研究等業績 - その他 - 今野　泰典

Aggregated eosinophils and neutrophils characterize the properties of mucus in chronic rhinosinusitis

Miyabe Y.

Journal of Allergy and Clinical Immunology ( Journal of Allergy and Clinical Immunology )    2024年

DOI

Fibrous dysplasia of the zygomatic bone and mandibular coronoid process: A case report

Fukuchi M.

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology ( Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology )  35 ( 6 ) 523 - 527   2023年11月

DOI

ニボルマブ投与後に多形紅斑重症型が生じた1例

鈴木 兼一郎, 髙野 裕史, 福地 峰世, 五十嵐 秀光, 今野 泰典, 福田 雅幸

日本口腔科学会雑誌 ( 特定非営利活動法人 日本口腔科学会 )  72 ( 1 ) 20 - 25   2023年

Nivolumab is an anti-PD-1 antibody that is an immune checkpoint inhibitor that blocks PD-1/PD-L1 signals and exerts an antitumor effect. Immune checkpoint inhibitors including nivolumab are known to cause various immune-related adverse events including skin disorders. We report a case of erythema multiforme major （EM major） after nivolumab administration.
<br>A 66-year-old female with mandibular gingival cancer （cT4aN2cM0） underwent bilateral neck dissection and mandibular segmental resection in January 2019. After postoperative concurrent chemoradiation （cisplatin + radiation）, multiple lung metastases were diagnosed three months postoperatively, and nivolumab 240mg every two weeks was started. Pruritus of the eyes, erythema of the trunk and extremities, and erosion of the oral mucosa occurred after seven doses of nivolumab had been administered. She was referred to a dermatologist and was admitted to the hospital because of suspicion of Stevens–Johnson syndrome. The symptoms improved daily with Prednisolone administration, and she was discharged from the hospital four weeks later. The final diagnosis was EM major.
<br>Nivolumab is effective for head and neck cancers, but adverse events are more diverse than with conventional chemotherapy. Although most of the skin disorders are reported to be mild, it may be necessary to observe them carefully and be important to treat them in the early stage.

DOI CiNii Research

上顎切除後にミリングバーを応用した広範囲顎骨支持型補綴にて咬合再建を行った3例

福地 峰世, 高野 裕史, 山崎 雅人, 有馬 実咲, 伊東 慶介, 鈴木 兼一郎, 今野 泰典, 五十嵐 秀光, 福田 雅幸

Japanese Journal of Maxillo Facial Implants ( (公社)日本顎顔面インプラント学会 )  21 ( 2 ) 107 - 117   2022年08月

上顎切除後の咬合再建は主に顎義歯によって行われているが、欠損が大きい場合や無歯顎である場合は十分な維持・安定が得られず機能回復が困難である。以前より上顎欠損症例に対しては、インプラント治療による咬合再建が行われ、QOLの向上に寄与してきた。本邦では2012年より従来のインプラント義歯は広範囲顎骨支持型装置および補綴として保険収載され、より多くの口腔がん患者に対してインプラント治療による咬合再建が可能となった。今回われわれは上顎切除後症例に対してミリングバーを応用した広範囲顎骨支持型補綴による咬合再建を行い、良好な機能回復が得られた症例を3例経験したので、機能評価の結果も含めて報告する。(著者抄録)

上唇に発生した血管脂肪腫の1例

及川 湧基, 五十嵐 秀光, 鈴木 兼一郎, 今野 泰典, 髙野 裕史, 福田 雅幸

日本口腔外科学会雑誌 ( 公益社団法人 日本口腔外科学会 )  68 ( 2 ) 94 - 98   2022年02月

<p>Angiolipoma is a benign tumor that shows a mixture of adipose tissue and hemangioma-like lesion histologically. It frequently occurs in the trunk and limbs, and it is very rare in the lip. We report a case of angiolipoma of the upper lip. The patient was a 28-year-old woman who was referred to our hospital because of a mass in the right upper lip. A painless elastic-soft tumor was found under the mucosa of the right upper lip. The skin and mucosa just above the swelling was normal. MRI showed an unclearly demarcated lesion measuring 13 × 11 × 5 mm in the right upper lip with a mixed pattern of high and low intensity on T1- and T2-weighted images. An incisional biopsy was performed under local anesthesia, and the histopathological diagnosis was angiolipoma. Based on this diagnosis, the tumor was resected under general anesthesia. Immunohistochemical examination revealed CD31, CD34, α-SMA and VEGF positive cells in the tumor. There has been no recurrence one year after surgery.</p>

