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Disruption of small GTPase Rab7 exacerbates the severity of acute pancreatitis in experimental mouse models.
, Mashima H, Miura K, Maeda D, Goto A, Goto T, Sun-Wada GH, Wada Y, Ohnishi H.
Scientific Reports 2017年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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急性膵炎発症・進展における細胞内膜小胞輸送の役割
眞嶋 浩聡, 大西 洋英
膵臓 ( 日本膵臓学会 ) 33 ( 4 ) 723 - 729 2018年08月
総説・解説（学術雑誌） 単著
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Chiba M.
Internal Medicine ( Internal Medicine ) 60 ( 2 ) 247 - 250 2021年01月
<p>We herein report a case of recurrence of epithelial ovarian carcinoma 41 years after the primary surgery that was diagnosed by an endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB). The differential diagnosis based on the imaging findings was difficult. We performed an EUS-FNB and compared the EUS-FNB specimen to the surgical specimen that had been resected in the primary surgery for ovarian carcinoma 41 years earlier, including immunohistochemical staining. Finally, we made a definitive diagnosis of extremely late recurrence of ovarian carcinoma of the retroperitoneum. An EUS-FNB enables an accurate histological diagnosis by obtaining a sample that is large enough to perform immunohistochemical staining. </p>
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The role of calcium-binding protein S100g (CalbindinD-9K) and annexin A10 in acute pancreatitis
Mashima H.
Biochemical and Biophysical Research Communications ( Biochemical and Biophysical Research Communications ) 526 ( 3 ) 692 - 698 2020年06月
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Matsuzawa H.
Internal Medicine ( Internal Medicine ) 59 ( 16 ) 2077 - 2081 2020年
<p>Splenic sarcoidosis is often diagnosed by splenectomy or an ultrasound-guided splenic biopsy. However, splenectomy is invasive and costly, and a percutaneous biopsy is sometimes difficult. We herein report a case of splenic sarcoidosis diagnosed with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). A 71-year-old man was referred to our hospital for abnormal shadows on a chest roentgenogram. Computed tomography showed multiple lesions in the spleen and pulmonary consolidations. Bronchoscopy revealed no definitive diagnosis. We therefore performed EUS-FNA for a splenic lesion that led to the diagnosis. This case suggests that EUS-FNA is useful in confirming the diagnosis of sarcoidosis with suspected splenic lesions. </p>
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高橋 健一, 眞嶋 浩聡, 大西 洋英
膵臓 ( 日本膵臓学会 ) 33 ( 4 ) 723 - 729 2018年
<p>膵腺房細胞は人体において各種蛋白合成が最も盛んな細胞の一つである．その機能維持には，消化酵素の膵管への分泌を司る調節性外分泌や，細胞内のクリアランス機構であるオートファジー，細胞外物質の取り込み機能であるエンドサイトーシスなど様々な細胞内膜小胞輸送機構が機能している．これら細胞内膜小胞輸送にはsoluble N-ethylmaleimide-sensitive factor attachment protein receptor（SNARE）蛋白やオートファジー関連遺伝子，低分子量G蛋白質Rabファミリーなどが関与しており，その分子機能の解析により細胞内膜小胞輸送系の異常と急性膵炎発症・進展の関連が示唆されている．膵炎発症・進展メカニズム解明において，各細胞内膜小胞輸送機構の詳細な検討，並びに各輸送機構間の相互作用を含めた網羅的検討が重要である．</p>