Graduate School of Medicine  Doctorial Course in Medicine  Bioregulatory Medicine  Department of Immunology

Research Fields, Keywords

Lipid mediator, Immunity, Evolution

Graduating School 【 display / non-display

  • 1997.04

    The University of Tokyo   Faculty of Science   Department of Biological Sciences   Graduated

Graduate School 【 display / non-display

  • 2004.04

    The University of Tokyo  Graduate School, Division of Science  Doctor's Course  Completed

  • 2001.04

    The University of Tokyo  Graduate School, Division of Science  Master's Course  Completed

Campus Career 【 display / non-display

  • 2021.05

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Bioregulatory Medicine   Department of Immunology   Assistant Professor  


Published Papers 【 display / non-display

  • The sequenced genomes of nonflowering land plants reveal the innovative evolutionary history of peptide signaling

    Chihiro Furumizu, Anders K Krabberød, Marta Hammerstad, Renate M Alling, Mari Wildhagen, Shinichiro Sawa, Reidunn B Aalen

    Plant Cell     2021.07  [Refereed]

    International Co-author


  • Method for Analyzing an Infection Process of Plant-parasitic Nematodes Using a Microfluidic Device

    Hirotaka Hida, Rika Ebara, Shumpei Hayashi, Isaku Kanno, Chihiro Furumizu, Shinichiro Sawa

      141 ( 5 ) 141 - 146   2021.05


  • Insight into early diversification of leucine-rich repeat receptor-like kinases provided by the sequenced moss and hornwort genomes

    Chihiro Furumizu, Shinichiro Sawa

    Plant Molecular Biology ( Springer Science and Business Media {LLC} )    2021.01  [Refereed]

    Domestic Co-author


  • The RGF/GLV/CLEL Family of Short Peptides Evolved Through Lineage-Specific Losses and Diversification and Yet Conserves Its Signaling Role Between Vascular Plants and Bryophytes.

    Chihiro Furumizu, Shinichiro Sawa

    Frontiers in plant science   12   703012 - 703012   2021  [Refereed]

    Domestic Co-author

    Short secreted plant peptides act as key signaling molecules and control a plethora of developmental and physiological processes. The ROOT GROWTH FACTOR (RGF)/GOLVEN (GLV)/CLE-Like (CLEL) family of peptides was discovered to be involved in root development in Arabidopsis thaliana. In contrast to active research efforts, which have been revealing receptors and downstream signaling components, little attention has been paid to evolutionary processes that shaped the RGF signaling system as we know it in angiosperms today. As a first step toward understanding how RGF signaling emerged and evolved, this study aimed to elucidate the phylogenetic distribution and functional conservation of RGF-like sequences. Using publicly available, genome and transcriptome data, RGF-like sequences were searched in 27 liverworts, 22 mosses, 8 hornworts, 23 lycophytes, 23 ferns, 38 gymnosperms, and 8 angiosperms. This led to the identification of more than four hundreds of RGF-like sequences in all major extant land plant lineages except for hornworts. Sequence comparisons within and between taxonomic groups identified lineage-specific characters. Notably, one of the two major RGF subgroups, represented by A. thaliana RGF6/GLV1/CLEL6, was found only in vascular plants. This subgroup, therefore, likely emerged in a common ancestor of vascular plants after its divergence from bryophytes. In bryophytes, our results infer independent losses of RGF-like sequences in mosses and hornworts. On the other hand, a single, highly similar RGF-like sequence is conserved in liverworts, including Marchantia polymorpha, a genetically tractable model species. When constitutively expressed, the M. polymorpha RGF-like sequence (MpRGF) affected plant development and growth both in A. thaliana and M. polymorpha. This suggests that MpRGF can exert known RGF-like effects and that MpRGF is under transcriptional control so that its potent activities are precisely controlled. These data suggest that RGFs are conserved as signaling molecules in both vascular plants and bryophytes and that lineage-specific diversification has increased sequence variations of RGFs. All together, our findings form a basis for further studies into RGF peptides and their receptors, which will contribute to our understandings of how peptide signaling pathways evolve.

    DOI PubMed

Review Papers 【 display / non-display

  • Methods for Analyzing Grope Behavior of Plant-parasitic Nematodes Using Microchamber Device

    肥田博隆, 森仁志, 神野伊策, 古水千尋, 澤進一郎

    化学とマイクロ・ナノシステム   19 ( 1 )   2020



  • Method for analyzing the effect of mechanical stress on infection process of plant-parasitic nematodes

    肥田博隆, 江原りか, 神野伊策, 古水千尋, 澤進一郎

    電気学会研究会資料   ( BMS-20-017-029 )   2020