研究等業績 - その他 - 和田　優貴

前立腺癌に対する密封小線源療法におけるPSA低下率の臨床的意義

小林 瑞貴, 沼倉 一幸, 武藤 弓奈, 佐藤 博美, 小泉 淳, 奈良 健平, 神田 壮平, 齋藤 満, 成田 伸太郎, 井上 高光, 佐藤 滋, 羽渕 友則, 熊谷 聡, 和田 優貴, 安倍 明

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  57回   P108 - 4   2019年10月

Correction to: Postmortem computed tomographic features in the diagnosis of drowning: a comparison of fresh water and salt water drowning cases

Makoto Sugawara, Koichi Ishiyama, Satoshi Takahashi, Takahiro Otani, Makoto Koga, Osamu Watanabe, Masazumi Matsuda, Tomoyuki Asano, Noriko Takagi, Tomoki Tozawa, Yuki Wada, Aoi Otaka, Satoshi Kumagai, Motoko Sasajima, Manabu Hashimoto

Japanese Journal of Radiology ( Springer Science and Business Media LLC )  37 ( 9 ) 666 - 667   2019年09月

Whereas in FWDCs, a significantly larger volume and lower density of fluid in the paranasal sinuses (P = 0.0195 and P = 0.0104, respectively), lower density of fluid in the central airways (P = 0.0077), lower stomach content density (P = 0.0216), lower density in the left atrium (P = 0.0029), and a difference of density between the atria (P = 0.0019) were observed.

DOI PubMed

Correction to: Postmortem computed tomographic features in the diagnosis of drowning: a comparison of fresh water and salt water drowning cases (Japanese Journal of Radiology, (2019), 37, 3, (220-229), 10.1007/s11604-018-0802-8)

Sugawara M.

Japanese Journal of Radiology ( Japanese Journal of Radiology )  37 ( 9 ) 666 - 667   2019年09月

DOI

Effect of the types of pretreatment imaging modalities on the treatment response to palliative radiation for painful bone metastases from solid cancer: A single-center retrospective analysis

Wada Y.

Radiation Oncology ( Radiation Oncology )  14 ( 1 ) 1 - 7   2019年06月

Background: Determining the appropriate gross tumor volume is important for irradiation planning in addition to palliative radiation for bone metastases. While irradiation planning is commonly performed using simulation computed tomography (CT), magnetic resonance imaging (MRI), bone scintigraphy, and 18fluorodeoxyglucose-positron emission tomography-CT (18FDG-PET-CT) are more sensitive for detecting bone metastasis and invasion areas. Therefore, this study evaluated whether pretreatment imaging modalities influenced the response to palliative radiation therapy (i.e., the irradiation effect) for painful bone metastases from solid malignant carcinomas. Methods: Consecutive patients with painful bone metastases treated with palliative radiation between January 2013 and December 2017 at our institution were included. We retrospectively investigated the pretreatment images from the different imaging modalities (CT, MRI, bone scintigraphy, and 18FDG-PET-CT) obtained between 1 month before and the initiation of palliative radiation and determined the primary site of carcinoma, histological type, metastatic lesion type (osteolytic, osteoblastic, or mixed), pathological fracture, and metastatic site (vertebral or not). We then evaluated the relationship between these factors and treatment response. We defined "response" as the condition in which patients achieved pain relief or reduced the use of painkiller medicines. Results: In total, 131 patients (78 men and 53 women) were included; the median age was 66 years (range, 24-89 years). Prescribed doses were 8-50 Gy/1-25 fractions with 2-8 Gy/fraction. Among the 131 patients, 105 were responders (response rate, 80%). The imaging modalities performed before irradiation were CT in 131 patients, MRI in 54, bone scintigraphy in 56, and 18FDG-PET-CT in 14. The Welch t-test and chi-square test showed no significant association between treatment response and each factor. Multiple logistic regression analysis including the imaging modality, metastatic site, and pathological fracture also showed no significant association with each factor. Conclusions: There was no significant relationship between the type of pretreatment imaging and treatment response for painful bone metastases. Thus, setting the appropriate radiation field according to CT images and clinical findings could help avoiding further image inspection before palliative radiation for painful bone metastases.

