研究等業績 - 原著論文 - 脇　裕典

The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

Hironori Waki, Kye Won Park, Nico Mitro, Liming Pei, Robert Damoiseaux, Damien C Wilpitz, Karen Reue, Enrique Saez, Peter Tontonoz

Cell metabolism   5 ( 5 ) 357 - 70   2007年05月  [査読有り]

研究論文（学術雑誌）  

Endocrine functions of adipose tissue.

Hironori Waki, Peter Tontonoz

Annual review of pathology   2   31 - 56   2007年

研究論文（学術雑誌）  

NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.

Liming Pei, Hironori Waki, Bhavapriya Vaitheesvaran, Damien C Wilpitz, Irwin J Kurland, Peter Tontonoz

Nature medicine   12 ( 9 ) 1048 - 55   2006年09月  [査読有り]

研究論文（学術雑誌）  

Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1.

Hironori Waki, Toshimasa Yamauchi, Junji Kamon, Shunbun Kita, Yusuke Ito, Yusuke Hada, Shoko Uchida, Atsushi Tsuchida, Sato Takekawa, Takashi Kadowaki

Endocrinology   146 ( 2 ) 790 - 6   2005年02月  [査読有り]

研究論文（学術雑誌）  

Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

Hironori Waki, Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Shoko Uchida, Shunbun Kita, Kazuo Hara, Yusuke Hada, Francis Vasseur, Philippe Froguel, Satoshi Kimura, Ryozo Nagai, Takashi Kadowaki

The Journal of biological chemistry   278 ( 41 ) 40352 - 63   2003年10月  [査読有り]

研究論文（学術雑誌）  

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.

Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Atsushi Tsuchida, Takehiko Yokomizo, Shunbun Kita, Takuya Sugiyama, Makoto Miyagishi, Kazuo Hara, Masaki Tsunoda, Koji Murakami, Toshiaki Ohteki, Shoko Uchida, Sato Takekawa, Hironori Waki, Nelson H Tsuno, Yoichi Shibata, Yasuo Terauchi, Philippe Froguel, Kazuyuki Tobe, Shigeo Koyasu, Kazunari Taira, Toshio Kitamura, Takao Shimizu, Ryozo Nagai, Takashi Kadowaki

Nature   423 ( 6941 ) 762 - 9   2003年06月  [査読有り]

研究論文（学術雑誌）  

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.

Toshimasa Yamauchi, Junji Kamon, Hironori Waki, Yasushi Imai, Nobuhiro Shimozawa, Kyouji Hioki, Shoko Uchida, Yusuke Ito, Keisuke Takakuwa, Junji Matsui, Makoto Takata, Kazuhiro Eto, Yasuo Terauchi, Kajuro Komeda, Masaki Tsunoda, Koji Murakami, Yasuyuki Ohnishi, Takeshi Naitoh, Kenichi Yamamura, Yoshito Ueyama, Philippe Froguel, Satoshi Kimura, Ryozo Nagai, Takashi Kadowaki

The Journal of biological chemistry   278 ( 4 ) 2461 - 8   2003年01月  [査読有り]

研究論文（学術雑誌）  

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.

Toshimasa Yamauchi, Junji Kamon, Yasuhiko Minokoshi, Yusuke Ito, Hironori Waki, Shoko Uchida, Shigeo Yamashita, Mitsuhiko Noda, Shunbun Kita, Kohjiro Ueki, Kazuhiro Eto, Yasuo Akanuma, Philippe Froguel, Fabienne Foufelle, Pascal Ferré, David Carling, Satoshi Kimura, Ryozo Nagai, Barbara B Kahn, Takashi Kadowaki

Nature medicine   8 ( 11 ) 1288 - 95   2002年11月  [査読有り]

研究論文（学術雑誌）  

Determination of endogenous levels of retinoic acid isomers in type II diabetes mellitus patients. Possible correlation with HbA1c values.

