Research Achievements - Other -
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Ccr4-NOT脱アデニル化酵素複合体は抗腫瘍性NK細胞活性を制御する(The Ccr4-Not deadenylase complex controls antitumor NK cell activity)
Tatematsu Megumi, Sawa Shinichiro, Ikuta Koichi, Ebihara Takashi
日本免疫学会総会・学術集会記録 ( (NPO)日本免疫学会 ) 50 ( Proceedings ) 3 - P 2021.11
Summary of the papers read (national conference and other science council)
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ILC2の活性化により生じる細胞死は慢性アレルギー性炎症に対し保護的に働く(Activation-induced cell death of ILC2s confersprotection against chronic allergic inflammation)
Yamada Toshiki, Tatematsu Megumi, Ebihara Takashi
日本免疫学会総会・学術集会記録 ( (NPO)日本免疫学会 ) 50 ( Proceedings ) 3 - P 2021.11
Summary of the papers read (national conference and other science council)
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肝特異的ホスファチジルグリセロールリン酸ホスファターゼ遺伝子欠損によるラロン型低身長症様疾患モデルマウス
高須賀 俊輔, 海老原 敬, 佐々木 雄彦
日本生化学会大会プログラム・講演要旨集 ( (公社)日本生化学会 ) 94回 [P - 991] 2021.11
Summary of the papers read (national conference and other science council)
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T細胞(1) T細胞発生とレパートリー選択 免疫系の発達におけるC末端アミノ酸配列によるRunx3活性の制御(T cell: T cell development and repertoire selection Regulation of Runx3 activity in immune system development by the C-terminal end amino acid sequence)
Kojo Satoshi, Ebihara Takashi, Ohno-Oishi Michiko, Muroi Sawako, Taniuchi Ichiro
日本免疫学会総会・学術集会記録 ( (NPO)日本免疫学会 ) 46 ( Proceedings ) 2 - O/P 2017.12
Summary of the papers read (national conference and other science council)
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免疫システム開発 免疫細胞発生におけるRunx転写因子の役割(Immunosystem development Roles of Runx Transcription Factors In Immune Cell Development)
Taniuchi Ichiro, Kojo Satoshi, Ebihara Takashi, Seo Wooseok, Tenno Mari
日本免疫学会総会・学術集会記録 ( (NPO)日本免疫学会 ) 46 ( Proceedings ) S8 - 5 2017.12
Summary of the papers read (national conference and other science council)
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自然リンパ球(2) (ILC1,2,3) Runxタンパク質はILC2の構成的活性を抑制し活性化後のILC2枯渇を予防する(Innate Lymphocyte (ILC1,2,3) Runx proteins suppress constitutive activity of ILC2 and prevent ILC2 exhaustion after activation)
Ebihara Takashi, Kojo Satoshi, Taniuchi Ishiro
日本免疫学会総会・学術集会記録 ( (NPO)日本免疫学会 ) 46 ( Proceedings ) 3 - O/P 2017.12
Summary of the papers read (national conference and other science council)
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自然リンパ球 成人の腸におけるILC1およびILC3に特異的な前駆細胞の同定(Innate lymphocytes Identification of progenitor cells specific to ILC1s and ILC3s in adult intestine)
Ebihara Takashi, Egawa Takeshi, Yokoyama M. Wayne
日本免疫学会総会・学術集会記録 ( (NPO)日本免疫学会 ) 44 ( Proceedings ) 40 - 40 2015.10
Summary of the papers read (national conference and other science council)
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Takaki, H., Honda, K., Atarashi, K., Kobayashi, F., Ebihara, T., Oshiumi, H., Matsumoto, M., Shingai, M., Seya, T.
Molecular Immunology ( Pergamon-elsevier science ltd ) 57 ( 2 ) 100 - 109 2014
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Dendritic cell-derived TNF-α is responsible for development of IL-10-producing CD4+ T cells
Hirata, N., Yanagawa, Y., Satoh, M., Ogura, H., Ebihara, T., Noguchi, M., Matsumoto, M., Togashi, H., Seya, T., Onoé, K., Iwabuchi, K.
Cellular Immunology ( Elsevier ) 261 ( 1 ) 37 - 41 2010
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IL-6 and IFN-α from dsRNA-stimulated dendritic cells control expansion of regulatory T cells
Kubota, N., Ebihara, T., Matsumoto, M., Gando, S., Seya, T.