DOI PubMed

乳房原発悪性リンパ腫に逐次的化学放射線療法を施行して長期完全寛解を得ている1例

熊谷 聡, 和田 優貴, 笹嶋 素子, 高木 倫子, 安倍 明, 橋本 学, 亀岡 吉弘, 南條 博

Japanese Journal of Radiology ( (公社)日本医学放射線学会 )  37 ( Suppl. ) 12 - 12   2019年02月

シスプラチン投与食道がん患者の腎機能に及ぼす降圧剤の影響

熊谷優, 赤嶺由美子, 安倍明, 和田優貴, 戸沢智樹, 笹嶋素子, 熊谷聡, 橋本学, 三浦昌朋

日本病院薬剤師会雑誌 ( (一社)日本病院薬剤師会 )  55 ( 7 ) 805 - 812   2019年

シスプラチンの腎毒性発現リスクはカルシウム拮抗薬(calcium channel blocker:以下、CCB)との併用によって増強されることが動物にて報告されているが、ヒトでの報告は少ない。今回、シスプラチン投与食道がん患者の腎機能に及ぼす降圧剤の影響を調査した。食道がん放射線化学療法施行患者のうち、降圧剤併用群42名、非併用群71名を調査対象とした。CCB併用群およびアンジオテンシンII受容体拮抗薬(angiotensin II receptor blocker:以下、ARB)あるいはアンジオテンシン変換酵素阻害薬(angiotensin-converting-enzyme inhibitor:以下、ACEI)併用群は非併用群と比べて急性腎障害(acute kidney injury:以下、AKI)の発現頻度が有意に高く(それぞれp=0.001、p=0.011)、またAKI発現時期はシスプラチン治療開始後7日目で最も高かった。シスプラチンと降圧剤の併用によって、AKI発現リスクが高まる可能性が示唆された。シスプラチン治療開始前にCCB、ARBおよびACEI以外の薬剤への変更を提案することが望まれるが、降圧剤使用継続の際は早期からの血液検査のモニタリングが必要と考える。(著者抄録)

Radiation therapy for stage IIIB uterine cervical cancer at our Insitution: treatment outcomes and prognostic factors.

Takagi N, Anbai A, Wada Y, Kumagai S, Okuyama E, Hatakeyama K, Hashimoto M

Akita Journal of Medicine   46 ( 3-4 ) 79 - 90   2019年

CiNii Research

Embosphereを用いた術前塞栓術を施行した頭頸部腫瘍における組織学的検討

松田雅純, 高橋聡, 大谷隆浩, 戸沢智樹, 和田優貴, 菅原真人, 石山公一, 橋本学, 国分康平, 清水宏明, 山崎一春, 山田武千代, 南條博

Japanese Journal of Radiology   37 ( Supplement )   2019年

J-GLOBAL

局所進行食道癌に対する治療戦略 局所進行食道癌に対する我々の治療戦略 化学放射線療法および食道切除

本山 悟, 佐藤 雄亮, 脇田 晃行, 川北 雄太, 長岐 雄志, 南谷 佳弘, 安倍 明, 和田 優貴

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 )  56回   SY18 - 4   2018年10月

Impact of oxygen status on 10B-BPA uptake into human glioblastoma cells, referring to significance in boron neutron capture therapy.

Yuki Wada, Katsumi Hirose, Takaomi Harada, Mariko Sato, Tsubasa Watanabe, Akira Anbai, Manabu Hashimoto, Yoshihiro Takai

Journal of Radiation Research ( Oxford University Press (OUP) )  59 ( 2 ) 122 - 128   2018年03月

Boron neutron capture therapy (BNCT) can potentially deliver high linear energy transfer particles to tumor cells without causing severe damage to surrounding normal tissue, and may thus be beneficial for cases with characteristics of infiltrative growth, which need a wider irradiation field, such as glioblastoma multiforme. Hypoxia is an important factor contributing to resistance to anticancer therapies such as radiotherapy and chemotherapy. In this study, we investigated the impact of oxygen status on 10B uptake in glioblastoma cells in vitro in order to evaluate the potential impact of local hypoxia on BNCT. T98G and A172 glioblastoma cells were used in the present study, and we examined the influence of oxygen concentration on cell viability, mRNA expression of L-amino acid transporter 1 (LAT1), and the uptake amount of 10B-BPA. T98G and A172 glioblastoma cells became quiescent after 72 h under 1% hypoxia but remained viable. Uptake of 10B-BPA, which is one of the agents for BNCT in clinical use, decreased linearly as oxygen levels were reduced from 20% through to 10%, 3% and 1%. Hypoxia with <10% O2 significantly decreased mRNA expression of LAT1 in both cell lines, indicating that reduced uptake of 10B-BPA in glioblastoma in hypoxic conditions may be due to reduced expression of this important transporter protein. Hypoxia inhibits 10B-BPA uptake in glioblastoma cells in a linear fashion, meaning that approaches to overcoming local tumor hypoxia may be an effective method of improving the success of BNCT treatment.

