SHIMODAIRA Yousuke

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Oncoregulatory Medicine  Department of Gastroenterology and Neurology

Research Interests 【 display / non-display

  • 消化器病態学分野

Graduating School 【 display / non-display

  •  
    -
    2007.03

    Tohoku University   Faculty of Medicine   Graduated

Graduate School 【 display / non-display

  •  
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    2014.03

    Tohoku University  Graduate School, Division of Medicine  Doctor's Course  Completed

Campus Career 【 display / non-display

  • 2019.01
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Oncoregulatory Medicine   Assistant Professor  

 

Research Achievements 【 display / non-display

    ◆Original paper【 display / non-display

  • Direct signaling ofTL1A‑DR3 on fbroblasts induces intestinal fbrosis in vivo

    Noam Jacob, Kotaro Kumagai , Jay P.Abraham , Yosuke Shimodaira , YuefangYe , Justin Luu , AnnaY. Blackwood , Sof L. Castanon , DaltonT. Stamps , Lisa S.Thomas , RivkahGonsky , David Q. Shih , Kathrin S. Michelsen & Stephan R.Targan

    Scientific Reports     2020.10  [Refereed]

    Research paper (journal)   International Co-author

  • Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

    Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute,Thomas Hanley, Svetlana Saveljeva, Thomas Gensollen, Jarom Heijmans, Hai Li,Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg, Shengbao Suo,Adrienne M. Luoma, Yosuke Shimodaira, Jinzhi Duan, David Q. Shih,Margaret E. Conner, Jonathan N. Glickman, Gwenny M. Fuhler, Noah W. Palm,Marcel R. de Zoete, C. Janneke van der Woude, Guo-Cheng Yuan,Kai W. Wucherpfennig, Stephan R. Targan, Philip Rosenstiel,Richard A. Flavell, Kathy D. McCoy, Andrew J. Macpherson,Arthur Kaser, Richard S. Blumberg

    SCIENCE     2019.03  [Refereed]

    Research paper (journal)   International Co-author

  • MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6

    Toshihiro Tadano, Yoichi Kakuta, Shin Hamada, Yosuke Shimodaira, Masatake Kuroha, Yoko Kawakami, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Atsushi Masamune, Seiichi Takahashi, Yoshitaka Kinouchi, and Tooru Shimosegawa

    World Journal of Gastrointestinal Oncology     2016.07  [Refereed]

    Research paper (journal)   International Co-author

  • Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells

    Yosuke Shimodaira, Seiichi Takahashi, Yoshitaka Kinouchi, Katsuya Endo, Hisashi Shiga, Yoichi Kakuta, Masatake Kuroha, Tooru Shimosegawa

    Biochemical and Biophysical Research Communications     2014.02  [Refereed]

    Research paper (journal)   International Co-author

  • FCGR3A-158 polymorphism influences the biological response to infliximab in Crohn’s disease through affecting the ADCC activity

    Rintaro Moroi, Katsuya Endo, Yoshitaka Kinouchi, Hisashi Shiga, Yoichi Kakuta, Masatake Kuroha, Yoshitake Kanazawa, Yosuke Shimodaira, Takahiko Horiuchi, Seiichi Takahashi & Tooru Shimosegawa

    Immunogenetics     2013.01  [Refereed]

    Research paper (journal)   International Co-author

  • display all >>

    ◆Introduction and explanation【 display / non-display

  • Intestinal infections and systemic diseases by PPI-induced alterations in gut microbiota.

        2023.01

    Introduction and explanation (scientific journal)   Single author

  • Analysis of the role of the endoplasmic reticulum stress response-related molecule CHOP in intestinal epithelial cells

    Shimodaira, Yosuke

    Impact     2021.07

    Introduction and explanation (others)   Single author

  • ◆Other【 display / non-display

  • VI. Intestinal Infections and Systemic Diseases by PPI-induced Alterations in Gut Microbiota

    Shimodaira Yosuke, Iijima Katsunori

    Nihon Naika Gakkai Zasshi ( The Japanese Society of Internal Medicine )  112 ( 1 ) 45 - 50   2023.01

    DOI CiNii Research

  • A case of severe inflammatory bowel disease triggered by vaccination with SARS-CoV-2 mRNA

    TAKAHASHI Yasutaka, SHIMODAIRA Yosuke, YOSHIDA Tatsuki, TAJIKA Munehiko, TAKAHASHI So, WATANABE Kenta, FUKUDA Sho, KOIZUMI Shigeto, MATSUHASHI Tamotsu, IIJIMA Katsunori

    Nippon Shokakibyo Gakkai Zasshi ( The Japanese Society of Gastroenterology )  120 ( 4 ) 325 - 329   2023

    <p>A 64-year-old woman received a third dose of SARS-CoV-2 mRNA vaccine. On the next day, she developed fever, diarrhea, and abdominal pain and had bloody stools. Total colonoscopy revealed deep ulceration on the whole colon. She was treated with corticosteroid and infliximab and her symptoms improved. She was diagnosed with severe enteritis resembling ulcerative colitis triggered by SARS-CoV-2 mRNA vaccination.</p>

    DOI PubMed CiNii Research

Grant-in-Aid for Scientific Research 【 display / non-display

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2022.04  -  2025.03 

  • Grant-in-Aid for Early-Career Scientists

    Project Year: 2020.04  -  2022.03 

  • Grant-in-Aid for Research Activity start-up

    Project Year: 2019.04  -  2021.03 

Presentations 【 display / non-display

  • The role of TL1A-DR3 system in intestinal epithelial cells

    Yosuke Shimodaira

    Annual Meeting of the Japanese Society for Immunology  2021.12  -  2021.12 

  • TL1A-DR3 system in naive T cells leads TH1 differentiation

    Yosuke Shimodaira

    JDDW  2019.11  -  2019.11 

  • NOVEL ROLE FOR DEATH RECEPTOR 3 (DR3) EXPRESSED ON INTESTINAL EPITHELIAL CELLS IN REGULATING HOMEOSTATIC INTESTINAL PERMEABILITY AND EPITHELIAL CELL PROLIFERATION, AS WELL AS REGENERATION AFTER INTESTINAL MUCOSAL INJURY

    Yosuke Shimodaira, Jay P. Abraham, Hussein Hamade, Anna Y. Blackwood, Lisa S. Thomas, Sofi L. Castanon, David Q. Shih, Stephan R. Targan, Kathrin S. Michelsen

    DDW  2019.05  -  2019.05 

  • TL1A-deficiency (but not DR3-deficiency) protects from the development of colitis in the chronic T cell transfer mouse model by decreasing TH1 cell accumulation in the intestinal mucosa

    Shimodaira Y, Kanazawa Y, Abraham J, Kumagai K, Jacob N, Ye Y, Luu J, Blackwood A, Michelsen K, Targan S, Shih D

    DDW  2018.06  -  2018.06