Biochemical and Biophysical Research Communications ( Elsevier ) 391 ( 3 ) 1421 - 1426 2010
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Dai Iwakiri, Li Zhou, Mrinal Samanta, Misako Matsumoto, Takashi Ebihara, Tsukasa Seya, Shosuke Imai, Mikiya Fujieda, Keisei Kawa, Kenzo Takada
The Journal of Experimental Medicine ( Rockefeller University Press ) 206 ( 10 ) 2091 - 2099 2009.08
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Takashi EBIHARA, Misako MATSUMOTO, Tsukasa SEYA
Uirusu ( Japanese Association of Virology ) 58 ( 1 ) 19 - 26 2008.06
Hepatitis C virus (HCV) is a single-strand, positive sense RNA virus belonging to the flaviviridae family. HCV develops persistent infection in >70% of infected patients, and eventually causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma in some patients. Once chronic infection is established in patients with HCV, spontaneous viral clearance fails, although how HCV remains persistently infecting the liver is largely unknown. Insufficient immune response, involving antiviral innate immune response including dendritic cells (DCs), has been focused. A number of controversial studies have been reported as to HCV genome replication and HCV-mediated immune responses in human DCs. A tantalizing point of these earlier studies is the lack of the system for viral propagation in HCV. Recently, an in vitro system was exploited to propagate HCV particles using the JFH1 strain. In this review, we review the previous reports about the subversion of innate immunity by HCV and show the innate response of monocyte-derived dendritic cells (MoDCs) against the JFH1 strain. We could not observe HCV direct interaction with MoDC maturation. MoDCs maturated by phagocytosing HCV-infected apoptotic cells containing virus-derived dsRNA, which interacted with TLR3 in the phagosomes. All of these data suggests the importance of TLR3 signal for the induction of anti-HCV innate immunity.
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TLR4とTLR2を介して刺激された樹状細胞における選択的かつ相乗的な抗炎症性サイトカインの産生
平田 徳幸, 柳川 芳毅, 海老原 敬, 瀬谷 司, 植松 智, 審良 静男, 林 史恵, 岩渕 和也, 小野江 和則
日本リンパ網内系学会会誌 ( (一社)日本リンパ網内系学会 ) 48 103 - 103 2008.05
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Seroepidemiology of human bocavirus in Hokkaido Prefecture, Japan
Endo, R., Ishiguro, N., Kikuta, H., Teramoto, S., Shirkoohi, R., Xiaoming, M., Ebihara, T., Ishiko, H., Ariga, T.
Journal of Clinical Microbiology ( American Society for Microbiology ) 45 ( 10 ) 3218 - 3223 2007
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Seya Tsukasa, Matsumoto Misako, Ebihara Takashi, Akazawa Takashi
The Hirosaki medical journal ( Hirosaki University ) 59 S43 - S51 2007
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小児の下気道感染症患者からのヒトボカウイルス(Human Bocavirus)の検出
石黒 信久, 遠藤 理香, 石古 博昭, 菊田 英明, 馬 暁明, 海老原 敬
感染症学雑誌 ( (一社)日本感染症学会 ) 80 ( 6 ) 742 - 742 2006.11
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小児の下気道感染症患者からのヒトボカウイルス(Human Bocavirus)の検出
石黒 信久, 遠藤 理香, 石古 博昭, 菊田 英明, 馬 暁明, 海老原 敬
感染症学雑誌 ( (一社)日本感染症学会 ) 80 ( 臨増 ) 248 - 248 2006.03
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Detection of human Bocavirus in Japanese children with lower respiratory tract infections
Ma, X., Endo, R., Ishiguro, N., Ebihara, T., Ishiko, H., Ariga, T., Kikuta, H.
Journal of Clinical Microbiology ( American Society of Microbiology ) 44 ( 3 ) 1132 - 1134 2006
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新たに発見された呼吸器感染症起因ウイルスであるヒト・メタニューモウイルスのG(attachment)蛋白塩基配列の多様性
石黒 信久, 遠藤 理香, 石古 博昭, 菊田 英明, 海老原 敬
感染症学雑誌 ( (一社)日本感染症学会 ) 79 ( 8 ) 586 - 586 2005.08
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新しく発見されたhuman metapneumovirusに対する抗体の測定
海老原 敬, 遠藤 理香, 馬 暁明, 吉岡 幹朗, 石黒 信久, 菊田 英明
日本小児科学会雑誌 ( (公社)日本小児科学会 ) 109 ( 7 ) 859 - 859 2005.07