脇 裕典 (ワキ ヒロノリ)

WAKI Hironori

写真a

所属

大学院医学系研究科(医学専攻等)  医学専攻  病態制御医学系  代謝・内分泌内科学講座

研究室住所

秋田市本道一丁目1の1

研究室電話

018-884-6769

メールアドレス

メールアドレス

研究分野・キーワード

糖尿病、代謝、内分泌、肥満、脂肪細胞、遺伝子、エピゲノム

出身大学 【 表示 / 非表示

  •  
    -
    1997年03月

    東京大学   医学部   医学科   卒業

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  •  
    -
    2003年03月

    東京大学  医学系研究科  内科学  博士課程  修了

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  • 東京大学 -  博士(医学)

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  • 2021年06月
    -
    継続中

    秋田大学   大学院医学系研究科(医学専攻等)   医学専攻   病態制御医学系   代謝・内分泌内科学講座   教授  

 

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  • NFIA determines the cis-effect of genetic variation on Ucp1 expression in murinethermogenic adipocytes

    Yuta Hiraike, Shuichi Tsutsumi, Takahito Wada, Misato Oguchi, Kaede Saito, Masahiro Nakamura, Satoshi Ota, Michinori Koebis, Harumi Nakao, Atsu Aiba, Gaku Nagano, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Takashi Kadowaki, Hiroyuki Aburatani, Hironori Waki, Toshimasa Yamauchi

    iScience ( Elsevier BV )  25 ( 8 ) 104729 - 104729   2022年08月

    ISSN:2589-0042

    DOI

  • A Pilot Study to Assess Glucose, Insulin, and Incretin Responses Following Novel High Resistant Starch Rice Ingestion in Healthy Men.

    Kazuyuki Takahashi, Hiroki Fujita, Naoko Fujita, Yuya Takahashi, Shunsuke Kato, Tatsunori Shimizu, Yumi Suganuma, Takehiro Sato, Hironori Waki, Yuichiro Yamada

    Diabetes therapy : research, treatment and education of diabetes and related disorders   13 ( 7 ) 1383 - 1393   2022年07月

    INTRODUCTION: A newly developed resistant starch (RS) rice line with double mutation of starch synthase IIIa and branching enzyme IIb (ss3a/be2b) exhibits a tenfold greater percentage RS value than the wild-type rice line. Currently, the effects of cooked rice with such high RS content on secretion and action of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are unclear. Therefore, we conducted a pilot study to assess postprandial responses of GLP-1 and GIP along with glucose and insulin and also gastric emptying after ingestion of the high-RS cooked rice with ss3a/be2b in healthy subjects. METHODS: In a non-randomized crossover design, five healthy men ingested two test foods, control (low-RS) and high-RS cooked rice, with at least 1-week washout period between testing days. Plasma glucose, serum insulin, plasma total GLP-1, plasma total GIP, and also gastric emptying rate were measured after ingestion of each test food, and the incremental area under the curves (iAUC) was calculated for each biochemical parameter using the values from 0 to 180 min after ingestion. RESULTS: The high-RS cooked rice ingestion tended to reduce iAUC-glucose (p = 0.06) and significantly reduced iAUC-insulin (p < 0.01) and iAUC-GLP-1 (p < 0.05) but not iAUC-GIP (p = 0.21) relative to control cooked rice ingestion. In addition, the high-RS cooked rice ingestion did not affect gastric emptying. CONCLUSIONS: The present results indicate that the suppressive effects of the high-RS cooked rice ingestion on postprandial responses of glucose and insulin may be provided through attenuation in GLP-1 secretion along with its low digestibility into glucose. We suggest that the high-RS rice with ss3a/be2b may serve as a better carbohydrate source and also as a novel functional food for dietary interventions to improve postprandial hyperglycemia and hyperinsulinemia without both enhancing GLP-1 secretion and affecting gastric emptying in patients with diabetes.

    DOI PubMed

  • Cases of fulminant type 1 and type 2 diabetes mellitus whose HbA1c levels were unmeasurable due to increased labile HbA1c

    Shunsuke Kato, Izumi Otaka, Hanako Toyama, Ryota Kusumi, Kazuyuki Takahashi, Mitsuhiko Nara, Yumi Suganuma, Takehiro Sato, Tsukasa Morii, Hiroki Fujita, Hironori Waki

    Diabetology International ( Springer Science and Business Media LLC )    2022年07月

    ISSN:2190-1678

    DOI

  • Pick the best of both glucose and lipid metabolism.

    Tatsunori Shimizu, Yuya Takahashi, Hiroki Fujita, Hironori Waki

    Journal of diabetes investigation     2022年02月

    DOI PubMed

  • A Case of Chronic Intestinal Pseudo-obstruction with Mitochondrial Diseases.

    Takanobu Jinnouchi, Yoshitaka Sakurai, Kengo Miyoshi, Chie Koizumi, Hironori Waki, Naoto Kubota, Toshimasa Yamauchi

    Internal medicine (Tokyo, Japan)     2021年08月

    Chronic intestinal pseudo-obstruction (CIPO) is a rare disorder of intestinal dysmotility characterized by chronic symptoms, including vomiting and abdominal pain, associated with bowel obstruction without any mechanical obstructive causes. We herein report a case of mitochondrial diseases with recurrent duodenal obstruction that was initially diagnosed as superior mesenteric artery syndrome (SMAS) for a few years but was later diagnosed as CIPO. Since CIPO is known to be associated with mitochondrial diseases, it should be considered in the differential diagnosis of patients with mitochondrial diseases presenting with recurrent intestinal obstruction.

    DOI PubMed

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