Yuko Yamakoshi, Hiroshi Fukasawa, Toshimasa Yamauchi, Hironori Waki, Takashi Kadowaki, Koichi Shudo, Hiroyuki Kagechi

Biological & pharmaceutical bulletin   25 ( 10 ) 1268 - 71   2002年10月  [査読有り]

研究論文（学術雑誌）  

Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene.

Kazuo Hara, Mitsuhiko Noda, Hironori Waki, Kazuyuki Tobe, Toshimasa Yamauchi, Hiroko Kadowaki, Hiroaki Satou, Kazuhisa Tsukamoto, Shinya Nagamatsu, Kazuhiro Yamagata, Yuji Matsuzawa, Yasuo Akanuma, Satoshi Kimura, Takashi Kadowaki

Internal medicine   41 ( 10 ) 848 - 52   2002年10月  [査読有り]

研究論文（学術雑誌）  

Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice.

Toshimasa Yamauchi, Yuichi Oike, Junji Kamon, Hironori Waki, Kajuro Komeda, Atsuko Tsuchida, Yukari Date, Meng-Xian Li, Hiroshi Miki, Yasuo Akanuma, Ryozo Nagai, Satoshi Kimura, Takeyori Saheki, Masamitsu Nakazato, Takeshi Naitoh, Kenichi Yamamura, Takashi Kadowaki

Nature genetics   30 ( 2 ) 221 - 6   2002年02月  [査読有り]

研究論文（学術雑誌）  

The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance.

Toshimasa Yamauchi, Junji Kamon, Hironori Waki, Koji Murakami, Kiyoto Motojima, Kajuro Komeda, Tomohiro Ide, Naoto Kubota, Yasuo Terauchi, Kazuyuki Tobe, Hiroshi Miki, Atsuko Tsuchida, Yasuo Akanuma, Ryozo Nagai, Satoshi Kimura, Takashi Kadowaki

The Journal of biological chemistry   276 ( 44 ) 41245 - 54   2001年11月  [査読有り]

研究論文（学術雑誌）  

Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.

Toshimasa Yamauchi, Hironori Waki, Junji Kamon, Koji Murakami, Kiyoto Motojima, Kajuro Komeda, Hiroshi Miki, Naoto Kubota, Yasuo Terauchi, Atsuko Tsuchida, Nobuyo Tsuboyama-Kasaoka, Naoko Yamauchi, Tomohiro Ide, Wataru Hori, Shigeaki Kato, Masashi Fukayama, Yasuo Akanuma, Osamu Ezaki, Akiko Itai, Ryozo Nagai, Satoshi Kimura, Kazuyuki Tobe, Hiroyuki Kagechika, Koichi Shudo, Takashi Kadowaki

The Journal of clinical investigation   108 ( 7 ) 1001 - 13   2001年10月  [査読有り]

研究論文（学術雑誌）  

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.

Toshimasa Yamauchi, Junji Kamon, Hironori Waki, Yasuo Terauchi, Naoto Kubota, Kazuo Hara, Yasumichi Mori, Tomohiro Ide, Koji Murakami, Nobuyo Tsuboyama-Kasaoka, Osamu Ezaki, Yasuo Akanuma, Oksana Gavrilova, Charles Vinson, Marc L Reitman, Hiroyuki Kagechika, Koichi Shudo, Madoka Yoda, Yasuko Nakano, Kazuyuki Tobe, Ryozo Nagai, Satoshi Kimura, Motowo Tomita, Philippe Froguel, Takashi Kadowaki

Nature medicine   7 ( 8 ) 941 - 6   2001年08月  [査読有り]

研究論文（学術雑誌）  

Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer.

Toshimasa Yamauchi, Naoko Yamauchi, Kohjiro Ueki, Takuya Sugiyama, Hironori Waki, Hiroshi Miki, Kazuyuki Tobe, Satoru Matsuda, Toshio Tsushimai, Tadashi Yamamoto, Toshiro Fujita, Yuji Taketani, Masashi Fukayama, Satoshi Kimura, Yoshio Yazaki, Ryozo Nagai, Takashi Kadowaki

The Journal of biological chemistry   275 ( 43 ) 33937 - 44   2000年10月  [査読有り]

研究論文（学術雑誌）