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Affiliation |
Hospital Dentistry and Oral Surgery |
Graduating School 【 display / non-display 】
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-2009.03
Tohoku University Faculty of Dentistry Graduated
Graduate School 【 display / non-display 】
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-2015.09
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2019.04-Now
Akita University Hospital Dentistry and Oral Surgery Assistant Professor
Research Achievements 【 display / non-display 】
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Fibrous dysplasia of the zygomatic bone and mandibular coronoid process: A case report
Mineyo Fukuchi, Hidemitsu Igarashi, Shoken Suzuki, Yasunori Konno, Hiroshi Takano, Masayuki Fukuda
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 35 ( 6 ) 523 - 527 2023.10
Research paper (journal) Domestic Co-author
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A case of ectopic impacted wisdom tooth which migrated to the mandibular notch
ARIMA Misaki, KUWAJIMA Seiichi, FUKUDA Masayuki, FUKUCHI Mineyo, IGARASHI Hidemitsu, TAKANO Hiroshi
Japanese Journal of Oral and Maxillofacial Surgery ( Japanese Society of Oral and Maxillofacial Surgeons ) 67 ( 5 ) 281 - 285 2022.02 [Refereed]
Research paper (journal) Domestic Co-author
<p>Ectopic impacted teeth are considered to be caused by congenital malposition of tooth germs, increased internal pressure from cysts, tumor growth, periodontal ligament traction, and rupture of the gubernacular cord. It often progresses asymptomatic, but has been reported to cause pain and infection. Here, we report a case of ectopic impacted tooth in which the mandibular horizontal impacted wisdom tooth migrated to the vicinity of the mandibular notch over 9 years.</p><p> A 42-year-old woman visited our department with the chief complaint of pain in the left mandible. Upon comparison with past radiographs, the left impacted mandibular wisdom tooth was found to have migrated to the mandibular notch over 9 years. We performed an ectopic impacted wisdom tooth extraction to improve the</p><p>pain.</p><p> Fragile soft tissue was found forward the tooth. Histopathological specimens showed no epithelial structure and numerous plasma cell infiltrates. Immunohistochemical staining was negative for cytokeratin. The cause of the migration was considered to be the gubernacular cord thickened by inflammation. After the operation, the pain disappeared, no relapse was observed, and the patient has shown good progress.</p>
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Abscopal effect of radiation therapy after nivolumab monotherapy in a patient with oral mucosal melanoma: A case report
Hidemitsu Igarashi, Masayuki Fukuda, Yasunori Konno, Hiroshi Takano
Oral Oncology 108 2020.09
Research paper (journal) Domestic Co-author
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Teratoid cyst of the sublingual region: A case report
Hidemitsu Igarashi, Masayuki Fukuda, Akira Nakata, Yasunori Konno, Masato Yamazaki, Hiroshi Takano
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 30 ( 6 ) 504 - 507 2018.06 [Refereed]
Research paper (journal) Domestic Co-author
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A case of angiolipoma of the upper lip
OIKAWA Yuki, IGARASHI Hidemitsu, SUZUKI Kenichiro, KONNO Yasunori, TAKANO Hiroshi, FUKUDA Masayuki
Japanese Journal of Oral and Maxillofacial Surgery ( Japanese Society of Oral and Maxillofacial Surgeons ) 68 ( 2 ) 94 - 98 2022.02 [Refereed]
Domestic Co-author
<p>Angiolipoma is a benign tumor that shows a mixture of adipose tissue and hemangioma-like lesion histologically. It frequently occurs in the trunk and limbs, and it is very rare in the lip. We report a case of angiolipoma of the upper lip. The patient was a 28-year-old woman who was referred to our hospital because of a mass in the right upper lip. A painless elastic-soft tumor was found under the mucosa of the right upper lip. The skin and mucosa just above the swelling was normal. MRI showed an unclearly demarcated lesion measuring 13 × 11 × 5 mm in the right upper lip with a mixed pattern of high and low intensity on T1- and T2-weighted images. An incisional biopsy was performed under local anesthesia, and the histopathological diagnosis was angiolipoma. Based on this diagnosis, the tumor was resected under general anesthesia. Immunohistochemical examination revealed CD31, CD34, α-SMA and VEGF positive cells in the tumor. There has been no recurrence one year after surgery.</p>
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A case of oxalosis with resorption of alveolar bone and tooth roots
IGARASHI Hidemitsu, FUKUDA Masayuki, FUKUCHI Mineyo, KONNO Yasunori, YAMAZAKI Masato, TAKANO Hiroshi
Japanese Journal of Oral and Maxillofacial Surgery ( Japanese Society of Oral and Maxillofacial Surgeons ) 66 ( 5 ) 251 - 255 2020.05
<p>Oxalosis is a rare disorder that deposits calcium oxalate in many organs of the body. We report a case of oxalosis with resorption of alveolar bone and tooth roots. The patient was a 60-year-old man who was given a diagnosis of oxalosis in another hospital and was referred to our hospital because of alveolar bone resorption in the right molar region of the mandible. Clinical and imaging examinations revealed resorption of alveolar bone and many teeth roots. Based on the results of histopathological examination, we attributed the resorption of alveolar bone and tooth roots to deposition of calcium oxalate. With time, resorption of the alveolar bone and tooth roots progressed.</p>
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Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.
