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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Department of Dermatology and Plastic Surgery |
KONO Michihiro
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Research Interests 【 display / non-display 】
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dyschromatosis
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mosaicism
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genetic diagnosis
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dyschromatosis symmetrica hereditaria
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reticulate acropigmentation of Kitamura
Graduating School 【 display / non-display 】
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-1994.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-1999.03
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2019.09-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Professor
Research Achievements 【 display / non-display 】
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Murasawa E.
Geriatrics and Gerontology International ( Geriatrics and Gerontology International ) 25 ( 1 ) 123 - 124 2025.01 [Refereed]
Research paper (journal) Domestic Co-author
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Trajectories of egg sensitization in childhood: Two birth cohorts in Asia and Europe
Nakamura T.
Allergy: European Journal of Allergy and Clinical Immunology ( Allergy: European Journal of Allergy and Clinical Immunology ) 80 ( 1 ) 193 - 204 2025.01 [Refereed]
Research paper (journal) International Co-author
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Kumagai Takuya, Saito Masaya, Sato Takahiko, Inoue Junichi, Ishikawa Norihisa, Ono Tsuyoshi, Kono Michihiro, Takahashi Naoto
Internal Medicine ( 一般社団法人 日本内科学会 ) advpub ( 0 ) 2025 [Refereed]
Research paper (journal) Domestic Co-author
<p>We herein report a case of cutaneous squamous cell carcinoma (SCC) characterized by paraneoplastic hypercalcemia-leukocytosis syndrome. The patient presented with systemic symptoms, including anorexia, a fever, and a tumoral lesion on the upper arm. Laboratory test results revealed hypercalcemia and leukocytosis. A tissue biopsy confirmed SCC, and further investigation revealed elevated parathyroid hormone-related protein (PTHrP) and granulocyte-colony stimulating factor (G-CSF) levels. Immunostaining demonstrated G-CSF production by the tumor cells. Radiation therapy was administered, which improved leukocytosis and decreased G-CSF and PTHrP levels. Through a case report and literature review, we explored the clinical characteristics of tumors that produce G-CSF and PTHrP. </p>
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Tanahashi K.
British Journal of Dermatology ( British Journal of Dermatology ) 191 ( 3 ) 397 - 404 2024.09 [Refereed]
Research paper (journal) Domestic Co-author
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Neonatal skin dysbiosis to infantile atopic dermatitis: Mitigating effects of skin care
Aoyama R.
Allergy: European Journal of Allergy and Clinical Immunology ( Allergy: European Journal of Allergy and Clinical Immunology ) 79 ( 6 ) 1618 - 1622 2024.06 [Refereed]
Research paper (journal) Domestic Co-author
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Research on skin hereditary diseases developed from daily medical practice
Kono Michihiro
47 ( 2 ) 45 - 57 2020.11 [Invited]
Research paper (university bulletin, research institution) Single author
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A Family of Familial Pityriasis Rubra Pilaris
Tahara Jumpei, Tanabe Hiroshi, Kanameishi Shuto, Sakurai Kenji, Ogawa Marie, Goto Kazuya, Fukumoto Takaya, Ohno Sayoko, Kono Michihiro, Akiyama Masashi
The Japanese Journal of Dermatology ( Japanese Dermatological Association ) 130 ( 11 ) 2379 - 2383 2020
<p>Familial pityriasis rubra pilaris (PRP) is caused by gain-of-function mutations in <i>CARD14</i>. We report familial cases of a 28-year old mother and a 11-month old daughter with well-demarcated salmon-coloured plaques accompanied by scales. The mother is tolerant with emollients and moisturizers, and her daughter's symptoms improved with topical vitamin D<sub>3</sub>, steroid, and oral vitamin A. After genetic counselling, genetic analysis revealed a heterozygous missense mutation in <i>CARD14</i>, c.467T>C (p.Leu156Pro) in the mother and the daughter, but not in the father. We diagnosed them with familial cases of PRP type V. This variant has been reported from a Israeli group. In Japan, 4 cases of PRP identified with a <i>CARD14</i> mutation have been reported, but none of them had this variant.</p>