Research Achievements - Other -

Development and Practicing in Senior High School of Teaching Materials for Infectious Diseases Education

YOSHINO Masami, KATSUKI Tomoaki, ASAHI Shunsuke, NUMATA Tomohiro, MATSUKAWA Masaki, HARADA Kazuo, HASEGAWA Tadashi

Bulletin of Tokyo Gakugei University. Division of natural sciences   75   63 - 75   2023.09

CiNii Research

The regulation mechanisms of mitochondrial Ca²⁺ signaling mediated by cardiac Sigma-1 receptor

Tagashira Hideaki, Shinoda Yasuharu, Numata Tomohiro, Fukunaga Kohji

Proceedings for Annual Meeting of The Japanese Pharmacological Society ( Japanese Pharmacological Society )  96   1-B-P-020   2022

Cardiovascular disease (CVD) is a leading cause of death worldwide. We previously reported that the Sigma-1 receptor (Sigmar1) is down-regulated in mice with cardiac dysfunction. Recent study suggested that Sigmar1 deficient mice display cardiac dysfunction via impairment of mitochondrial function. However, the mechanism of mitochondrial quality control mediated by Sigmar1 has not been investigated in detail. In this study, we investigated the role of Sigmar1 for ER-mitochondrial tethering and mitochondrial Ca²⁺ signaling using a Sigmar1-knockdown cardiomyocytes. We found that disruption of ER-mitochondrial tethering and reduction of ER-mitochondrial Ca²⁺ transport was induced by Sigmar1 knockdown in cardiomyocytes. We also demonstrated that Endothelin-1-induced cardiomyocyte hypertrophy is aggravated associated with induction of mitophagy in Sigmar1 knockdown cardiomyocytes. These data suggest that reduction of cardiac Sigmar1 is involved in myocyte hypertrophy by maintaining of intracellular Ca²⁺ signaling mediated by regulation of ER-mitochondrial tethering.

DOI CiNii Research

Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation.

Yamamoto S, Ishii T, Mikami R, Numata T, Shimizu S

Biochemical and biophysical research communications   520 ( 3 ) 520 - 525   2019.12

DOI PubMed

SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation.

Komatsu S, Nomiyama T, Numata T, Kawanami T, Hamaguchi Y, Iwaya C, Horikawa T, Fujimura-Tanaka Y, Hamanoue N, Motonaga R, Tanabe M, Inoue R, Yanase T, Kawanami D

Endocrine journal   67 ( 1 ) 99 - 106   2019.11

DOI PubMed

Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels.

Numata T, Sato-Numata K, Okada Y

Scientific reports   9 ( 1 ) 15554 - 15554   2019.10

DOI PubMed

TRPM4チャネルと心血管の生理・病態生理

井上隆司, 胡耀鵬, 沼田朋大

医学のあゆみ ( 医歯薬出版 )  270 ( 10 ) 954 - 960   2019.09

J-GLOBAL

TRPM7 is involved in acid-induced necrotic cell death in a manner sensitive to progesterone in human cervical cancer cells.

Numata T, Sato-Numata K, Okada Y

Physiological reports ( Wiley )  7 ( 13 ) e14157   2019.07

DOI PubMed

Cell Volume-Activated and Volume-Correlated Anion Channels in Mammalian Cells: Their Biophysical, Molecular, and Pharmacological Properties.

Okada Y, Okada T, Sato-Numata K, Islam MR, Ando-Akatsuka Y, Numata T, Kubo M, Shimizu T, Kurbannazarova RS, Marunaka Y, Sabirov RZ

Pharmacological reviews   71 ( 1 ) 49 - 88   2019.01

DOI PubMed

Roles of volume-regulatory anion channels, VSOR and Maxi-Cl, in apoptosis, cisplatin resistance, necrosis, ischemic cell death, stroke and myocardial infarction.

Okada Y, Numata T, Sato-Numata K, Sabirov RZ, Liu H, Mori SI, Morishima S

Current topics in membranes   83   205 - 283   2019

DOI PubMed

TRPM7-mediated spontaneous Ca²⁺ entry regulates the proliferation and differentiation of human leukemia cell line K562.

