研究等業績 - 原著論文 - 小玉 鮎人
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The Cholinergic Receptor Nicotinic α3 Was Reduced in the Hippocampus of Early Cognitively Impaired Adult Male Mice and Upregulated by Nicotine and Cytisine in HT22 Cells
Hidetaka Ota, Takako Ohnuma, Ayuto Kodama, Tatsunori Shimizu, Kaoru Sugawara, Fumio Yamamoto
Cells 2025年02月
研究論文（学術雑誌）
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Patty Doran, Sophie Yarker, Tine Buffel, Hisami Satake, Fumito Watanabe, Minoru Kimoto, Ayuto Kodama, Yu Kume, Keiko Suzuki, Sachiko Makabe, OTA HIDETAKA
International Journal of Environmental Research and Public Health 2025年01月
研究論文（学術雑誌）
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Senior Theater Projects: Enhancing Physical Health and Reducing Depression in Older Adults.
Ayuto Kodama, Nobuko Watanabe, Hitomi Ozawa, Shinsuke Imamura, Yoko Umetsu, Manabu Sato, Hidetaka Ota
International journal of environmental research and public health 21 ( 10 ) 2024年09月
研究論文（学術雑誌）
BACKGROUND: The aim of this study was to clarify the effects of a theater training program intervention on the physical and cognitive functions in community-dwelling older people. METHODS: Of the 59 participants, 30 were the control group, and 29 were the intervention group. We assessed physical and mental/cognitive functions and criteria of physical frailty. RESULTS: Statistical analysis showed that the usual walking speed (UWS) (p < 0.01), grip strength (GS) (p < 0.01), and GDS-15 (p < 0.05) improved significantly in the intervention group, whereas the Geriatric Depression Scale short-form (GDS-15) (p < 0.01) worsened significantly in the control group. Cognitive function was not significantly different between the two groups. Physical frailty was unchanged in the control group but significantly improved in the intervention group (p < 0.05), and a significant interaction was found for GDS-15 in ANOVA (F = 5.76, p < 0.05). CONCLUSIONS: The results of this study suggest that a theater intervention for the older adults may be effective in preventing and improving depression and physical frailty in old age.
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Improvement of social frailty is associated with stability of nonparametric characteristics of the rest-activity rhythm and improvement of the usual walking ability in the elderly.
Yu Kume, Ayuto Kodama, Sayaka Arai, Makiko Nagaoka, Akiko Sato, Akira Saito, Hidetaka Ota, Hideaki Ando
Chronobiology international 1 - 9 2024年08月
研究論文（学術雑誌）
Our study, conducted between April 2022 and January 2024, was aimed at clarifying components of the rest-activity rhythm (RAR) involved in improvement of social frailty state before or after a 3-month multi-component exercise intervention in the elderly. Participants were recruited from the general population in Akita prefecture, Japan. We administered a four-item social frailty screening questionnaire to classify the severity of social frailty in each participant before and after the 3-month intervention. The RAR parameters were measured on an Actiwatch Spectrum Plus device worn by the subjects for 7 continuous days. As the final sample, 65 participants classified into the improved/maintained group (n = 36) or the deteriorated group (n = 29) according to the change in the social frailty classification after the intervention were included in the analysis. The results of a binomial logistic regression analysis showed significantly higher values of interdaily stability (IS) and usual walking speed at the post-test after the intervention. Based on our findings, we propose that stability of the rest-activity rhythm related to synchronization with external stimuli (such as social effect and physical activity) might have clinical impact on improvement of social frailty state in elderly community-dwellers.
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Unmodulated 40 Hz Stimulation as a Therapeutic Strategy for Aging: Improvements in Metabolism, Frailty, and Cognitive Function in Senescence-Accelerated Prone 10 Mice.
