|
所属 |
大学院医学系研究科（医学専攻等） 医学専攻 病態制御医学系 総合診療・検査診断学講座 |
職務経歴（学内） 【 表示 ／ 非表示 】
-
2022年04月-継続中
秋田大学 大学院医学系研究科（医学専攻等） 医学専攻 病態制御医学系 総合診療・検査診断学講座 助教
-
2021年02月-2022年03月
秋田大学 附属病院 総合診療医センター 特任助教
研究等業績 【 表示 ／ 非表示 】
-
Hikichi H.
Traditional and Kampo Medicine ( Traditional and Kampo Medicine ) 13 ( 2 ) 2026年08月
-
Hasegawa Ryo, Hizuka Keinosuke, Saga Akiko, Hikichi Haruka, Moritoki Yuki, Ueki Shigeharu
Internal Medicine ( 一般社団法人 日本内科学会 ) advpub ( 0 ) 2026年
<p>Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis characterized by asthma, chronic rhinosinusitis with nasal polyps, eosinophil-driven tissue inflammation, and necrotizing small- to medium-sized vessel vasculitis. Myeloperoxidase - Anti-Neutrophil Cytoplasmic Antibody (MPO-ANCA) is detectable in approximately 30%-40% of patients, and ANCA-positive and ANCA-negative diseases exhibit distinct yet overlapping clinical patterns. Type 2 immune responses are predominant, with interleukin-5 (IL-5) driving eosinophil differentiation and survival, and IL-4 and IL-13 promoting eosinophil recruitment and IgE-associated pathways. Activated eosinophils contribute to tissue injury through degranulation and eosinophil extracellular trap formation (EETosis). Glucocorticoids remain the foundation of therapy, but they are often insufficient to achieve a sustained remission as monotherapy. Conventional immunosuppressants are used for severe disease, and B-cell-targeted therapy may be considered for selected vasculitic presentations. Biological agents targeting the IL-5/IL-5 receptor axis have been shown to prolong remission, reduced relapse risk, and enabled glucocorticoid sparing. However, some patients remain symptomatic, and reliable biomarkers to guide individualized therapy are lacking. Ongoing research focuses on biomarker panels and cell-free DNA to clarify the role of EETosis and define molecular endotypes to support precision-medicine approaches. </p>
-
Seasonal occurrence of nonepisodic angioedema with eosinophilia: A case series of 12 patients
Takahashi K.
Asia Pacific Allergy ( Asia Pacific Allergy ) 15 ( 3 ) 221 - 224 2025年09月
-
特集 検体検査のポイントとピットフォール 診察室にこの1冊 A.スクリーニングに用いる検査 7.総IgE,アレルゲン特異的IgE[免疫学的検査]
肥塚 慶之助, 嵯峨 亜希子, 植木 重治
診断と治療 ( 診断と治療社 ) 113 ( 13 ) 40 - 43 2025年03月
-
Onoue M.
Allergology International ( Allergology International ) 73 ( 1 ) 177 - 179 2024年01月