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Affiliation |
Hospital General Physician Center |
Research Interests 【 display / non-display 】
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Emergency medicine
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Intensive care medicine
Graduating School 【 display / non-display 】
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-2014.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2020.03
The University of Tokyo Graduate School, Division of Medicine Master's Course Completed
Campus Career 【 display / non-display 】
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2022.07-Now
Akita University Hospital General Physician Center Specially-appointed Assistant Professor
Research Achievements 【 display / non-display 】
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Suzuki Y.
Therapeutic Apheresis and Dialysis ( Therapeutic Apheresis and Dialysis ) 27 ( 6 ) 1028 - 1034 2023.12 [Refereed]
Research paper (journal)
INTRODUCTION: Coronavirus disease 2019 (COVID-19) is associated with a marked increase in the inflammatory cytokines, IL-6 and IL-18. Blood purification therapy aimed at controlling cytokines is one treatment option; however, evidence of its effectiveness is needed. Plasma exchange with dialysis (PED) is a blood purification method involving selective plasma exchange with dialysate flowing through the outer hollow fiber of the plasma separator. In this retrospective study, we investigated the efficacy of continuous PED (cPED) over 48 h in five patients with severe COVID-19. METHODS: We assessed changes in IL-6 and IL-18, as well as adiponectin (APN). RESULTS: There were no significant differences in changes in IL-6 and IL-18, but there was a marked improvement in cases with abnormally high IL-6 and IL-18 levels at baseline. APN, which inhibits inflammatory cytokines, was significantly elevated post-cPED. CONCLUSION: Our results suggest that cPED therapy is an effective treatment for COVID-19.
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Makyoyokukanto use in patients with painful afflictions
Hirasawa Nobuhisa, Nakae Hajime, Tanaka Hidenori, Irie Yasuhito
Personalized Medicine Universe ( 一般社団法人 国際個別化医療学会 ) 12 ( 0 ) 16 - 22 2023.11 [Refereed]
Research paper (journal)
<p>Aim: Makyoyokukanto (MKYK) is a traditional Japanese medicine used for relieving arthralgia, neuralgia, and myalgia. However, the effectiveness and safety of MKYK remains unclear. In this study, we assessed the effectiveness of MKYK in patients with painful afflictions.</p><p>Methods: One hundred and sixty-three patients (42 men and 121 women) with painful afflictions were recruited into the study. All participants were treated using non-invasive methods and administered MKYK. The effectiveness of MKYK was assessed following administration by evaluating the need for NSAIDs or other medication. In addition, adverse reactions were monitored.</p><p>Results: 85.9% of the patients were effectively treated with MKYK. Comorbidities were present in 52.8% of the study participants. The median duration of MKYK treatment was 14 days (2–364 days). The adverse event rate was 1.2%. The adverse events were insomnia caused by Ephedra herb and pseudoaldosteronism by Glycyrrhiza root. All symptoms improved after MKYK withdrawal.</p><p>Conclusion: The adverse event rate associated with MKYK use was low, and its onset was relatively rapid. This adverse event rate can be further reduced by focusing on the pharmacological action of Ephedra herb and Glycyrrhiza root. This study suggests that MKYK can be used more widely for painful afflictions.</p>
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A case of ethylene glycol intoxication caused by the pesticides
Kyohei Maeno, Kasumi Satoh, Manabu Okuyama, Nobuhisa Hirasawa, Kenji Yoshida, Hajime Nakae
Journal of Japanese Association for Acute Medicine 33 ( 7 ) 299 - 303 2022.07 [Refereed]
Research paper (journal)
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Use of the term “triage" in academic research in Japan: A scoping review
Shimada Yuhei, Miwa Eriko, Sakai Eri, Ishibashi Maho, Hirasawa Yasuhisa, Minamitani Kenta, Tomio Jun
Japanese Journal of Disaster Medicine ( Japanese Association for Disaster Medicine ) 30 ( 2 ) 72 - 81 2025.05
<p>【Purpose】 This study aims to clarify and compare the usage of the term “triage" in academic research in Japan to facilitate interdisciplinary discussion. 【Method】 We undertook a scoping review of academic literature on medicine, sociology, law, and ethics in Japanese, including “triage" and covering publications from 1990 to 2023. 【Results】 In total, 438 documents were reviewed. We found that triage is used in multiple ways while sharing the core element of `prioritizing someone or something' and can be discussed from at least seven perspectives. In the medical field, there was a tendency to discuss triage after clearly defining the situations where it is carried out, but there was a marked difference between disaster medicine and emergency medicine in whether or not the black or deceased/expectant category was considered. In the non-medical fields, various aspects of triage were discussed across different articles, even within the same discipline. This caused multiple interpretations of triage to coexist. 【Conclusion】 It is necessary to specify definitions and contexts of triage to facilitate discussion among different academic backgrounds.</p>
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Retrospective study on efficacy and safety of Jidabokuippo in real-world clinical practice
Nakae Hajime, Kitamura Toshiharu, Satoh Kasumi, Hirasawa Nobuhisa, Kameyama Koumei, Nara Tasuku, Suzuki Yuya, Yoshida Kenji, Maeno Kyohei, Tsuchida Hideomi, Yasuda Takuto, Saruta Rio, Okuyama Manabu
Personalized Medicine Universe ( 一般社団法人 国際個別化医療学会 ) 13 ( 0 ) 38 - 45 2024.11
<p>Purpose: Few studies have investigated the treatment outcomes and adverse events after using jidabokuippo (JDI), including the concomitant use of Kampo prescriptions and analgesics. In this study, we retrospectively analyzed the efficacy and safety of JDI in real-world clinical practice.</p><p>Methods: The study included 306 patients who were treated with JDI. Treatment outcomes and adverse events were compared according to age, sex, presence or absence of comorbidities, concomitant use of Kampo prescriptions and analgesics, daily dose of JDI, duration of administration, and the starting time of administration. The patients were divided into two groups: effective and ineffective.</p><p>Results: Concomitant use of Kampo prescriptions and analgesics was observed in 14.1% and 58.2% of the patients, respectively. The efficacy rate of JDI was 97.7%. The duration of JDI treatment in the analgesic group was significantly longer than that in the non-analgesic group (<i>p</i> = 0.0100). None of the patients reported any adverse events.</p><p>Conclusion: The efficacy rate of JDI was as high as 97.7% and no adverse events were observed. Adverse events can be prevented by being cautious of the side effects of Kampo prescriptions. However, the rate of concomitant use of analgesics was high, and the effects of reducing the dosage and frequency of analgesics remains to be determined.</p>
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Chest Pain Diagnosed as Acute Leukemia: Focus on Coagulation Abnormalities Rather Than White Blood Cell Count.