Tatsunori Shimizu, Hidetaka Ota, Ayuto Kodama, Yasuhiro Suzuki, Takako Ohnuma, Rieko Suzuki, Kaoru Sugawara, Yasushi Sato, Hiroyuki Kodama
Biomolecules 14 ( 9 ) 2024年08月
研究論文（学術雑誌）
With aging populations in many countries, including Japan, efforts to mitigate the aging-related decline in physical function have gained importance not only for improving individual quality of life but also for mitigating the effects of this loss of function on society. Impaired glucose tolerance, muscle weakness, and cognitive decline are well-known effects of aging. These interrelated factors can create a vicious cycle because impaired glucose tolerance can accelerate muscle weakness and cognitive decline. Unmodulated 40 Hz (u40Hz) stimulation is imperceptible to the human ear and has been reported to improve cognitive function in humans and mice. However, research on the effects of u40Hz stimulation is still limited. This study aimed to report the effects of u40Hz stimulation on glucose tolerance and muscle strength in senescence-accelerated prone (SAMP)-10 mice, a model of accelerated aging. SAMP-10 mice underwent five weeks of u40Hz stimulation followed by glucose-tolerance tests, cognitive and behavioral assessments, and frailty evaluations. In comparison with the control group, the u40Hz-stimulation group showed mitigation of age-related decline in glucose tolerance, a better frailty index (FI), and notably preserved muscle strength. Microarray analysis of stimulated muscle tissue revealed significant upregulation of β-oxidation genes and genes functioning downstream of peroxisome proliferator-activated receptor gamma, and significant downregulation of clock genes. These findings indicate the beneficial effects of u40Hz stimulation on glucose tolerance, muscle strength, and cognitive function, warranting further research in this area.
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Comparative Analysis of Frailty Risk and Associated Factors: Community-Based vs. Open Recruitment Groups.
Tatsunori Shimizu, Ayuto Kodama, Yu Kume, Masahiro Iwakura, Katsuya Iijima, Hidetaka Ota
International journal of environmental research and public health 21 ( 5 ) 2024年05月
研究論文（学術雑誌）
BACKGROUND: Frailty leads to vulnerability to stress, impaired daily functioning, and an increased need for care. Frailty is considered reversible, and it is crucial to detect the risk of frailty early and investigate factors that may delay its progression. OBJECTIVES: To identify tests that can explain frailty risk and compare the situation of local residents with and without frailty support. METHODS: Participants were recruited in two ways: through public advertisements in Akita City (open recruitment group) and through invites from frailty supporters in their immediate communities (community-based group). We examined the differences in frailty risk and oral, motor, and social functions between the two groups and identified factors associated with frailty risk in both groups. RESULTS: The community-based group exhibited a lower risk of frailty than the open recruitment group despite having more older members on average. Additionally, the community-based group demonstrated better social functioning than the open-recruitment group. Furthermore, factors such as oral diadochokinesis (ODK), one-leg stand test (OLS), and grip strength (GS) showed significant association with frailty risk. CONCLUSION: The ODK, OLS, and GS were identified as factors explaining frailty risk, and Frailty Supporters may reduce the risk of frailty.
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Effect of a multicomponent programme based on reality orientation therapy on the physical performance and cognitive function of elderly community-dwellers: a quasi-experimental study.
Yu Kume, Makiko Nagaoka, Sachiko Uemura, Akira Saito, Megumi Tsugaruya, Tomoe Fujita, Yoshino Terui, Ayuto Kodama, Akiko Sato, Hidetaka Ota, Hideaki Ando
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 23 ( 5 ) 847 - 855 2023年09月
研究論文（学術雑誌）
BACKGROUND: Effects of a multicomponent exercise programme have an impact on the physical, cognitive, and psychological domains in elderly community-dwellers. However, some individuals aged 65 years or more have not shown positive effects after the intervention as reported in similar research. The objective of this quasi-experimental study was to clarify the effectiveness of a multicomponent programme based on reality orientation therapy (ROT) on the physical performance, cognitive ability, and psychological state in the elderly. METHOD: Participants were recruited from the general public in 20 areas of Akita Prefecture, Japan, and they took part in each exercise programme for 90 min a day, once every 2 weeks, for 3 months, according to the group classification using cluster randomization into 20 cohorts in Akita. Physical, cognitive, and geriatric depression assessments were performed at baseline and after the 3-month intervention in both the ROT-based intervention group and the control group. RESULT: The final samples for analysis consisted of 31 participants in the control group and 30 participants in the intervention group. The results of the statistical analysis comparing the two groups showed that the 5-repetition sit-to-stand test was performed significantly faster (P < 0.05) and that the results of the word list memory (WM) test and the Symbol Digit Substitution Task also had significantly improved (P < 0.05) after the intervention in both groups. The WM score did not show an interactive effect between the group and time factors, but it had a significant main effect on time in both groups (P < 0.05). CONCLUSION: The results of our quasi-experimental study indicated that the multicomponent programme based on the ROT would be as effective as the original multicomponent programme combined with aerobic exercise and cognitive tasks, as highlighted in the WM.