Akira Takeda, Daichi Kobayashi, Keita Aoi, Naoko Sasaki, Yuki Sugiura, Hidemitsu Igarashi, Kazuo Tohya, Asuka Inoue, Erina Hata, Noriyuki Akahoshi, Haruko Hayasaka, Junichi Kikuta, Elke Scandella, Burkhard Ludewig, Satoshi Ishii, Junken Aoki, Makoto Suematsu, Masaru Ishii, Kiyoshi Takeda, Sirpa Jalkanen, Masayuki Miyasaka, Eiji Umemoto
eLife 5 e10561 2016.02
Lymph nodes (LNs) are highly confined environments with a cell-dense three-dimensional meshwork, in which lymphocyte migration is regulated by intracellular contractile proteins. However, the molecular cues directing intranodal cell migration remain poorly characterized. Here we demonstrate that lysophosphatidic acid (LPA) produced by LN fibroblastic reticular cells (FRCs) acts locally to LPA2 to induce T-cell motility. In vivo, either specific ablation of LPA-producing ectoenzyme autotaxin in FRCs or LPA2 deficiency in T cells markedly decreased intranodal T cell motility, and FRC-derived LPA critically affected the LPA2-dependent T-cell motility. In vitro, LPA activated the small GTPase RhoA in T cells and limited T-cell adhesion to the underlying substrate via LPA2. The LPA-LPA2 axis also enhanced T-cell migration through narrow pores in a three-dimensional environment, in a ROCK-myosin II-dependent manner. These results strongly suggest that FRC-derived LPA serves as a cell-extrinsic factor that optimizes T-cell movement through the densely packed LN reticular network.
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The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.
Hidemitsu Igarashi, Noriyuki Akahoshi, Takayo Ohto-Nakanishi, Daisuke Yasuda, Satoshi Ishii
Scientific reports 5 11410 - 11410 2015.06
Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that acts through G protein-coupled receptors (LPA1-6). Although several biological roles of LPA4 are becoming apparent, its role in hematopoiesis has remained unknown. Here, we show a novel regulatory role for LPA4 in hematopoiesis. Lpar4 mRNA was predominantly expressed in mouse bone marrow (BM) PDGFRα(+) stromal cells, known as the components of the hematopoietic stem/progenitor cell (HSPC) niche. Compared with wild-type mice, LPA4-deficient mice had reduced HSPC numbers in the BM and spleen and were hypersusceptible to myelosuppression, most likely due to impairments in HSPC recovery and stem cell factor production in the BM. Analysis of reciprocal BM chimeras (LPA4-deficient BM into wild-type recipients and vice versa) indicated that stromal cells likely account for these phenotypes. Consistently, LPA4-deficient BM stromal cells showed downregulated mRNA expression of stem cell factor and tenascin-c in vitro. Taken together, these results suggest a critical and novel role for the LPA/LPA4 axis in regulating BM stromal cells.
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TDAG8 activation inhibits osteoclastic bone resorption.
Hisako Hikiji, Daisuke Endo, Kyoji Horie, Takeshi Harayama, Noriyuki Akahoshi, Hidemitsu Igarashi, Yasuyuki Kihara, Keisuke Yanagida, Junji Takeda, Takehiko Koji, Takao Shimizu, Satoshi Ishii
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 ( 2 ) 871 - 9 2014.02
Although the roles of acids in bone metabolism are well characterized, the function of proton-sensing receptors in bone metabolism remains to be explored. In this study, we evaluated the role of proton-sensing receptor T-cell death-associated gene 8 (TDAG8) in osteoclastic activity during bone loss after ovariectomy. Through observations of bone mineral content, we found that pathological bone resorption was significantly exacerbated in mice homozygous for a gene trap mutation in the Tdag8 gene. Furthermore, osteoclasts from the homozygous mutant mice resorbed calcium in vitro more than the osteoclasts from the heterozygous mice did. Impaired osteoclast formation under acidic conditions was ameliorated in cultures of bone marrow cells by Tdag8 gene mutation. Extracellular acidification changed the cell morphology of osteoclasts via the TDAG8-Rho signaling pathway. These results suggest that the enhancement of TDAG8 function represents a new strategy for preventing bone resorption diseases, such as osteoporosis.
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Establishment of cancer immunotherapy via CysLT2 receptor
Grant-in-Aid for Young Scientists(B)
Project Year： 2016.04 - 2019.03 Investigator(s): Igarashi Hidemitsu