DOI CiNii Research

Eosinophil ETosis–Mediated Release of Galectin-10 in Eosinophilic Granulomatosis With Polyangiitis

Fukuchi M.

Arthritis and Rheumatology ( Arthritis and Rheumatology )  73 ( 9 ) 1683 - 1693   2021年09月

DOI

A case of secretory carcinoma of the minor salivary gland in the buccal mucosa

Takano H.

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology ( Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology )  33 ( 2 ) 136 - 140   2021年03月

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Abscopal effect of radiation therapy after nivolumab monotherapy in a patient with oral mucosal melanoma: A case report

Igarashi H.

Oral Oncology ( Oral Oncology )  108   2020年09月

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歯槽骨と歯根の吸収を認めたシュウ酸症の1例

五十嵐 秀光, 福田 雅幸, 福地 峰世, 今野 泰典, 山崎 雅人, 髙野 裕史

日本口腔外科学会雑誌 ( 社団法人 日本口腔外科学会 )  66 ( 5 ) 251 - 255   2020年05月

<p>Oxalosis is a rare disorder that deposits calcium oxalate in many organs of the body. We report a case of oxalosis with resorption of alveolar bone and tooth roots. The patient was a 60-year-old man who was given a diagnosis of oxalosis in another hospital and was referred to our hospital because of alveolar bone resorption in the right molar region of the mandible. Clinical and imaging examinations revealed resorption of alveolar bone and many teeth roots. Based on the results of histopathological examination, we attributed the resorption of alveolar bone and tooth roots to deposition of calcium oxalate. With time, resorption of the alveolar bone and tooth roots progressed.</p>

DOI CiNii Research

Comparison of CD16-negative selection vs. MACSxpress system for isolation of blood eosinophils

Fukuchi M.

Allergology International ( Allergology International )  68 ( Supplement.1 ) S11 - S13   2019年09月

DOI CiNii Research

Critical role of CCL4 in eosinophil recruitment into the airway

Kobayashi Y.

Clinical and Experimental Allergy ( Clinical and Experimental Allergy )  49 ( 6 ) 853 - 860   2019年06月

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Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death

Ueki S.

Blood ( Blood )  132 ( 20 ) 2183 - 2187   2018年11月

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Teratoid cyst of the sublingual region: A case report

Igarashi H.

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology ( Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology )  30 ( 6 ) 504 - 507   2018年11月

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ETosis-derived DNA trap production in middle ear effusion is a common feature of eosinophilic otitis media

Ohta N.

Allergology International ( Allergology International )  67 ( 3 ) 414 - 416   2018年07月

DOI CiNii Research

アレルギー性気管支肺アスペルギルス症の粘液栓への好酸球Etosisの関与

竹田 正秀, 植木 重治, Josiane Neves, 福地 峰世, 今野 泰典, 佐藤 一洋, 佐野 正明, 廣川 誠, 蛇澤 晶, 浅野 浩一郎

アレルギー ( (一社)日本アレルギー学会 )  67 ( 4-5 ) 662 - 662   2018年05月

ICAM-1 upregulation is not required for retinoic acid-induced human eosinophil survival

Ueki S.

Immunology Letters ( Immunology Letters )  196   68 - 73   2018年04月

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Eosinophilic Otitis Media: the Aftermath of Eosinophil Extracellular Trap Cell Death

Ueki S.

Current Allergy and Asthma Reports ( Current Allergy and Asthma Reports )  17 ( 5 )   2017年05月

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