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Effectiveness of a Theater Program Intervention on the Cognitive, Physical, and Social Functions of Elderly People Living in the Community: A Pilot Survey
Kodama A, Kume Y, Watanabe N, Iino Y, Imamura S, Ota H
Clinical Case Reports International 7 ( 1 ) 1591 2023年08月 [査読有り]
研究論文（学術雑誌）
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A multicomponent program improved cognitive and physical functions of older adults with lower GDS values
Kodama Ayuto, Kodama Miyuki, Kato Mitsuyo, Sugawara Kaoru, Ota Hidetaka
Annals of Alzheimer's and Dementia Care ( Peertechz Publications Private Limited ) 6 ( 1 ) 026 - 031 2022年11月 [査読有り]
研究論文（学術雑誌）
Background: MCI is an intermediate stage between cognitive impairment status and persons with MCI are at high risk of developing AD. This study aimed to investigate the effects of a multicomponent program (aerobic, resistance exercises, cognitive training, music, myofascial release exercises, acupoint stimulation, and oral gymnastics) on the cognitive and physical functions of older adults in community dwellers and it is to clarify which measurement factors are predictive to reverse MCI to normal. Results: In this study, we measured cognitive functions, physical functions, and the diagnosis of MCI. We assessed factors before (pre-test), and after treatment of 12 training sessions (post-test). The participants were divided into two groups (Improve group and the Non-Improve group). The Mann-Whitney test was used to analyze the differences between pre-and post-test and revealed significant differences in the UWS (p < 0.05), WM (p < 0.01), SDST (p < 0.01), and MMSE (p < 0.01). Moreover, binomial logistic regression analysis revealed a significant association of the Improved group with the GDS-15 (Odds ratio, 0.587; 95% Confidence Interval [95% CI], 0.309-0.791; p = 0.003) and MMSE (Odds ratio, 0.494; 95 % CI, 0.360-0.957, p = 0.033). Conclusion: This study indicated that this program improved physical and cognitive functions in those who were not prone to depression before treatment and suggests that the GDS measurement might be able to predict the intervention effects of a multicomponent program.
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Tatsunori Shimizu, Ayuto Kodama, Kaoru Sugawara, Mariko Asano, Yuji Okuda, Hidetaka Ota
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics ( The Japan Geriatrics Society ) 59 ( 4 ) 543 - 550 2022年10月 [査読有り]
研究論文（学術雑誌）
<p><b>目的：</b>認知症地域支援推進員の効率的な事業展開に向けて必要なことを検討する．<b>方法：</b>当センターがある秋田県において，25市町村の認知症地域支援推進員を対象に活動の現状を把握し，事業を効率的に展開するためにはどういったことが必要かを検討するための簡易アンケート調査を行った．<b>結果：</b>第一に認知症支援推進員の存在を地域住民に認知されていないことが判明し，その存在や活動を周知するような機会が必要であることが明らかになった．また推進員同士の情報共有や認知症の支援体制を構築するための社会資源を把握するツールなどが不足していることも明らかになった．また連携の面では，初期集中支援チームや疾患医療センターとの連携はとれているものの，認知症サポーターとの連携が不十分であることが判明した．さらに推進員の大きな役割である認知症ケアパスの作成や活動にはあまり関与しない実態が見えてきた．<b>結論：</b>今回の結果より，事業を効率的に展開するためのポイントとして，1．地域住民に対する認知症地域推進員を周知するための情報発信，2．認知症サポーターや民生委員との連携づくり，3．社会資源マップの作成やその把握，認知症ケアパスの有効活用，4．地域支援推進員が兼務しなくてよい労働環境の整備，5．認知症施策全体を理解するための学習の場づくり，の以上5点を提案する．</p>
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A Pilot Survey: Oral Function as One of the Risk Factors for Physical Frailty
Kodama A.
International Journal of Environmental Research and Public Health ( International Journal of Environmental Research and Public Health ) 19 ( 10 ) 2022年05月 [査読有り]
研究論文（学術雑誌）
Background: The aim of this study was to examine the association of the multiple facets of oral, motor, and social functions in community-dwelling older adults, to identify factors that might influence the risk of frailty. Methods: Of the 82 participants included in the study, 39 (5 males and 34 females) were young-old adults, with an average age of 70.5 ± 2.8 years, and 43 (14 males and 29 females) were old-old adults, with an average age of 78.7 ± 2.9 years. We assessed the risk factors for frailty among oral, motor, and social functions. Results: Statistical analysis showed a significant difference in the oral diadochokinesis between the groups (p = 0.006). According to the Spearman correlation analysis, a significant association was observed with age and oral diadochokinesis (rs = −0.262, p = 0.018), and social support (rs = −0.219, p = 0.049). Moreover, binomial logistic regression analysis revealed a significant association of frailty with the occlusal force (odds ratio, 0.031; 95% confidence interval (95% CI), 0.002–0.430; p = 0.010), General Oral Health Index (odds ratio, 0.930; 95% CI, 0.867–0.999, p = 0.046), and availability of social support (odds ratio, 0.803, 95% CI, 0.690–0.934, p = 0.004). Conclusions: To prevent frailty at an early stage, assessments of oral functions, and also that of the availability of social support, are important.