Kyohei Maeno, Kasumi Satoh, Nobuhisa Hirasawa, Manabu Okuyama, Hajime Nakae
Cureus 15 ( 3 ) e35992 2023.03
Chest pain is an important symptom for emergency physicians. It is one of the most common causes for admission in emergency departments. Acute leukemia (AL) rarely causes chest symptoms due to ostalgia, and it is difficult to diagnose leukemia as the cause of chest pain. An 83-year-old woman with no history of trauma presented to the emergency department with a one-day history of severe chest pain. There were no abnormalities on electrocardiography, echocardiography, specific biomarkers for cardiac injury, or contrast computed tomography of the chest and pelvis. The white blood cell count was normal, but the patient had prominent thrombocytopenia with platelets of 68,000/µL, prothrombin time-international normalized ratio (PT-INR) of 1.2, activated partial thromboplastin time (APTT) of 25.3 s, and D-dimer of 73.55 µg/mL. Due to the holiday, blast cells could not be measured on the same day. The next day's examination revealed blast cells in the peripheral blood. The patient was admitted to the hematology department and discharged three months later. This case suggests the need to consider AL in chest pain associated with coagulation abnormalities and thrombocytopenia, regardless of the white blood cell count.
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Severe Drug-Induced Liver Injury From Over-the-Counter Medication.
Kasumi Satoh, Manabu Okuyama, Nobuhisa Hirasawa, Hajime Nakae
Cureus 15 ( 1 ) e33558 2023.01
Drug-induced liver injury (DILI) is difficult to diagnose as it presents with a wide variety of clinical manifestations and there is no established specific biomarker. However, clinicians require expertise in diagnosing DILI as it can lead to critical illness, is relatively common, and can be caused by a variety of drugs, herbal medicines, and supplements. A 67-year-old male was admitted to the hospital with a fever, jaundice, and fatigue. Abdominal ultrasonography, computed tomography, and magnetic resonance cholangiopancreatography revealed no morphological abnormalities in the hepatobiliary system. On the third day of hospitalization, the liver damage and acute kidney injury progressed, and the patient was transferred to our intensive care unit. To further investigate the cause of multiple organ damage, the patient underwent repeated history taking and additional laboratory testing. In addition to the common causes of hepatic and renal damage, we also tested for rickettsiosis and leptospirosis, as the patient reported partaking regularly in outdoor leisure activities. On day seven of hospitalization, the patient recalled taking over-the-counter herbal flu medications approximately five days prior to admission; therefore, we suspected DILI and performed a drug-induced lymphocyte stimulation test (DLST). The DLST was positive for one drug. As other causes had been ruled out, the patient was diagnosed with severe DILI. The clinical course of the patient was observed with the patient's laboratory data and fever improving spontaneously. This case taught us several important lessons for the investigation of liver injury. Firstly, even with over-the-counter drugs, liver injury can be severe. Secondly, while the DLST is available for investigating DILI, false positives, especially for medicinal herbs, should be noted, and it is necessary to adequately rule out other diseases. Finally, when the cause of liver injury is unclear, patient history taking should be repeated carefully.
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Severe acute respiratory distress syndrome caused by Otsujito.
Nobuhisa Hirasawa, Hajime Nakae, Kasumi Satoh, Kenji Yoshida, Manabu Okuyama
Acute medicine & surgery 10 ( 1 ) e874 2023 [Refereed]
BACKGROUND: Kampo prescriptions can cause drug-induced lung injury (DLI) and acute respiratory distress syndrome (ARDS). However, severe respiratory failure induced by Otsujito (OJT) is extremely rare. High-dose steroid pulse therapy is generally given to patients with severe DLI. CASE PRESENTATION: A 63-year-old man with respiratory distress was admitted to our hospital. The patient was diagnosed with severe ARDS caused by OJT, which had been prescribed 4 weeks prior to admission. Thus, OJT was discontinued, and intensive care for ARDS, including ventilation and prone positioning, was implemented. His respiratory condition rapidly improved after treatment with an initial methylprednisolone dose (1.5 mg/kg/day). He was extubated on day 4 and discharged on day 16. The steroid dose was gradually reduced and discontinued by day 116. CONCLUSION: A severe case of ARDS caused by OJT was successfully treated with low-dose steroids and specialized intensive care.