DOI PubMed CiNii Research

食道がん患者におけるシスプラチンと降圧薬併用による腎機能への影響

熊谷優, 赤嶺由美子, 安倍明, 和田優貴, 戸沢智樹, 笹嶋素子, 熊谷聡, 橋本学, 三浦昌朋

日本医療薬学会年会講演要旨集(Web)   28   2018年

J-GLOBAL

局所進行食道癌に対する化学放射線療法および手術治療

本山悟, 佐藤雄亮, 脇田晃行, 川北雄大, 長岐雄志, 和田優貴, 安倍明

癌の臨床   64 ( 4 ) 243 - 250   2018年

術後リンパ漏に対するリンパ節リンパ管造影の検討

石山 公一, 古賀 誠, 浅野 友之, 菅原 真人, 戸沢 智樹, 和田 優貴, 橋本 学, 劉 嘉嘉, 佐藤 雄亮, 本山 悟

IVR: Interventional Radiology ( (一社)日本インターベンショナルラジオロジー学会 )  32 ( Suppl. ) 306 - 306   2017年04月

Unruptured giant aneurysm of the inferior pancreaticoduodenal artery with superior mesenteric artery stenosis obstructed by spontaneous thrombosis after superior mesenteric artery angioplasty: a case report.

Yuki Wada, Satoshi Takahashi, Makoto Koga, Katsuhito Seki, Manabu Hashimoto

Interventional Radiology ( 一般社団法人 日本インターベンショナルラジオロジー学会 )  1 ( 2 ) 53 - 58   2017年03月

<p>Most pancreaticoduodenal artery aneurysms involve celiac trunk stenosis or occlusion. Few cases have been related to superior mesenteric artery (SMA) stenosis, and none of these was treated with SMA angioplasty before transcatheter arterial embolization (TAE) or operative resection of the aneurysm. We treated a 79-year-old woman with incidentally detected inferior pancreaticoduodenal artery aneurysms, presumably secondary to SMA stenosis. Abdominal angiography indicated that TAE of the aneurysms would disturb collateral flow and cause SMA ischemia, so SMA angioplasty was performed before TAE of the aneurysms. Arteriography of the SMA six days after angioplasty revealed partial thrombosis in the giant aneurysm. The smaller aneurysm was then embolized to occlude collateral flow, which facilitated further thrombosis of the giant aneurysm without recurrence.</p>

DOI

Evaluation of the CT angiogram sign and its relationship with the pathological finding of resected primary solid lung cancer in light of modern advances in the technology of CT scanners.

Wada Yuki, Ishiyama Kouichi, Tozawa Tomoki, Otaka Aoi, Takagi Noriko, Asano Tomoyuki, Sugawara Makoto, Nanjo Hiroshi, Saito Hajime, Minamiya Yoshihiro, Hashimoto Manabu

Akita Journal of Medicine   44 ( 3 ) 139 - 146   2017年  [査読有り]

海綿静脈洞部硬膜動静脈瘻の経静脈性塞栓術における蝶形頭頂静脈洞造影の有用性

高橋聡, 大谷隆浩, 古賀誠, 戸沢智樹, 和田優貴, 松田雅純, 橋本学, 国分康平, 柳澤俊晴, 清水宏明

日本神経放射線学会プログラム・抄録集   46th   2017年

J-GLOBAL

切除不能甲状腺原発扁平上皮癌に対してlenvatinibに放射線外照射を併用し良好な局所制御が得られた1例

和田優貴、安倍明、髙木倫子、高橋絵梨子、寺田かおり、伊藤亜樹、南條博、橋本学

臨床放射線   61 ( 7 ) 953 - 958   2016年07月  [査読有り]

研究論文（その他学術会議資料等）   国内共著

当院救命救急センターにおける死後CT検査の有用性の検討

和田優貴、宮内孝治、橋本学

秋田赤十字病院医学雑誌   3 ( 1 ) 8 - 11   2015年04月  [査読有り]

研究論文（その他学術会議資料等）   国内共著

外傷性頭蓋内出血に及ぼす抗血栓薬と易転倒性の影響

和田優貴、照井元、西巻啓一、五十嵐厳、岩谷真人、青木勇

日赤医学   64 ( 2 ) 406 - 409   2013年09月  [招待有り]

研究論文（その他学術会議資料等）   国内共著