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Kume Y.
Chronobiology International ( Chronobiology International ) 39 ( 12 ) 1665 - 1673 2022年 [査読有り]
研究論文（学術雑誌）
Reversibility of frailty in the elderly has been discussed comprehensively and but association between recovery of frail state and rest-activity rhythm (RAR) patterns remains unclear. The aim of the current study was to examine a predictor of RAR patterns at the baseline against change of frail state after the intervention in the elderly community-dwellers. This study was performed during Covid-19 pandemic, at the period from April in 2020 to March in 2022. Participants were publicly recruited from senior’s exercise program hosted by Akita city or Yurihonjo city. The revised Japanese version of the Cardiovascular Health Study criteria (revised J-CHS criteria) was used to assess frail state in each participant before and after the 6-month intervention. To measure the nonparametric RAR parameters consisting of interdaily stability (IS), intra-daily variability (IV), relative amplitude (RA) and average physical activity for the most active 10-h span (M10) or for the least active 5-h span (L5) over the average 24-h profile, an Actiwatch Spectrum Plus device was worn on each participant’s non-dominant wrist for seven continuous days. The final samples were 75 participants except for persons with uncompleted data, classified into the improved group (n = 12), the maintained group (n = 53) and the deteriorated group (n = 10) according to frail alteration after the six-month intervention. As a result of the multinomial logistic regression analysis with the reference of the maintained group, the improvement of frail state associated with a low value of IS and total night-sleep time at the baseline, and M10 and L5 at the initial time were also able to predict worsening of frail state after the six-months intervention. A result of this follow-up study provides grounds for our proposal that alterations of RAR patterns in the elderly could be observed in association with recovery or worsening of frail state after the intervention. The potential finding, however, warrants further longitudinal investigation.
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Examination of the effect of Deep Micro Vibrotactile stimulation on cognitive function for elderly with Alzheimer’s Disease
Ayuto Kodama, Yasuhiro Suzuki, Yu Kume, Hidetaka Ota
Annals of Alzheimer's and Dementia Care 5 ( 1 ) 1 - 3 2021年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Examination of the effect of Deep Micro Vibrotactile stimulation on cognitive function for elderly with Alzheimer’s Disease
Ayuto Kodama, Yasuhiro Suzuki, Yu Kume, Hidetaka Ota
Annals of Alzheimer's and Dementia Care 5 ( 1 ) 1 - 3 2021年01月 [査読有り]
研究論文（学術雑誌）
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ドライブレコーダーを用いた実車評価と心身機能評価との関連からみた地域在住高齢者の自働車運転の特徴
田中祐汰, 久米裕, 小玉鮎人
日本安全運転・医療研究会プログラム・抄録集(Web) 5th 2021年 [査読有り]
研究論文（学術雑誌）
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新型コロナウイルス感染拡大下における在宅高齢者の肥満とうつに与える影響
小玉鮎人, 菅原薫, 久米裕, 高橋智子, 小野剛, 大田秀隆
日本老年医学会雑誌 58 2021年 [査読有り]
研究論文（学術雑誌）
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地域高齢者におけるフレイルと身体活動量および生活リズムとの関連性
小玉鮎人, 菅原絵美子, 加藤廉, 久米裕
日本作業療法学会抄録集(CD-ROM) 54th 2020年 [査読有り]
研究論文（学術雑誌）
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Deriving the reference value from the circadian motor active patterns in the “non-dementia” population, compared to the “dementia” population: What is the amount of physical activity to the good circadian rhythm.
Yu Kume, Megumi Tsugaruya, Takashi Ishikawa
Chronobiology International 33 2016年07月 [査読有り]
研究論文（学術雑誌） 単著
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Sleep/awake status throughout the night and circadian motor activity patterns in older nursing-home residents with or without dementia, and older community-dwelling people without dementia.
Yu Kume, Ayuto Kodama, Kotaro Sato, Satoko Kurosawa, Takashi Ishikawa, Sachiko Ishikawa
Chronobiology International 28 2016年07月 [査読有り]
研究論文（学術雑誌） 単著