirus disease 2019 (COVID-19) is associated with a marked increase in the inflammatory cytokines, IL-6 and IL-18. Blood purification therapy aimed at controlling cytokines is one treatment option; however, evidence of its effectiveness is needed. Plasma exchange with dialysis (PED) is a blood purification method involving selective plasma exchange with dialysate flowing through the outer hollow fiber of the plasma separator. In this retrospective study, we investigated the efficacy of continuous PED (cPED) over 48 h in five patients with severe COVID-19. METHODS: We assessed changes in IL-6 and IL-18, as well as adiponectin (APN). RESULTS: There were no significant differences in changes in IL-6 and IL-18, but there was a marked improvement in cases with abnormally high IL-6 and IL-18 levels at baseline. APN, which inhibits inflammatory cytokines, was significantly elevated post-cPED. CONCLUSION: Our results suggest that cPED therapy is an effective treatment for COVID-19.
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Makyoyokukanto use in patients with painful afflictions
Hirasawa Nobuhisa, Nakae Hajime, Tanaka Hidenori, Irie Yasuhito
Personalized Medicine Universe ( 一般社団法人 国際個別化医療学会 ) 12 ( 0 ) 16 - 22 2023年11月 [査読有り]
研究論文（学術雑誌）
<p>Aim: Makyoyokukanto (MKYK) is a traditional Japanese medicine used for relieving arthralgia, neuralgia, and myalgia. However, the effectiveness and safety of MKYK remains unclear. In this study, we assessed the effectiveness of MKYK in patients with painful afflictions.</p><p>Methods: One hundred and sixty-three patients (42 men and 121 women) with painful afflictions were recruited into the study. All participants were treated using non-invasive methods and administered MKYK. The effectiveness of MKYK was assessed following administration by evaluating the need for NSAIDs or other medication. In addition, adverse reactions were monitored.</p><p>Results: 85.9% of the patients were effectively treated with MKYK. Comorbidities were present in 52.8% of the study participants. The median duration of MKYK treatment was 14 days (2–364 days). The adverse event rate was 1.2%. The adverse events were insomnia caused by Ephedra herb and pseudoaldosteronism by Glycyrrhiza root. All symptoms improved after MKYK withdrawal.</p><p>Conclusion: The adverse event rate associated with MKYK use was low, and its onset was relatively rapid. This adverse event rate can be further reduced by focusing on the pharmacological action of Ephedra herb and Glycyrrhiza root. This study suggests that MKYK can be used more widely for painful afflictions.</p>
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Hyperthyroidism With Non-chylous Ascites: A Case Report
Shodai Takahashi, Kasumi Satoh, Manabu Okuyama, Nobuhisa Hirasawa, Hajime Nakae
Cureus ( Springer Science and Business Media LLC ) 2023年10月
研究論文（学術雑誌）
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前野 恭平, 佐藤 佳澄, 奥山 学, 平澤 暢史, 吉田 健二, 中永 士師明
日本救急医学会雑誌 ( Wiley ) 33 ( 7 ) 299 - 303 2022年07月 [査読有り]
研究論文（学術雑誌）