Takahashi K, Umebayashi C, Numata T, Honda A, Ichikawa J, Hu Y, Yamaura K, Inoue R

Physiological reports   6 ( 14 ) e13796   2018.07

DOI PubMed

Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl−/water secretion that involves cAMP-dependent activation of CFTR

Tomohiro Numata, Kaori Sato-Numata, Yasunobu Okada, Ryuji Inoue

Journal of Natural Medicines ( Springer Tokyo )  72 ( 3 ) 694 - 705   2018.06

DOI PubMed

Functional Charaterization of Zebrafish Transient Receptor Potential Melastatin 2

Tran Ha Nam, Hederih Jure, Numata Tomohiro, Mori Masayuki X, Maegawa Shingo, Hosokawa Hiroshi, Mori Yasuo

BIOPHYSICAL JOURNAL   114 ( 3 ) 641A - 642A   2018.02

Strategy to Attain Remarkably High Photoinduced Charge-Separation Yield of Donor-Acceptor Linked Molecules in Biological Environment via Modulating Their Cationic Moieties

Ning Cai, Yuta Takano, Tomohiro Numata, Ryuji Inoue, Yasuo Mori, Tatsuya Murakami, Hiroshi Imahori

JOURNAL OF PHYSICAL CHEMISTRY C   121 ( 32 ) 17457 - 17465   2017.08

DOI

FUNCTIONAL CHARATERIZATION OF ZEBRAFISH TRANSIENT RECEPTOR POTENTIAL MELASTATIN 2 IN HEK 293 CELL LINE

Ha Nam Tran, Numata Tomohiro, Mori Masayuki X, Maegawa Shingo, Hosokawa Hiroshi, Tanaka Shingo, Mori Yasuo

JOURNAL OF PHARMACOLOGICAL SCIENCES   133 ( 3 ) S126   2017.03

The regulatory effect of oxaliplatin on human TRPA1 cold sensitivity

Miyake Takahito, Nakamura Saki, Zhao Meng, So Kanako, Inoue Keisuke, Numata Tomohiro, Takahashi Nobuaki, Shirakawa Hisashi, Mori Yasuo, Nakagawa Takayuki, Kaneko Shuji

JOURNAL OF PHARMACOLOGICAL SCIENCES   133 ( 3 ) S85   2017.03

Allosteric activation of glutamate receptors by on-cell coordination chemistry

Kiyonaka, Ryou Kubota, Yukiko Michibata, Masayoshi Sakakura, Hideo Takahashi, Tomohiro Numata, Ryuji Inoue, Michisuke Yuzaki, Itaru Hamachi

Nature Chemistry   8 ( 10 ) 958 - 967   2016

DOI

Optical control of neuronal firing via photoinduced electron transfer in donor-acceptor conjugates

Yuta Takano, Tomohiro Numata, Kazuto Fujishima, Kazuaki Miyake, Kazuya Nakao, Wesley David Grove, Ryuji Inoue, Mineko Kengaku, Shigeyoshi Sakaki, Yasuo Mori, Tatsuya Murakami, Hiroshi Imahori

CHEMICAL SCIENCE   7 ( 5 ) 3331 - 3337   2016

DOI PubMed

A screening of TRPC channels activators identifies novel neurotrophic compounds

Sawamura Seishiro, Hatano Masahiko, Sasaki Hajime, Takada Yoshinori, Kuwamura Takashi, Numata Tomohiro, Kiyonaka Shigeki, Hino Kyosuke, Kawamura Tetsuya, Tanikawa Jun, Nakagawa Hiroshi, Nagata Ryu, Inoue Ryuji, Mori Yasuo

JOURNAL OF PHARMACOLOGICAL SCIENCES   128 ( 3 ) S90 - S90   2015.07

Characterization of redox-sensitive TRP channels in acetaminophen-induced death of human hepatoma cell line

Elsaid Heba A, Numata Tomohiro, Mori Yasuo

JOURNAL OF PHARMACOLOGICAL SCIENCES   128 ( 3 ) S178   2015.07

Involvement of TRPA1 activation through distinct modifications in oxaliplatin-induced acute peripheral neuropathy

Nakamura Saki, Miyake Takahito, Zhao Meng, Hamano Satoshi, Inoue Keisuke, Takahashi Nobuaki, Numata Tomohiro, Shirakawa Hisashi, Mori Yasuo, Nakagawa Takayuki, Kaneko Shuji

JOURNAL OF PHARMACOLOGICAL SCIENCES   128 ( 3 ) S232   2015.07